21 results on '"Ru Xue, Zhang"'
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2. Synthesis of
- Author
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Ru Zhong, Zhang, Wanqiao, Huang, Ru Xue, Zhang, Cong, Xu, and Mang, Wang
- Abstract
An efficient methodology for the synthesis of a wide range of
- Published
- 2022
3. Distribution and Transition of Stable Conformations in Unfolding of Bovine Insulin Induced by Urea and Guanidine Hydrochloride
- Author
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Liujiao Bian, Wen-Li Liu, Huan Chen, Jia-Xin Zhang, and Ru-Xue Zhang
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Transition (genetics) ,Hydrochloride ,010401 analytical chemistry ,Biological activity ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Crystallography ,chemistry ,biological sciences ,Urea ,0210 nano-technology ,Guanidine ,Bovine insulin - Abstract
The distribution and transition characteristics of bovine insulin’s stable conformations in the unfolding induced by urea and guanidine hydrochloride were explored in items of energy and structure. The results showed that in the three-state unfolding of bovine insulin induced by urea, native bovine insulins were in their most stable conformations in both of energy and structure, while the intermediates were easily accumulated in the unfolding. In the four-state unfolding induced by guanidine hydrochloride, the native bovine insulins were in their most stable conformations in energy, while the first intermediates were in the most stable conformations in structure and more easily accumulated in the unfolding. In addition, it was found that in all these unfolding, more hydrophobic regions were exposed to the surface of bovine insulins in the intermediates and completely unfolded states than that in the native bovine insulins, and the change of biological activity was consistent with the variation in the structure.
- Published
- 2020
4. Experimental Study on Chloride Diffusion in Structural Concrete considering the Effect of Damages Induced by the Cyclic Impact Loading
- Author
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Jia Kou, Ru-xue Zhang, Yonglai Zheng, Peng-yu Zhu, Shuxin Deng, and Wen-bin Luo
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Materials science ,Impact loading ,Immersion (virtual reality) ,medicine ,Diffusion (business) ,Composite material ,Power function ,Chloride ,Civil and Structural Engineering ,medicine.drug - Abstract
An experimental investigation on chloride diffusion in structural concrete under the cyclic impact loading is conducted. Effects of magnitudes and loading times are studied. Relationship between damage coefficients and chloride diffusion coefficients is obtained. The cyclic impact loading causes the initiation of new cracks and the propagation of existing cracks, which brings an obvious promotion for chloride diffusion. There should be a damage threshold. If the magnitude of the external loading is large enough to make the damage exceed the threshold, initiation and propagation of cracks become quite significant and chloride diffusion can be greatly promoted. With the increase of the damage coefficient, the chloride diffusion coefficient increases. The increasing rates decrease with long immersion times. Relationship curves of damage coefficients and chloride diffusion coefficients show a good correlation and can be well described with power functions.
- Published
- 2019
5. An N-Trifluoromethylation/Cyclization Strategy for Accessing Diverse N-Trifluoromethyl Azoles from Nitriles and 1,3-Dipoles
- Author
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Shuang Wang, Ru Zhong Zhang, Mang Wang, Ru Xue Zhang, Cong Xu, and Wei Guan
- Subjects
Trifluoromethyl ,Trifluoromethylation ,Synthon ,General Chemistry ,General Medicine ,Combinatorial chemistry ,Catalysis ,chemistry.chemical_compound ,chemistry ,Functional group ,Sodium azide ,Diazo ,Nitrilium ,Methylene - Abstract
N-Trifluoromethyl azoles are valuable targets in medicinal chemistry, but their synthesis is challenging. Classical preparation of N-CF3 azoles relies on the functional group interconversions but suffers from tedious N-pre-functionalization and unfriendly agents. Introduction of the CF3 onto the nitrogen of heterocycles provides a direct route to such motifs, but the N-trifluoromethylation remains underdeveloped. Reported here is an alternative and scalable cyclization strategy based on NCF3 -containing synthons for constructing N-CF3 azoles. The approach involves the N-trifluoromethylation of nitriles followed by a [3+2] cyclization between resulting N-CF3 nitrilium derivatives and 1,3-dipoles. PhICF3 Cl was an effective CF3 source for the transformation. As a result, a generic platform is established to divergently synthesize N-trifluoromethylated tetrazoles, imidazoles, and 1,2,3-triazoles by using sodium azide, activated methylene isocyanides, and diazo compounds as dipoles.
- Published
- 2021
6. Synthesis of N-CF3 Amidines/Imidates/Thioimidates via N-CF3 Nitrilium Ions.
- Author
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Ru Zhong Zhang, Wanqiao Huang, Ru Xue Zhang, Cong Xu, and Mang Wang
- Published
- 2022
- Full Text
- View/download PDF
7. [Effects and HPA Axis Related Mechanism of Kaixin-San and Danggui-Shaoyao-San on Glucose and Lipid Metabolism in Chronic Stress Rats with High-fat Diet]
- Author
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Deng, Wang, Jun, Zhou, Jin, Zhang, Mao-xing, Li, Jian-guo, Qiu, Zheng-ping, Jia, and Ru-xue, Zhang
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Male ,Hypothalamo-Hypophyseal System ,Glucose ,Stress, Physiological ,Animals ,Pituitary-Adrenal System ,Rats, Wistar ,Diet, High-Fat ,Lipid Metabolism ,Drugs, Chinese Herbal ,Melatonin ,Rats - Abstract
To study the effects and potential mechanism of Kaixin-San and Danggui-Shaoyao-San on glucose and lipid metabolism in chronic stress rats fed with high-fat diet.50 male Wistar rats were randomly divided into normal control group (distilled water), high-fat diet with chronic stress group (distilled water), melatonin group(20 mg/kg), Kaixin-San group (445 mg/kg) and Danggui-Shaoyao-San group (3360 mg/kg). All drugs were orally administered. In addition to the normal control group, each group of rats were fed with high-fat, diet. Simultaneously, stress were carried out after drugs administration 1 h daily. The duration was lasted for six weeks. The rat body weight daily was recorded, and the 24 h period urine was collected to detect the level of urine corticosterone (CORT) after three weeks. The level of plasma intraperitoneal glucose tolerance (IVGTT) was detected after six weeks. Finally, rats were executed, and serum fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), insulin (INS), adrenocorticotropic hormone releasing hormone (CRH), adrenocorticotropic hormone (ACTH), CORT and melatonin ( MLT) were determined. The weight of adrenal gland, liver glycogen and muscle glycogen levels were detected. The adrenal gland index, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and insulin sensitivity index( ISI) were calculated.Compared with normal group, model rats body weight, IVGTT (120 min), plasm CORT were decreased significantly. Serum TG, TC, LDL-C and urine CORT after three weeks were increased significantly. Kaixin-San and Danggui- Shaoyao-San could regulate the above indexes.Kaixin-San and Danggui-Shaoyao-San may regulate the activity of HPA axis, and improve glucose and lipid metabolism disorder in model rats by increasing melatonin secretion.
- Published
- 2016
8. Phytochemical and Biological Studies of Plants from the GenusPhlomis
- Author
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Mao-Xing, Li, Xiao-Fei, Shang, Zheng-Ping, Jia, and Ru-Xue, Zhang
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Analgesics ,Anti-Inflammatory Agents ,Antimutagenic Agents ,Bioengineering ,General Chemistry ,General Medicine ,Biochemistry ,Antioxidants ,Phlomis ,Anti-Infective Agents ,Humans ,Hypoglycemic Agents ,Molecular Medicine ,Organic Chemicals ,Molecular Biology ,Cell Proliferation - Published
- 2010
9. [Study on the ultraviolet protective effects of the cream of the total flavonoids from Oxytropis falcata]
- Author
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Mao-Xing, Li, Zhi-Hui, Lan, Xi-Rui, He, Ru-Xue, Zhang, Zheng-Ping, Jia, Qing-Yun, Du, and Jia-Ni, Hong
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Flavonoids ,Glutathione Peroxidase ,Superoxide Dismutase ,Ultraviolet Rays ,Body Weight ,Radiation-Protective Agents ,Hydrogen Peroxide ,Oxytropis ,Antioxidants ,Rats ,Disease Models, Animal ,Oxidative Stress ,Random Allocation ,Malondialdehyde ,Animals ,Female ,Rats, Wistar ,Glutathione Transferase ,Skin - Abstract
To study the protective effects of the cream of the total flavonoids from Oxytropis falcata on the destructed skin of mice induced by moderate-wave ultraviolet (UVB) irradiation.Dorsal skin of Wistar mice were treated with the cream of the total flavonoids from Oxytropis falcata and then irradiated with UVB in the dosage of 5 min once a day for one week. The tissue of skin was pathological diagnosed and the activities or contents of superoxide dismutase (SOD), malondialdehyde (MDA), hydroxyproline (Hyp), glutathione peroxidease (GSH-Px), glutathione (GSH), glutathion-s-transferase (GST), catalase (CAT) and hydroxy radical (*OH) were determined with chromatometry.The ultraviolet protective effects of the cream could be observed with appearance and pathology examine. The cream could increase the activities of SOD (P0.001), GSH-Px (P0.001), GST (P0.05) and CAT (P0.01), raise the content of Hyp (P0.001) significantly. The cream could also decrease the contents of MDA and *OH (P0.001), and the activities of GSH significantly (P0.001).The cream of the total flavonoids from Oxytropis falcata has protective effect on the destructed skin of mice induced by moderate-wave ultraviolet (UVB) irradiation.
- Published
- 2011
10. ChemInform Abstract: Phytochemical and Biological Studies of Plants from the Genus Phlomis
- Author
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Xiao‐Fei Shang, Zheng‐Ping Jia, Ru‐Xue Zhang, and Mao‐Xing Li
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Biological studies ,Phlomis ,biology ,Phytochemical ,Chemistry ,Genus ,Botany ,General Medicine ,biology.organism_classification - Published
- 2010
11. The genus Scutellaria an ethnopharmacological and phytochemical review
- Author
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He Xiaoying, Xi-Rui He, Quanlong Zhang, Pengcheng Fan, Ru-Xue Zhang, Xiaofei Shang, Zhengping Jia, and Maoxing Li
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Scutellaria ,Traditional Chinese medicine ,Pharmacology ,Antioxidants ,Drug Discovery ,Medicine ,Humans ,Medicine, Chinese Traditional ,Medicinal plants ,Flavonoids ,Lamiaceae ,biology ,Traditional medicine ,business.industry ,Biological activity ,Plants ,biology.organism_classification ,Terpenoid ,Europe ,Phytochemical ,Ethnobotany ,Ethnopharmacology ,business - Abstract
Scutellaria (HUANG QIN) (Lamiaceae), which includes about 350 species commonly known as skullcaps, is widespread in Europe, the United States and East Asia. Some species are taken to clear away the heat-evil and expel superficial evils in traditional Chinese medicine (TCM). The present paper reviews the ethnopharmacology, the biological activities and the correlated chemical compounds of Scutellaria species. More than 295 compounds have been isolated, among them flavonoids and diterpenes. Studies show that Scutellaria and its active principles possess wide pharmacological actions, such as antitumor, anti-angiogenesis, hepatoprotective, antioxidant, anticonvulsant, antibacterial and antiviral activities. Currently, effective monomeric compounds or active parts have been screened for pharmacological activity from Scutellaria in vivo and in vitro. Increasing data supports application and exploitation for new drug development.
- Published
- 2009
12. [Study on chemical constituents of Delphinium grandiflorum]
- Author
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Xue-hua, Yang, Zheng-Ping, Jia, Mao-Xing, Li, Ru-Xue, Zhang, and Chong, Li
- Subjects
Alkaloids ,Magnetic Resonance Spectroscopy ,Plants, Medicinal ,Molecular Structure ,Aconitine ,Palmitic Acid ,Delphinium ,Diterpenes ,Plant Roots ,Sitosterols - Abstract
To study the chemical constituents isolated from the roots of Delphinium grandiflorum L. var. leiocarpum W. T. Wang.The constituents were isolated and purified by various chromatographic methods and their structures were identified by spectral analysis.Five known diterpenoid alkaloids lycoctonine (I), methyllycaconitine (II), delsemine A (III), delavaine A (IV) , delajadine (V) and the other two beta-sitosterol (VI), plamitic acid (VII) were isolated from the roots of Delphinium grandiflorum.All these compounds are isolated from this plant for the first time.
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- 2008
13. [Effects of rat serum containing total flavonoid extract of Epimedium sagittatum on development of osteoblasts]
- Author
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Hui-Ping, Ma, Zheng-Ping, Jia, Ke-Ming, Cheng, Ru-Xue, Zhang, Mao-Xing, Li, and Juan, Wang
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Flavonoids ,Calcification, Physiologic ,Osteoblasts ,Animals ,Calcium ,Cell Differentiation ,Rats, Wistar ,Cell Proliferation ,Drugs, Chinese Herbal ,Epimedium ,Rats - Abstract
To investigate the effects of total flavonoid extract of Epimedium sagittatum (TFE) on the proliferation and differentiation of newborn rat calvarial osteoblasts (ROB).TFE was supplemented into the culture medium of ROB at 0. 1, 1, 10 and 100 microg x mL(-1) respectively. The serum of rats administered TFES (SRAT) was also added into the medium in a parallel treatment at 2.5%, 5% and 10% respectively. Their effects on cell proliferation and differentiation was studied by MTT and the analysis of osteogenic differentiation marks.TFE had no appreciable and on cell proliferation and differentiation at any concentration. However, 2.5% and 5% SRAT stimulated cell proliferation strongly and, 5% SRAT significantly promoted the maturation and function of osteoblast by improving the alkaline phosphatase activity, osteocalcin secretion, calcium deposition and the number of mineralized nodular structures.The metabolites of TFE should be the anti-osteoporosis constitutes of Epimedium sagittatum.
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- 2008
14. [Study on the effect of Part III from Cynomorium songaricum on immunosuppressive mice induced by cyclophosphamide]
- Author
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Ru-Xue, Zhang, Zheng-Ping, Jia, Mao-Xing, Li, Juan, Wang, Qiang, Yin, Jun-De, Luo, and Hong-Yan, Liu
- Subjects
Male ,Mice, Inbred BALB C ,Phagocytes ,Cynomorium ,Plants, Medicinal ,Macrophages ,Immunity ,Organ Size ,Hemolysin Proteins ,Immunocompromised Host ,Mice ,Adjuvants, Immunologic ,Phagocytosis ,Animals ,Lymphocyte Count ,Cyclophosphamide ,Immunosuppressive Agents ,Spleen ,Drugs, Chinese Herbal - Abstract
To study the immunomodulatory effect of Part III of Cynomorium songaricum Rupr. on the immunosuppressive mice.The immunity-deficiency model was induced by intraperitoneal injection of cyclophosphamide (CTX) at the dose of 100 mg/kg in mice; all the animals were divided into normal control group, immunity-deficiency model group, Part III treated group (300 mg/kg) and positive control group (TSPG, 300 mg/kg). The hemogram of peripheral blood, the index of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin were measured.The index of organs, the phagocytosis activity of macrophage and the content of serum hemolysin in the model group increased after administrated of Part III.Part III from Cynomorium songaricum Rupr. has protective effect on the immunosuppressive mice, which may be related to the increasing of humoral immunity and nonspecific immunity.
- Published
- 2008
15. [Establishing and identifying insulin resistance 3T3-L1 adipocytes cell model]
- Author
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Xiao-Nong, Guo, Ju-Tian, Yang, Feng, Niu, Ru-Xue, Zhang, and Zheng-Ping, Jia
- Subjects
Reverse Transcriptase Polymerase Chain Reaction ,Dexamethasone ,Culture Media ,Mice ,Glucose ,Gene Expression Regulation ,3T3-L1 Cells ,Adipocytes ,Animals ,Resistin ,RNA, Messenger ,Insulin Resistance ,Cells, Cultured ,Cell Proliferation - Abstract
To establish insulin-resistant 3T3-L1 adipocytes cell model.3T3-L1 preadipocytes were cultured and induced to differentation. We established insulin resistant 3T3-L1 induced by dexamethasone and determined the change of glucose concentration in cell culture.In high glucose DMEM culture media, the glusose concentration significantly decreased. Achieved the peak of insulin-resisitant at the 96th hour induced by dexamethasone, and at this time compared with the blank the mRNA expression of Resistin of the model step up about three times.3T3-L1 adipocyte exposed to 1 micromol/L dexamethasone for 24 hours are able to induce a state of insulin resistance which can be maintained for 216 hours.
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- 2008
16. [Research on isolation and purification of total iridoid glycosides from herbal Lamiophlomis rotata]
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Mao-xing, Li, Zheng-ping, Jia, Zhi-de, Hu, Ru-xue, Zhang, Xiao-ling, Ren, Juan, Wang, and Jing, Hu
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Resins, Synthetic ,Lamiaceae ,Plants, Medicinal ,Technology, Pharmaceutical ,Iridoids ,Glycosides ,Plant Roots - Abstract
Enriching the hemostatic active part total iridoid glycosides from the aqueous extract of herbal Lamiophlomis rotata.First derivative spectrophotometry was used as the detection method and the content of total iridoid glycosides was used as tracking target. The abilities of absorption and anti-absorption of ten different types of macroreticular resin were compared, after being used to absorb the iridoid glycosides from aqueous extract of herbal L. rotata. The best purification process was optimized.With the optimized purification process, the content of total iridoid glycosides was 67.53%.XDA-1 macroreticular resin has good ability of absorption and anti-absorption for iridoid glycosides and 50% ethanol was the best solvent for anti-absorption. The macroreticular resin could be reused.
- Published
- 2007
17. [Protective effect of Sankang Capsule on immunity-deficiency mice induced by cyclophosphamide]
- Author
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Xu, Zhang, Ru-Xue, Zhang, Hong-Hai, Tu, Zheng-Ping, Jia, Mao-Xing, Li, and Juan, Wang
- Subjects
Male ,Mice, Inbred BALB C ,Phagocytes ,Plants, Medicinal ,Immunity ,Capsules ,Organ Size ,Drug Combinations ,Hemolysin Proteins ,Immunocompromised Host ,Leukocyte Count ,Mice ,Random Allocation ,Adjuvants, Immunologic ,Phagocytosis ,Animals ,Female ,Cyclophosphamide ,Immunosuppressive Agents ,Spleen ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
To study the immunomodulatory effect of Sankang Capsule( SKC) on the immunity-deficiency mice.The immunity-deficiency model was induced by intraperitoneal injection (ip) of cyclophosphamide (CTX) at the dose of 100 mg/ kg in mice which were randomly divided into normal control group, immunity-deficiency model group, SKC treated group (250 mg/kg, 500 mg/kg) and positive control group (500 mg/kg). The number of WBC in peripheral blood, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the spleen were measured.The number of WBC, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the model group were all decreased compared with those of normal control group. After the administration of SKC, the index mentioned above was increased compared with those of model group.SKC has a protective effect on the immunity-deficiency mice, which may be related to the increasing of cellular immunity, humoral immunity and nonspecific immunity.
- Published
- 2007
18. [Effects of Rehmannia glutinosa oligosaccharides on proliferation of HepG2 and insulin resistance]
- Author
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Li-min, Guo, Ru-xue, Zhang, Zheng-ping, Jia, Mao-xing, Li, Juan, Wang, and Qiang, Yin
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Carcinoma, Hepatocellular ,Plants, Medicinal ,Dose-Response Relationship, Drug ,Cell Survival ,Liver Neoplasms ,Oligosaccharides ,Rehmannia ,Glucose ,Drug Resistance, Neoplasm ,Cell Line, Tumor ,Humans ,Hypoglycemic Agents ,Insulin ,Insulin Resistance ,Cell Proliferation - Abstract
To investigate the effects of Rehmannia glutinosa oligosaccharides (ROS) on the proliferation of HepG2 and insulin resistance.The HepG2 cells were divided into control group, rosiglitazone (3.4 mg x L(-1)) treated group and ROS (0.1-30 mg x L(-1)) treated group. The proliferation of HepG2 was detected by MTT method. Insulin resistant HepG2 cells model was induced by high concentration of insulin, then the effects of ROS on glucose consumption in insulin resistant HepG2 cells were investigated.In the middle glucose culture medium, the absorbance at 570 nm of HepG2 was increased by high concentration of ROS, and decreased by low concentration of ROS by using MTT method, a concentration-dependent manner. ROS increased glucose consumption in HepG2 cells, and showed a better effect at the dose of 10 mg x L(-1). ROS promoted the glucose consumption in insulin resistance of HepG2 cells, improved the sensitivity of insulin resistance of HepG2 cells to insulin.High concentration of ROS can promote the proliferation of HepG2, and however low concentration of ROS inhibits the proliferation of HepG2. ROS can significantly improve insulin resistance of HepG2 cells induced by high insulin.
- Published
- 2007
19. Rehmannia glutinosa: review of botany, chemistry and pharmacology
- Author
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Zhengping Jia, Maoxing Li, and Ru-Xue Zhang
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food.ingredient ,Ethnobotany ,Traditional Chinese medicine ,Pharmacology ,Pharmacognosy ,law.invention ,food ,law ,Chinese traditional ,Drug Discovery ,Botany ,Animals ,Humans ,Medicine, Chinese Traditional ,biology ,Traditional medicine ,fungi ,Rehmannia glutinosa ,biology.organism_classification ,Pharmacological action ,Rehmannia ,Herb ,Phytotherapy - Abstract
Rehmannia glutinosa, a widely used traditional Chinese herb, belongs to the family of Scrophulariaceae, and is taken to nourish Yin and invigorate the kidney in traditional Chinese medicine (TCM) and has a very high medicinal value. In recent decades, a great number of chemical and pharmacological studies have been done on Rehmannia glutinosa. More than 70 compounds including iridoids, saccharides, amino acid, inorganic ions, as well as other trace elements have been found in the herb. Studies show that Rehmannia glutinosa and its active principles possess wide pharmacological actions on the blood system, immune system, endocrine system, cardiovascular system and the nervous system. Currently, the effective monomeric compounds or active parts have been screened for the pharmacological activity of Rehmannia glutinosa and the highest quality scientific data is delivered to support the further application and exploitation for new drug development.
- Published
- 2007
20. [Effects of Rehmannia glutinosa oligosaccharides on proliferation of 3T3-L1 adipocytes and insulin resistance]
- Author
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Xiao-nong, Guo, Ru-xue, Zhang, Zheng-ping, Jia, Mao-xing, Li, and Juan, Wang
- Subjects
Rehmannia ,Mice ,Plants, Medicinal ,Dose-Response Relationship, Drug ,3T3-L1 Cells ,Adipocytes ,Animals ,Oligosaccharides ,Insulin Resistance ,Dexamethasone ,Cell Proliferation - Abstract
To investigate the influence of Rehmannia glutinosa oligosaccharides (ROS) on the proliferation of 3T3-L1 adipocytes and insulin resistance.3T3-L1 preadipocytes were cultured, the proliferation of 3T3-L1 preadipocytes was detected by MTT method. Insulin resistant 3T3-L1 adipocytes cell model was induced by dexamethasone and the change of glucose concentration in cell culture was determined after ROS treatment.In the high glucose DMEM culture media, MTT method showed that the absorbance at 570nm of 3T3-L1 preadipocytes was increased and that of 3T3-L1 adipocytes was decreased. ROS significantly increased glucose consumption in 3T3-L1 preadipocytes and adipocytes culture in a concentration-dependent manner. ROS improved the sensitivity of 3T3-L1 adipocytes to insulin.ROS can promote the proliferation of 3T3-L1 preadipocytes, inhibite the proliferation of 3T3-L1 adipocytes, and also, significantly improve insulin resistance induced by dexamethasone.
- Published
- 2006
21. [Effect of Herba Lamiophlomis Rotata extract on rats blood conglomeration parameters by oral administration]
- Author
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Mao-xing, Li, Zheng-ping, Jia, Tao, Shen, Ru-xue, Zhang, Hua-xin, Zhang, and Zhi-ying, Li
- Subjects
Lamiaceae ,Plants, Medicinal ,Time Factors ,Dose-Response Relationship, Drug ,Plant Extracts ,Administration, Oral ,Hemostatics ,Rats ,Animals ,Female ,Blood Coagulation Tests ,Rats, Wistar ,Blood Coagulation ,Rhizome - Abstract
To study the effect of Tibet medicine Herba Lamiophlomis Rotata exect (HLRE) on blood conglomeration parameters by oral administration.High dose (3 g/kg), middle dose (1.5 g/kg) and low dose (0.75 g/kg) of HLRE had been given orally in rats for 7, 14, 21 days. Blood samples were collected from common carotid artery and prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) were tested.After 7 days, as compared to the control, the high, middle doses of HLRE induced significant TT reduction, and all doses of HLRE could induce significant hyperfibrinogenemia. But there was no change in PT and APTL. After 14 days, in all groups treated with HLRE, TT decreased and FIB increased. As compared to the control, only the high dose had significantly changes in TT and FIB. After 21 days, as compared to the control, TT of high and middle groups decreased and FIB of high group increased visibly. PT decurtation could also be seen in all groups. There was a decrease in TT paralleling an increase of fibrinogen in our study.The aqueous extract of Herba Lamiophlomis Rotata orally administered in rats can increase the contents of FIB and shorten TT. The shorten of PT is found after treated with high dose for a long time. Hemostatic effect of HLRE has a dose-effect and time-effect relationship.
- Published
- 2006
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