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14 results on '"Ruckdeschel, Anna"'

1. Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Author

Leipold, Alexander M., Werner, Rudolf A., Düll, Johannes, Jung, Pius, John, Mara, Stanojkovska, Emilia, Zhou, Xiang, Hornburger, Hannah, Ruckdeschel, Anna, Dietrich, Oliver, Imdahl, Fabian, Krammer, Tobias, Knop, Stefan, Rosenwald, Andreas, Buck, Andreas, Sander, Leif Erik, Einsele, Hermann, Kortüm, K. Martin, Saliba, Antoine-Emmanuel, and Rasche, Leo

Published
2023
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2. Changes in T‐cell subsets, preexisting cytopenias and hyperferritinaemia correlate with cytopenias after BCMA targeted CAR T‐cell therapy in relapsed/refractory multiple myeloma: Results from a prospective comprehensive biomarker study

Author

Zhou, Xiang, primary, Wagner, Vivien, additional, Scheller, Lukas, additional, Stanojkovska, Emilia, additional, Riedhammer, Christine, additional, Xiao, Xianghui, additional, Steinhardt, Maximilian Johannes, additional, Vogt, Cornelia, additional, Nerreter, Silvia, additional, Eisele, Florian, additional, John, Mara, additional, Munawar, Umair, additional, Kadel, Sofie‐Katrin, additional, Mersi, Julia, additional, Ruckdeschel, Anna, additional, Schimanski, Sven, additional, Haertle, Larissa, additional, Waldschmidt, Johannes Moritz, additional, Han, Seungbin, additional, Topp, Max, additional, Duell, Johannes, additional, Einsele, Hermann, additional, Riedel, Angela, additional, Kortüm, K. Martin, additional, and Rasche, Leo, additional

Published
2024
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3. Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Author

Leipold, Alexander M., primary, Werner, Rudolf A., additional, Düll, Johannes, additional, Jung, Pius, additional, John, Mara, additional, Stanojkovska, Emilia, additional, Zhou, Xiang, additional, Hornburger, Hannah, additional, Ruckdeschel, Anna, additional, Dietrich, Oliver, additional, Imdahl, Fabian, additional, Krammer, Tobias, additional, Knop, Stefan, additional, Rosenwald, Andreas, additional, Buck, Andreas, additional, Sander, Leif Erik, additional, Einsele, Hermann, additional, Kortüm, K. Martin, additional, Saliba, Antoine-Emmanuel, additional, and Rasche, Leo, additional

Published
2022
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4. Pseudoprogression and Sarcoidosis-like Phenomena after CART-Cells and Bispecific Antibodies in Multiple Myeloma

Author

Leipold, Alexander, primary, Werner, Rudolf, additional, Duell, Johannes, additional, Jung, Pius, additional, John, Mara, additional, Stanojkovska, Emilia, additional, Zhou, Xiang, additional, Ruckdeschel, Anna, additional, Dietrich, Oliver, additional, Imdahl, Fabian, additional, Krammer, Tobias, additional, Buck, Andreas, additional, Mersi, Julia, additional, Einsele, Hermann, additional, Kortuem, K. Martin, additional, Saliba, Antoine-Emmanuel, additional, and Rasche, Leo, additional

Published
2022
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6. Single- and double-hit events in genes encoding immune targets before and after T cell–engaging antibody therapy in MM

Author

Truger, Marietta S., Duell, Johannes, Zhou, Xiang, Heimeshoff, Larissa, Ruckdeschel, Anna, John, Mara, Riedel, Angela, Hüper, Sebastian, Peter, Jessica, Walter, Wencke, Haertle, Larissa, Meggendorfer, Manja, Topp, Max S., Rosenwald, Andreas, Da Via, Matteo Claudio, Bolli, Niccolo, Weinhold, Niels, Einsele, Hermann, Haferlach, Claudia, Kortüm, K. Martin, and Rasche, Leo

Published
2021
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7. Salvage therapy with “Dara‐KDT‐P(A)CE” in heavily pretreated, high‐risk, proliferative, relapsed/refractory multiple myeloma

Author

Zhou, Xiang, primary, Ruckdeschel, Anna, additional, Peter, Jessica, additional, Böckle, David, additional, Hornburger, Hannah, additional, Danhof, Sophia, additional, Steinhardt, Maximilian Johannes, additional, Heimeshoff, Larissa, additional, Einsele, Hermann, additional, Kortüm, Klaus Martin, additional, and Rasche, Leo, additional

Published
2021
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8. Cereblon enhancer methylation and IMiD resistance in multiple myeloma

Author

Haertle, Larissa, primary, Barrio, Santiago, additional, Munawar, Umair, additional, Han, Seungbin, additional, Zhou, Xiang, additional, Vogt, Cornelia, additional, Fernández, Rafael Alonso, additional, Bittrich, Max, additional, Ruiz-Heredia, Yanira, additional, Da Viá, Matteo, additional, Zovko, Josip, additional, Garitano-Trojaola, Andoni, additional, Bolli, Niccolò, additional, Ruckdeschel, Anna, additional, Stühmer, Thorsten, additional, Chatterjee, Manik, additional, Kull, Miriam, additional, Krönke, Jan, additional, Agirre, Xabier, additional, Martin-Subero, Jose I., additional, Raab, Peter, additional, Einsele, Hermann, additional, Rasche, Leo, additional, Martinez-Lopez, Joaquin, additional, Haaf, Thomas, additional, and Kortüm, K. Martin, additional

Published
2021
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10. Salvage therapy with "Dara‐KDT‐P(A)CE" in heavily pretreated, high‐risk, proliferative, relapsed/refractory multiple myeloma.

Author

Zhou, Xiang, Ruckdeschel, Anna, Peter, Jessica, Böckle, David, Hornburger, Hannah, Danhof, Sophia, Steinhardt, Maximilian Johannes, Heimeshoff, Larissa, Einsele, Hermann, Kortüm, Klaus Martin, and Rasche, Leo

Subjects
MULTIPLE myeloma, SALVAGE therapy, CHIMERIC antigen receptors, LACTATE dehydrogenase, PROGRESSION-free survival
Abstract

The multi‐agent therapy "VDT‐PACE" represents an established regimen in relapsed/refractory multiple myeloma (RRMM). Here, we report on our experience with a "modified VDT‐PACE" incorporating new generation anti‐MM agents daratumumab and carfilzomib ("Dara‐KDT‐P(A)CE"). We retrospectively analyzed 38 patients with RRMM treated with "Dara‐KDT‐P(A)CE". The median age was 62 (range 45–82) years, and the patients were heavily pretreated with a median of 5 (range 2–12) prior lines of therapy. Twenty‐one (55%) patients suffered from penta‐refractory MM. High‐risk cytogenetics was present in 31 (81%) patients. The patients received a median of 2 (range 1–10) cycles of this therapy, and the overall response rate (ORR) was 70%. Patients with penta‐refractory MM and high‐risk cytogenetics showed similar ORR of 65% and 79%, respectively. The median progression‐free survival (PFS) and overall survival were 4.1 (95% CI 2.7–5.4) and 8.4 (95% CI 6.7–10.0) months, respectively. Patients with lactate dehydrogenase >250 IU/L showed significantly shorter PFS in comparison with others patients (p = 0.006). We used this regimen as bridging therapy prior to chimeric antigen receptor T‐cell infusion in four patients. In conclusion, "Dara‐KDT‐P(A)CE" is an effective salvage therapy for patients with heavily pretreated, multi‐refractory, high‐risk RRMM lacking alternative options. [ABSTRACT FROM AUTHOR]

Published
2022
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11. JAM-A as a Prognostic Factor and New Therapeutic Target in Multiple Myeloma

Author

Solimando, Antonio, primary, Brandl, Andreas, additional, Katharina, Mattenheimer, additional, Graf, Carolin, additional, Ritz, Miriram, additional, Ruckdeschel, Anna, additional, Stühmer, Thorsten, additional, Rudelius, Martina, additional, Frassanito, Maria Antonia, additional, Andreas, Rosenwald, additional, Jakob, Franz, additional, Vacca, Angelo, additional, Einsele, Hermann, additional, and Beilhack, Andreas, additional

Published
2016
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13. Tafasitamab and Lenalidomide in Relapsed/Refractory B-Cell Lymphoma: A Multicenter Retrospective Real-World-Study of Patients from Germany and Austria

Author

Ruckdeschel, Anna, Sabrina, Koemm, Topp, Max S., Greil, Richard, Melchardt, Thomas, Lenz, Georg, Kerkhoff, Andrea, Shumilov, Evgenii, Hess, Georg, Baumgaertner, Marta, Thurner, Lorenz, Age Kos, Igor, Mayer, Stephanie, Ayuk, Francis A., Krause, Rolf, Herling, Marco, Vucinic, Vladan, Chapuy, Claudia, Illerhaus, Gerald, Knott, Markus, Viardot, Andreas, Grunenberg, Alexander, Dietrich, Sascha, Caille, Leandra, Tometten, Mareike C., Cho, Hyunyee Rosa, Scholz, Julia, Mueller, Fabian, Prochazka, Katharina, Chapuy, Bjoern, Böckle, David, von Tresckow, Bastian, Schub, Natalie, Gelbrich, Götz, Einsele, Hermann, and Duell, Johannes

Abstract

Background

Published
2023
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