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11 results on '"Ruggio, Natalie"'

1. Abstract 3245: AXL as a therapeutic target in STK11 mutant NSCLC

Author

Blø, Magnus, primary, Rayford, Austin, additional, Madeleine, Noëlly, additional, Gärtner, Fabian, additional, Bohan, Dana, additional, Ruggio, Natalie, additional, Li, Huiyu, additional, Girard, Luc, additional, Brekken, Rolf, additional, Minna, John, additional, Ånerud, Marianne, additional, Maury, Wendy, additional, Gorcea-Carson, Claudia, additional, Gausdal, Gro, additional, Micklem, David R., additional, and McCracken, Nigel, additional

Published
2023
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2. Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein

Author

Van Ert, Hanora A., primary, Bohan, Dana W., additional, Rogers, Kai, additional, Fili, Mohammad, additional, Rojas Chávez, Roberth A., additional, Qing, Enya, additional, Han, Changze, additional, Dempewolf, Spencer, additional, Hu, Guiping, additional, Schwery, Nathan, additional, Sevcik, Kristina, additional, Ruggio, Natalie, additional, Boyt, Devlin, additional, Pentella, Michael A., additional, Gallagher, Tom, additional, Jackson, J. Brooks, additional, Merrill, Anna E., additional, Knudson, C. Michael, additional, Brown, Grant D., additional, Maury, Wendy, additional, and Haim, Hillel, additional

Published
2022
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3. Phosphatidylserine receptors enhance SARS-CoV-2 infection

Author

Bohan, Dana, primary, Van Ert, Hanora, additional, Ruggio, Natalie, additional, Rogers, Kai J., additional, Badreddine, Mohammad, additional, Aguilar Briseño, José A., additional, Elliff, Jonah M., additional, Rojas Chavez, Roberth Anthony, additional, Gao, Boning, additional, Stokowy, Tomasz, additional, Christakou, Eleni, additional, Kursula, Petri, additional, Micklem, David, additional, Gausdal, Gro, additional, Haim, Hillel, additional, Minna, John, additional, Lorens, James B., additional, and Maury, Wendy, additional

Published
2021
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5. Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein

Author

Van Ert, Hanora A., primary, Bohan, Dana W., additional, Rogers, Kai, additional, Fili, Mohammad, additional, Rojas Chávez, Roberth A., additional, Qing, Enya, additional, Han, Changze, additional, Dempewolf, Spencer, additional, Hu, Guiping, additional, Schwery, Nathan, additional, Sevcik, Kristina, additional, Ruggio, Natalie, additional, Boyt, Devlin, additional, Pentella, Michael A., additional, Gallagher, Tom, additional, Jackson, J. Brooks, additional, Merrill, Anna E., additional, Knudson, C. Michael, additional, Brown, Grant D., additional, Maury, Wendy, additional, and Haim, Hillel, additional

Published
2021
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6. Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19

Author

Bohan, Dana, primary, Van Ert, Hanora, additional, Ruggio, Natalie, additional, Rogers, Kai J., additional, Badreddine, Mohammad, additional, Aguilar Briseño, José A., additional, Chavez, Roberth Anthony Rojas, additional, Gao, Boning, additional, Stokowy, Tomasz, additional, Christakou, Eleni, additional, Micklem, David, additional, Gausdal, Gro, additional, Haim, Hillel, additional, Minna, John, additional, Lorens, James B., additional, and Maury, Wendy, additional

Published
2021
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7. Optimizing immunoassay-based selection of donors for COVID-19 convalescent plasma

Author

Van Ert, Hanora A, primary, Rogers, Kai, additional, Bohan, Dana, additional, Han, Chanze, additional, Dempewolf, Spencer, additional, Sevcik, Kristina, additional, Ruggio, Natalie, additional, Rojas-Chavez, Anthony, additional, Boyt, Devlin, additional, Pentella, Michael, additional, Jackson, Brooks, additional, Merrill, Anna, additional, Knudson, Michael, additional, Maury, Wendy, additional, and Haim, Hillel, additional

Published
2021
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9. DNA Aptamers for Early Detection of Ebolavirus

Author

Banerjee, Soma, primary, Hoinka, Jan, additional, Gosai, Agnivo, additional, Zhu, Zhichen, additional, Devarakonda, Sivaranjani, additional, Geekiyanage, Charith, additional, Shubham, Shambhavi, additional, Lennemann, Nicholas, additional, Dillard, Jake, additional, Ruggio, Natalie, additional, Przytycka, Teresa, additional, Maury, Wendy, additional, Shrotriya, Pranav, additional, and Nilsen‐Hamilton, Marit, additional

Published
2021
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11. Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19.

Author

Bohan D, Ert HV, Ruggio N, Rogers KJ, Badreddine M, Aguilar Briseño JA, Rojas Chavez RA, Gao B, Stokowy T, Christakou E, Micklem D, Gausdal G, Haim H, Minna J, Lorens JB, and Maury W

Abstract

Phosphatidylserine (PS) receptors are PS binding proteins that mediate uptake of apoptotic bodies. Many enveloped viruses utilize this PS/PS receptor mechanism to adhere to and internalize into the endosomal compartment of cells and this is termed apoptotic mimicry. For viruses that have a mechanism(s) of endosomal escape, apoptotic mimicry is a productive route of virus entry. We evaluated if PS receptors serve as cell surface receptors for SARS-CoV-2 and found that the PS receptors, AXL, TIM-1 and TIM-4, facilitated virus infection when low concentrations of the SARS-CoV-2 cognate receptor, ACE2, was present. Consistent with the established mechanism of PS receptor utilization by other viruses, PS liposomes competed with SARS-CoV-2 for binding and entry. We demonstrated that this PS receptor enhances SARS-CoV-2 binding to and infection of an array of human lung cell lines and is an under-appreciated but potentially important host factor facilitating SARS-CoV-2 entry.

Published
2021
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