Search

Your search keyword '"Ruf, Stephanie"' showing total 372 results
Start Over Author "Ruf, Stephanie"
372 results on '"Ruf, Stephanie"'

4. Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases

Author

Gómez, Maria Lobato, Huang, Xin, Alvarez, Derry, He, Wenshu, Baysal, Can, Zhu, Changfu, Armario‐Najera, Victoria, Perera, Amaya Blanco, Bennasser, Pedro Cerda, Saba‐Mayoral, Andera, Sobrino‐Mengual, Guillermo, Vargheese, Ashwin, Abranches, Rita, Abreu, Isabel Alexandra, Balamurugan, Shanmugaraj, Bock, Ralph, Buyel, Johannes F, da Cunha, Nicolau B, Daniell, Henry, Faller, Roland, Folgado, André, Gowtham, Iyappan, Häkkinen, Suvi T, Kumar, Shashi, Ramalingam, Sathish Kumar, Lacorte, Cristiano, Lomonossoff, George P, Luís, Ines M, K.‐C., Julian, McDonald, Karen A, Murad, Andre, Nandi, Somen, O’Keefe, Barry, Oksman‐Caldentey, Kirsi‐Marja, Parthiban, Subramanian, Paul, Mathew J, Ponndorf, Daniel, Rech, Elibio, Rodrigues, Julio CM, Ruf, Stephanie, Schillberg, Stefan, Schwestka, Jennifer, Shah, Priya S, Singh, Rahul, Stoger, Eva, Twyman, Richard M, Varghese, Inchakalody P, Vianna, Giovanni R, Webster, Gina, Wilbers, Ruud HP, Capell, Teresa, and Christou, Paul

Subjects
Immunization, Prevention, Vaccine Related, Biotechnology, Emerging Infectious Diseases, Biodefense, Infectious Diseases, Infection, Good Health and Well Being, COVID-19, Communicable Diseases, Humans, Pandemics, SARS-CoV-2, Molecular farming, plant-made pharmaceuticals, HIV/AIDS, Biological Sciences, Technology, Medical and Health Sciences
Abstract

Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause ˜17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programmes, hygiene measures and drugs that suppress the pathogen, treat the disease symptoms or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focussing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world.

Published
2021

5. Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re‐emerging diseases

Author

He, Wenshu, Baysal, Can, Gómez, Maria Lobato, Huang, Xin, Alvarez, Derry, Zhu, Changfu, Armario‐Najera, Victoria, Perera, Aamaya Blanco, Bennaser, Pedro Cerda, Saba‐Mayoral, Andrea, Sobrino‐Mengual, Guillermo, Vargheese, Ashwin, Abranches, Rita, Abreu, Isabel Alexandra, Balamurugan, Shanmugaraj, Bock, Ralph, Buyel, Johannes F, Cunha, Nicolau B, Daniell, Henry, Faller, Roland, Folgado, André, Gowtham, Iyappan, Häkkinen, Suvi T, Kumar, Shashi, Kumar, Ramalingam Sathish, Lacorte, Cristiano, Lomonossoff, George P, Luís, Ines M, K.‐C., Julian, McDonald, Karen A, Murad, Andre, Nandi, Somen, O’Keef, Barry, Parthiban, Subramanian, Paul, Mathew J, Ponndorf, Daniel, Rech, Elibio, Rodrigues, Julio CM, Ruf, Stephanie, Schillberg, Stefan, Schwestka, Jennifer, Shah, Priya S, Singh, Rahul, Stoger, Eva, Twyman, Richard M, Varghese, Inchakalody P, Vianna, Giovanni R, Webster, Gina, Wilbers, Ruud HP, Christou, Paul, Oksman‐Caldentey, Kirsi‐Marja, and Capell, Teresa

Subjects
Prevention, Vaccine Related, Biodefense, Rare Diseases, Emerging Infectious Diseases, Biotechnology, Infectious Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Animals, Artemisia annua, Communicable Diseases, Humans, Molecular Farming, Pharmaceutical Preparations, Plants, Edible, molecular farming, plant-made pharmaceuticals, oral delivery, endemic disease, re-emerging disease, Biological Sciences, Technology, Medical and Health Sciences
Abstract

The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.

Published
2021

6. Contributions of the international plant science community to the fight against human infectious diseases - part 1: epidemic and pandemic diseases.

Author

Lobato Gómez, Maria, Huang, Xin, Alvarez, Derry, He, Wenshu, Baysal, Can, Zhu, Changfu, Armario-Najera, Victoria, Blanco Perera, Amaya, Cerda Bennasser, Pedro, Saba-Mayoral, Andera, Sobrino-Mengual, Guillermo, Vargheese, Ashwin, Abranches, Rita, Abreu, Isabel Alexandra, Balamurugan, Shanmugaraj, Bock, Ralph, Buyel, Johannes F, da Cunha, Nicolau B, Daniell, Henry, Faller, Roland, Folgado, André, Gowtham, Iyappan, Häkkinen, Suvi T, Kumar, Shashi, Ramalingam, Sathish Kumar, Lacorte, Cristiano, Lomonossoff, George P, Luís, Ines M, Ma, Julian K-C, McDonald, Karen A, Murad, Andre, Nandi, Somen, O'Keefe, Barry, Oksman-Caldentey, Kirsi-Marja, Parthiban, Subramanian, Paul, Mathew J, Ponndorf, Daniel, Rech, Elibio, Rodrigues, Julio CM, Ruf, Stephanie, Schillberg, Stefan, Schwestka, Jennifer, Shah, Priya S, Singh, Rahul, Stoger, Eva, Twyman, Richard M, Varghese, Inchakalody P, Vianna, Giovanni R, Webster, Gina, Wilbers, Ruud HP, Capell, Teresa, and Christou, Paul

Subjects
Humans, Communicable Diseases, Pandemics, COVID-19, SARS-CoV-2, HIV/AIDS, Molecular farming, plant-made pharmaceuticals, Emerging Infectious Diseases, Vaccine Related, Biotechnology, Infectious Diseases, Immunization, Biodefense, Prevention, Infection, Biological Sciences, Technology, Medical and Health Sciences
Abstract

Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause ˜17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programmes, hygiene measures and drugs that suppress the pathogen, treat the disease symptoms or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focussing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results