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9. Fungiscope – a global registry for rare fungal infections

Author

Rueping, M. J., Heinz, W. J., Kindo, A. J., Hamprecht, A., Fischer, G., Hoog, S., Jörg Janne Vehreschild, Cornely, O. A., and Fungiscope Ecmm Isham Working Grp

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objectives: We are coordinating a global registry for cases of rare invasive fungal diseases (IFD). Our objective is to broaden the knowledge on epidemiology, to determine the clinical pattern of disease, to describe and improve diagnostic procedures and therapeutic regimens, as well as to facilitate[for full text, please go to the a.m. URL], 10. Kongress für Infektionskrankheiten und Tropenmedizin (KIT 2010)

Published
2010
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10. Oxygen switch in visible-light photoredox catalysis: Radical additions and cyclizations and unexpected C-C-bond cleavage reactions

Author

Zhu, S, Das, A, Bui, L, Zhou, H, Curran, DP, Rueping, M, Zhu, S, Das, A, Bui, L, Zhou, H, Curran, DP, and Rueping, M

Abstract

Visible light photoredox catalyzed inter- and intramolecular C-H functionalization reactions of tertiary amines have been developed. Oxygen was found to act as chemical switch to trigger two different reaction pathways and to obtain two different types of products from the same starting material. In the absence of oxygen, the intermolecular addition of N,N-dimethyl-anilines to electron-deficient alkenes provided γ-amino nitriles in good to high yields. In the presence of oxygen, a radical addition/cyclization reaction occurred which resulted in the formation of tetrahydroquinoline derivatives in good yields under mild reaction conditions. The intramolecular version of the radical addition led to the unexpected formation of indole-3-carboxaldehyde derivatives. Mechanistic investigations of this reaction cascade uncovered a new photoredox catalyzed C-C bond cleavage reaction. © 2013 American Chemical Society.

Published
2013

11. Current issues in the clinical management of invasive aspergillosis - the AGIHO, DMykG, OGMM and PEG web-based survey and expert consensus conference 2009

Author

Rueping, M. J. G. T., Vehreschild, J. J., Groll, A., Lass-Floerl, C., Ostermann, H., Ruhnke, M., Cornely, O. A., Rueping, M. J. G. T., Vehreschild, J. J., Groll, A., Lass-Floerl, C., Ostermann, H., Ruhnke, M., and Cornely, O. A.

Abstract

The objectives of this study were to identify unsolved issues in the management of invasive aspergillosis, identify controversies and achieve consensus. The German Speaking Mycological Society (Deutschsprachige Mykologische Gesellschaft, DMykG) invited other German infectious diseases (ID) and mycological societies to submit unsolved issues concerning the diagnosis and treatment of invasive aspergillosis. Based on these contributions, a digital web-based questionnaire of 12 questions on Aspergillus spp. was designed to be completed by experts of the participating societies. Controversial results were identified by a mathematical model and were discussed at a consensus conference during the 43rd Annual Meeting of the DMykG in Cologne, Germany. Forty-two individuals completed the questionnaire. Analysis showed a strong consensus on effective preventive measures, choice of antifungal agents for pre-emptive, empiric and targeted treatment, as well as the evaluation of early chest CT control scans as a measure of treatment response assessment. Opinions on the indication for a pulmonary biopsy of a halo sign in high-risk neutropenic patients and on the role of Aspergillus spp. PCR as well as galactomannan from serum in the assessment of treatment duration diverged in spite of discussion such that a consensus could not be reached. Using a recently published two-step approach - web-based survey plus classical panel discussion - expert consensus was achieved on 10 of 12 questions concerning the diagnosis and treatment of invasive aspergillosis.

Published
2011

12. Current issues in the clinical management of invasive candida infections - the AGIHO, DMykG, OGMM and PEG web-based survey and expert consensus conference 2009

Author

Karthaus, M., Rueping, M. J. G. T., Cornely, O. A., Steinbach, A., Groll, A. H., Lass-Floerl, C., Ostermann, H., Ruhnke, M., Vehreschild, J. J., Karthaus, M., Rueping, M. J. G. T., Cornely, O. A., Steinbach, A., Groll, A. H., Lass-Floerl, C., Ostermann, H., Ruhnke, M., and Vehreschild, J. J.

Abstract

The objectives of this study were to identify unsolved issues in the management of invasive candidiasis, identify controversies and achieve consensus. The German Speaking Mycological Society (Deutschsprachige Mykologische Gesellschaft, DMykG e.V.) asked other German infectious diseases (ID) and mycological societies to submit unsolved issues concerning the diagnosis and treatment of fungal infections. Based on these contributions, a digital web-based questionnaire of 12 questions on Candida infections was designed to be completed by experts of the participating societies. Controversial results were identified by a mathematical model and were discussed at a consensus conference during the 43rd Annual Meeting of the DMykG e.V. in Cologne, Germany. Forty-two individuals completed the questionnaire. Analysis showed a strong consensus on treatment indications, choice of antifungals for clinical situations, handling of central venous catheters, duration of treatment and role of susceptibility testing. Opinions diverged on: initial treatment of haemodynamically stable neutropenic and haemodynamically unstable non-neutropenic patients, step down to oral treatment and the differential role of the echinocandins. These questions were presented for discussion at the expert consensus conference. In three of four questions, consensus was achieved. A two-step approach - web-based survey plus classical panel discussion - allows to capture expeditiously the opinions of a large and diverse group of individuals, to identify controversial issues and to resolve them in a personal, interactive setting. Thus, expert consensus was achieved on nine of 12 important questions on how to treat invasive candidiasis.

Published
2011

20. On the Structure of Poly(3-hydroxybutanoic acid) in Solution and in Phospholipid Bilayers. Circular Dichroism and Fluorescence Spectroscopy with Oligo(3-hydroxybutanoic acid) Derivatives

Author

Rueping, M., Dietrich, A., Buschmann, V., Fritz, M. G., Sauer, M., and Seebach, D.

Abstract

Oligomers of (R)-3-hydroxybutanoic acid (OHBs) consisting of 8, 16, and 32 HB units have been investigated by CD spectroscopy in solution and in a racemic phospholipid bilayer. A Freudenberg plot (Θ/n vs (n − 2)/n) of the data obtained in solution can be interpreted as an indication for the presence of a chiral secondary structure of the oligoester chain&sbd;on the very short time scale of UV spectroscopy! The OHBs were also combined with fluorescent groups, including donor/acceptor pairs (coumarin, rhodamine, cyanine, oxazine). This enabled their detection by fluorescent microscopy and fluorescence-resonance-energy-transfer (FRET) measurements. With these techniques it was possible to calculate the distance between the fluorescent groups, thus providing information about the conformation of the OHB chain. With a calculated Förster distance R0 of 60 Å the distance (in 10-6 M CHCl3) between the termini of HB 8-, 16-, and 32-mer were calculated to be 41, 38, and 49 Å, respectively. This result is compatible with conclusions drawn from other observations, indicating that longer HB chains fold in a hairpin-type fashion. Incorporation of fluorescent 16- and 32-mers in liposomes shows that the latter tend to aggregate while the former do not:  The investigation described here did not lead to a decision as to whether an OHB chain, and thus also the poly(hydroxybutanoate) (PHB) chain, attains a 21- or a 31-helical arrangement in solution.

Published
2001

21. Enantioselective Brønsted Acid Catalyzed Transfer Hydrogenation:  Organocatalytic Reduction of Imines

Author

Rueping, M., Sugiono, E., Azap, C., Theissmann, T., and Bolte, M.

Abstract

The first enantioselective Brønsted acid catalyzed reduction of imines has been developed. This new organocatalytic transfer hydrogenation of ketimines with Hantzsch dihydropyridine as the hydrogen source offers a mild method to various chiral amines with high enantioselectivity. The stereochemistry of the chiral amines can be rationalized by a stereochemical model derived from an X-ray crystal structure of a chiral BINOL phosphate catalyst.

Published
2005

22. Under the fungiscope: 41 cases of invasive zygomycosis

Author

Rueping, M. J. G. T., Jörg Janne Vehreschild, Beisel, C., Heinz, W. J., Rickerts, V., Lass-Floerl, C., Ullmann, A. J., Groll, A. H., Maertens, J., Herbrecht, R., Kindo, A. J., Roth, Y., Wattad, M., Egerer, G., Maschmeyer, G., Simon, A., Borchert, K., Fischer, G., and Cornely, O. A.

27. Forty-one cases of invasive zygomycosis from a global clinical registry

Author

Rueping, M. J. G. T., Heinz, W. J., Kindo, A. J., Rickerts, V., Lass-Floerl, C., Beisel, C., Herbrecht, R., Silling, G., Roth, Y., Ullmann, A. J., Borchert, K., Egerer, G., Maertens, J., Maschmeyer, G., Simon, A., Wattad, M., Fischer, G., Vehreschild, J. J., and Oliver Cornely

32. From the biopolymer PHB to biological investigations of unnatural β- and γ-peptides

Author

Seebach, D., Albert, M., Per I Arvidsson, Rueping, M., and Schreiber, J. V.

Subjects
General Medicine, General Chemistry
Abstract

An overview is given of the past and present activities of our group in the field of chemical biology. Thus, the polymer of 3-hydroxybutanoic acid (PHS), which is omnipresent in living organisms, triggered our search for a better analytical method for detecting PHB and our syntheses of oligomers of 3-hydroxyalkanoic acids (OHSs). Also, the regulation of DNA replication by poly(β-malic acid) (PMA) in certain eukaryotes inspired synthetic work on the corresponding cyclic and open-chain oligomers. With these oligomers we not only tested the mechanisms of depolymerases, but were able to study the properties and activities of well-characterized compounds (also with isotope and fluorescence labeling). The role of PHS as component of ion transport systems through phospholipid bilayers was unambiguously established, and models for the channel structure were proposed. Replacement of amino acids by 3-hydroxybutanoic acid residues in peptides and replacement of the chain-bound oxygens in OHB by NH paved our way into the world of β- and γ-peptides, the synthesis and physiological and pharmacological properties of which are being investigated. β-Peptides are stable to peptidases, have a long lifetime in mammalian serum and are rather resistant to environmental microbial degradation. The peptides consisting of homologated (β) or doubly homologated (γ) amino acids form stable secondary structures in solution (helices, turns, sheets) which can be used as scaffolds for peptide mimics, such as a β-tetrapeptide with affinity to a somatostatin receptor or a β-nonapeptide that inhibits intestinal lipid-transport protein (SR-BI) in Caco-2 cells. Certain β-peptides have antibacterial, antiproliferative and haemolytic properties. The lessons from studies of β- and γ-peptides teach us about the central role of natural α-peptidic proteins.

50. Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole

Author

Stuart L. Warriner, Hester A. Beard, Katherine E. Jolley, Mary E. Bayana, Robin S. Bon, Hauser, and Rueping, M

Subjects
Letter, DABCO, Cyanation, 010402 general chemistry, ACBT, 01 natural sciences, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Organic chemistry, organocatalysis, lcsh:Science, cyanation, Octane, luciferins, 010405 organic chemistry, Organic Chemistry, Luciferin, 0104 chemical sciences, Chemistry, chemistry, Organocatalysis, lcsh:Q, Amine gas treating, Bioorthogonal chemistry, 2-cyanobenzothiazoles, 2-cyanobenzothiazole
Abstract

2-Cyanobenzothiazoles (CBTs) are useful building blocks for: 1) luciferin derivatives for bioluminescent imaging; and 2) handles for bioorthogonal ligations. A particularly versatile CBT is 6-amino-2-cyanobenzothiazole (ACBT), which has an amine handle for straight-forward derivatisation. Here we present an economical and scalable synthesis of ACBT based on a cyanation catalysed by 1,4-diazabicyclo[2.2.2]octane (DABCO), and discuss its advantages for scale-up over previously reported routes.

Published
2016

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