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1. Prognostic value of total tumor volume in patients with colorectal liver metastases: A secondary analysis of the randomized CAIRO5 trial with external cohort validation

Author

Michiel Zeeuw, J., Wesdorp, Nina J., Ali, Mahsoem, Bakker, Anne-Joëlle J.J., Voigt, Kelly R., Starmans, Martijn P.A., Roor, Joran, Kemna, Ruby, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M.G.C., Moos, Shira I., van Dieren, Susan, van Amerongen, Martinus J., Bond, Marinde J.G., Chapelle, Thiery, van Dam, Ronald M., Engelbrecht, Marc R.W., Gerhards, Michael F., van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Quintus Molenaar, I., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., de Wilt, Johannes H.W., Verpalen, Inez M., Stoker, Jaap, Grunhagen, Dirk J., Swijnenburg, Rutger-Jan, Punt, Cornelis J.A., Huiskens, Joost, Verhoef, Cornelis, and Kazemier, Geert

Published
2024
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2. Deep learning models for automatic tumor segmentation and total tumor volume assessment in patients with colorectal liver metastases

Author

Wesdorp, Nina J., Zeeuw, J. Michiel, Postma, Sam C. J., Roor, Joran, van Waesberghe, Jan Hein T. M., van den Bergh, Janneke E., Nota, Irene M., Moos, Shira, Kemna, Ruby, Vadakkumpadan, Fijoy, Ambrozic, Courtney, van Dieren, Susan, van Amerongen, Martinus J., Chapelle, Thiery, Engelbrecht, Marc R. W., Gerhards, Michael F., Grunhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S. L., van Lienden, Krijn P., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Marquering, Henk A., Stoker, Jaap, Swijnenburg, Rutger-Jan, Punt, Cornelis J. A., Huiskens, Joost, and Kazemier, Geert

Published
2023
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3. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Bond, Marinde J. G., Kuiper, Babette I., Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H. C., Engelbrecht, Marc R. W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas, Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F. M., Leclercq, Wouter K. G., Liem, Mike S. L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Kazemier, Geert, May, Anne M., Punt, Cornelis J. A., and Swijnenburg, Rutger-Jan

Published
2023
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4. The role of tumour biological factors in technical anatomical resectability assessment of colorectal liver metastases following induction systemic treatment: An analysis of the Dutch CAIRO5 trial

Author

Bolhuis, Karen, Bond, Marinde J.G., Van Amerongen, Martin J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Hermans, John J., De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., May, Anne M., Punt, Cornelis J.A., and Swijnenburg, Rutger-Jan

Published
2023
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5. Prognostic value of total tumor volume in patients with colorectal liver metastases: A secondary analysis of the randomized CAIRO5 trial with external cohort validation

Author

Hart- en Vaatziekten Team A, Epi Kanker Team B, Cancer, MS CGO, Zorgeenheid Kinderchirurgie Medisch, Researchgr. Beeldg. Moleculaire Interv., Michiel Zeeuw, J., Wesdorp, Nina J., Ali, Mahsoem, Bakker, Anne Joëlle J.J., Voigt, Kelly R., Starmans, Martijn P.A., Roor, Joran, Kemna, Ruby, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M.G.C., Moos, Shira I., van Dieren, Susan, van Amerongen, Martinus J., Bond, Marinde J.G., Chapelle, Thiery, van Dam, Ronald M., Engelbrecht, Marc R.W., Gerhards, Michael F., van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Quintus Molenaar, I., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., de Wilt, Johannes H.W., Verpalen, Inez M., Stoker, Jaap, Grunhagen, Dirk J., Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Verhoef, Cornelis, Kazemier, Geert, Hart- en Vaatziekten Team A, Epi Kanker Team B, Cancer, MS CGO, Zorgeenheid Kinderchirurgie Medisch, Researchgr. Beeldg. Moleculaire Interv., Michiel Zeeuw, J., Wesdorp, Nina J., Ali, Mahsoem, Bakker, Anne Joëlle J.J., Voigt, Kelly R., Starmans, Martijn P.A., Roor, Joran, Kemna, Ruby, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M.G.C., Moos, Shira I., van Dieren, Susan, van Amerongen, Martinus J., Bond, Marinde J.G., Chapelle, Thiery, van Dam, Ronald M., Engelbrecht, Marc R.W., Gerhards, Michael F., van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Quintus Molenaar, I., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., de Wilt, Johannes H.W., Verpalen, Inez M., Stoker, Jaap, Grunhagen, Dirk J., Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Verhoef, Cornelis, and Kazemier, Geert

Published
2024

6. Prognostic value of total tumor volume in patients with colorectal liver metastases:A secondary analysis of the randomized CAIRO5 trial with external cohort validation

Author

Michiel Zeeuw, J., Wesdorp, Nina J., Ali, Mahsoem, Bakker, Anne Joëlle J.J., Voigt, Kelly R., Starmans, Martijn P.A., Roor, Joran, Kemna, Ruby, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M.G.C., Moos, Shira I., van Dieren, Susan, van Amerongen, Martinus J., Bond, Marinde J.G., Chapelle, Thiery, van Dam, Ronald M., Engelbrecht, Marc R.W., Gerhards, Michael F., van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Quintus Molenaar, I., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., de Wilt, Johannes H.W., Verpalen, Inez M., Stoker, Jaap, Grunhagen, Dirk J., Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Verhoef, Cornelis, Kazemier, Geert, Michiel Zeeuw, J., Wesdorp, Nina J., Ali, Mahsoem, Bakker, Anne Joëlle J.J., Voigt, Kelly R., Starmans, Martijn P.A., Roor, Joran, Kemna, Ruby, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M.G.C., Moos, Shira I., van Dieren, Susan, van Amerongen, Martinus J., Bond, Marinde J.G., Chapelle, Thiery, van Dam, Ronald M., Engelbrecht, Marc R.W., Gerhards, Michael F., van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Quintus Molenaar, I., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., de Wilt, Johannes H.W., Verpalen, Inez M., Stoker, Jaap, Grunhagen, Dirk J., Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Verhoef, Cornelis, and Kazemier, Geert

Abstract

Background:This study aimed to assess the prognostic value of total tumor volume (TTV) for early recurrence (within 6 months) and overall survival (OS) in patients with colorectal liver metastases (CRLM), treated with induction systemic therapy followed by complete local treatment.Methods: Patients with initially unresectable CRLM from the multicenter randomized phase 3 CAIRO5 trial (NCT02162563) who received induction systemic therapy followed by local treatment were included. Baseline TTV and change in TTV as response to systemic therapy were calculated using the CT scan before and the first after systemic treatment, and were assessed for their added prognostic value. The findings were validated in an external cohort of patients treated at a tertiary center. Results:In total, 215 CAIRO5 patients were included. Baseline TTV and absolute change in TTV were significantly associated with early recurrence (P = 0.005 and P = 0.040, respectively) and OS in multivariable analyses (P = 0.024 and P = 0.006, respectively), whereas RECIST1.1 was not prognostic for early recurrence (P = 0.88) and OS (P = 0.35). In the validation cohort (n = 85), baseline TTV and absolute change in TTV remained prognostic for early recurrence (P = 0.041 and P = 0.021, respectively) and OS in multivariable analyses (P < 0.0001 and P = 0.012, respectively), and showed added prognostic value over conventional clinicopathological variables (increase C-statistic, 0.06; 95 % CI, 0.02 to 0.14; P = 0.008). Conclusion: Total tumor volume is strongly prognostic for early recurrence and OS in patients who underwent complete local treatment of initially unresectable CRLM, both in the CAIRO5 trial and the validation cohort. In contrast, RECIST1.1 did not show prognostic value for neither early recurrence nor OS.

Published
2024

7. Outcomes of Resectability Assessment of the Dutch Colorectal Cancer Group Liver Metastases Expert Panel

Author

Van Amerongen, M.J., Dejong, Cornelis HC., Gerhards, Michael F., Grunhagen, Dirk, Heijmen, Linda, Hermans, John J., Keijser, Astrid, Klaase, Joost M., Van Lienden, Krijn P, Molenaar, Quintus I., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Swijnenburg, Rutger-Jan, van Tinteren, Harm, Huiskens, Joost, Bolhuis, Karen, Engelbrecht, Marc RW., De Jong, Koert P., Kazemier, Geert, Liem, Mike SL., Verhoef, Cornelis, de Wilt, Johannes HW., Punt, Cornelis JA., and van Gulik, Thomas M.

Published
2019
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8. The Prognostic Value of Total Tumor Volume Response Compared With RECIST1.1 in Patients With Initially Unresectable Colorectal Liver Metastases Undergoing Systemic Treatment

Author

Wesdorp, Nina J., Bolhuis, Karen, Roor, Joran, van Waesberghe, Jan-Hein T. M., van Dieren, Susan, van Amerongen, Martin J., Chapelle, Thiery, Dejong, Cornelis H. C., Engelbrecht, Marc R. W., Gerhards, Michael F., Grunhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S. L., van Lienden, Krijn P., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Swijnenburg, Rutger-Jan, Punt, Cornelis J. A., Huiskens, Joost, and Kazemier, Geert

Published
2021
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9. Short-Term Outcomes of Secondary Liver Surgery for Initially Unresectable Colorectal Liver Metastases Following Modern Induction Systemic Therapy in the Dutch CAIRO5 Trial

Author

Bolhuis, Karen, Grosheide, Lodi, Wesdorp, Nina J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H. C., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Huiskens, Joost, De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Liem, Mike S. L., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H. W., Punt, Cornelis J. A., and Swijnenburg, Rutger-Jan

Published
2021
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10. ASO Visual Abstract: Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases—Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Bond, Marinde J. G., primary, Kuiper, Babette I., additional, Bolhuis, Karen, additional, Komurcu, Aysun, additional, van Amerongen, Martinus J., additional, Chapelle, Thiery, additional, Dejong, Cornelis H. C., additional, Engelbrecht, Marc R. W., additional, Gerhards, Michael F., additional, Grünhagen, Dirk J., additional, van Gulik, Thomas, additional, Hermans, John J., additional, de Jong, Koert P., additional, Klaase, Joost M., additional, Kok, Niels F. M., additional, Leclercq, Wouter K. G., additional, Liem, Mike S. L., additional, van Lienden, Krijn P., additional, Quintus Molenaar, I., additional, Neumann, Ulf P., additional, Patijn, Gijs A., additional, Rijken, Arjen M., additional, Ruers, Theo M., additional, Verhoef, Cornelis, additional, de Wilt, Johannes H. W., additional, Kazemier, Geert, additional, May, Anne M., additional, Punt, Cornelis J. A., additional, and Swijnenburg, Rutger-Jan, additional

Published
2023
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11. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases:Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Bond, Marinde J.G., Kuiper, Babette I., Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas, Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Kazemier, Geert, May, Anne M., Punt, Cornelis J.A., Swijnenburg, Rutger Jan, Bond, Marinde J.G., Kuiper, Babette I., Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas, Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Kazemier, Geert, May, Anne M., Punt, Cornelis J.A., and Swijnenburg, Rutger Jan

Abstract

Background: Consensus on resectability criteria for colorectal cancer liver metastases (CRLM) is lacking, resulting in differences in therapeutic strategies. This study evaluated variability of resectability assessments and local treatment plans for patients with initially unresectable CRLM by the liver expert panel from the randomised phase III CAIRO5 study. Methods: The liver panel, comprising surgeons and radiologists, evaluated resectability by predefined criteria at baseline and 2-monthly thereafter. If surgeons judged CRLM as resectable, detailed local treatment plans were provided. The panel chair determined the conclusion of resectability status and local treatment advice, and forwarded it to local surgeons. Results: A total of 1149 panel evaluations of 496 patients were included. Intersurgeon disagreement was observed in 50% of evaluations and was lower at baseline than follow-up (36% vs. 60%, p < 0.001). Among surgeons in general, votes for resectable CRLM at baseline and follow-up ranged between 0–12% and 27–62%, and for permanently unresectable CRLM between 3–40% and 6–47%, respectively. Surgeons proposed different local treatment plans in 77% of patients. The most pronounced intersurgeon differences concerned the advice to proceed with hemihepatectomy versus parenchymal-preserving approaches. Eighty-four percent of patients judged by the panel as having resectable CRLM indeed received local treatment. Local surgeons followed the technical plan proposed by the panel in 40% of patients. Conclusion: Considerable variability exists among expert liver surgeons in assessing resectability and local treatment planning of initially unresectable CRLM. This stresses the value of panel-based decisions, and the need for consensus guidelines on resectability criteria and technical approach to prevent unwarranted variability in clinical practice.

Published
2023

12. The role of tumour biological factors in technical anatomical resectability assessment of colorectal liver metastases following induction systemic treatment:An analysis of the Dutch CAIRO5 trial

Author

Bolhuis, Karen, Bond, Marinde J.G., Van Amerongen, Martin J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Hermans, John J., De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., May, Anne M., Punt, Cornelis J.A., Swijnenburg, Rutger Jan, Bolhuis, Karen, Bond, Marinde J.G., Van Amerongen, Martin J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Hermans, John J., De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., May, Anne M., Punt, Cornelis J.A., and Swijnenburg, Rutger Jan

Abstract

Background: Large inter-surgeon variability exists in technical anatomical resectability assessment of colorectal cancer liver-only metastases (CRLM) following induction systemic therapy. We evaluated the role of tumour biological factors in predicting resectability and (early) recurrence after surgery for initially unresectable CRLM. Methods: 482 patients with initially unresectable CRLM from the phase 3 CAIRO5 trial were selected, with two-monthly resectability assessments by a liver expert panel. If no consensus existed among panel surgeons (i.e. same vote for (un)resectability of CRLM), conclusion was based on majority. The association of tumour biological (sidedness, synchronous CRLM, carcinoembryonic antigen and RAS/BRAFV600E mutation status) and technical anatomical factors with consensus among panel surgeons, secondary resectability and early recurrence (<6 months) without curative-intent repeat local treatment was analysed by uni- and pre-specified multivariable logistic regression. Results: After systemic treatment, 240 (50%) patients received complete local treatment of CRLM of which 75 (31%) patients experienced early recurrence without repeat local treatment. Higher number of CRLM (odds ratio 1.09 [95% confidence interval 1.03–1.15]) and age (odds ratio 1.03 [95% confidence interval 1.00–1.07]) were independently associated with early recurrence without repeat local treatment. In 138 (52%) patients, no consensus among panel surgeons was present prior to local treatment. Postoperative outcomes in patients with and without consensus were comparable. Conclusions: Almost a third of patients selected by an expert panel for secondary CRLM surgery following induction systemic treatment experience an early recurrence only amenable to palliative treatment. Number of CRLM and age, but no tumour biological factors are predictive, suggesting that until there are better biomarkers; resectability assessment remains primarily a technical anatomical de

Published
2023

13. Deep learning models for automatic tumor segmentation and total tumor volume assessment in patients with colorectal liver metastases

Author

MS CGO, Cancer, Epi Kanker Team B, Wesdorp, Nina J., Zeeuw, J. Michiel, Postma, Sam C.J., Roor, Joran, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M., Moos, Shira, Kemna, Ruby, Vadakkumpadan, Fijoy, Ambrozic, Courtney, van Dieren, Susan, van Amerongen, Martinus J., Chapelle, Thiery, Engelbrecht, Marc R.W., Gerhards, Michael F., Grunhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Marquering, Henk A., Stoker, Jaap, Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Kazemier, Geert, MS CGO, Cancer, Epi Kanker Team B, Wesdorp, Nina J., Zeeuw, J. Michiel, Postma, Sam C.J., Roor, Joran, van Waesberghe, Jan Hein T.M., van den Bergh, Janneke E., Nota, Irene M., Moos, Shira, Kemna, Ruby, Vadakkumpadan, Fijoy, Ambrozic, Courtney, van Dieren, Susan, van Amerongen, Martinus J., Chapelle, Thiery, Engelbrecht, Marc R.W., Gerhards, Michael F., Grunhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Marquering, Henk A., Stoker, Jaap, Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, and Kazemier, Geert

Published
2023

14. ASO Visual Abstract: Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases-Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Quintus Molenaar, I, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, Swijnenburg, Rutger-Jan, Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Quintus Molenaar, I, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, and Swijnenburg, Rutger-Jan

Published
2023

15. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Molenaar, I Quintus, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, Swijnenburg, Rutger-Jan, Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Molenaar, I Quintus, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, and Swijnenburg, Rutger-Jan

Published
2023

16. Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases

Author

Wesdorp, Nina J, Kemna, Ruby, Bolhuis, Karen, van Waesberghe, Jan H T M, Nota, Irene M G C, Struik, Femke, Oulad Abdennabi, Ikrame, Phoa, Saffire S K S, van Dieren, Susan, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk, van Gulik, Thomas M, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Liem, Mike S L, van Lienden, Krijn P, Molenaar, I Quintus, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Swijnenburg, Rutger-Jan, Punt, Cornelis J A, Huiskens, Joost, Stoker, Jaap, Kazemier, Geert, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Internal medicine, Radiology and nuclear medicine, AGEM - Re-generation and cancer of the digestive system, VU University medical center, CCA - Imaging and biomarkers, Radiology & Nuclear Medicine, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, AGEM - Digestive immunity, APH - Methodology, Oncology, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Value, Affordability and Sustainability (VALUE)

Subjects
Colorectal Neoplasms/diagnostic imaging, Male, Tumor Response, Abdomen/Gastrointestinal, Tomography, X-Ray Computed/methods, Observer Performance, Metastases, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Liver Neoplasms/diagnostic imaging, Humans, Prospective Studies, Tomography, Original Research, Computer. Automation, Observer Variation, Liver Neoplasms, General Medicine, Middle Aged, X-Ray Computed/methods, Liver, Oncology, Female, Human medicine, Colorectal Neoplasms, Tomography, X-Ray Computed, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], CT
Abstract

Item does not contain fulltext Purpose To evaluate interobserver variability in the morphologic tumor response assessment of colorectal liver metastases (CRLM) managed with systemic therapy and to assess the relation of morphologic response with gene mutation status, targeted therapy, and Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 measurements. Materials and Methods Participants with initially unresectable CRLM receiving different systemic therapy regimens from the randomized, controlled CAIRO5 trial (NCT02162563) were included in this prospective imaging study. Three radiologists independently assessed morphologic tumor response on baseline and first follow-up CT scans according to previously published criteria. Two additional radiologists evaluated disagreement cases. Interobserver agreement was calculated by using Fleiss κ. On the basis of the majority of individual radiologic assessments, the final morphologic tumor response was determined. Finally, the relation of morphologic tumor response and clinical prognostic parameters was assessed. Results In total, 153 participants (median age, 63 years [IQR, 56-71]; 101 men) with 306 CT scans comprising 2192 CRLM were included. Morphologic assessment performed by the three radiologists yielded 86 (56%) agreement cases and 67 (44%) disagreement cases (including four major disagreement cases). Overall interobserver agreement between the panel radiologists on morphology groups and morphologic response categories was moderate (κ = 0.53, 95% CI: 0.48, 0.58 and κ = 0.54, 95% CI: 0.47, 0.60). Optimal morphologic response was particularly observed in patients treated with bevacizumab (P = .001) and in patients with RAS/BRAF mutation (P = .04). No evidence of a relationship between RECIST 1.1 and morphologic response was found (P = .61). Conclusion Morphologic tumor response assessment following systemic therapy in participants with CRLM demonstrated considerable interobserver variability. Keywords: Tumor Response, Observer Performance, CT, Liver, Metastases, Oncology, Abdomen/Gastrointestinal Clinical trial registration no. NCT02162563 Supplemental material is available for this article. © RSNA, 2022.

Published
2022
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17. Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases

Author

MS CGO, Cancer, CTC, Wesdorp, Nina J., Kemna, Ruby, Bolhuis, Karen, van Waesberghe, Jan H.T.M., Nota, Irene M.G.C., Struik, Femke, Abdennabi, Ikrame Oulad, Phoa, Saffire S.K.S., van Dieren, Susan, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Stoker, Jaap, Kazemier, Geert, MS CGO, Cancer, CTC, Wesdorp, Nina J., Kemna, Ruby, Bolhuis, Karen, van Waesberghe, Jan H.T.M., Nota, Irene M.G.C., Struik, Femke, Abdennabi, Ikrame Oulad, Phoa, Saffire S.K.S., van Dieren, Susan, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk, van Gulik, Thomas M., Hermans, John J., de Jong, Koert P., Klaase, Joost M., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I Quintus, Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Swijnenburg, Rutger Jan, Punt, Cornelis J.A., Huiskens, Joost, Stoker, Jaap, and Kazemier, Geert

Published
2022

18. Outcomes of Resectability Assessment of the Dutch Colorectal Cancer Group Liver Metastases Expert Panel

Author

Huiskens, Joost, primary, Bolhuis, Karen, additional, RW. Engelbrecht, Marc, additional, De Jong, Koert P., additional, Kazemier, Geert, additional, SL. Liem, Mike, additional, Verhoef, Cornelis, additional, HW. de Wilt, Johannes, additional, JA. Punt, Cornelis, additional, van Gulik, Thomas M., additional, Van Amerongen, M. J., additional, HC. Dejong, Cornelis, additional, Gerhards, Michael F., additional, Grunhagen, Dirk, additional, Heijmen, Linda, additional, Hermans, John J., additional, Keijser, Astrid, additional, Klaase, Joost M., additional, P Van Lienden, Krijn, additional, Molenaar, Quintus I., additional, Patijn, Gijs A., additional, Rijken, Arjen M., additional, Ruers, Theo M., additional, Swijnenburg, Rutger-Jan, additional, and van Tinteren, Harm, additional

Published
2019
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19. Feasibility of a national expert panel to determine resectability in patients with initially unresectable colorectal cancer liver metastases (CRLM).

Author

Bolhuis, Karen, primary, Huiskens, Joost, additional, Dejong, Cornelis H.C., additional, Engelbrecht, Marc R.W., additional, Gerhards, Michael F., additional, Grunhagen, Dirk J., additional, de Jong, Koert P., additional, Kazemier, Geert, additional, Klaase, Joost M., additional, Liem, Mike S.L., additional, van Lienden, Krijn P, additional, Molenaar, I. Quintus, additional, Patijn, Gijs A., additional, Rijken, Arjen M., additional, Ruers, Theo M., additional, Swijnenburg, Rutger-Jan, additional, Verhoef, Cornelis, additional, de Wilt, Johannes H.W., additional, Punt, Cornelis J. A., additional, and van Gulik, Thomas M, additional

Published
2019
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20. Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases, a study protocol of the randomised phase 3 CAIRO5 study of the Dutch Colorectal Cancer Group (DCCG)

Author

Huiskens, Joost, primary, van Gulik, Thomas M, additional, van Lienden, Krijn P, additional, Engelbrecht, Marc RW, additional, Meijer, Gerrit A, additional, van Grieken, Nicole CT, additional, Schriek, Jonne, additional, Keijser, Astrid, additional, Mol, Linda, additional, Molenaar, I Quintus, additional, Verhoef, Cornelis, additional, de Jong, Koert P, additional, Dejong, Kees HC, additional, Kazemier, Geert, additional, Ruers, Theo M, additional, de Wilt, Johanus HW, additional, van Tinteren, Harm, additional, and Punt, Cornelis JA, additional

Published
2015
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