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4. The OVAREX study: Establishment of ex vivo ovarian cancer models to validate innovative therapies and to identify predictive biomarkers

Author

Thorel, Lucie, Divoux, Jordane, Lequesne, Justine, Babin, Guillaume, Morice, Pierre-Marie, Florent, Romane, Desmartin, Guillaume, Lecouflet, Lucie, Marde Alagama, Chloé, Leconte, Alexandra, Clarisse, Bénédicte, Briand, Mélanie, Rouzier, Roman, Gaichies, Léopold, Martin-Françoise, Sandrine, Le Brun, Jean-François, Denoyelle, Christophe, Vigneron, Nicolas, Jeanne, Corinne, Blanc-Fournier, Cécile, Leman, Raphaël, Vaur, Dominique, Figeac, Martin, Meryet-Figuiere, Matthieu, Joly, Florence, Weiswald, Louis-Bastien, Poulain, Laurent, and Dolivet, Enora

Published
2024
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5. Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway

Author

Licaj, Monika, Mhaidly, Rana, Kieffer, Yann, Croizer, Hugo, Bonneau, Claire, Meng, Arnaud, Djerroudi, Lounes, Mujangi-Ebeka, Kevin, Hocine, Hocine R., Bourachot, Brigitte, Magagna, Ilaria, Leclere, Renaud, Guyonnet, Lea, Bohec, Mylene, Guérin, Coralie, Baulande, Sylvain, Kamal, Maud, Le Tourneau, Christophe, Lecuru, Fabrice, Becette, Véronique, Rouzier, Roman, Vincent-Salomon, Anne, Gentric, Geraldine, and Mechta-Grigoriou, Fatima

Published
2024
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13. Contribution of endocrine therapy in oestrogen receptor-positive pT1a-b breast cancer: Results of a retrospective study

Author

Houvenaeghel, Gilles, de Nonneville, Alexandre, Cohen, Monique, Classe, Jean-Marc, Reyal, Fabien, Mazouni, Chafika, Faure, Christelle, Martinez, Alejandra, Chauvet, Marie-Pierre, Daraï, Emile, Coutant, Charles, Colombo, Pierre-Emmanuel, Gimbergues, Pierre, Azuar, Anne-Sophie, Rouzier, Roman, Tunon de Lara, Christine, Crochet, Patrice, Rua, Sandrine, and Gonçalves, Anthony

Published
2022
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14. Optimal timing of interval debulking surgery for advanced epithelial ovarian cancer: A retrospective study from the ESME national cohort

Author

Thomas, Quentin Dominique, Boussere, Amal, Classe, Jean-Marc, Pomel, Christophe, Costaz, Hélène, Rodrigues, Manuel, Ray-Coquard, Isabelle, Gladieff, Laurence, Rouzier, Roman, Rouge, Thibault De La Motte, Gouy, Sébastien, Barranger, Emmanuel, Sabatier, Renaud, Floquet, Anne, Marchal, Frédéric, Guillemet, Cécile, Polivka, Valentine, Martin, Anne-Laure, Colombo, Pierre-Emmanuel, and Fiteni, Frédéric

Published
2022
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16. Prevention of lymphocele or seroma after mastectomy and axillary lymphadenectomy for breast cancer: systematic review and meta-analysis

Author

Crestani Adrien, Mahiou Katia, Bodet Marie-Lucile, Roosen Alice, Bonneau Claire, and Rouzier Roman

Subjects
Medicine, Science
Abstract

Abstract Seroma or lymphocele remains the most common complication after mastectomy and lymphadenectomy for breast cancer. Many different techniques are available to prevent this complication: wound drainage, reduction of the dead space by flap fixation, use of various types of energy, external compression dressings, shoulder immobilization or physical activity, as well as numerous drugs and glues. We searched MEDLINE, clinicaltrials.gov, Cochrane Library, and Web of Science databases for publications addressing the issue of prevention of lymphocele or seroma after mastectomy and axillary lymphadenectomy. Quality was assessed using Hawker’s quality assessment tool. Incidence of seroma or lymphocele were collected. Fifteen randomized controlled trials including a total of 1766 patients undergoing radical mastectomy and axillary lymphadenectomy for breast cancer were retrieved. The incidence of lymphocele or seroma in the study population was 24.2% (411/1698): 25.2% (232/920) in the test groups and 23.0% (179/778) in the control groups. Neither modification of surgical technique (RR 0.86; 95% CI [0.72, 1.03]) nor application of a medical treatment (RR 0.96; 95% CI [0.72, 1.29]) was effective in preventing lymphocele. On the contrary, decreasing the drainage time increased the risk of lymphocele (RR 1.88; 95% CI [1.43, 2.48). There was no publication bias but the studies were of medium to low quality. To conclude, despite the heterogeneity of study designs, drainage appears to be the most effective technique, although the overall quality of the data is low.

Published
2022
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21. Clinicopathological characterization of a real-world multicenter cohort of endometrioid ovarian carcinoma: Analysis of the French national ESME-Unicancer database

Author

De Nonneville, Alexandre, Zemmour, Christophe, Frank, Sophie, Joly, Florence, Ray-Coquard, Isabelle, Costaz, Hèlène, Classe, Jean-Marc, Floquet, Anne, De la Motte Rouge, Thibault, Colombo, Pierre-Emmanuel, Sauterey, Baptiste, Leblanc, Eric, Pomel, Christophe, Marchal, Frédéric, Barranger, Emmanuel, Savoye, Aude-Marie, Guillemet, Cécile, Petit, Thierry, Pautier, Patricia, Rouzier, Roman, Gladieff, Laurence, Simon, Gaëtane, Courtinard, Coralie, and Sabatier, Renaud

Published
2021
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22. Correction to: Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

Author

Kamal, Maud, Lameiras, Sonia, Deloger, Marc, Morel, Adeline, Vacher, Sophie, Lecerf, Charlotte, Dupain, Célia, Jeannot, Emmanuelle, Girard, Elodie, Baulande, Sylvain, Dubot, Coraline, Kenter, Gemma, Jordanova, Ekaterina S., Berns, Els M. J. J., Bataillon, Guillaume, Popovic, Marina, Rouzier, Roman, Cacheux, Wulfran, Le Tourneau, Christophe, Nicolas, Alain, Servant, Nicolas, Scholl, Suzy M., and Bièche, Ivan

Published
2023
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23. A catalog of numerical centrosome defects in epithelial ovarian cancers

Author

Morretton, Jean‐Philippe, Simon, Anthony, Herbette, Aurélie, Barbazan, Jorge, Pérez‐González, Carlos, Cosson, Camille, Mboup, Bassirou, Latouche, Aurélien, Popova, Tatiana, Kieffer, Yann, Macé, Anne‐Sophie, Gestraud, Pierre, Bataillon, Guillaume, Becette, Véronique, Meseure, Didier, Nicolas, André, Mariani, Odette, Vincent‐Salomon, Anne, Stern, Marc‐Henri, Mechta‐Grigoriou, Fatima, Roman Roman, Sergio, Vignjevic, Danijela Matic, Rouzier, Roman, Sastre‐Garau, Xavier, Goundiam, Oumou, and Basto, Renata

Published
2022
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26. Recommandations francophones pour la pratique clinique concernant la prise en charge des cancers du sein de Saint-Paul-de-Vence 2022-2023

Author

Aapro, Matti, Al-Ghazali, Hesham, Bachelot, Thomas, Barranger, Emmanuel, Berrada, Narjiss, Bidard, François-Clément, Bounedjar, Adda, Boussen, Hamouda, Campone, Mario, Cardoso, Fatima, Ceugnart, Luc, Classe, Jean-Marc, Cohen, Monique, Coutant, Charles, Cutuli, Bruno, Dalenc, Florence, Dieras, Véronique, Dohollou, Nadine, Giacchetti, Sylvie, Goncalves, Anthony, Freyer, Gilles, Hannoun-Levi, Jean-Michel, Hardy-Bessard, Anne-Claire, Jacquin, Jean-Philippe, Jacot, William, Kerrou, Khaldoun, Ladoire, Sylvain, Lerebours, Florence, Levy, Christelle, Llombart-Cussac, Antonio, Loirat, Delphine, Thomassin, Isabelle, Piccart, Martine, Petit, Thierry, Radosevic-Robin, Nina, Rotenberg, Luc, Rouzier, Roman, Salmon, Rémy, Vincent-Salomon, Anne, Spano, Jean-Philippe, Tallet, Agnès, Teixera, Luis, Tredan, Olivier, Verret, Benjamin, Zarca, Daniel, Zelek, Laurent, Zerbib, Eric, Gligorov, Joseph, Benderra, Marc-Antoine, Barthere, Xavier, de Forceville, Louise, Antoine, Eric Charles, Cottu, Paul Henri, Delaloge, Suzette, Pierga, Jean-Yves, Belkacemi, Yazid, Houvenaegel, Gilles, Pujol, Pascal, Rivera, Sofia, Spielmann, Marc, Penault-Llorca, Frédérique, and Namer, Moise

Published
2023
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27. Eligibility for Adjuvant Cyclin-Dependent Kinase 4/6 Inhibitors in Endocrine Receptor-Positive and HER2-Negative Early Breast Cancer by Age and Type of Surgery.

Author

Houvenaeghel, Gilles, Classe, Jean-Marc, Chauvet, Marie-Pierre, Colombo, Pierre-Emmanuel, Jouve, Eva, Reyal, Fabien, Daraï, Emile, Rouzier, Roman, Faure-Virelizier, Christelle, Gimbergues, Pierre, Coutant, Charles, Mazouni, Chafika, Azuar, Anne-Sophie, Martino, Marc, Bouteille, Catherine, Cohen, Monique, and de Nonneville, Alexandre

Subjects
BREAST cancer prognosis, BREAST tumors, PROTEIN-tyrosine kinase inhibitors, AGE distribution, RETROSPECTIVE studies, TUMOR grading, ADJUVANT chemotherapy, ONCOGENES, HORMONE therapy, MEDICAL records, ACQUISITION of data, CYCLIN-dependent kinases, LUMPECTOMY, CHEMICAL inhibitors
Abstract

Simple Summary: Improved outcomes have been reported with adjuvant treatment combining cyclin-dependent kinase 4/6 inhibitors with endocrine therapy, in high-risk patients with ER-positive and HER2-negative breast cancer, regardless of age. In this real-world data analysis, MonarchE and NataLEE high-risk patients accounted for 9.5% and 33% of patients undergoing upfront surgery, respectively. Significantly higher eligibility rates were observed in patients who underwent a mastectomy, >70 years and ≤40 years for adjuvant abemaciclib and ribociclib, and in patients >80 years for ribociclib. A higher discontinuation rate for abemaciclib was reported in patients ≥65 years and it can be assumed that discontinuation rates may increase with more older patients. If the results of the NataLEE trial translate into clinical practice, the number of patients potentially eligible for adjuvant CDK4/6 inhibitors may increase, especially in the elderly population. Background: Despite early diagnosis, approximately 20% of patients with ER-positive and HER2-negative breast cancer (BC) will experience disease recurrence. Improved survival has been reported with adjuvant treatment combining cyclin-dependent kinase 4/6 inhibitors with endocrine therapy, in high-risk patients with ER-positive and HER2-negative BC, regardless of age. Older patients have higher rates of ER-positive/HER2-negative BC than younger patients. Methods: In this real-world data analysis, MonarchE and NataLEE high-risk patients accounted for 9.5% and 33% of patients undergoing upfront surgery, respectively. Significantly higher eligibility rates were observed in patients who underwent a mastectomy, >70 years and ≤40 years for adjuvant abemaciclib and ribociclib, and in patients >80 years for ribociclib. Results: Eligibility rates in patients ≤40 years and >80 years who underwent mastectomy were 27.8% and 24.7% for abemaciclib, respectively, and 56.6% and 65.2% for ribociclib, respectively. A higher discontinuation rate for abemaciclib was reported in patients aged ≥65 years and it can be assumed that discontinuation rates may increase in even older patients. Conclusions: If the results of the NataLEE trial translate into clinical practice, the number of patients potentially eligible for adjuvant CDK4/6 inhibitors may increase, especially in the elderly population. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Genetic markers and phosphoprotein forms of beta-catenin pβ-Cat552 and pβ-Cat675 are prognostic biomarkers of cervical cancer

Author

Scholl, Suzy M, Beal, Jonas, de Koning, Leanne, Girard, Elodie, Popovic, Marina, de la Rochefordière, Anne, Lecuru, Fabrice, Fourchotte, Virginie, Ngo, Charlotte, Floquet, Anne, Berns, Els MJJ, Kenter, Gemma, Gestraud, Pierre, von der Leyen, Heiko, Lecerf, Charlotte, Puard, Vincent, Roman, Sergio Roman, Latouche, Aurelien, Kereszt, Attila, Balint, Balazs, Rouzier, Roman, and Kamal, Maud

Published
2020
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30. Quand le féminin est mis à mal … À propos d’une prise de poids significative chez des jeunes femmes en post-annonce diagnostique d’une agénésie utéro-vaginale

Author

Ouallouche, Chloé, Nataf, Nicole, Bidet, Maud, Cheikhelard, Alaa, Paniel, Jean-Bertrand, Louis-Sylvestre, Christine, Morcel, Karine, Viaud, Magali, Elie, Caroline, Baptiste, Amandine, Aigrain, Yves, Darai, Emile, Rouzier, Roman, Descamps, Philippe, Brun, Jean-Luc, Ranke, Aline, Lopes, Patrice, Pienkowski, Catherine, Leguevaque, Pierre, Gueniche, Karinne, Vibert, Sarah, Guinard, Maïa, and Polak, Michel

Published
2020
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32. COVID-19 et personnes suivies pour un cancer du sein : recommandations françaises pour la pratique clinique de Nice-St Paul de Vence, en collaboration avec le Collège Nationale des Gynécologues et Obstétriciens Français (CNGOF), la Société d’Imagerie de la Femme (SIFEM), la Société Française de Chirurgie Oncologique (SFCO), la Société Française de Sénologie et Pathologie Mammaire (SFSPM) et le French Breast Cancer Intergroup-UNICANCER (UCBG)

Author

Gligorov, Joseph, Bachelot, Thomas, Pierga, Jean-Yves, Antoine, Eric-Charles, Balleyguier, Corinne, Barranger, Emmanuel, Belkacemi, Yazid, Bonnefoi, Hervé, Bidard, François-Clément, Ceugnart, Luc, Classe, Jean-Marc, Cottu, Paul, Coutant, Charles, Cutuli, Bruno, Dalenc, Florence, Darai, Emile, Dieras, Veronique, Dohollou, Nadine, Giacchetti, Sylvie, Goncalves, Anthony, Hardy-Bessard, Anne-Claire, Houvenaeghel, Gilles, Jacquin, Jean-Philippe, Jacot, William, Levy, Christelle, Mathelin, Carole, Nisand, Israel, Petit, Thierry, Poncelet, Edouard, Rivera, Sofia, Rouzier, Roman, Salmon, Rémy, Scotté, Florian, Spano, Jean-Philippe, Uzan, Catherine, Zelek, Laurent, Spielmann, Marc, Penault-Llorca, Frédérique, Namer, Moise, and Delaloge, Suzette

Published
2020
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33. Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

Author

Kamal, Maud, Lameiras, Sonia, Deloger, Marc, Morel, Adeline, Vacher, Sophie, Lecerf, Charlotte, Dupain, Célia, Jeannot, Emmanuelle, Girard, Elodie, Baulande, Sylvain, Dubot, Coraline, Kenter, Gemma, Jordanova, Ekaterina S., Berns, Els M. J. J., Bataillon, Guillaume, Popovic, Marina, Rouzier, Roman, Cacheux, Wulfran, Le Tourneau, Christophe, Nicolas, Alain, Servant, Nicolas, Scholl, Suzy M., and Bièche, Ivan

Published
2021
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38. Fertility preservation, contraception and menopause hormone therapy in women treated for rare ovarian tumours: guidelines from the French national network dedicated to rare gynaecological cancers

Author

Rousset-Jablonski, Christine, Selle, Fréderic, Adda-Herzog, Elodie, Planchamp, François, Selleret, Lise, Pomel, Christophe, Daraï, Emile, Chabbert-Buffet, Nathalie, Pautier, Patricia, Trémollières, Florence, Guyon, Frederic, Rouzier, Roman, Laurence, Valérie, Chopin, Nicolas, Faure-Conter, Cécile, Bentivegna, Enrica, Vacher-Lavenu, Marie-Cécile, Lhomme, Catherine, Floquet, Anne, Treilleux, Isabelle, Lecuru, Fabrice, Gouy, Sébastien, Kalbacher, Elsa, Genestie, Catherine, Thibault, de la Motte Rouge, Ferron, Gwenael, Devouassoux, Mojgan, Kurtz, Jean-Emmanuel, Provansal, Magali, Namer, Moise, Joly, Florence, Pujade-Lauraine, Eric, Grynberg, Michael, Querleu, Denis, Morice, Philippe, Gompel, Anne, and Ray-Coquard, Isabelle

Published
2019
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39. Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome

Author

Scholl, Suzy, Popovic, Marina, de la Rochefordiere, Anne, Girard, Elodie, Dureau, Sylvain, Mandic, Aljosa, Koprivsek, Katarina, Samet, Nina, Craina, Marius, Margan, Madalin, Samuels, Sanne, Zijlmans, Henry, Kenter, Gemma, Hillemanns, Peter, Dema, Sorin, Dema, Alis, Malenkovic, Goran, Djuran, Branislav, Floquet, Anne, Garbay, Delphine, Guyon, Frédéric, Colombo, Pierre Emmanuel, Fabbro, Michel, Kerr, Christine, Ngo, Charlotte, Lecuru, Fabrice, Campo, Eleonor Rivin del, Coutant, Charles, Marchal, Frédéric, Mesgouez-Nebout, Nathalie, Fourchotte, Virginie, Feron, Jean Guillaume, Morice, Philippe, Deutsch, Eric, Wimberger, Pauline, Classe, Jean-Marc, Gleeson, Noreen, von der Leyen, Heiko, Minsat, Mathieu, Dubot, Coraline, Gestraud, Pierre, Kereszt, Attila, Nagy, Istvan, Balint, Balazs, Berns, Els, Jordanova, Ekaterina, Saint-Jorre, Nicolas de, Savignoni, Alexia, Servant, Nicolas, Hupe, Philippe, de Koning, Leanne, Fumoleau, Pierre, Rouzier, Roman, and Kamal, Maud

Published
2019
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41. Recommandations francophones pour la pratique clinique concernant la prise en charge des cancers du sein de Saint-Paul-de-Vence 2022-2023

Author

Gligorov, Joseph, primary, Benderra, Marc-Antoine, additional, Barthere, Xavier, additional, de Forceville, Louise, additional, Antoine, Eric Charles, additional, Cottu, Paul Henri, additional, Delaloge, Suzette, additional, Pierga, Jean-Yves, additional, Belkacemi, Yazid, additional, Houvenaegel, Gilles, additional, Pujol, Pascal, additional, Rivera, Sofia, additional, Spielmann, Marc, additional, Penault-Llorca, Frédérique, additional, Namer, Moise, additional, Aapro, Matti, additional, Al-Ghazali, Hesham, additional, Bachelot, Thomas, additional, Barranger, Emmanuel, additional, Berrada, Narjiss, additional, Bidard, François-Clément, additional, Bounedjar, Adda, additional, Boussen, Hamouda, additional, Campone, Mario, additional, Cardoso, Fatima, additional, Ceugnart, Luc, additional, Classe, Jean-Marc, additional, Cohen, Monique, additional, Coutant, Charles, additional, Cutuli, Bruno, additional, Dalenc, Florence, additional, Dieras, Véronique, additional, Dohollou, Nadine, additional, Giacchetti, Sylvie, additional, Goncalves, Anthony, additional, Freyer, Gilles, additional, Hannoun-Levi, Jean-Michel, additional, Hardy-Bessard, Anne-Claire, additional, Jacquin, Jean-Philippe, additional, Jacot, William, additional, Kerrou, Khaldoun, additional, Ladoire, Sylvain, additional, Lerebours, Florence, additional, Levy, Christelle, additional, Llombart-Cussac, Antonio, additional, Loirat, Delphine, additional, Thomassin, Isabelle, additional, Piccart, Martine, additional, Petit, Thierry, additional, Radosevic-Robin, Nina, additional, Rotenberg, Luc, additional, Rouzier, Roman, additional, Salmon, Rémy, additional, Vincent-Salomon, Anne, additional, Spano, Jean-Philippe, additional, Tallet, Agnès, additional, Teixera, Luis, additional, Tredan, Olivier, additional, Verret, Benjamin, additional, Zarca, Daniel, additional, Zelek, Laurent, additional, and Zerbib, Eric, additional

Published
2023
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42. Medullary Breast Carcinoma, a Triple-Negative Breast Cancer Associated with BCLG Overexpression

Author

Romero, Pierre, Benhamo, Vanessa, Deniziaut, Gabrielle, Fuhrmann, Laetitia, Berger, Frédérique, Manié, Elodie, Bhalshankar, Jaydutt, Vacher, Sophie, Laurent, Cécile, Marangoni, Elisabetta, Gruel, Nadège, MacGrogan, Gaëtan, Rouzier, Roman, Delattre, Olivier, Popova, Tatiana, Reyal, Fabien, Stern, Marc-Henri, Stoppa-Lyonnet, Dominique, Marchiò, Caterina, Bièche, Ivan, and Vincent-Salomon, Anne

Published
2018
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43. Préservation de la fertilité, contraception et traitement hormonal de la ménopause chez les femmes traitées pour tumeurs malignes rares de l’ovaire : recommandations du réseau national dédié aux cancers gynécologiques rares (TMRG/GINECO)

Author

Rousset-Jablonski, Christine, Selle, Fréderic, Adda-Herzog, Elodie, Planchamp, François, Selleret, Lise, Pomel, Christophe, Chabbert-Buffet, Nathalie, Daraï, Emile, Pautier, Patricia, Trémollières, Florence, Guyon, Frederic, Rouzier, Roman, Laurence, Valérie, Chopin, Nicolas, Faure-Conter, Cécile, Bentivegna, Enrica, Vacher-Lavenu, Marie-Cécile, Lhomme, Catherine, Floquet, Anne, Treilleux, Isabelle, Lecuru, Fabrice, Gouy, Sébastien, Kalbacher, Elsa, Genestie, Catherine, de la Motte Rouge, Thibault, Ferron, Gwenael, Devouassoux-Shisheboran, Mojgan, Kurtz, Jean-Emmanuel, Namer, Moise, Joly, Florence, Pujade-Lauraine, Eric, Grynberg, Michael, Querleu, Denis, Morice, Philippe, Gompel, Anne, and Ray-Coquard, Isabelle

Published
2018
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45. Adjuvant chemotherapy in lobular carcinoma of the breast: a clinicopathological score identifies high-risk patient with survival benefit

Author

de Nonneville, Alexandre, Jauffret, Camille, Gonçalves, Anthony, Classe, Jean-Marc, Cohen, Monique, Reyal, Fabien, Mazouni, Chafika, Chauvet, Marie-Pierre, Chopin, Nicolas, Colombo, Pierre-Emmanuel, Jouve, Eva, Darai, Emile, Rouzier, Roman, Coutant, Charles, Gimbergues, Pierre, Azuar, Anne-Sophie, de Lara, Christine Tunon, Lambaudie, Eric, and Houvenaeghel, Gilles

Published
2019
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46. Relevance of a molecular tumour board (MTB) for patients’ enrolment in clinical trials: experience of the Institut Curie

Author

Basse, Clémence, Morel, Claire, Alt, Marie, Sablin, Marie Paule, Franck, Coralie, Pierron, Gaëlle, Callens, Céline, Melaabi, Samia, Masliah-Planchon, Julien, Bataillon, Guillaume, Gardrat, Sophie, Lavigne, Marion, Bonsang, Benjamin, Vaflard, Pauline, Pons Tostivint, Elvire, Dubot, Coraline, Loirat, Delphine, Marous, Miguelle, Geiss, Romain, Clément, Nathalie, Schleiermacher, Gudrun, Kamoun, Choumouss, Girard, Elodie, Ardin, Maude, Benoist, Camille, Bernard, Virginie, Mariani, Odette, Rouzier, Roman, Tresca, Patricia, Servois, Vincent, Vincent-Salomon, Anne, Bieche, Ivan, Le Tourneau, Christophe, and Kamal, Maud

Published
2018
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