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Materials-based drug delivery approaches have garnered substantial attention in recent years due to their potential to revolutionize pharmaceutical interventions. This abstract provides a concise overview of recent advancements and future prospects in this rapidly evolving field. Materials such as nanoparticles, liposomes, polymers, and hydrogels have emerged as versatile carriers for drug delivery. These materials facilitate precise control over drug release kinetics, enabling targeted and sustained therapeutic effects. Smart materials with responsiveness to external stimuli or physiological conditions have further enhanced drug delivery precision. Personalized medicine approaches are gaining traction, tailoring drug delivery systems to individual patient profiles and needs. The horizon for materials-based drug delivery is bright. Ongoing research is focused on refining material design, streamlining production processes, and ensuring safety profiles. Collaborative efforts among researchers, clinicians, and industry stakeholders are crucial for translating these advancements into clinical practice. Additionally, the convergence of drug delivery with diagnostics and imaging holds immense potential for personalized and efficient healthcare solutions. As materials-based drug delivery continues to evolve, it stands poised to reshape the landscape of pharmaceuticals, offering the promise of more effective and patient-centered therapies for a wide range of medical conditions.

Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the therapeutic potentials of cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches of major scientific databases, relevant studies published up to March 2024 were included, focusing on clinical trials utilizing advanced nanoparticles for therapeutic purposes. The review discusses the diverse applications of nanoparticles in oncology, infectious diseases, neurology, and other medical fields. Additionally, it scrutinizes the safety profiles, efficacy outcomes, and challenges associated with nanoparticle-based therapies. The findings underscore significant progress in translating nanoparticle research into clinical practice and highlight the potential of these innovative platforms to revolutionize medical treatments. This review contributes valuable insights into the growing field of nanoparticle-based therapeutics, fostering a deeper understanding of their clinical applications and implications in medical practice. [ABSTRACT FROM AUTHOR]