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4. A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Author

Meric, Ilker, Alagoz, Enver, Hysing, Liv B., Kögler, Toni, Lathouwers, Danny, Lionheart, William R. B., Mattingly, John, Obhodas, Jasmina, Pausch, Guntram, Pettersen, Helge E. S., Ratliff, Hunter N., Rovituso, Marta, Schellhammer, Sonja M., Setterdahl, Lena M., Skjerdal, Kyrre, Sterpin, Edmond, Sudac, Davorin, Turko, Joseph A., and Ytre-Hauge, Kristian S.

Published
2023
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7. Development of an Ex Vivo Functional Assay for Prediction of Irradiation Related Toxicity in Healthy Oral Mucosa Tissue

Author

Pachler, Katrin S., Lauwers, Iris, Verkaik, Nicole S., Rovituso, Marta, van der Wal, Ernst, Mast, Hetty, Jonker, Brend P., Sewnaik, Aniel, Hardillo, Jose A., Keereweer, Stijn, Monserez, Dominiek, Kremer, Bernd, Koppes, Sjors, van den Bosch, Thierry P.P., Verduijn, Gerda M., Petit, Steven, Sørensen, Brita S., van Gent, Dik C., Capala, Marta E., Pachler, Katrin S., Lauwers, Iris, Verkaik, Nicole S., Rovituso, Marta, van der Wal, Ernst, Mast, Hetty, Jonker, Brend P., Sewnaik, Aniel, Hardillo, Jose A., Keereweer, Stijn, Monserez, Dominiek, Kremer, Bernd, Koppes, Sjors, van den Bosch, Thierry P.P., Verduijn, Gerda M., Petit, Steven, Sørensen, Brita S., van Gent, Dik C., and Capala, Marta E.

Abstract

Radiotherapy in the head-and-neck area is one of the main curative treatment options. However, this comes at the cost of varying levels of normal tissue toxicity, affecting up to 80% of patients. Mucositis can cause pain, weight loss and treatment delays, leading to worse outcomes and a decreased quality of life. Therefore, there is an urgent need for an approach to predicting normal mucosal responses in patients prior to treatment. We here describe an assay to detect irradiation responses in healthy oral mucosa tissue. Mucosa specimens from the oral cavity were obtained after surgical resection, cut into thin slices, irradiated and cultured for three days. Seven samples were irradiated with X-ray, and three additional samples were irradiated with both X-ray and protons. Healthy oral mucosa tissue slices maintained normal morphology and viability for three days. We measured a dose-dependent response to X-ray irradiation and compared X-ray and proton irradiation in the same mucosa sample using standardized automated image analysis. Furthermore, increased levels of inflammation-inducing factors—major drivers of mucositis development—could be detected after irradiation. This model can be utilized for investigating mechanistic aspects of mucositis development and can be developed into an assay to predict radiation-induced toxicity in normal mucosa.

Published
2024

10. Development and characterization of a [formula omitted]E-TOF detector prototype for the FOOT experiment

Author

Morrocchi, Matteo, Ciarrocchi, Esther, Alexandrov, Andrey, Alpat, Behcet, Ambrosi, Giovanni, Argirò, Stefano, Arteche Diaz, Raul, Bartosik, Nazar, Battistoni, Giuseppe, Belcari, Nicola, Bertazzoni, Matteo, Biondi, Silvia, Bruni, Graziano, Camarlinghi, Niccolò, Carra, Pietro, Cerello, Piergiorgio, Clozza, Alberto, Colombi, Sofia, De Lellis, Giovanni, Del Guerra, Alberto, Simoni, Micol De, Crescenzo, Antonia Di, Donetti, Marco, Dong, Yunsheng, Durante, Marco, Embriaco, Alessia, Emde, Max, Faccini, Riccardo, Ferrero, Veronica, Ferroni, Fernando, Fiandrini, Emanuele, Finck, Christian, Fiorina, Elisa, Fischetti, Marta, Francesconi, Marco, Franchini, Matteo, Galli, Luca, Garbini, Marco, Gentile, Valerio, Giraudo, Giuseppe, Hetzel, Ronja, Hild, Sebastian, Ionica, Maria, Kanxheri, Keida, Kraan, Aafke Christine, Lante, Valeria, Lauria, Adele, La Tessa, Chiara, Lopez Torres, Ernesto, Marafini, Michela, Mattei, Ilaria, Mengarelli, Alberto, Mirabelli, Riccardo, Montesi, Maria Cristina, Morone, Maria Cristina, Muraro, Silvia, Narici, Livio, Pastore, Alessandra, Pastrone, Nadia, Patera, Vincenzo, Pennazio, Francesco, Placidi, Pisana, Pullia, Marco, Ramello, Luciano, Ridolfi, Riccardo, Rosso, Valeria, Rovituso, Marta, Sanelli, Claudio, Sarti, Alessio, Sartorelli, Gabriella, Sato, Osamu, Savazzi, Simone, Scavarda, Lorenzo, Schiavi, Angelo, Schuy, Christoph, Scifoni, Emanuele, Sciubba, Adalberto, Selvi, Marco, Servoli, Leonello, Silvestre, Gianluigi, Sitta, Mario, Spighi, Roberto, Spiriti, Eleuterio, Sportelli, Giancarlo, Stahl, Achim, Tomassini, Sandro, Tommasino, Francesco, Traini, Giacomo, Tioukov, Valeri, Valle, Serena Marta, Vanstalle, Marie, Villa, Mauro, Weber, Ulrich, Zoccoli, Antonio, and Bisogni, Maria Giuseppina

Published
2019
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15. Analytic prediction of droplet vaporization events to estimate the precision of ultrasound-based proton range verification

Author

Collado-Lara, Gonzalo, Heymans, Sophie V., Rovituso, Marta, Sterpin, Edmond, D'hooge, Jan, Vos, Hendrik J., Abeele, Koen Van Den, de Jong, Nico, Collado-Lara, Gonzalo, Heymans, Sophie V., Rovituso, Marta, Sterpin, Edmond, D'hooge, Jan, Vos, Hendrik J., Abeele, Koen Van Den, and de Jong, Nico

Abstract

Background: The safety and efficacy of proton therapy is currently hampered by range uncertainties. The combination of ultrasound imaging with injectable radiation-sensitive superheated nanodroplets was recently proposed for in vivo range verification. The proton range can be estimated from the distribution of nanodroplet vaporization events, which is stochastically related to the stopping distribution of protons, as nanodroplets are vaporized by protons reaching their maximal LET at the end of their range. Purpose: Here, we aim to estimate the range estimation precision of this technique. As for any stochastic measurement, the precision will increase with the sample size, that is, the number of detected vaporizations. Thus, we first develop and validate a model to predict the number of vaporizations, which is then applied to estimate the range verification precision for a set of conditions (droplet size, droplet concentration, and proton beam parameters). Methods: Starting from the thermal spike theory, we derived a model that predicts the expected number of droplet vaporizations in an irradiated sample as a function of the droplet size, concentration, and number of protons. The model was validated by irradiating phantoms consisting of size-sorted perfluorobutane droplets dispersed in an aqueous matrix. The number of protons was counted with an ionization chamber, and the droplet vaporizations were recorded and counted individually using high frame rate ultrasound imaging. After validation, the range estimate precision was determined for different conditions using a Monte Carlo algorithm. Results: A good agreement between theory and experiments was observed for the number of vaporizations, especially for large (5.8 ± 2.2 µm) and medium (3.5 ± 1.1 µm) sized droplets. The number of events was lower than expected in phantoms with small droplets (2.0 ± 0.7 µm), but still within the same order of magnitude. The inter-phantom variability was considerably larger (up to

Published
2023

17. A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Author

Meric, Ilker, primary, Alagoz, Enver, additional, Hysing, Liv, additional, Kögler, Toni, additional, Lathouwers, Danny, additional, Lionheart, William, additional, Mattingly, John, additional, Obhodas, Jasmina, additional, Pausch, Guntram, additional, Pettersen, Helge, additional, Ratliff, Hunter, additional, Rovituso, Marta, additional, Schellhammer, Sonja, additional, Setterdahl, Lena, additional, Skjerdal, Kyrre, additional, Sterpin, Edmond, additional, Sudac, Davorin, additional, Turko, Joseph, additional, and Ytre-Hauge, Kristian, additional

Published
2022
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18. Sources of Single Event Effects in the NVIDIA Xavier SoC Family under Proton Irradiation

Author

Rodríguez Ferrández, Iván, Tali, Maris, Kosmidis, Leonidas, Rovituso, Marta, Steenari, David, Universitat Politècnica de Catalunya. Doctorat en Arquitectura de Computadors, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions

Subjects
Satellites, Radiation effects, Space vehicles, Single event upsets, Vehicles espacials, Protons, Ordinadors immersos, Sistemes d', Informàtica::Arquitectura de computadors [Àrees temàtiques de la UPC], Graphics processing units, Embedded computer systems, Unitats de processament gràfic, System-on-chip
Abstract

In this paper we characterise two embedded GPU devices from the NVIDIA Xavier family System-on-Chip (SoC) using a proton beam. We compare the NVIDIA Xavier NX and Industrial devices, that respectively target commercial and automotive applications. We evaluate the Single-Event Effect (SEE) rate of both modules and their sub-components, both the CPU and GPU, using different power modes, and we try for the first time to identify their exact sources using the on-line testing facilities included in their ARM based system. Our conclusion is that the most sensitive part of the CPU complex of the SoC is the tag array of the various cache structures, while no errors were observed in the GPU, probably because of its fast execution compared to the CPU part of the application during the radiation campaign. This work was supported by ESA through the 4000136514/21/NL/GLC/my co-funded PhD activity ”Mixed Software/Hardware-based Fault-tolerance Techniques for Complex COTS System-on-Chip in Radiation Environments” and the GPU4S (GPU for Space) project. Moreover, it was partially supported by the Spanish Ministry of Economy and Competitiveness under grants PID2019-107255GB-C21 and IJC2020-045931-I (Spanish State Research Agency / http://dx.doi.org/10.13039/501100011033) and the HiPEAC Network of Excellence.

Published
2022
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20. Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature

Author

Heymans, Sophie V., Collado-Lara, Gonzalo, Rovituso, Marta, Vos, Hendrik J., D'hooge, Jan, De Jong, Nico, Van Abeele, Koen Den, Heymans, Sophie V., Collado-Lara, Gonzalo, Rovituso, Marta, Vos, Hendrik J., D'hooge, Jan, De Jong, Nico, and Van Abeele, Koen Den

Abstract

Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the door to ultrasound-based in vivo proton range verification. However, at body temperature and physiological pressures, perfluorobutane nanodroplets (PFB-NDs), which offer a good compromise between stability and radiation sensitivity, are not directly sensitive to primary protons. Instead, they are vaporized by infrequent secondary particles, which limits the precision for range verification. The radiation-induced vaporization threshold (i.e., sensitization threshold) can be reduced by lowering the pressure in the droplet such that ND vaporization by primary protons can occur. Here, we propose to use an acoustic field to modulate the pressure, intermittently lowering the proton sensitization threshold of PFB-NDs during the rarefactional phase of the ultrasound wave. Simultaneous proton irradiation and sonication with a 1.1 MHz focused transducer, using increasing peak negative pressures (PNPs), were applied on a dilution of PFB-NDs flowing in a tube, while vaporization was acoustically monitored with a linear array. Sensitization to primary protons was achieved at temperatures between 29 °C and 40 °C using acoustic PNPs of relatively low amplitude (from 800 to 200 kPa, respectively), while sonication alone did not lead to ND vaporization at those PNPs. Sensitization was also measured at the clinically relevant body temperature (i.e., 37 °C) using a PNP of 400 kPa. These findings confirm that acoustic modulation lowers the sensitization threshold of superheated NDs, enabling a direct proton response at body temperature.

Published
2022

21. Sources of single event effects in the NVIDIA Xavier SoC family under proton irradiation

Author

Universitat Politècnica de Catalunya. Doctorat en Arquitectura de Computadors, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions, Rodríguez Ferrández, Iván, Tali, Maris, Kosmidis, Leonidas, Rovituso, Marta, Steenari, David, Universitat Politècnica de Catalunya. Doctorat en Arquitectura de Computadors, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions, Rodríguez Ferrández, Iván, Tali, Maris, Kosmidis, Leonidas, Rovituso, Marta, and Steenari, David

Abstract

In this paper we characterise two embedded GPU devices from the NVIDIA Xavier family System-on-Chip (SoC) using a proton beam. We compare the NVIDIA Xavier NX and Industrial devices, that respectively target commercial and automotive applications. We evaluate the Single-Event Effect (SEE) rate of both modules and their sub-components, both the CPU and GPU, using different power modes, and we try for the first time to identify their exact sources using the on-line testing facilities included in their ARM based system. Our conclusion is that the most sensitive part of the CPU complex of the SoC is the tag array of the various cache structures, while no errors were observed in the GPU, probably because of its fast execution compared to the CPU part of the application during the radiation campaign., This work was supported by ESA through the 4000136514/21/NL/GLC/my co-funded PhD activity ”Mixed Software/Hardware-based Fault-tolerance Techniques for Complex COTS System-on-Chip in Radiation Environments” and the GPU4S (GPU for Space) project. Moreover, it was partially supported by the Spanish Ministry of Economy and Competitiveness under grants PID2019-107255GB-C21 and IJC2020-045931-I (Spanish State Research Agency / http://dx.doi.org/10.13039/501100011033) and the HiPEAC Network of Excellence., Peer Reviewed, Postprint (author's final draft)

Published
2022

22. Spatiotemporal Distribution of Nanodroplet Vaporization in a Proton Beam Using Real-Time Ultrasound Imaging for Range Verification

Author

Collado-Lara, Gonzalo, Heymans, Sophie V., Rovituso, Marta, Carlier, Bram, Toumia, Yosra, Verweij, Martin, Paradossi, Gaio, Sterpin, Edmond, Vos, Hendrik J., D'hooge, Jan, de Jong, Nico, Van Den Abeele, Koen, Daeichin, Verya, Collado-Lara, Gonzalo, Heymans, Sophie V., Rovituso, Marta, Carlier, Bram, Toumia, Yosra, Verweij, Martin, Paradossi, Gaio, Sterpin, Edmond, Vos, Hendrik J., D'hooge, Jan, de Jong, Nico, Van Den Abeele, Koen, and Daeichin, Verya

Abstract

The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous studies, offline ultrasound images of phantoms with dispersed nanodroplets were acquired after irradiation, relating the induced vaporization profiles to the proton range. However, the aforementioned method did not enable the counting of individual vaporization events, and offline imaging cannot provide real-time feedback. In this study, we overcame these limitations using high-frame-rate ultrasound imaging with a linear array during proton irradiation of phantoms with dispersed perfluorobutane nanodroplets at 37°C and 50°C. Differential image analysis of subsequent frames allowed us to count individual vaporization events and to localize them with a resolution beyond the ultrasound diffraction limit, enabling spatial and temporal quantification of the interaction between ionizing radiation and nanodroplets. Vaporization maps were found to accurately correlate with the stopping distribution of protons (at 50°C) or secondary particles (at both temperatures). Furthermore, a linear relationship between the vaporization count and the number of incoming protons was observed. These results indicate the potential of real-time high-frame-rate contrast-enhanced ultrasound imaging for proton range verification and dosimetry.

Published
2022

25. Spatiotemporal Distribution of Nanodroplet Vaporization in a Proton Beam Using Real-Time Ultrasound Imaging for Range Verification

Author

Collado-Lara, Gonzalo, primary, Heymans, Sophie V., additional, Rovituso, Marta, additional, Carlier, Bram, additional, Toumia, Yosra, additional, Verweij, Martin, additional, Paradossi, Gaio, additional, Sterpin, Edmond, additional, Vos, Hendrik J., additional, D'hooge, Jan, additional, de Jong, Nico, additional, Van Den Abeele, Koen, additional, and Daeichin, Verya, additional

Published
2022
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28. Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification

Author

Adi, Wihan, Arico, Giulia, Brinkmann, Kai-Thomas, Durante, Marco, Reidel, Claire-Anne, Rovituso, Marta, Weber, Uli, Zaunick, Hans-Georg, and Zink, Klemens

Abstract

Physics in medicine and biology 64(20), 205012 (2019). doi:10.1088/1361-6560/ab4511, Published by IOP Publ., Bristol

Published
2019
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29. Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification

Author

Horst, Felix, primary, Adi, Wihan, additional, Aricò, Giulia, additional, Brinkmann, Kai-Thomas, additional, Durante, Marco, additional, Reidel, Claire-Anne, additional, Rovituso, Marta, additional, Weber, Uli, additional, Zaunick, Hans-Georg, additional, Zink, Klemens, additional, and Schuy, Christoph, additional

Published
2019
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30. Helium ions for radiotherapy? Physical and biological verifications of a novel treatment modality

Author

Krämer, Michael, Scifoni, Emanuele, Parodi, Katia, Durante, Marco, Schuy, Christoph, Rovituso, Marta, Tinganelli, Walter, Maier, Andreas, Kaderka, Robert, Kraft-Weyrather, Wilma, Brons, Stephan, Tessonnier, Thomas, Krämer, Michael, Scifoni, Emanuele, Schuy, Christoph, Rovituso, Marta, Tinganelli, Walter, Maier, Andrea, Kaderka, Robert, Kraft Weyrather, Wilma, Brons, Stephan, Tessonnier, Thoma, Parodi, Katia, and Durante, Marco

Subjects
ion beam radiotherapy, Radiology, Nuclear Medicine and Imaging, Animal, Radiotherapy Planning, Computer-Assisted, Heavy Ion Radiotherapy, Radiotherapy Dosage, CHO Cells, Helium, Cricetulus, CHO Cell, Biophysic, Cricetinae, helium ion, Animals, ddc:610, treatment planning system, Cricetulu
Abstract

Medical physics 43(4), 1995 - 2004(2016). doi:10.1118/1.4944593, Published by AIP Publishing, New York, NY

Published
2016
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31. Development and characterization of aΔE-TOF detector prototype for the FOOT experiment

Author

Morrocchi, Matteo, primary, Ciarrocchi, Esther, additional, Alexandrov, Andrey, additional, Alpat, Behcet, additional, Ambrosi, Giovanni, additional, Argirò, Stefano, additional, Arteche Diaz, Raul, additional, Bartosik, Nazar, additional, Battistoni, Giuseppe, additional, Belcari, Nicola, additional, Bertazzoni, Matteo, additional, Biondi, Silvia, additional, Bruni, Graziano, additional, Camarlinghi, Niccolò, additional, Carra, Pietro, additional, Cerello, Piergiorgio, additional, Clozza, Alberto, additional, Colombi, Sofia, additional, De Lellis, Giovanni, additional, Del Guerra, Alberto, additional, Simoni, Micol De, additional, Crescenzo, Antonia Di, additional, Donetti, Marco, additional, Dong, Yunsheng, additional, Durante, Marco, additional, Embriaco, Alessia, additional, Emde, Max, additional, Faccini, Riccardo, additional, Ferrero, Veronica, additional, Ferroni, Fernando, additional, Fiandrini, Emanuele, additional, Finck, Christian, additional, Fiorina, Elisa, additional, Fischetti, Marta, additional, Francesconi, Marco, additional, Franchini, Matteo, additional, Galli, Luca, additional, Garbini, Marco, additional, Gentile, Valerio, additional, Giraudo, Giuseppe, additional, Hetzel, Ronja, additional, Hild, Sebastian, additional, Ionica, Maria, additional, Kanxheri, Keida, additional, Kraan, Aafke Christine, additional, Lante, Valeria, additional, Lauria, Adele, additional, La Tessa, Chiara, additional, Lopez Torres, Ernesto, additional, Marafini, Michela, additional, Mattei, Ilaria, additional, Mengarelli, Alberto, additional, Mirabelli, Riccardo, additional, Montesi, Maria Cristina, additional, Morone, Maria Cristina, additional, Muraro, Silvia, additional, Narici, Livio, additional, Pastore, Alessandra, additional, Pastrone, Nadia, additional, Patera, Vincenzo, additional, Pennazio, Francesco, additional, Placidi, Pisana, additional, Pullia, Marco, additional, Ramello, Luciano, additional, Ridolfi, Riccardo, additional, Rosso, Valeria, additional, Rovituso, Marta, additional, Sanelli, Claudio, additional, Sarti, Alessio, additional, Sartorelli, Gabriella, additional, Sato, Osamu, additional, Savazzi, Simone, additional, Scavarda, Lorenzo, additional, Schiavi, Angelo, additional, Schuy, Christoph, additional, Scifoni, Emanuele, additional, Sciubba, Adalberto, additional, Selvi, Marco, additional, Servoli, Leonello, additional, Silvestre, Gianluigi, additional, Sitta, Mario, additional, Spighi, Roberto, additional, Spiriti, Eleuterio, additional, Sportelli, Giancarlo, additional, Stahl, Achim, additional, Tomassini, Sandro, additional, Tommasino, Francesco, additional, Traini, Giacomo, additional, Tioukov, Valeri, additional, Valle, Serena Marta, additional, Vanstalle, Marie, additional, Villa, Mauro, additional, Weber, Ulrich, additional, Zoccoli, Antonio, additional, and Bisogni, Maria Giuseppina, additional

Published
2019
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33. Accelerator-Based Tests of Shielding Effectiveness of Different Materials and Multilayers using High-Energy Light and Heavy Ions

Author

Giraudo, Martina (author), Schuy, Christoph (author), Weber, Uli (author), Rovituso, Marta (author), Santin, Giovanni (author), Norbury, John W. (author), Tracino, Emanuele (author), Menicucci, A. (author), Bocchini, Luca (author), Giraudo, Martina (author), Schuy, Christoph (author), Weber, Uli (author), Rovituso, Marta (author), Santin, Giovanni (author), Norbury, John W. (author), Tracino, Emanuele (author), Menicucci, A. (author), and Bocchini, Luca (author)

Abstract

The roadmap for space exploration foresees longer journeys and further excursions outside low-Earth orbit as well as the establishment of permanent outposts on other celestial bodies, such as the Moon or Mars. The design of spacecrafts and habitats depends heavily on the mission scenario and must consider the radiation protection properties of the structural components as well as dedicated shielding. In fact, short- and long-term effects caused by exposure to cosmic radiation are now considered among the main health risks of space travel. One of the current strategies is to find multifunctional materials that combine excellent mechanical properties with a high shielding effectiveness to minimize the overall load. In this work, the shielding effectiveness of a wide variety of single and multilayer materials of interest for different mission scenarios has been characterized. In the experimental campaign, reference and innovative materials, as well as simulants of Moon and Mars in situ resources, were irradiated with 1,000 MeV/u 4He, 430 MeV/u 12C and 962-972 MeV/u 56Fe. The results are presented in terms of Bragg curves and dose reduction per unit area density. To isolate the shielding effectiveness only due to nuclear fragmentation, a correction for the energy loss in the material is also considered. These findings indicate that the best shield is lithium hydride, which performs even better than polyethylene. However, the technical feasibility of shielding needs to be investigated. The classification of all materials in terms of shielding effectiveness is not influenced by the ion species, but the value changes dramatically depending on the beam energy. The output of this investigation represents a useful database for benchmarking Monte Carlo and deterministic transport codes used for space radiation transport calculations. These findings also contribute to recommendations for optimizing the design of space vessels and habitats in, Space Systems Egineering

Published
2018
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34. The HEPD particle detector and the EFD electric field detector for the CSES satellite

Author

Alfonsi, L., Ambroglini, F., Ambrosi, G., Ammendola, R., Assante, D., Badoni, D., Belyaev, V. A., Burger, William Jerome, Cafagna, A., Cipollone, P., Consolini, G., Conti, L., Contin, A., Angelis, E. De, Donato, C. De, Franceschi, G. De, Santis, A. De, Santis, C. De, Diego, P., Durante, Marco, Fornaro, C., Guandalini, C., Laurenti, G., Laurenza, M., Lazzizzera, Ignazio, Lolli, M., Manea, C., Marcelli, L., Marcucci, F., Masciantonio, G., Osteria, G., Palma, Francesco, Palmonari, F., Panico, B., Patrizii, L., Picozza, P., Pozzato, Michele, Rashevskaya, I., Ricci, M., Rovituso, Marta, Scotti, V., Sotgiu, A, Sparvoli, R., Spataro, B., Spogli, L., Tommasino, Francesco, Ubertini, P., Vannaroni, G., Xuhui, S., Zoffoli, S., CSES LIMADOU Collaboration, Alfonsi, L., Ambroglini, F., Ambrosi, G., Ammendola, R., Assante, D., Badoni, D., Belyaev, V.A., Burger, W.J., Cafagna, A., Cipollone, P., Consolini, G., Conti, L., Contin, A., Angelis, E.De, Donato, C.De, Franceschi, G.De, Santis, A.De, Santis, C.De, Diego, P., Durante, M., Fornaro, C., Guandalini, C., Laurenti, G., Laurenza, M., Lazzizzera, I., Lolli, M., Manea, C., Marcelli, L., Marcucci, F., Masciantonio, G., Osteria, G., Palma, F., Palmonari, F., Panico, B., Patrizii, L., Picozza, P., Pozzato, M., Rashevskaya, I., Ricci, M., Rovituso, M., Scotti, V., Sotgiu, A., Sparvoli, R., Spataro, B., Spogli, L., Tommasino, F., Ubertini, P., Vannaroni, G., Xuhui, S., Zoffoli, S., Belyaev, V. A., Burger, W. J., Angelis, E. De, Donato, C. De, Franceschi, G. De, Santis, A. De, Santis, C. De, Lolli, Franco, Sparvoli, Roberta, and Tommasino, Simona

Subjects
Earthquake, 010504 meteorology & atmospheric sciences, Meteorology, Magnetosphere, Cosmic ray, Space weather, 01 natural sciences, Particle detector, symbols.namesake, Electric Field Detector, 0103 physical sciences, Particle Detector, Ionosphere, Space Weather, Cosmic rays, Seismic-precursors, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Settore FIS/01, Physics, Radiation, Solar energetic particles, Detector, Charged particle, Computational physics, Van Allen radiation belt, Physics::Space Physics, symbols, Electric field detector, Seismic-precursor
Abstract

The CSES satellite, developed by Chinese (CNSA) and Italian (ASI) space Agencies, will investigate iono-magnetospheric disturbances (induced by seismicity and electromagnetic emissions of tropospheric and anthropogenic origin); will monitor the temporal stability of the inner Van Allen radiation belts and will study the solar-terrestrial coupling by measuring fluxes of cosmic rays and solar energetic particles. In particular the mission aims at confirming the existences (claimed from several analyses) of a temporal correlations between the occurrence of earthquakes and the observation in space of electromagnetic disturbances, plasma fluctiations and anomalous fluxes of high-energy particles precipitating from the inner Van Allen belt. CSES will be launched in the summer of 2017 with a multi-instruments payload able to measure: e.m. fields, charged particles, plasma, TEC, etc. The Italian LIMADOU collaboration will provide the High-Energy Particle Detector (HEPD), designed for detecting electrons (3–200 MeV) and proton (30–300 MeV)), and participates to develop the Electric Field Detector (EFD) conceived for measuring electric field from ∼DC up to 5 MHz.

Published
2017

35. Fragmentation and lateral scattering of 120 and 200 MeV/u 4He ions on water targets

Author

Rovituso, Marta

Abstract

Along with an increased popularity of heavy ions in cancer therapy, 4He ions have regained the interest of the medical community as a compromise between protons and 12C ions. Al- though 2054 patients have been treated with 4He beams at Lawrence Berkeley Laboratory (LBL) (Berkeley CA, US) between 1975 and 1992, a comprehensive database of biological and physics measurements in the therapeutic energy range is still missing. One of the first steps necessary for introducing 4He ions in particle therapy, is the develop- ment of a dedicated treatment planning system, for which basic physics information such as the characterization of the beam lateral scattering and fragmentation cross sections describing the loss of primary particles and the build up of secondary fragments are required. Examination of data found in the literature reveals a gap in the therapeutic energy range. These measurements are essential for benchmarking not only the new model developed for the in-house treatment planning code TRiP98 (Treatment Planning for Particles) [1], but also for already existing beam algorithms [2, 3] and for Monte Carlo codes like Geant4 [4] and Fluka [5]. The aim of this work is to provide fragmentation cross sections of 4He ions in the therapeutic energy range. The experimental data presented here were measured at Heidelberg Ion Beam Therapy Cen- ter (HIT) (Heidelberg, Germany) using 120 MeV/u and 200 MeV/u 4He beams. The attenuation of 200 MeV/u 4He beam in water was studied together with the build up of the secondary frag- ments produced by nuclear fragmentation processes. Target thicknesses between 1 and 25 cm H2O were chosen to investigate nuclear fragmentation also beyond the maximum penetration depth of the 4He ions. The mixed radiation field produced by the interaction of 120 and 200 4He ions with wa- ter targets (4.28 and 13.96 cm thick, respectively) has also been investigated in this work by measuring double differential cross sections. A combination of energy deposition and Time of Flight (TOF) acquired with a ∆E-E telescope system provided yields and kinetic energy spectra of all particle species emitted between 0◦ and 23◦ with respect to the primary beam direction. Coupling the angular distributions and the kinetic energy spectra gave an estimate of the dose contribution from all particles types. A direct measurement of the beam dose profile was per- formed independently. For this purpose, a two dimensional (2D) Ionization Chamber (IC) array and radiographic films were used to get information not only on the core of the radial dose distribution but also on its halo. The two datasets have been compared and showed consistent results. As a good parametrization of the beam lateral dose profile is a crucial element in a treatment planning systems, a fit of the measured distribution was performed and compared to the simple Gaussian approach still used by some treatment planning systems. The gap of experimental data in the energy range between 100 and 300 MeV/u proves the significance of this work not only for therapeutic applications but also for any other applications where the benchmark of Monte Carlo codes in simulating 4He fragmentation is required.

Published
2016

36. The FOOT (Fragmentation Of Target) Experiment

Author

Battistoni, Giuseppe, primary, Alexandrov, Andrey, additional, Argiro, Stefano, additional, Belcari, Nicola, additional, Biondi, Silvia, additional, Bisogni, Maria Giuseppina, additional, Bruni, Graziano, additional, Brambilla, Sergio, additional, Camarlinghi, Niccolò, additional, Cerello, Piergiorgio, additional, Ciarrocchi, Esther, additional, Clozza, Alberto, additional, De Lellis, Giovanni, additional, Di Crescenzo, Antonia, additional, Durante, Marco, additional, Faccini, Riccardo, additional, Ferrero, Veronica, additional, Ferroni, Fernando, additional, Finck, Christian, additional, Francesconi, Marco, additional, Franchini, Matteo, additional, Galli, Luca, additional, Garbini, Marco, additional, Giraudo, Giuseppe, additional, Iarocci, Enzo, additional, Kanxheri, Keida, additional, Lauria, Adele, additional, La Tessa, Chiara, additional, Marafini, Michela, additional, Mattei, Ilaria, additional, Mirabelli, Riccardo, additional, Montesi, Maria Cristina, additional, Morone, Maria Cristina, additional, Morrocchi, Matteo, additional, Muraro, Silvia, additional, Narici, Livio, additional, Paramatti, Riccardo, additional, Pastore, Alessandra, additional, Pastrone, Nadia, additional, Patera, Vincenzo, additional, Peroni, Cristiana, additional, Pullia, Marco, additional, Ramello, Luciano, additional, Rosso, Valeria, additional, Rovituso, Marta, additional, Sanelli, Claudio, additional, Sarti, Alessio, additional, Sartorelli, Gabriella, additional, Sato, Osamu, additional, Schiavi, Angelo, additional, Schuy, Christoph, additional, Scifoni, Emanuele, additional, Sciubba, Adalberto, additional, Selvi, Marco, additional, Servoli, Leonello, additional, Sitta, Mario, additional, Spighi, Roberto, additional, Spiriti, Eleuterio, additional, Sportelli, Giancarlo, additional, Testa, Marianna, additional, Tioukov, Valery, additional, Tommasino, Francesco, additional, Traini, Giacomo, additional, Valle, Serena Marta, additional, Vanstalle, Marie, additional, Villa, Mauro, additional, Weber, Ulrich, additional, and Zoccoli, Antonio, additional

Published
2017
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38. Benchmarking Geant4 hadronic models for prompt‐γ monitoring in carbon ion therapy

Author

Vanstalle, Marie, primary, Mattei, Ilaria, additional, Sarti, Alessio, additional, Bellini, Fabio, additional, Bini, Fabiano, additional, Collamati, Francesco, additional, Lucia, Erika De, additional, Durante, Marco, additional, Faccini, Riccardo, additional, Ferroni, Fernando, additional, Finck, Christian, additional, Fiore, Salvatore, additional, Marafini, Michela, additional, Patera, Vincenzo, additional, Piersanti, Luca, additional, Rovituso, Marta, additional, Schuy, Christoph, additional, Sciubba, Adalberto, additional, Traini, Giacomo, additional, Voena, Cecilia, additional, and Tessa, Chiara La, additional

Published
2017
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39. Proof-of-principle results of proton Computed Tomography

Author

Civinini, C, Scaringella, M, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Romano, F, Rovituso, M, Sipala, V, Talamonti, C, Tommasino, F, Vanzi, E, Bruzzi, M, Civinini, Carlo, Scaringella, Monica, Bonanno, Danilo, Brianzi, Mirko, Carpinelli, Massimo, Cirrone, G. A. Pablo, Cuttone, Giacomo, Lo Presti, Domenico, Maccioni, Giorgia, Pallotta, Stefania, Randazzo, Nunzio, Romano, Francesco, Rovituso, Marta, Sipala, Valeria, Talamonti, Cinzia, Tommasino, Francesco, Vanzi, Eleonora, Bruzzi, Mara, Civinini, C, Scaringella, M, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Romano, F, Rovituso, M, Sipala, V, Talamonti, C, Tommasino, F, Vanzi, E, Bruzzi, M, Civinini, Carlo, Scaringella, Monica, Bonanno, Danilo, Brianzi, Mirko, Carpinelli, Massimo, Cirrone, G. A. Pablo, Cuttone, Giacomo, Lo Presti, Domenico, Maccioni, Giorgia, Pallotta, Stefania, Randazzo, Nunzio, Romano, Francesco, Rovituso, Marta, Sipala, Valeria, Talamonti, Cinzia, Tommasino, Francesco, Vanzi, Eleonora, and Bruzzi, Mara

Abstract

A proof of principle proton Computed Tomography (pCT) apparatus, based on a silicon microstrip tracker and a YAG:Ce calorimeter, has been manufactured. Tests with a 175 MeV proton beam at The Svedberg Laboratory (TSL, Uppsala, Sweden) aiming at collecting data for reconstructing a tomographic image have been carried out. Algebraic iterative reconstruction methods, together with the most likely path formalism, have been used to obtain non-homogeneous phantom images to eventually extract density and spatial resolutions. The heavy computation load required by the algebraic algorithms has been approached fully exploiting the high calculation parallelism of Graphics Processing Units. The dose delivered to the phantom during the tomographic data-taking has been estimated as well as spatial and density resolutions dependence on dose. An upgraded pCT apparatus with an extended field-of-view able to reconstruct objects of the size of a human head, thus suitable to be used in pre-clinical tests, is now at an advanced construction stage. Using this new apparatus radiographies of an anthropomorphic phantom have been taken at the proton experimental beam line of the 'Trento Proton Therapy Center' (Trento, Italy).

Published
2017

40. Proof-of-Principle results of proton computed tomography

Author

Civinini, Carlo, primary, Scaringella, Monica, additional, Bonanno, Danilo, additional, Brianzi, Mirko, additional, Carpinelli, Massimo, additional, Cirrone, G. A. Pablo, additional, Cuttone, Giacomo, additional, Lo Presti, Domenico, additional, Maccioni, Giorgia, additional, Pallotta, Stefania, additional, Randazzo, Nunzio, additional, Romano, Francesco, additional, Rovituso, Marta, additional, Sipala, Valeria, additional, Talamonti, Cinzia, additional, Tommasino, Francesco, additional, Vanzi, Eleonora, additional, and Bruzzi, Mara, additional

Published
2016
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41. Development and characterization of a ΔE-TOF detector prototype for the FOOT experiment

Author

R. Hetzel, Silvia Biondi, Giuseppe Battistoni, Alessandra Pastore, M. Pullia, Marco Francesconi, Giovanni De Lellis, M. C. Morone, Pisana Placidi, Giuseppe Giraudo, Mario Sitta, Alberto Mengarelli, Graziano Bruni, Nicola Belcari, Adalberto Sciubba, E. Fiandrini, Niccolò Camarlinghi, A.C. Kraan, S. Colombi, Esther Ciarrocchi, Maria Ionica, A. Embriaco, Eleuterio Spiriti, Nadia Pastrone, Livio Narici, N. Bartosik, Alberto Del Guerra, Christoph Schuy, Sebastian Hild, P. Carra, L. Scavarda, M. Selvi, V. Lante, Elisa Fiorina, G. Silvestre, Sandro Tomassini, Osamu Sato, Adele Lauria, Behcet Alpat, Stefano Argiro, Marco Durante, Valeria Rosso, Giancarlo Sportelli, M. G. Bisogni, F. Ferroni, M. Emde, Ulrich Weber, R. Mirabelli, Veronica Ferrero, Francesco Pennazio, Keida Kanxheri, G. Ambrosi, M. Garbini, Valeri Tioukov, Alessio Sarti, R. Ridolfi, Giacomo Traini, Leonello Servoli, Achim Stahl, M. Fischetti, Raul Arteche Diaz, Silvia Muraro, S. M. Valle, Antonia Di Crescenzo, Micol De Simoni, M. Rovituso, Chiara La Tessa, C. Finck, Matteo Bertazzoni, Andrey Alexandrov, Alberto Clozza, S. Savazzi, Y. Dong, E. Scifoni, V. Gentile, Ilaria Mattei, Marco Donetti, Gabriella Sartorelli, Matteo Morrocchi, M. Villa, Vincenzo Patera, Luciano Ramello, A. Schiavi, Roberto Spighi, Piergiorgio Cerello, L. Galli, C. Sanelli, Maria Cristina Montesi, Riccardo Faccini, M. Marafini, Ernesto Lopez Torres, Antonio Zoccoli, M. Vanstalle, Francesco Tommasino, Matteo Franchini, Morrocchi, Matteo, Ciarrocchi, Esther, Alexandrov, Andrey, Alpat, Behcet, Ambrosi, Giovanni, Argirò, Stefano, Arteche Diaz, Raul, Bartosik, Nazar, Battistoni, Giuseppe, Belcari, Nicola, Bertazzoni, Matteo, Biondi, Silvia, Bruni, Graziano, Camarlinghi, Niccolò, Carra, Pietro, Cerello, Piergiorgio, Clozza, Alberto, Colombi, Sofia, De Lellis, Giovanni, Del Guerra, Alberto, Simoni, Micol De, Crescenzo, Antonia Di, Donetti, Marco, Dong, Yunsheng, Durante, Marco, Embriaco, Alessia, Emde, Max, Faccini, Riccardo, Ferrero, Veronica, Ferroni, Fernando, Fiandrini, Emanuele, Finck, Christian, Fiorina, Elisa, Fischetti, Marta, Francesconi, Marco, Franchini, Matteo, Galli, Luca, Garbini, Marco, Gentile, Valerio, Giraudo, Giuseppe, Hetzel, Ronja, Hild, Sebastian, Ionica, Maria, Kanxheri, Keida, Kraan, Aafke Christine, Lante, Valeria, Lauria, Adele, La Tessa, Chiara, Lopez Torres, Ernesto, Marafini, Michela, Mattei, Ilaria, Mengarelli, Alberto, Mirabelli, Riccardo, Montesi, Maria Cristina, Morone, Maria Cristina, Muraro, Silvia, Narici, Livio, Pastore, Alessandra, Pastrone, Nadia, Patera, Vincenzo, Pennazio, Francesco, Placidi, Pisana, Pullia, Marco, Ramello, Luciano, Ridolfi, Riccardo, Rosso, Valeria, Rovituso, Marta, Sanelli, Claudio, Sarti, Alessio, Sartorelli, Gabriella, Sato, Osamu, Savazzi, Simone, Scavarda, Lorenzo, Schiavi, Angelo, Schuy, Christoph, Scifoni, Emanuele, Sciubba, Adalberto, Selvi, Marco, Servoli, Leonello, Silvestre, Gianluigi, Sitta, Mario, Spighi, Roberto, Spiriti, Eleuterio, Sportelli, Giancarlo, Stahl, Achim, Tomassini, Sandro, Tommasino, Francesco, Traini, Giacomo, Tioukov, Valeri, Valle, Serena Marta, Vanstalle, Marie, Villa, Mauro, Weber, Ulrich, Zoccoli, Antonio, Bisogni, Maria Giuseppina, Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Département de Radiobiologie, Hadronthérapie et Imagerie Moléculaire (DRHIM-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Quantenoptik (MPQ), Max-Planck-Gesellschaft, Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), Department of Basic and Applied Sciences for Engineering, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INFN Istituto Nazionale di Fisica Nucleare [Frascati], Dipartimento di Scienze di Base e Applicate per l'Ingegneria (SBAI), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Union Internationale des Transports Publics (UITP), and UITP

Subjects
Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Particle therapy, Particle detectors, Particle detectors Particle therapy Plastic scintillator Silicon photomultiplier, Scintillator, Silicon photomultiplier, Kinetic energy, 01 natural sciences, Ion, Settore FIS/04 - Fisica Nucleare e Subnucleare, Optics, 0103 physical sciences, Plastic scintillator, Instrumentation, Irradiation, 010306 general physics, Image resolution, Particle detectors, Particle therapy, Plastic scintillator, Silicon photomultiplier, [PHYS]Physics [physics], Physics, 010308 nuclear & particles physics, business.industry, Detector, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Time of flight, High Energy Physics::Experiment, business
Abstract

This paper describes the development and characterization of a Δ E-TOF detector composed of a plastic scintillator bar coupled at both ends to silicon photomultipliers. This detector is a prototype of a larger version which will be used in the FOOT (FragmentatiOn Of Target) experiment to identify the fragments produced by ion beams accelerated onto a hydrogen-enriched target. The final Δ E-TOF detector will be composed of two layers of plastic scintillator bars with orthogonal orientation and will measure, for each crossing fragment, the energy deposited in the plastic scintillator ( Δ E), the time of flight (TOF), and the coordinates of the interaction position in the scintillator. To meet the FOOT experimental requirements, the detector should have energy resolution of a few percents and time resolution of 70 ps, and it should allow to discriminate multiple fragments belonging to the same event. To evaluate the achievable performances, the detector prototype was irradiated with protons of kinetic energy in the 70–230 MeV range and interacting at several positions along the bar. The measured energy resolution σ Δ E ∕ Δ E was 6–14%, after subtracting the fluctuations of the deposited energy. A time resolution σ between 120 and 180 ps was obtained with respect to a trigger detector. A spatial resolution σ of 1.9 cm was obtained for protons interacting at the center of the bar.

Published
2019
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42. The FOOT (FragmentatiOn Of Target) experiment

Author

Andrey, A., Behcet, A., Giovanni, A., Stefano, A., Giuseppe, B., Giuseppina, B. M., Nicola, B., Silvia, B., Graziano, B., Niccolò, C., Pietro, C., Piergiorgio, C., Esther, C. -R, Alberto, C., Sofia, C., Lellis, G., Del Guerra, A., Micol De Simoni, Di Crescenzo, A., Marco, D., Yunsheng, D., Alessia, E., Max, E., Riccardo, F., Veronica, F., Fernando, F., Emanuele, F., Christian, F., Elisa, F., Marta, F., Marco, F., Matteo, F., Luca, G., Marco, G., Valerio, G., Giuseppe, G., Ronja, H., Sebastian, H., Maria, I., Keida, K., Christine, K. A., Valeria, L., Adele, L., La Tessa, C., Ernesto, L. T., Michela, M., Ilaria, M., Alberto, M., Riccardo, M., Cristina, M. M., Matteo, M., Silvia, M., Livio, N., Alessandra, P., Nadia, P., Francesco, P., Pisana, P., Marco, P., Luciano, R., Riccardo, R., Valeria, R., Marta, R., Claudio, S., Alessio, S., Gabriella, S., Osamu, S., Simone, S., Angelo, S., Christoph, S., Emanuele, S., Adal-Berto, S., Marco, S., Leonello, S., Gianluigi, S., Mario, S., Roberto, S., Eleuterio, S., Giancarlo, S., Achim, S., Sandro, T., Francesco, T., Giacomo, T., Tioukov, V., Marta, V. S., Marie, V., Mauro, V., Ulrich, W., Antonio, Z., Vin-Cenzo, P., Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), HEP, INSPIRE, Valle, S. M., Alexandrov, A., Alpat, B., Ambrosi, G., Argiro, S., Bisogni, M. G., Belcari, N., Biondi, S., Bruni, G., Camarlinghi, N., Carra, P., Cerello, P., Ciarrocchi, E., Clozza, A., Colombi, S., De Lellis, G., Del Guerra, A., De Simoni, M., Di Crescenzo, A., Donetti, M., Dong, Y., Durante, M., Embriaco, A., Emde, M., Faccini, R., Ferrero, V., Ferroni, F., Fiandrini, E., Finck, C., Fiorina, E., Fischetti, M., Francesconi, M., Franchini, M., Galli, L., Garbini, M., Gentile, V., Giraudo, G., Hetzel, R., Hild, S., Ionica, M., Kanxheri, K., Kraan, A. C., Lante, V., Lauria, A., La Tessa, C., Lopez Torres, E., Marafini, M., Mattei, I., Mengarelli, A., Mirabelli, R., Montesi, M. C., Morone, M. C., Morrocchi, M., Muraro, S., Narici, L., Pastore, A., Pastrone, N., Patera, V., Pennazio, F., Placidi, P., Pullia, M., Ramello, L., Ridolfi, R., Rosso, V., Rovituso, M., Sanelli, C., Sarti, A., Sartorelli, G., Sato, O., Savazzi, S., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Selvi, M., Servoli, L., Silvestre, G., Sitta, M., Spighi, R., Spiriti, E., Sportelli, G., Stahl, A., Tomassini, S., Tommasino, F., Traini, G., Valeri, T., Vanstalle, M., Villa, M., Weber, U., Zoccoli, A., Battistoni, G., Alexandrov Andrey, Alpat Behcet, Ambrosi Giovanni, Argirò Stefano, Battistoni Giuseppe, Bisogni Maria Giuseppina, Belcari Nicola, Biondi Silvia, Bruni Graziano, Camarlinghi Niccolò, Carra Pietro, Cerello Piergiorgio, Ciarrocchi Esther, Clozza Alberto, Colombi Sofia, De Lellis Giovanni, Del Guerra Alberto, De Simoni Micol, Di Crescenzo Antonia, Donetti Marco, Dong Yunsheng, Durante Marco, Embriaco Alessia, Emde Max, Faccini Riccardo, Ferrero Veronica, Ferroni Fernando, Fiandrini Emanuele, Finck Christian, Fiorina Elisa, Fischetti Marta, Francesconi Marco, Franchini Matteo, Galli Luca, Garbini Marco, Gentile Valerio, Giraudo Giuseppe, Hetzel Ronja, Hild Sebastian, Ionica Maria, Kanxheri Keida, Kraan Aafke Christine, Lante Valeria, Lauria Adele, La Tessa Chiara, Lopez Torres Ernesto, Marafini Michela, Mattei Ilaria , Mengarelli Alberto, Mirabelli Riccardo, Montesi Maria Cristina, Morone Maria Cristina, Morrocchi Matteo, Muraro Silvia, Narici Livio, Pastore Alessandra, Pastrone Nadia, Pennazio Francesco, Placidi Pisana, Pullia Marco, Ramello Luciano, Ridolfi Riccardo, Rosso Valeria, Rovituso Marta, Sanelli Claudio, Sarti Alessio, Sartorelli Gabriella, Sato Osamu, Savazzi Simone, Schiavi Angelo, Schuy Christoph, Scifoni Emanuele, Sciubba Adalberto, Selvi Marco, Servoli Leonello, Silvestre Gianluigi, Sitta Mario, Spighi Roberto, Spiriti Eleuterio, Sportelli Giancarlo, Stahl Achim, Tomassini Sandro, Tommasino Francesco, Traini Giacomo, Valeri Tioukov, Valle Serena Marta, Vanstalle Marie, Villa Mauro, Weber Ulrich, Zoccoli Antonio, Patera Vincenzo, Valle S.M., Alexandrov A., Alpat B., Ambrosi G., Argiro S., Bisogni M.G., Belcari N., Biondi S., Bruni G., Camarlinghi N., Carra P., Cerello P., Ciarrocchi E., Clozza A., Colombi S., De Lellis G., Del Guerra A., De Simoni M., Di Crescenzo A., Donetti M., Dong Y., Durante M., Embriaco A., Emde M., Faccini R., Ferrero V., Ferroni F., Fiandrini E., Finck C., Fiorina E., Fischetti M., Francesconi M., Franchini M., Galli L., Garbini M., Gentile V., Giraudo G., Hetzel R., Hild S., Ionica M., Kanxheri K., Kraan A.C., Lante V., Lauria A., La Tessa C., Lopez Torres E., Marafini M., Mattei I., Mengarelli A., Mirabelli R., Montesi M.C., Morone M.C., Morrocchi M., Muraro S., Narici L., Pastore A., Pastrone N., Patera V., Pennazio F., Placidi P., Pullia M., Ramello L., Ridolfi R., Rosso V., Rovituso M., Sanelli C., Sarti A., Sartorelli G., Sato O., Savazzi S., Schiavi A., Schuy C., Scifoni E., Sciubba A., Selvi M., Servoli L., Silvestre G., Sitta M., Spighi R., Spiriti E., Sportelli G., Stahl A., Tomassini S., Tommasino F., Traini G., Valeri T., Vanstalle M., Villa M., Weber U., Zoccoli A., Battistoni G., and Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], Settore FIS/04, Settore FIS/07, Physics::Medical Physics, hadrontherapy, fragmentation, foot, RBE, Proton therapy, [PHYS] Physics [physics], foot, fragmentation, hadrotherapy, cross section, Fragmentation, Physics::Accelerator Physics, Fragmentation, Proton therapy, RBE, Other, Nuclear Experiment
Abstract

International audience; Particle therapy uses proton and ion beams to treat deep-seated solid tumors, exploiting the favorable energy deposition profile of charged particles. Nuclear interactions with patient tissues can induce fragments production that must be taken into account in treatment planning: in proton treatments target fragmentation produces low-energy, short-range fragments depositing a non-negligible dose in the entry channel, while in heavier-ion beam treatments long-range fragments due to projectile fragmentation release dose in tissues surrounding the tumor. The FOOT experiment aims to study these processes to improve the nuclear interactions description in next generation Treatment Planning Systems softwares and hence the treatments quality. Target (16O and 12C) fragmentation induced by 150–250 MeV proton beams will be studied via inverse kinematics: 16O and 12C beams (150–250 MeV/u) collide on graphite and hydrocarbon targets to provide nuclear fragmentation cross sections on hydrogen. The projectile fragmentation of these beams will be explored as well. The FOOT detector includes a magnetic spectrometer to measure fragments momentum, a plastic scintillator for ΔE and TOF measurements and a scintillating crystal calorimeter to measure fragments kinetic energy. These measurements will be combined to accurately identify fragments charge and mass.

Published
2018
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43. Development of an Ex Vivo Functional Assay for Prediction of Irradiation Related Toxicity in Healthy Oral Mucosa Tissue.

Author

Pachler KS, Lauwers I, Verkaik NS, Rovituso M, van der Wal E, Mast H, Jonker BP, Sewnaik A, Hardillo JA, Keereweer S, Monserez D, Kremer B, Koppes S, van den Bosch TPP, Verduijn GM, Petit S, Sørensen BS, van Gent DC, and Capala ME

Subjects
Humans, X-Rays adverse effects, Radiation Injuries etiology, Radiation Injuries pathology, Male, Mucositis etiology, Mucositis pathology, Female, Dose-Response Relationship, Radiation, Stomatitis etiology, Stomatitis pathology, Adult, Middle Aged, Mouth Mucosa radiation effects
Abstract

Radiotherapy in the head-and-neck area is one of the main curative treatment options. However, this comes at the cost of varying levels of normal tissue toxicity, affecting up to 80% of patients. Mucositis can cause pain, weight loss and treatment delays, leading to worse outcomes and a decreased quality of life. Therefore, there is an urgent need for an approach to predicting normal mucosal responses in patients prior to treatment. We here describe an assay to detect irradiation responses in healthy oral mucosa tissue. Mucosa specimens from the oral cavity were obtained after surgical resection, cut into thin slices, irradiated and cultured for three days. Seven samples were irradiated with X-ray, and three additional samples were irradiated with both X-ray and protons. Healthy oral mucosa tissue slices maintained normal morphology and viability for three days. We measured a dose-dependent response to X-ray irradiation and compared X-ray and proton irradiation in the same mucosa sample using standardized automated image analysis. Furthermore, increased levels of inflammation-inducing factors-major drivers of mucositis development-could be detected after irradiation. This model can be utilized for investigating mechanistic aspects of mucositis development and can be developed into an assay to predict radiation-induced toxicity in normal mucosa.

Published
2024
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