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2,005 results on '"Rubello, Domenico"'

2. Effect of hyperglycemia on brain and liver 18F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging

Author

Viglianti, Benjamin L, Wong, Ka Kit, Wimer, Stephanie M, Paraeswaran, Aishwarya, Nan, Bin, Ky, Christy, Townsend, Danyelle M, Rubello, Domenico, Frey, Kirk A, and Gross, Milton D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Bioengineering, Biomedical Imaging, Clinical Trials and Supportive Activities, Clinical Research, Liver Disease, Basal Ganglia, Blood Glucose, Brain, Female, Fluorodeoxyglucose F18, Humans, Hyperglycemia, Linear Models, Liver, Male, Middle Aged, Multivariate Analysis, Positron-Emission Tomography, (18)F-FDG biodistribution, Alzheimer’s, PERCIST, PET, Quantitative imaging, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Pharmacology and pharmaceutical sciences
Abstract

PurposeBlood glucose is routinely measured prior to 18F-fluorodeoxyglucose (FDG) administration in positron emission tomography (PET) imaging to identify hyperglycemia that may affect image quality. In this study we explore the effects of blood glucose levels upon semi-quantitative standardized uptake value (SUV) measurements of target organs and tissues of interest and in particular address the relationship of blood glucose to FDG accumulation in the brain and liver.Methods436 FDG PET/CT consecutive studies performed for oncology staging in 229 patients (226 male) at the Ann Arbor Veterans Administration Healthcare System were reviewed. All patients had blood glucose measured (112.4±34.1mg/dL) prior to injection of 466.2±51.8MBq (12.6±1.4mCi) of FDG. SUV measurements of brain, aortic arch blood-pool, liver, and spleen were obtained at 64.5±10.2min' post-injection.ResultsWe found a negative inverse relationship of brain SUV with increasing plasma glucose, levels for both absolute and normalized (either to blood-pool or liver) values. Higher blood glucose levels had a mild effect upon liver and blood-pool SUV. By contrast, spleen SUV was independent of blood glucose, but demonstrated the greatest variability (deviation on linear regression). In contrast to other tissues, liver and spleen SUV normalized to blood-pool SUV were not dependent upon blood glucose levels.ConclusionThe effects of hyperglycemia upon FDG uptake in brain and liver, over a range of blood glucose values generally considered acceptable for clinical PET imaging, may have measurable effects on semi-quantitative image analysis.

Published
2017

3. Machine learning-based differentiation between multiple sclerosis and glioma WHO II°-IV° using O-(2-[18F] fluoroethyl)-L-tyrosine positron emission tomography

Author

Kebir, Sied, Rauschenbach, Laurèl, Weber, Manuel, Lazaridis, Lazaros, Schmidt, Teresa, Keyvani, Kathy, Schäfer, Niklas, Milia, Asma, Umutlu, Lale, Pierscianek, Daniela, Stuschke, Martin, Forsting, Michael, Sure, Ulrich, Kleinschnitz, Christoph, Antoch, Gerald, Colletti, Patrick M., Rubello, Domenico, Herrmann, Ken, Herrlinger, Ulrich, Scheffler, Björn, Bundschuh, Ralph A., and Glas, Martin

Published
2021
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7. 68Ga-PSMA-PET/CT in Patients With Biochemical Prostate Cancer Recurrence and Negative 18F-Choline-PET/CT

Author

Bluemel, Christina, Krebs, Markus, Polat, Bülent, Linke, Fränze, Eiber, Matthias, Samnick, Samuel, Lapa, Constantin, Lassmann, Michael, Riedmiller, Hubertus, Czernin, Johannes, Rubello, Domenico, Bley, Thorsten, Kropf, Saskia, Wester, Hans-Juergen, Buck, Andreas K, and Herrmann, Ken

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Bioengineering, Prostate Cancer, Clinical Research, Urologic Diseases, Biomedical Imaging, Cancer, Aged, Aged, 80 and over, Antigens, Surface, Choline, Gallium Radioisotopes, Glutamate Carboxypeptidase II, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Positron Emission Tomography Computed Tomography, Prostatic Neoplasms, choline-PET/CT, PSMA-PET/CT, prostate cancer, recurrence, restaging, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeInvestigating the value of Ga-PSMA-PET/CT in biochemically recurring prostate cancer patients with negative F-choline-PET/CT.Patients and methodsOne hundred thirty-nine consecutive patients with biochemical recurrence after curative (surgery and/or radiotherapy) therapy were offered participation in this sequential clinical imaging approach. Patients first underwent an F-choline-PET/CT. If negative, an additional Ga-PSMA-PET/CT was offered. One hundred twenty-five of 139 eligible patients were included in the study; 32 patients underwent additional Ga-PSMA-PET/CT. Patients with equivocal findings (n = 5) on F-choline-PET/CT and those who declined the additional Ga-PSMA-PET/CT (n = 9) were excluded. Images were analyzed visually for the presence of suspicious lesions. Findings on PET/CT were correlated with PSA level, PSA doubling time (dt), and PSA velocity (vel).ResultsThe overall detection rates were 85.6% (107/125) for the sequential imaging approach and 74.4% (93/125) for F-choline-PET/CT alone. Ga-PSMA-PET/CT detected sites of recurrence in 43.8% (14/32) of the choline-negative patients. Detection rates of the sequential imaging approach and F-choline-PET/CT alone increased with higher serum PSA levels and PSA vel. Subgroup analysis of Ga-PSMA-PET/CT in F-choline negative patients revealed detection rates of 28.6%, 45.5%, and 71.4% for PSA levels of 0.2 or greater to less than 1 ng/mL, 1 to 2 ng/mL, and greater than 2 ng/mL, respectively.ConclusionsThe sequential imaging approach designed to limit Ga-PSMA imaging to patients with negative choline scans resulted in high detection rates. Ga-PSMA-PET/CT identified sites of recurrent disease in 43.8% of the patients with negative F-choline PET/CT scans.

Published
2016

9. Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model

Author

de Oliveira Silva, Juliana, Fernandes, Renata Salgado, Ramos Oda, Caroline Mari, Ferreira, Tiago Hilário, Machado Botelho, Ana Flávia, Martins Melo, Marília, de Miranda, Marcelo Coutinho, Assis Gomes, Dawidson, Dantas Cassali, Geovanni, Townsend, Danyelle M., Rubello, Domenico, Oliveira, Mônica Cristina, and de Barros, André Luís Branco

Published
2019
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20. European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma

Author

Taïeb, David, Hicks, Rodney J., Hindié, Elif, Guillet, Benjamin A., Avram, Anca, Ghedini, Pietro, Timmers, Henri J., Scott, Aaron T., Elojeimy, Saeed, Rubello, Domenico, Virgolini, Irène J., Fanti, Stefano, Balogova, Sona, Pandit-Taskar, Neeta, and Pacak, Karel

Published
2019
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49. Comparison of L-Methyl-11C-Methionine PET With Magnetic Resonance Spectroscopy in Detecting Newly Diagnosed Glioma

Author

Kebir, Sied, Lazaridis, Lazaros, Weber, Manuel, Deuschl, Cornelius, Stoppek, Ann-Kathrin, Schmidt, Teresa, Mönninghoff, Christoph, Blau, Tobias, Keyvani, Kathy, Umutlu, Lale, Pierscianek, Daniela, Forsting, Michael, Stuschke, Martin, Antoch, Gerald, Sure, Ulrich, Kleinschnitz, Christoph, Scheffler, Björn, Colletti, Patrick M., Rubello, Domenico, Herrmann, Ken, and Glas, Martin

Published
2019
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