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2. Device-detected atrial sensing amplitudes as a marker of increased risk for new onset and progression of atrial high-rate episodes

Author

Biffi, Mauro, Celentano, Eduardo, Giammaria, Massimo, Curnis, Antonio, Rovaris, Giovanni, Ziacchi, Matteo, Miracapillo, Gennaro, Saporito, Davide, Baroni, Matteo, Quartieri, Fabio, Marini, Massimiliano, Pepi, Patrizia, Senatore, Gaetano, Caravati, Fabrizio, Calvi, Valeria, Tomasi, Luca, Nigro, Gerardo, Bontempi, Luca, Notarangelo, Francesca, Santobuono, Vincenzo Ezio, Boggian, Giulio, Arena, Giuseppe, Solimene, Francesco, Giaccardi, Marzia, Maglia, Giampiero, Perini, Alessandro Paoletti, Volpicelli, Mario, Giacopelli, Daniele, Gargaro, Alessio, and Iacopino, Saverio

Published
2024
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4. Left ventricular assist device in the presence of subcutaneous implantable cardioverter defibrillator: Data from a multicenter experience

Author

Migliore, Federico, Schiavone, Marco, Pittorru, Raimondo, Forleo, Giovanni B., De Lazzari, Manuel, Mitacchione, Gianfranco, Biffi, Mauro, Gulletta, Simone, Kuschyk, Jurgen, Dall'Aglio, Pietro Bernardo, Rovaris, Giovanni, Tilz, Roland, Mastro, Florinda Rosaria, Iliceto, Sabino, Tondo, Claudio, Di Biase, Luigi, Gasperetti, Alessio, Tarzia, Vincenzo, and Gerosa, Gino

Published
2024
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5. Differences in underlying cardiac substrate among S-ICD recipients and its impact on long-term device-related outcomes: Real-world insights from the iSUSI registry

Author

Gasperetti, A., Arosio, R., Viecca, M., Forleo, G.B., Schiavone, M., Tondo, C., Ziacchi, M., Diemberger, I., Angeletti, A., Biffi, M., Fierro, N., Gulletta, S., Della Bella, P., Curnis, G. Mitacchione.A., Compagnucci, P., Casella, M., Russo, A. Dello, Santini, L., Pignalberi, C., Magnocavallo, M., Piro, A., Lavalle, C., Picarelli, F., Ricciardi, D., Bressi, E., Calò, L., Montemerlo, E., Rovaris, G., De Bonis, S., Bisignani, A., Bisignani, G., Russo, G., Pisanò, E., Palmisano, P., Guarracini, F., Vitali, F., Bertini, M., Vogler, J., Fink, T., Tilz, R., Fastenrath, F., Kuschyk, J., Kaiser, L., Hakmi, S., Laredo, M., Waintraub, X., Gandjbakhch, E., Badenco, N., Breitenstein, A., Saguner, A.M., Martine, M., Seidl, S., Di Biase, L., Gasperetti, Alessio, Schiavone, Marco, Milstein, Jenna, Compagnucci, Paolo, Vogler, Julia, Laredo, Mikael, Breitenstein, Alexander, Gulletta, Simone, Martinek, Martin, Casella, Michela, Kaiser, Lukas, Santini, Luca, Rovaris, Giovanni, Curnis, Antonio, Biffi, Mauro, Kuschyk, Jürgen, Di Biase, Luigi, Tilz, Roland, Tondo, Claudio, and Forleo, Giovanni B.

Published
2024
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6. Long-Term Performance of Subcutaneous Implantable Defibrillators in Athletes: A Multicenter, Real-World Analysis of Sport Activities from the iSUSI Registry

Author

Gasperetti, Alessio, Schiavone, Marco, Vogler, Julia, Compagnucci, Paolo, Laredo, Mikael, Breitenstein, Alexander, Gulletta, Simone, Martinek, Martin, Kaiser, Lukas, Lavalle, Carlo, Gaine, Sean, Santini, Luca, Dello Russo, Antonio, Palmisano, Pietro, Rovaris, Giovanni, Curnis, Antonio, Ventrella, Nicoletta, Kuschyk, Jürgen, Biffi, Mauro, Tilz, Roland, Di Biase, Luigi, Tondo, Claudio, and Forleo, Giovanni B.

Published
2024
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7. Leadless pacemakers in patients with different stages of chronic kidney disease: Real-world data from the updated i-LEAPER registry

Author

Mitacchione, Gianfranco, Schiavone, Marco, Gasperetti, Alessio, Tripepi, Giovanni L., Cerini, Manuel, Montemerlo, Elisabetta, Del Monte, Alvise, Bontempi, Luca, Moltrasio, Massimo, Breitenstein, Alexander, Monaco, Cinzia, Palmisano, Pietro, Rovaris, Giovanni, Chierchia, Gian-Battista, Dello Russo, Antonio, Biffi, Mauro, de Asmundis, Carlo, Mazzone, Patrizio, Di Biase, Luigi, Gallieni, Maurizio, Tondo, Claudio, Curnis, Antonio, and Forleo, Giovanni B.

Published
2024
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8. Sex differences in leadless pacemaker implantation: A propensity-matched analysis from the i-LEAPER registry

Author

Mitacchione, Gianfranco, Schiavone, Marco, Gasperetti, Alessio, Arabia, Gianmarco, Tundo, Fabrizio, Breitenstein, Alexander, Montemerlo, Elisabetta, Monaco, Cinzia, Gulletta, Simone, Palmisano, Pietro, Hofer, Daniel, Rovaris, Giovanni, Dello Russo, Antonio, Biffi, Mauro, Pisanò, Ennio C.L., Della Bella, Paolo, Di Biase, Luigi, Chierchia, Gian Battista, Saguner, Ardan M., Tondo, Claudio, Curnis, Antonio, and Forleo, Giovanni B.

Published
2023
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9. Outcomes of leadless pacemaker implantation following transvenous lead extraction in high-volume referral centers: Real-world data from a large international registry

Author

Mitacchione, Gianfranco, Schiavone, Marco, Gasperetti, Alessio, Arabia, Gianmarco, Breitenstein, Alexander, Cerini, Manuel, Palmisano, Pietro, Montemerlo, Elisabetta, Ziacchi, Matteo, Gulletta, Simone, Salghetti, Francesca, Russo, Giulia, Monaco, Cinzia, Mazzone, Patrizio, Hofer, Daniel, Tundo, Fabrizio, Rovaris, Giovanni, Russo, Antonio Dello, Biffi, Mauro, Pisanò, Ennio C.L., Chierchia, Gian Battista, Della Bella, Paolo, de Asmundis, Carlo, Saguner, Ardan M., Tondo, Claudio, Forleo, Giovanni B., and Curnis, Antonio

Published
2023
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11. Prognostic significance of remotely monitored nocturnal heart rate in heart failure patients with reduced ejection fraction

Author

D’Onofrio, Antonio, Marini, Massimiliano, Rovaris, Giovanni, Zanotto, Gabriele, Calvi, Valeria, Iacopino, Saverio, Biffi, Mauro, Solimene, Francesco, Della Bella, Paolo, Caravati, Fabrizio, Pisanò, Ennio C., Amellone, Claudia, D’Alterio, Giuliano, Pedretti, Stefano, Santobuono, Vincenzo E., Russo, Antonio Dello, Nicolis, Daniele, De Salvia, Alberto, Baroni, Matteo, Quartieri, Fabio, Manzo, Michele, Rapacciuolo, Antonio, Saporito, Davide, Maines, Massimiliano, Marras, Elena, Bontempi, Luca, Morani, Giovanni, Giacopelli, Daniele, Gargaro, Alessio, and Giammaria, Massimo

Published
2023
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12. Peri-procedural and mid-term follow-up age-related differences in leadless pacemaker implantation: Insights from a multicenter European registry

Author

Gulletta, Simone, Schiavone, Marco, Gasperetti, Alessio, Breitenstein, Alexander, Palmisano, Pietro, Mitacchione, Gianfranco, Chierchia, Gian Battista, Montemerlo, Elisabetta, Statuto, Giovanni, Russo, Giulia, Casella, Michela, Vitali, Francesco, Mazzone, Patrizio, Hofer, Daniel, Arabia, Gianmarco, Moltrasio, Massimo, Lipartiti, Felicia, Fierro, Nicolai, Bertini, Matteo, Dello Russo, Antonio, Pisanò, Ennio C.L., Biffi, Mauro, Rovaris, Giovanni, de Asmundis, Carlo, Tondo, Claudio, Curnis, Antonio, Della Bella, Paolo, Saguner, Ardan M., and Forleo, Giovanni B.

Published
2023
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13. Ventricular Arrhythmias and Implantable Cardioverter-Defibrillator Therapy in Women: A Propensity Score-Matched Analysis

Author

Maglia, Giampiero, Giammaria, Massimo, Zanotto, Gabriele, D’Onofrio, Antonio, Della Bella, Paolo, Marini, Massimiliano, Rovaris, Giovanni, Iacopino, Saverio, Calvi, Valeria, Pisanò, Ennio C., Ziacchi, Matteo, Curnis, Antonio, Senatore, Gaetano, Caravati, Fabrizio, Saporito, Davide, Forleo, Giovanni B., Pedretti, Stefano, Santobuono, Vincenzo Ezio, Pepi, Patrizia, De Salvia, Alberto, Balestri, Giulia, Maines, Massimiliano, Orsida, Daniela, Bisignani, Giovanni, Baroni, Matteo, Lissoni, Fabio, Bertini, Matteo, Giacopelli, Daniele, Gargaro, Alessio, and Biffi, Mauro

Published
2022
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14. Subcutaneous implantable cardioverter-defibrillator and defibrillation testing: A propensity-matched pilot study

Author

Forleo, Giovanni B., Gasperetti, Alessio, Breitenstein, Alexander, Laredo, Mikael, Schiavone, Marco, Ziacchi, Matteo, Vogler, Julia, Ricciardi, Danilo, Palmisano, Pietro, Piro, Agostino, Compagnucci, Paolo, Waintraub, Xavier, Mitacchione, Gianfranco, Carrassa, Gianmarco, Russo, Giulia, De Bonis, Silvana, Angeletti, Andrea, Bisignani, Antonio, Picarelli, Francesco, Casella, Michela, Bressi, Edoardo, Rovaris, Giovanni, Calò, Leonardo, Santini, Luca, Pignalberi, Carlo, Lavalle, Carlo, Viecca, Maurizio, Pisanò, Ennio, Olivotto, Iacopo, Curnis, Antonio, Dello Russo, Antonio, Tondo, Claudio, Love, Charles J., Di Biase, Luigi, Steffel, Jan, Tilz, Roland, Badenco, Nicolas, and Biffi, Mauro

Published
2021
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15. Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis

Author

Genovesi, Simonetta, Porcu, Luca, Slaviero, Giorgio, Casu, Gavino, Bertoli, Silvio, Sagone, Antonio, Buskermolen, Monique, Pieruzzi, Federico, Rovaris, Giovanni, Montoli, Alberto, Oreglia, Jacopo, Piccaluga, Emanuela, Molon, Giulio, Gaggiotti, Mario, Ettori, Federica, Gaspardone, Achille, Palumbo, Roberto, Viazzi, Francesca, Breschi, Marco, Gallieni, Maurizio, Contaldo, Gina, D’Angelo, Giuseppe, Merella, Pierluigi, Galli, Fabio, Rebora, Paola, Valsecchi, Mariagrazia, and Mazzone, Patrizio

Published
2021
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16. Sex differences among subcutaneous implantable cardioverter-defibrillator recipients: a propensity-matched, multicentre, international analysis from the i-SUSI project.

Author

Schiavone, Marco, Gasperetti, Alessio, Vogler, Julia, Compagnucci, Paolo, Laredo, Mikael, Breitenstein, Alexander, Gulletta, Simone, Martinek, Martin, Kaiser, Lukas, Tundo, Fabrizio, Palmisano, Pietro, Rovaris, Giovanni, Curnis, Antonio, Kuschyk, Jürgen, Biffi, Mauro, Tilz, Roland, Biase, Luigi Di, Tondo, Claudio, Forleo, Giovanni B, and investigators, i-SUSI

Abstract

Aims Women have been historically underrepresented in implantable cardioverter-defibrillator (ICD) trials. No data on sex differences regarding subcutaneous ICDs (S-ICD) carriers have been described. Aim of our study was to investigate sex-related differences among unselected S-ICD recipients. Methods and results Consecutive patients enrolled in the multicentre, international i-SUSI registry were analysed. Comparisons between sexes were performed using a 1:1 propensity matching adjusted analysis for age, body mass index (BMI), left ventricular function, and substrate. The primary outcome was the rate of appropriate shocks during follow-up. Inappropriate shocks and other device-related complications were deemed secondary outcomes. A total of 1698 patients were extracted from the i-SUSI registry; 399 (23.5%) were females. After propensity matching, two cohorts of 374 patients presenting similar baseline characteristics were analysed. Despite similar periprocedural characteristics and a matched BMI, women resulted at lower risk of conversion failure as per PRAETORIAN score (73.4% vs. 81.3%, P = 0.049). Over a median follow-up time of 26.5 [12.7–42.5] months, appropriate shocks were more common in the male cohort (rate/year 3.4% vs. 1.7%; log-rank P = 0.049), while no significant differences in device-related complications (rate/year: 6.3% vs. 5.8%; log-rank P = 0.595) and inappropriate shocks (rate/year: 4.3% vs. 3.1%; log-rank P = 0.375) were observed. After controlling for confounders, sex remained significantly associated with the primary outcome (aHR 1.648; CI 0.999–2.655, P = 0.048), while not resulting predictor of inappropriate shocks and device-related complications. Conclusion In a propensity-matched cohort of S-ICD recipients, women are less likely to experience appropriate ICD therapy, while not showing higher risk of device-related complications. Clinical trial registration ClinicalTrials.gov Identifier: NCT0473876. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Impact of ventricular tachycardia ablation in subcutaneous implantable cardioverter defibrillator carriers: a multicentre, international analysis from the iSUSI project.

Author

Schiavone, Marco, Gasperetti, Alessio, Compagnucci, Paolo, Vogler, Julia, Laredo, Mikael, Montemerlo, Elisabetta, Gulletta, Simone, Breitenstein, Alexander, Ziacchi, Matteo, Martinek, Martin, Casella, Michela, Palmisano, Pietro, Kaiser, Lukas, Lavalle, Carlo, Calò, Leonardo, Seidl, Sebastian, Saguner, Ardan M, Rovaris, Giovanni, Kuschyk, Jürgen, and Biffi, Mauro

Abstract

Aims Catheter ablation (CA) of ventricular tachycardia (VT) has become an important tool to improve clinical outcomes in patients with appropriate transvenous implantable cardioverter defibrillator (ICD) shocks. The aim of our analysis was to test whether VT ablation (VTA) impacts long-term clinical outcomes even in subcutaneous ICD (S-ICD) carriers. Methods and results International Subcutaneous Implantable Cardioverter Defibrillator (iSUSI) registry patients who experienced either an ICD shock or a hospitalization for monomorphic VT were included in this analysis. Based on an eventual VTA after the index event, patients were divided into VTA+ vs. VTA− cohorts. Primary outcome of the study was the occurrence of a combination of device-related appropriate shocks, monomorphic VTs, and cardiovascular mortality. Secondary outcomes were addressed individually. Among n = 1661 iSUSI patients, n = 211 were included: n = 177 experiencing ICD shocks and n = 34 hospitalized for VT. No significant differences in baseline characteristics were observed. Both the crude and the yearly event rate of the primary outcome (5/59 and 3.8% yearly event rate VTA+ vs. 41/152 and 16.4% yearly event rate in the VTA−; log-rank: P value = 0.0013) and the cardiovascular mortality (1/59 and 0.7% yearly event rate VTA+ vs. 13/152 and 4.7% yearly event rate VTA−; log-rank P = 0.043) were significantly lower in the VTA + cohort. At multivariate analysis, VTA was the only variable remaining associated with a lower incidence of the primary outcome [adjusted hazard ratio 0.262 (0.100–0.681), P = 0.006]. Conclusion In a real-world registry of S-ICD carriers, the combined study endpoint of arrhythmic events and cardiovascular mortality was lower in the patient cohort undergoing VTA at long-term follow-up. ClinicalTrials.gov identifier NCT0473876. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Atrial fibrillation recurrences during the blanking period after catheter ablation with the laser balloon technique

Author

Schiavone, Marco, primary, Gasperetti, Alessio, additional, Martignani, Cristian, additional, Montemerlo, Elisabetta, additional, Ciconte, Giuseppe, additional, Ziacchi, Matteo, additional, Arosio, Roberto, additional, Piazzi, Elena, additional, Spadotto, Alberto, additional, Ruggiero, Diego, additional, Angeletti, Andrea, additional, Pozzi, Mattia, additional, Biffi, Mauro, additional, Rovaris, Giovanni, additional, and Forleo, Giovanni Battista, additional

Published
2023
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19. Long-term safety and efficacy of left atrial appendage occlusion in dialysis patients with atrial fibrillation: a multi-center, prospective, open label, observational study

Author

Genovesi, Simonetta, primary, Porcu, Luca, additional, Rebora, Paola, additional, Slaviero, Giorgio, additional, Casu, Gavino, additional, Bertoli, Silvio, additional, Airoldi, Flavio, additional, Buskermolen, Monique, additional, Gallieni, Maurizio, additional, Pieruzzi, Federico, additional, Rovaris, Giovanni, additional, Montoli, Alberto, additional, Piccaluga, Emanuela, additional, Molon, Giulio, additional, Alberici, Federico, additional, Adamo, Marianna, additional, Gaspardone, Achille, additional, D'Angelo, Giuseppe, additional, Merella, Pierluigi, additional, Vezzoli, Giuseppe, additional, Trezzi, Barbara, additional, and Mazzone, Patrizio, additional

Published
2023
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22. Design and rationale of the Impact of MultiPoint pacing in CRT patients with reduced RV-to-LV delay (IMAGE-CRT) study

Author

Solimene, Francesco, Nigro, Gerardo, Canciello, Michelangelo, Tavoletta, Vincenzo, Shopova, Gergana, Calvanese, Raimondo, Rago, Anna, La Rosa, Concetto, Nappi, Felice, Viscusi, Miguel, Urraro, Francesco, Manzo, Gianluca, Gallo, Paolo, Andriani, Andrea, Rovaris, Giovanni, Palmisano, Pietro, Innocenti, Sara, and D’Onofrio, Antonio

Published
2020
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23. Correction to: Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis

Author

Genovesi, Simonetta, Porcu, Luca, Slaviero, Giorgio, Casu, Gavino, Bertoli, Silvio, Sagone, Antonio, Buskermolen, Monique, Pieruzzi, Federico, Rovaris, Giovanni, Montoli, Alberto, Oreglia, Jacopo, Piccaluga, Emanuela, Molon, Giulio, Gaggiotti, Mario, Ettori, Federica, Gaspardone, Achille, Palumbo, Roberto, Viazzi, Francesca, Breschi, Marco, Gallieni, Maurizio, Contaldo, Gina, D’Angelo, Giuseppe, Merella, Pierluigi, Galli, Fabio, Rebora, Paola, Valsecchi, Mariagrazia, and Mazzone, Patrizio

Published
2021
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24. Temporal association between drops in thoracic impedance and malignant ventricular arrhythmia: A longitudinal analysis of remote monitoring trends

Author

Rodio, Giovanna, primary, Iacopino, Saverio, additional, Pisanò, Ennio C, additional, Calvi, Valeria, additional, Rovaris, Giovanni, additional, Marini, Massimiliano, additional, Giammaria, Massimo, additional, Caravati, Fabrizio, additional, Maglia, Giampiero, additional, Zanotto, Gabriele, additional, Della Bella, Paolo, additional, Biffi, Mauro, additional, Curnis, Antonio, additional, Maines, Massimiliano, additional, Orsida, Daniela, additional, Santamaria, Matteo, additional, Bisignani, Giovanni, additional, Baroni, Matteo, additional, Lissoni, Fabio, additional, Duca, Antonio, additional, Forleo, Giovanni B, additional, Piemontese, Carlo, additional, De Salvia, Alberto, additional, Miracapillo, Gennaro, additional, Celentano, Eduardo, additional, Zecchin, Massimo, additional, Luzzi, Giovanni, additional, Giacopelli, Daniele, additional, Gargaro, Alessio, additional, and D'Onofrio, Antonio, additional

Published
2023
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25. Leadless Pacemaker Implantation in the Emergency Bradyarrhythmia Setting: Results from a Multicenter European Registry

Author

Schiavone, Marco, primary, Filtz, Annalisa, additional, Gasperetti, Alessio, additional, Breitenstein, Alexander, additional, Palmisano, Pietro, additional, Mitacchione, Gianfranco, additional, Gulletta, Simone, additional, Chierchia, Gian Battista, additional, Montemerlo, Elisabetta, additional, Statuto, Giovanni, additional, Russo, Giulia, additional, Casella, Michela, additional, Vitali, Francesco, additional, Mazzone, Patrizio, additional, Hofer, Daniel, additional, Arabia, Gianmarco, additional, Tundo, Fabrizio, additional, Ruggiero, Diego, additional, Fierro, Nicolai, additional, Moltrasio, Massimo, additional, Bertini, Matteo, additional, Dello Russo, Antonio, additional, Pisanò, Ennio C. L., additional, Della Bella, Paolo, additional, Rovaris, Giovanni, additional, de Asmundis, Carlo, additional, Biffi, Mauro, additional, Curnis, Antonio, additional, Tondo, Claudio, additional, Saguner, Ardan M., additional, and Forleo, Giovanni B., additional

Published
2022
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26. Outcomes of transvenous lead extraction of very old leads using bidirectional rotational mechanical sheaths: Results of a multicentre study

Author

Migliore, Federico, primary, Pittorru, Raimondo, additional, Dall'Aglio, Pietro Bernardo, additional, De Lazzari, Manuel, additional, Rovaris, Giovanni, additional, Piazzi, Elena, additional, Dentico, Alessia, additional, Ferrieri, Alessandra, additional, D'Angelo, Giuseppe, additional, Marzi, Alessandra, additional, Sawaf, Basma El, additional, Bertaglia, Emanuele, additional, Iliceto, Sabino, additional, Gerosa, Gino, additional, Tarzia, Vincenzo, additional, Carretta, Domenico, additional, and Mazzone, Patrizio, additional

Published
2022
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27. 336 TEMPORAL CONNECTION BETWEEN HOME MONITORING TRENDS OF THORACIC IMPEDANCE AND SUSTAINED VENTRICULAR ARRHYTHMIAS

Author

Rodio, Giovanna, primary, Iacopino, Saverio, additional, Pisanò, Ennio C, additional, Calvi, Valeria, additional, Rovaris, Giovanni, additional, Marini, Massimiliano, additional, Giammaria, Massimo, additional, Caravati, Fabrizio, additional, Maglia, Giampiero, additional, Maines, Massimiliano, additional, Orsida, Daniela, additional, Santamaria, Matteo, additional, Bisignani, Giovanni, additional, Baroni, Matteo, additional, Lissoni, Fabio, additional, Duca, Antonio, additional, Luzzi, Giovanni, additional, Giacopelli, Daniele, additional, Gargaro, Alessio, additional, and D´onofrio, Antonio, additional

Published
2022
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28. 929 LEADLESS PACEMAKER IMPLANTATION FOLLOWING TRANSVENOUS LEAD EXTRACTION: DATA FROM HIGH-VOLUME REFERRAL CENTERS

Author

Mitacchione, Gianfranco, primary, Schiavone, Marco, additional, Arabia, Gianmarco, additional, Gasperetti, Alessio, additional, Denora, Marialessia, additional, Arosio, Roberto, additional, Palmisano, Pietro, additional, Montemerlo, Elisabetta, additional, Manuel, Cerini, additional, Russo, Giulia, additional, Mazzone, Patrizio, additional, Ziacchi, Matteo, additional, Pisanò, Ennio, additional, Rovaris, Giovanni, additional, Gulletta, Simone, additional, Steffel, Jan, additional, De Asmundis, Carlo, additional, Breitenstein, Alexander, additional, Biffi, Mauro, additional, Battista Chierchia, Giovanni, additional, Dello Russo, Antonio, additional, Bella, Paolo Della, additional, Claudio, Tondo, additional, Battista Forleo, Giovanni, additional, and Curnis, Antonio, additional

Published
2022
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30. Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project

Author

Bertaglia, Emanuele, primary, Iacopino, Saverio, additional, Verlato, Roberto, additional, Arena, Giuseppe, additional, Pieragnoli, Paolo, additional, Tondo, Claudio, additional, Molon, Giulio, additional, Manfrin, Massimiliano, additional, Perego, Giovanni B., additional, Rovaris, Giovanni, additional, Rivezzi, Francesco, additional, Mantica, Massimo, additional, Startari, Umberto, additional, and Sciarra, Luigi, additional

Published
2022
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31. Role of CHA2DS2-VASc score in predicting atrial fibrillation recurrence in patients undergoing pulmonary vein isolation with cryoballoon ablation

Author

Rordorf, Roberto, primary, Iacopino, Saverio, additional, Verlato, Roberto, additional, Arena, Giuseppe, additional, Tondo, Claudio, additional, Molon, Giulio, additional, Manfrin, Massimiliano, additional, Rovaris, Giovanni, additional, Perego, Giovanni Battista, additional, Sciarra, Luigi, additional, Mantica, Massimo, additional, Sacchi, Riccardo, additional, and Pieragnoli, Paolo, additional

Published
2022
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32. Predictors of Zero X-Ray Ablation for Supraventricular Tachycardias in a Nationwide Multicenter Experience

Author

Pani, Antonio, Giuseppina, Belotti, Bonanno, Carlo, Grazia Bongiorni, Maria, Bottoni, Nicola, Brambilla, Roberta, Ceglia, Sergio de, Della Bella, Paolo, Vito, Giovanni de, Malaspina, Daniele, Menardi, Endrj, Napoli, Velia, Negroni, Maria Silvia, Ocello, Salvatore, Orsida, Daniela, Pandozi, Claudio, Pedretti, Stefano, Penela, Diego, Pepi, Patrizia, Rossi, Luca, Rovaris, Giovanni, Scopinaro, Alice, Vincenti, Antonello, Viola, Graziana, Zacà, Valerio, Zoppo, Franco, Vergara, Pasquale, Badolati, Sandra, Baiocchi, Claudia, Belletti, Sebastiano, Cori, Andrea Di, Galeazzi, Marco, Gandolfi, Edoardo, Iori, Matteo, Isola, Francesco, Massa, Riccardo, Motta, Giovanni, Pala, Massimo, Piazzi, Elena, Quartieri, Fabio, Segreti, Luca, Vado, Antonello, and Vignati, Gabriele

Published
2018
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33. Role of CHA2DS2-VASc score in predicting atrial fibrillation recurrence in patients undergoing pulmonary vein isolation with cryoballoon ablation.

Author

Rordorf, Roberto, Iacopino, Saverio, Verlato, Roberto, Arena, Giuseppe, Tondo, Claudio, Molon, Giulio, Manfrin, Massimiliano, Rovaris, Giovanni, Perego, Giovanni Battista, Sciarra, Luigi, Mantica, Massimo, Sacchi, Riccardo, and Pieragnoli, Paolo

Abstract

Background: Pulmonary vein isolation by cryoablation (PVI-C) is a standard therapy for the treatment of atrial fibrillation (AF). The CHA2DS2-VASc score is a well-established predictor of AF-related stroke. Whether the CHA2DS2-VASc score can also be useful in predicting the long-term clinical outcomes following PVI-C is still unsettled. The aim of this analysis was to evaluate the role of the CHA2DS2-VASc score in predicting AF recurrence after PVI-C. Methods: Patients with symptomatic AF underwent an index PVI-C. Data were collected prospectively in the framework of the 1STOP ClinicalService project. Patients were categorized into two groups: low risk (LR) and high risk (HR) based on CHA2DS2-VASc score (0–1 and ≥ 2, respectively). Results: Out of 3313 patients, 1910 (57.6%) had a CHA2DS2-VASc score between 0 and 1, while 1403 (42.3%) had CHA2DS2-VASc > = 2. Patient characteristics were significantly different between the two cohorts, including age, sex, BMI, paroxysmal AF, history of stroke, diabetes, and ischemic cardiomyopathy. On the contrary, procedural times and acute complications were comparable. The 36-month freedom from AF after a single procedure was 72.5% (95% CI: 69.8–75.0) in the LR group and 65.9% (95% CI: 62.3–69.2) in the HR score group (HR: 1.26, 95% CI: 1.08–1.47, p = 0.001). After multivariate analysis, higher CHA2DS2-VASc score was still a significant predictor of the risk of AF recurrence (HR: 1.33; 1.10–1.60, p = 0.003). Conclusions: PVI-C is highly effective in the treatment of AF over the long term. A CHA2DS2-VASc score ≥ 2 is an independent predictor of AF recurrence during the follow-up and should be considered during the clinical management after the index procedure. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Outcomes of transvenous lead extraction of very old leads using bidirectional rotational mechanical sheaths: Results of a multicentre study.

Author

Migliore, Federico, Pittorru, Raimondo, Dall'Aglio, Pietro Bernardo, De Lazzari, Manuel, Rovaris, Giovanni, Piazzi, Elena, Dentico, Alessia, Ferrieri, Alessandra, D'Angelo, Giuseppe, Marzi, Alessandra, Sawaf, Basma El, Bertaglia, Emanuele, Iliceto, Sabino, Gerosa, Gino, Tarzia, Vincenzo, Carretta, Domenico, and Mazzone, Patrizio

Subjects
RESEARCH, PATIENT aftercare, MEDICAL device removal, CONFIDENCE intervals, IMPLANTABLE cardioverter-defibrillators, TREATMENT effectiveness, DESCRIPTIVE statistics, ODDS ratio, PATIENT safety
Abstract

Introduction: Lead dwell time >10 years is a recognized predictor for transvenous lead extraction (TLE) failure and complications. Data on the efficacy and safety of TLE using the bidirectional rotational mechanical sheaths in patients with very old leads are lacking. In this multicenter study, we reported the outcomes of transvenous rotational mechanical lead extraction in patients with leads implanted for ≥10 years. Methods: A total of 441 leads (median: 159 months [135–197]; range: 120–487) in 189 consecutive patients were removed with the Evolution RL sheaths (Cook Medical, Bloomingtom, IN, USA) and mechanical ancillary tools supporting the procedures. Results: The main indication for TLE was infection in 74% of cases. Complete procedural success rate, clinical success rate, per lead were 94.8% and 98.2%, respectively. Failure of lead extraction was seen in 1.8% of leads. The additional use of a snare via the femoral approach was required in 9% of patients. Lead dwell time was the only predictor of incomplete led removal (odds ratio: 1.009; 95% confidence interval [CI]: 1.003–1.014; p =.002). Four major complication (2%) were encountered. During a mean time follow‐up of 31 ± 27 months, 21 patients (11%) died. No procedure‐related mortality occurred. Predictors of mortality included severe left ventricular systolic dysfunction (hazard ratio [HR]: 8.06; 95% CI: 2.99–21.73; p =.001), TLE for infection (HR: 8.0; 95% CI: 1.04–62.5; p =.045), diabetes (HR: 3.7; 95% CI: 1.48–9.5; p =.005), and previous systemic infection (HR: 3.1; 95% CI: 1.17–8.24; p =.022). Incomplete lead removal or failure lead extraction did not impact on survival during follow‐up. Conclusion: Our findings demonstrated that the use of bidirectional rotational TLE mechanical sheaths combined with different mechanical tools and femoral approach allows reasonable success and safety in patients with very old leads at experienced specialized centers. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Second versus fourth generation of cryoballoon catheters: The 1STOP real‐world multicenter experience

Author

Manfrin, Massimiliano, primary, Verlato, Roberto, additional, Arena, Giuseppe, additional, Pieragnoli, Paolo, additional, Molon, Giulio, additional, Tondo, Claudio, additional, Perego, Giovanni Battista, additional, Rovaris, Giovanni, additional, Sciarra, Luigi, additional, Mantica, Massimo, additional, Sacchi, Riccardo, additional, Ricciardi, Danilo, additional, Marini, Massimiliano, additional, and Iacopino, Saverio, additional

Published
2022
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36. Long-term comparisons of atrial fibrillation ablation outcomes with a cryoballoon or laser-balloon: A propensity-matched analysis based on continuous rhythm monitoring

Author

Schiavone, Marco, primary, Gasperetti, Alessio, additional, Montemerlo, Elisabetta, additional, Pozzi, Mattia, additional, Sabato, Federica, additional, Piazzi, Elena, additional, Ruggiero, Diego, additional, De Ceglia, Sergio, additional, Viecca, Maurizio, additional, Calkins, Hugh, additional, Rovaris, Giovanni, additional, and Forleo, Giovanni B., additional

Published
2022
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37. MP-470547-009 LEADLESS PACEMAKER IMPLANTATION CLINICAL OUTCOMES AFTER CARDIAC SURGERY: A MULTICENTER, REAL-WORLD EXPERIENCE

Author

Schiavone, Marco, Gasperetti, Alessio, Breitenstein, Alexander, Mitacchione, Gianfranco, Tundo, Fabrizio, Montemerlo, Elisabetta, Monaco, Cinzia, Gulletta, Simone, Palmisano, Pietro, Compagnucci, Paolo, Rovaris, Giovanni, Hofer, Daniel, Chierchia, Gian B., Fassini, Gaetano, Biffi, Mauro, Russo, Antonio Dello, Moltrasio, Massimo, de Asmundis, Carlo, Curnis, Antonio, Tondo, Claudio, and Forleo, Giovanni B.

Published
2024
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38. Safety and Efficacy of Cryoballoon Ablation of Atrial Fibrillation in relation to the Patients’ Age: Results from a Large Real-World Multicenter Observational Project

Author

Sciarra, Luigi, primary, Iacopino, Saverio, additional, Arena, Giuseppe, additional, Tondo, Claudio, additional, Pieragnoli, Paolo, additional, Molon, Giulio, additional, Manfrin, Massimiliano, additional, Curnis, Antonio, additional, Russo, Antonio Dello, additional, Rovaris, Giovanni, additional, Stabile, Giuseppe, additional, Calò, Leonardo, additional, Boscolo, Gabriele, additional, and Verlato, Roberto, additional

Published
2021
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39. Prognostic significance of remotely monitored nocturnal heart rate in heart failure patients with reduced ejection fraction.

Author

D'Onofrio, Antonio, Marini, Massimiliano, Rovaris, Giovanni, Zanotto, Gabriele, Calvi, Valeria, Iacopino, Saverio, Biffi, Mauro, Solimene, Francesco, Della Bella, Paolo, Caravati, Fabrizio, Pisanò, Ennio C., Amellone, Claudia, D'Alterio, Giuliano, Pedretti, Stefano, Santobuono, Vincenzo E., Russo, Antonio Dello, Nicolis, Daniele, De Salvia, Alberto, Baroni, Matteo, and Quartieri, Fabio

Abstract

Elevated resting heart rate is a risk factor for cardiovascular events. The purpose of this study was to investigate the clinical significance of nocturnal heart rate (nHR) and 24-hour mean heart rate (24h-HR) obtained by continuous remote monitoring (RM) of implantable devices. We analyzed daily-sampled trends of nHR, 24h-HR, and physical activity in patients on β-blocker therapy for chronic heart failure and with implantable cardioverter-defibrillators or cardiac resynchronization therapy defibrillators (CRT-Ds). Patients were grouped by average nHR and 24h-HR quartile during follow-up to estimate the respective incidence of nonarrhythmic death and device-treated ventricular tachycardia/fibrillation (VT/VF). The study cohort included 1330 patients (median age 69 years [interquartile range 61–77 years]; 41% [n = 550] with CRT-D; median follow-up 25 months [interquartile range 13–42 months]). Compared with patients in the lowest nHR quartile (≤57 beats/min) group, patients in the highest quartile group (>65 beats/min) had an increased risk of nonarrhythmic death (adjusted hazard ratio [AHR] 2.25; 95% confidence interval [CI] 1.13–4.50; P =.021) and VT/VF (AHR 1.98; 95% CI 1.40–2.79; P <.001) and were characterized by the lowest level of physical activity (P ≤.0004 vs every other nHR quartiles). The highest 24h-HR quartile group (>75 beats/min) showed an increased risk of VT/VF (AHR 2.13; 95% CI 1.52–2.99; P <.001) and a weaker though significant association with nonarrhythmic mortality (AHR 1.80; 95% CI 1.00–3.22; P =.05) as compared with the lowest 24h-HR quartile group (≤65 beats/min). In remotely monitored patients with implantable cardioverter-defibrillator/CRT-D on β-blocker therapy for heart failure, elevated heart rates (nHR >65 beats/min and 24h-HR >75 beats/min) were associated with increased mortality and VT/VF risk. nHR showed a stronger association than 24h-HR with worst prognosis and lowest physical activity. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project.

Author

Bertaglia, Emanuele, Iacopino, Saverio, Verlato, Roberto, Arena, Giuseppe, Pieragnoli, Paolo, Tondo, Claudio, Molon, Giulio, Manfrin, Massimiliano, Perego, Giovanni B., Rovaris, Giovanni, Rivezzi, Francesco, Mantica, Massimo, Startari, Umberto, and Sciarra, Luigi

Subjects
ATRIAL fibrillation, PATIENTS' attitudes, CRYOSURGERY, OLDER patients, MIDDLE-aged persons, YOUNG adults
Abstract

Background: Atrial fibrillation (AF) is an uncommon arrhythmia in young adults without structural heart disease, and cryoballoon pulmonary vein isolation (CB‐PVI) is an important therapeutic strategy for rhythm control in patients with drug‐refractory AF. The aim of this analysis was to evaluate efficacy and safety of CB‐PVI in a large cohort of young patients in comparison with middle‐aged adults in a real‐world setting. Methods: From 2012 to 2020, a total of 3033 patients with AF underwent CB‐PVI and were followed prospectively in the framework of the 1STOP Clinical Service project, involving 34 Italian centers. Out of 3033 total 1STOP project subjects, a subgroup of 1318 patients were defined which included a YOUNG group (age ≤ 45 years; n = 368) and a MIDDLE‐AGED group (age 60–65 years; n = 950). Results: The acute success rate of PVI did not differ between the two cohorts (99.9 ± 1.3% vs. 99.8 ± 3.2%, p = 0.415). There was no difference in procedural characteristics, and periprocedural complication rates were similar among the two cohort (1.9% vs. 2.3%, p = 0.646). The 12‐month freedom from AF recurrence was 88.9% (95% confidence interval [CI]: 84.7–92.0) in the YOUNG cohort and 85.6% (95% CI: 82.9–88.0) in the MIDDLE‐AGED group. At 36‐month follow‐up, freedom from AF recurrence was 72.4% (65.5%–78.2%) and 71.8% (67.7%–75.6%), respectively with no significant difference among groups (p = 0.550). Conclusion: CB‐PVI had similar efficacy and safety in YOUNG and MIDDLE‐AGED patients. Younger age did not affect acute procedural results, complication rate, or AF recurrence after a single procedure. WHAT'S NEW?: This is the first multicenter analysis to evaluate the differences in efficacy and safety of a single ablation technique (cryoballoon pulmonary veins isolation) for atrial fibrillation between young and middle‐aged patients.Our analysis demonstrated the same rate of acute success, freedom from recurrent atrial fibrillation between young and middle‐aged patients, despite (as expected) older patients having more comorbidities.Safety outcomes of the procedure did not differ between young and middle‐aged patients, with a very low complication rate overall in both cohorts.The rate of repeat ablations following the index procedure was higher in young as compared to middle‐aged [ABSTRACT FROM AUTHOR]

Published
2023
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41. Cardiac resynchronization therapy defibrillators in patients with permanent atrial fibrillation

Author

Rapacciuolo, Antonio, primary, Iacopino, Saverio, additional, D'Onofrio, Antonio, additional, Curnis, Antonio, additional, Pisanò, Ennio C., additional, Biffi, Mauro, additional, Della Bella, Paolo, additional, Dello Russo, Antonio, additional, Caravati, Fabrizio, additional, Zanotto, Gabriele, additional, Calvi, Valeria, additional, Rovaris, Giovanni, additional, Senatore, Gaetano, additional, Nicolis, Daniele, additional, Santamaria, Matteo, additional, Giammaria, Massimo, additional, Maglia, Giampiero, additional, Duca, Antonio, additional, Ammirati, Giuseppe, additional, Romano, Salvo Andrea, additional, Piacenti, Marcello, additional, Celentano, Eduardo, additional, Bisignani, Giovanni, additional, Vaccaro, Paola, additional, Miracapillo, Gennaro, additional, Bertini, Matteo, additional, Nigro, Gerardo, additional, Giacopelli, Daniele, additional, Gargaro, Alessio, additional, and Bisceglia, Caterina, additional

Published
2021
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42. Circadian periodicity affects the type of ventricular arrhythmias and efficacy of implantable defibrillator therapies

Author

Vergara, Pasquale, primary, Pignalberi, Carlo, additional, Pisanò, Ennio C., additional, Maglia, Giampiero, additional, Della Bella, Paolo, additional, Zanotto, Gabriele, additional, Iacopino, Saverio, additional, Solimene, Francesco, additional, Calvi, Valeria, additional, Marini, Massimiliano, additional, Giammaria, Massimo, additional, Biffi, Mauro, additional, Rovaris, Giovanni, additional, Caravati, Fabrizio, additional, Quartieri, Fabio, additional, Curnis, Antonio, additional, Rapacciuolo, Antonio, additional, Senatore, Gaetano, additional, Pedretti, Stefano, additional, Saporito, Davide, additional, Dello Russo, Antonio, additional, Santobuono, Vincenzo E., additional, Pepi, Patrizia, additional, Duca, Antonio, additional, Baroni, Matteo, additional, Falasconi, Giulio, additional, Giacopelli, Daniele, additional, Gargaro, Alessio, additional, and D'Onofrio, Antonio, additional

Published
2021
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43. Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study

Author

Rovaris, Giovanni, primary, Ciconte, Giuseppe, additional, Schiavone, Marco, additional, Mitacchione, Gianfranco, additional, Gasperetti, Alessio, additional, Piazzi, Elena, additional, Negro, Gabriele, additional, Montemerlo, Elisabetta, additional, Rondine, Roberto, additional, Pozzi, Mattia, additional, Casiraghi, Mirko, additional, De Ceglia, Sergio, additional, Giacopelli, Daniele, additional, Viecca, Maurizio, additional, Vicedomini, Gabriele, additional, Forleo, Giovanni B, additional, and Pappone, Carlo, additional

Published
2021
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44. First-line therapy: insights from a real-world analysis of cryoablation in patients with atrial fibrillation

Author

Moltrasio, Massimo, primary, Iacopino, Saverio, additional, Arena, Giuseppe, additional, Pieragnoli, Paolo, additional, Molon, Giulio, additional, Manfrin, Massimiliano, additional, Verlato, Roberto, additional, Ottaviano, Luca, additional, Rovaris, Giovanni, additional, Catanzariti, Domenico, additional, Cipolletta, Laura, additional, Nicolis, Daniele, additional, Cattafi, Giuseppe, additional, and Tondo, Claudio, additional

Published
2021
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46. Dataset related to the article 'Cryoballoon Ablation in Patients With Paroxysmal Atrial Fibrillation: An Evaluation of Cohorts With and Without Structural Heart Disease'

Author

Perego, Giovanni Battista, Iacopino, Saverio, Pieragnoli, Paolo, Verlato, Roberto, Arena, Giuseppe, Molon, Giulio, Rovaris, Giovanni, Manfrin, Massimiliano, Mantica, Massimo, Senatore, Gaetano, Stabile, Giuseppe, Bertaglia, Emanuele, Brasca, Francesco, Tondo, Claudio, and ClinicalService 1STOP Project Investigators

Abstract

This record contains raw data related to the article "Cryoballoon Ablation in Patients With Paroxysmal Atrial Fibrillation: An Evaluation of Cohorts With and Without Structural Heart Disease". Abstract Background:Pulmonary vein isolation (PVI) is the most widely adopted strategy for paroxysmal atrial fibrillation (PAF) ablation. Limited evidence on acute results and late outcomes of cryoballoon (CB)-PVI in patients with structural heart disease (SHD) exist. The aim of this analysis was to compare acute procedural results and the 1-year recurrence rate of a single CB-PVI procedure in a PAF population with and without SHD. Method:From April 2012 to May 2017, a total of 2,031 patients with AF underwent CB-PVI and were followed prospectively in the framework of the One Shot TO Pulmonary vein isolation (1STOP) ClinicalService project, involving 36 Italian cardiology centres. We identified patients with SHD according to criteria proposed by current ESC guidelines: left ventricular (LV) systolic or diastolic dysfunction, long-standing hypertension with LV hypertrophy, and/or other structural heart disease. Data on procedural outcomes and long-term freedom from AF recurrence were evaluated. Results:Our population consisted of 1,452 patients, of whom 282 (19.4%) were classified as having SHD. Compared to non-SHD patients, the SHD cohort was older (mean ± standard deviation, 62.9 ± 9.0 vs 58.2 ± 11.4 years; p < 0.001), was more frequently male (79.1% vs 69.8%; p < 0.002), had a higher thrombo-embolic risk (CHA2DS2VASc ≥2: 63.4% vs 40.2%; p < 0.001), had a higher body mass index (27.7 ± 3.9 vs 26.4 ± 3.9 kg/m2; p < 0.001), had a larger atrial diameter (43.8 ± 7.0 vs 40.2 ± 5.8 mm; p < 0.001), and had a lower LV ejection fraction (57.2 ± 7.7% vs 60.7 ± 6.0%; p < 0.001). At the time of ablation, 73% of patients were on class Ic or III anti-arrhythmic drugs. Procedure time (106.9 ± 41.5 vs 112.1 ± 46.8 min; p = 0.248), fluoroscopic time (28.7 ± 14.7 vs 28.6 ± 15.2 min; p = 0.819), and complication rate (3.9% vs 4.8%; p = 0.525) were not different between the SHD and non-SHD cohorts. However, the acute success rate (98.9% vs 97.7%; p = 0.016) was higher in patients with SHD. After a follow-up of 13.4 ± 12.8 months, freedom from symptomatic recurrence was 78.0% for SHD and 78.4% for non-SHD (p = 0.895). Recurrence rate was not related to either left atrial size or LVEF. In the SHD cohort, Class Ic or III anti-arrhythmic drugs treatment decreased from 70.7% of patients before ablation to 28.7% of patients after CB-PVI (p = 0.001). Conclusions:CB-PVI was extensively applied to treat patients with PAF. Unlike previous PVI experiences, the acute success and recurrence rate after a single procedure was not related to the presence of SHD or to the degree of cardiac remodelling. Further studies are required to define whether CB-PVI has a useful role in patients with a significantly reduced ejection fraction as those patients were under-represented in the current population.

Published
2020
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47. Cryoablation for pulmonary veins isolation in obese patients with atrial fibrillation compared to nonobese patients

Author

Malaspina, Daniele, primary, Brasca, Francesco, additional, Iacopino, Saverio, additional, Arena, Giuseppe, additional, Molon, Giulio, additional, Pieragnoli, Paolo, additional, Tondo, Claudio, additional, Manfrin, Massimiliano, additional, Rovaris, Giovanni, additional, Verlato, Roberto, additional, Dello Russo, Antonio, additional, Startari, Umberto, additional, Sgarito, Giuseppe, additional, and Perego, Giovanni Battista, additional

Published
2021
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