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13 results on '"Rowell, Rachel"'

1. Decoding human fetal liver haematopoiesis

Author

Popescu, Dorin-Mirel, Botting, Rachel A., Stephenson, Emily, Green, Kile, Webb, Simone, Jardine, Laura, Calderbank, Emily F., Polanski, Krzysztof, Goh, Issac, Efremova, Mirjana, Acres, Meghan, Maunder, Daniel, Vegh, Peter, Gitton, Yorick, Park, Jong-Eun, Vento-Tormo, Roser, Miao, Zhichao, Dixon, David, Rowell, Rachel, McDonald, David, Fletcher, James, Poyner, Elizabeth, Reynolds, Gary, Mather, Michael, Moldovan, Corina, Mamanova, Lira, Greig, Frankie, Young, Matthew D., Meyer, Kerstin B., Lisgo, Steven, Bacardit, Jaume, Fuller, Andrew, Millar, Ben, Innes, Barbara, Lindsay, Susan, Stubbington, Michael J. T., Kowalczyk, Monika S., Li, Bo, Ashenberg, Orr, Tabaka, Marcin, Dionne, Danielle, Tickle, Timothy L., Slyper, Michal, Rozenblatt-Rosen, Orit, Filby, Andrew, Carey, Peter, Villani, Alexandra-Chloé, Roy, Anindita, Regev, Aviv, Chédotal, Alain, Roberts, Irene, Göttgens, Berthold, Behjati, Sam, Laurenti, Elisa, Teichmann, Sarah A., and Haniffa, Muzlifah

Published
2019
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4. Supplemental Materials from Clinical Relevance of KRAS-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy

Author

Laurent-Puig, Pierre, primary, Pekin, Deniz, primary, Normand, Corinne, primary, Kotsopoulos, Steve K., primary, Nizard, Philippe, primary, Perez-Toralla, Karla, primary, Rowell, Rachel, primary, Olson, Jeff, primary, Srinivasan, Preethi, primary, Le Corre, Delphine, primary, Hor, Thevy, primary, El Harrak, Zakaria, primary, Li, Xinyu, primary, Link, Darren R., primary, Bouché, Olivier, primary, Emile, Jean-François, primary, Landi, Bruno, primary, Boige, Valérie, primary, Hutchison, J. Brian, primary, and Taly, Valerie, primary

Published
2023
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5. Deciding How to Decide.

Author

ROWELL, RACHEL WESTON

Subjects
SOCIAL media, INFORMATION technology security, IMPROVISATION (Acting), HIRING freeze (Management)
Abstract

The article discusses decision-making in uncertain and challenging situations, using "The Five Modes of Decision-Making" by Peter Senge as a tool. Topics include the five modes are Telling, Selling, Testing, Consulting, and Co-Creating; it emphasizes the importance of clarity in decision-making intent; and it suggests leveraging existing guardrails such as vision, values and mission to make informed decisions during foggy times.

Published
2023

6. Decoding the development of the blood and immune systems during human fetal liver haematopoiesis

Author

Popescu, Dorin-Mirel, primary, Botting, Rachel A., additional, Stephenson, Emily, additional, Green, Kile, additional, Jardine, Laura, additional, Calderbank, Emily F., additional, Efremova, Mirjana, additional, Acres, Meghan, additional, Maunder, Daniel, additional, Vegh, Peter, additional, Goh, Issac, additional, Gitton, Yorick, additional, Park, Jongeun, additional, Polanski, Krzysztof, additional, Vento-Tormo, Roser, additional, Miao, Zhichao, additional, Rowell, Rachel, additional, McDonald, David, additional, Fletcher, James, additional, Dixon, David, additional, Poyner, Elizabeth, additional, Reynolds, Gary, additional, Mather, Michael, additional, Moldovan, Corina, additional, Mamanova, Lira, additional, Greig, Frankie, additional, Young, Matthew, additional, Meyer, Kerstin, additional, Lisgo, Steven, additional, Bacardit, Jaume, additional, Fuller, Andrew, additional, Millar, Ben, additional, Innes, Barbara, additional, Lindsay, Susan, additional, Stubbington, Michael J. T., additional, Kowalczyk, Monika S., additional, Li, Bo, additional, Ashenbrg, Orr, additional, Tabaka, Marcin, additional, Dionne, Danielle, additional, Tickle, Timothy L., additional, Slyper, Michal, additional, Rozenblatt-Rosen, Orit, additional, Filby, Andrew, additional, Villani, Alexandra-Chloe, additional, Roy, Anindita, additional, Regev, Aviv, additional, Chedotal, Alain, additional, Roberts, Irene, additional, Göttgens, Berthold, additional, Laurenti, Elisa, additional, Behjati, Sam, additional, Teichmann, Sarah A., additional, and Haniffa, Muzlifah, additional

Published
2019
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7. Limitations of Animal Epilepsy Research Models: Can Epileptic Human Tissue Provide Translational Benefit?

Author

Morris, Gareth, Rowell, Rachel, and Cunningham, Mark O.

Abstract

Advancement of understanding the etiology and treatment of epilepsy has largely depended on the use of acute and chronic animal models. An alternative approach, which is being increasingly used by a select number of laboratories worldwide, is to perform functional mechanistic studies in brain slices of living human tissue resected during surgery for drug resistant epilepsies. Pharmacoresistant epilepsy is a major clinical problem with a significant proportion of patients not receiving any symptomatic benefit from available anti-epileptic drugs. Animal models of epilepsy have dominated the landscape with regard to research and development, however they have failed to deliver new agents that would provide seizure control in patients with drug refractory epilepsy. Moreover, these models have considerable issues with respect to validity and animal welfare considerations. A compelling alternative is the use of live human epileptic tissue, which recapitulates a number of key features of refractory epilepsy. The use of live epileptic human tissue offers unprecedented opportunities to understand the mechanisms associated with difficult to treat epilepsy whilst also permitting studies of efficacy of novel agents that are being developed to alleviate epilepsy in drug resistant patients. [ABSTRACT FROM AUTHOR]

Published
2021
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11. An observational study investigating failure of primary endocrine therapy for operable breast cancer in the elderly.

Author

Thomas, Robert, Rowell, Rachel, Crichton, Siobhan, and Cain, Henry

Abstract

Background: Elderly patients are more likely to have oestrogen receptor positive cancers that can be treated without surgery with primary endocrine therapy (PET). Few studies have sought to identify predictors of failure of PET and so the aim of this study was to evaluate treatment failures in elderly breast cancer patients treated with PET and to determine predictors of failure.Methods: A retrospective observational study was performed on consecutive patients with ER-positive early stage breast cancer treated with PET between 2005 and 2015 in the three breast units in the North East of England. The primary outcome measure was treatment failure and secondary outcome measure was disease progression.Results: 488 patients were included with mean follow-up 31 months (SD 23). Overall, 206 patients were still alive with their disease controlled at the end of follow-up, 219 had died with their disease controlled and 63 (12%) experienced treatment failure. Younger age [SHR 0.96 (95% CI 0.94–0.99) p 0.013], larger tumours [SHR 1.03 (1.01–1.06) p 0.015], grade 3 cancers [SHR 3.58 (1.93–6.63) p < 0.001] and axillary lymph node metastases [SHR 1.93 (1.06–3.52) p 0.030] were all independent predictors of treatment failure. Disease progression was reported in 86 (17.6%) of patients.Conclusions: This is the largest retrospective series evaluating PET treatment failure. Clear predictors of failure have been identified, which can be used to facilitate treatment decision making. These results support previous analyses, further validating our results. [ABSTRACT FROM AUTHOR]

Published
2018
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12. Clinical Relevance of KRAS-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy

Author

Laurent-Puig, Pierre, primary, Pekin, Deniz, additional, Normand, Corinne, additional, Kotsopoulos, Steve K., additional, Nizard, Philippe, additional, Perez-Toralla, Karla, additional, Rowell, Rachel, additional, Olson, Jeff, additional, Srinivasan, Preethi, additional, Le Corre, Delphine, additional, Hor, Thevy, additional, El Harrak, Zakaria, additional, Li, Xinyu, additional, Link, Darren R., additional, Bouché, Olivier, additional, Emile, Jean-François, additional, Landi, Bruno, additional, Boige, Valérie, additional, Hutchison, J. Brian, additional, and Taly, Valerie, additional

Published
2015
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13. Decoding human fetal liver haematopoiesis

Author

Popescu, Dorin-Mirel, Botting, Rachel A, Stephenson, Emily, Green, Kile, Webb, Simone, Jardine, Laura, Calderbank, Emily F, Polanski, Krzysztof, Goh, Issac, Efremova, Mirjana, Acres, Meghan, Maunder, Daniel, Vegh, Peter, Gitton, Yorick, Park, Jong-Eun, Vento-Tormo, Roser, Miao, Zhichao, Dixon, David, Rowell, Rachel, McDonald, David, Fletcher, James, Poyner, Elizabeth, Reynolds, Gary, Mather, Michael, Moldovan, Corina, Mamanova, Lira, Greig, Frankie, Young, Matthew D, Meyer, Kerstin B, Lisgo, Steven, Bacardit, Jaume, Fuller, Andrew, Millar, Ben, Innes, Barbara, Lindsay, Susan, Stubbington, Michael JT, Kowalczyk, Monika S, Li, Bo, Ashenberg, Orr, Tabaka, Marcin, Dionne, Danielle, Tickle, Timothy L, Slyper, Michal, Rozenblatt-Rosen, Orit, Filby, Andrew, Carey, Peter, Villani, Alexandra-Chloé, Roy, Anindita, Regev, Aviv, Chédotal, Alain, Roberts, Irene, Göttgens, Berthold, Behjati, Sam, Laurenti, Elisa, Teichmann, Sarah A, and Haniffa, Muzlifah

Subjects
Blood Cells, Lymphoid Tissue, Gene Expression Profiling, Stem Cells, Flow Cytometry, 3. Good health, Hematopoiesis, Fetus, Cellular Microenvironment, Liver, embryonic structures, Humans, Female, Single-Cell Analysis
Abstract

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using single-cell transcriptome profiling of approximately 140,000 liver and 74,000 skin, kidney and yolk sac cells, we identify the repertoire of human blood and immune cells during development. We infer differentiation trajectories from HSC/MPPs and evaluate the influence of the tissue microenvironment on blood and immune cell development. We reveal physiological erythropoiesis in fetal skin and the presence of mast cells, natural killer and innate lymphoid cell precursors in the yolk sac. We demonstrate a shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs, which we functionally validate. Our integrated map of fetal liver haematopoiesis provides a blueprint for the study of paediatric blood and immune disorders, and a reference for harnessing the therapeutic potential of HSC/MPPs., We acknowledge funding from the Wellcome Human Cell Atlas Strategic Science Support (WT211276/Z/18/Z); M.H. is funded by Wellcome (WT107931/Z/15/Z), The Lister Institute for Preventive Medicine and NIHR and Newcastle-Biomedical Research Centre; S.A.T. is funded by Wellcome (WT206194), ERC Consolidator and EU MRG-Grammar awards and; S.B. is funded by Wellcome (WT110104/Z/15/Z) and St. Baldrick’s Foundation; E.L. is funded by a Wellcome Sir Henry Dale and Royal Society Fellowships, European Haematology Association, Wellcome and MRC to the Wellcome-MRC Cambridge Stem Cell Institute and BBSRC.

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