98 results on '"Ruiqin Xie"'
Search Results
2. Clinical Results and Safety of Intracardiac Echocardiography Guidance for Combined Catheter Ablation and Left Atrial Appendage Occlusion
- Author
-
Qian Liu, Ling You, Jing Yang, Yan Zhang, Jinglan Wu, Hongning Yin, Yanan Zhang, and Ruiqin Xie
- Subjects
atrial fibrillation ,intracardiac echocardiography ,left atrial appendage occlusion ,radiofrequency ablation ,transesophageal echocardiography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The goal of this study was to compare the procedural safety and long-term outcome associated with a combined catheter ablation and left atrial appendage occlusion (LAAO) procedure utilizing intracardiac echocardiography (ICE) guidance versus transesophageal echocardiography (TEE) guidance. The study focuses on implementing LAmbre and Watchman devices in patients diagnosed with nonvalvular atrial fibrillation (AF). Methods: A total of 363 patients diagnosed with nonvalvular AF and who underwent a combined procedure were prospectively enrolled between November 2017 and May 2022. Following 1:1 propensity score matching, the TEE group (n = 132) and ICE group (n = 132) were systematically compared in terms of the combined procedure, imaging parameters, events related to the procedure, and subsequent outcomes during follow-up, including mortality, stroke, bleeding, device-related thrombus (DRT), and peri-device leaks (PDLs). Results: The ICE group exhibited a significant reduction in total procedural duration (153.71 ± 31.71 vs. 174.74 ± 18.79 min), fluoroscopy radiation dosage (207.24 ± 108.39 vs. 268.61 ± 122.88 mGy), left atrial appendage occlusion procedure time (34.69 ± 10.91 vs. 51.46 ± 15.84 min), and contrast agent exposure (108.71 ± 37.59 vs. 158.41 ± 45.00 mL) compared to the TEE group. Angiography and ICE demonstrated a substantial correlation between the left atrial appendage (LAA) orifice and landing zone/LAA ostium (Pearson’s correlation coefficient r = 0.808 and 0.536/0.697, two-tailed p < 0.001). No occurrences of device-related embolism, thromboembolism, significant bleeding, or unexpected fatalities were observed in either group. Comparable rates of all-cause death (0.76% vs. 0.76%), stroke or transient ischemic attack (2.27% vs. 1.52%), severe bleeding (1.52% vs. 0.76%), PDL (23.81% vs. 24.62%), and DRT (1.52% vs. 1.52%) were noted after an average follow-up of 18.46 ± 7.70 months in both groups, with no discernible differences. Multivariate logistic regression analysis identified a correlation between LAA velocity and the risk of PDL. Conclusions: The effectiveness and safety of ICE-guided combined treatment were demonstrated to be comparable to TEE guidance, accompanied by the additional advantages of decreased procedure time and fluoroscopy radiation exposure. Clinical Trial Registration: NCT04391504, https://register.clinicaltrials.gov.
- Published
- 2024
- Full Text
- View/download PDF
3. Editorial: Left atrial appendage occlusion: basic and clinical
- Author
-
Nan Zhang, Wilber Su, Yuxin Li, Junxian Song, Tong Liu, and Ruiqin Xie
- Subjects
atrial fibrillation ,left atrial appendage occlusion ,stroke ,prevention ,radiofrequency ablation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2023
- Full Text
- View/download PDF
4. The effect of different preoperative left atrial appendage emptying speeds on left atrial function in patients with persistent atrial fibrillation after left atrial appendage closure combined with catheter ablation
- Author
-
Chao Yang, Jing Yang, Qian Liu, Ling You, Jinglan Wu, Yanan Zhang, Lianxia Wang, and Ruiqin Xie
- Subjects
Left atrial appendage closure ,Catheter ablation ,Left atrial function ,Left atrial appendage emptying velocity ,Spot tracking echocardiography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Objective The present study aimed to investigate whether different preoperative left atrial appendage emptying speeds (LAAEVs) have an effect on left atrial function in patients with sinus arrhythmia after left atrial appendage closure (LAAC) combined with catheter ablation (CA). Methods A total of 163 patients with persistent non-valvular atrial fibrillation who received combined LAAC+CA surgery were included in the present study. Regular follow-up was conducted for 12 months, and patients with complete data and successful sinus rhythm recovery were selected as the study subjects (n = 82). The patients were divided into two groups: the LAAEV
- Published
- 2022
- Full Text
- View/download PDF
5. Effect of radiofrequency catheter ablation on left atrial structure and function in patients with different types of atrial fibrillation
- Author
-
Yue Liu, Qian Liu, Ying Yang, Chenfeng Zhang, Hongning Yin, Jinglan Wu, Lixia Yao, Lili Jin, Jing Yang, Liang Feng, and Ruiqin Xie
- Subjects
Medicine ,Science - Abstract
Abstract Radiofrequency catheter ablation (RFCA) is widely used to treat atrial fibrillation (AF), but its effect on left atrial (LA) remodeling in patients with AF is not completely clarified. Few studies have reported the changes in structure and function of the left atrium in patients with different types of AF after RFCA. To analyze the effect of RFCA on the LA structure and function in patients with nonvalvular paroxysmal AF, persistent AF and long-standing persistent AF (LSPAF). RFCA was performed in 180 patients with paroxysmal AF, persistent AF and LSPAF. The changes of LA structure and function in echocardiogram and speckle-tracking echocardiography findings were compared before the procedure, and at 1, 2, 3, 4 weeks, and 2, 3, 6, and 9–12 months after the procedure. There were 60 patients in the paroxysmal AF group, 60 in the persistent AF group and 60 patients in LSPAF group. The pre-procedure LA diameter and volume were smaller in the paroxysmal AF group than persistent AF and LSPAF group. There was no significant change of in the LA structure and function in the paroxysmal AF group within 1 year. In the persistent AF and LSPAF groups, LA structure (anteroposterior diameter, LA volume) significantly decreased, but remained larger than that in paroxysmal AF group. In persistent and LSPAF, function (LA ejection fraction, strain, strain rate) increased significantly within 1 week, then gradually increased. RFCA improved the LA structure and function and resulted in heart reverse remodeling, especially for persistent AF and LSPAF.
- Published
- 2022
- Full Text
- View/download PDF
6. Relationship among atrial fibrillation, the CHA2DS2-VASc score and ischaemic stroke in patients with coronary artery disease: a propensity score matching study in Hebei, China
- Author
-
Boqun Shi, Demin Liu, Qian Wang, Xue Geng, Qian Hou, Guoqiang Gu, Ruiqin Xie, and Wei Cui
- Subjects
Atrial fibrillation ,CHA2DS2-VASc score ,Coronary artery disease ,Ischaemic stroke ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Recent evidence has shown that the pathogenesis of ischaemic stroke associated with atrial fibrillation (AF) is complex and involves other factors in addition to arrhythmias. The purpose of this study was to investigate the relationship among AF, CHA2DS2-VASc score and ischaemic stroke in patients with coronary artery disease (CAD) in Hebei, China. Methods A total of 2,335 patients with CAD from September 2016 to May 2019 at the Second Hospital of Hebei Medical University were included (mean age 62.73 ± 10.35 years, range 26–92 years; 41.58% female). This was a cross-sectional study, and participants were divided into non-stroke (n = 1997) and ischaemic stroke groups (n = 338). Propensity score matching (PSM) was performed to match ischaemic stroke patients with non-stroke patients in a 1:4 ratio. The relationship among AF, the CHA2DS2-VASc score and ischaemic stroke was evaluated using univariable generalized linear models for different sex, age, body mass index (BMI), CAD and CHA2DS2-VASc score subgroups. Univariable and multivariable generalized linear models were used to evaluate the relationship between AF and ischaemic stroke in the different models. Results Compared with that in the non-stroke group, the prevalence of AF (8.81% vs. 14.20%, P = 0.002) in the ischaemic stroke group was higher. The proportion of patients with ischaemic stroke was significantly different between the AF group and the non-AF group (28.74% vs. 19.04%, P = 0.003). An increasing CHA2DS2-VASc score was associated with a gradual increase in the prevalence of AF (P for trend
- Published
- 2021
- Full Text
- View/download PDF
7. Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score
- Author
-
Ming Zhang, Demin Liu, Qian Wang, Xue Geng, Qian Hou, Guoqiang Gu, Ruiqin Xie, and Wei Cui
- Subjects
Gastrointestinal Bleeding ,Cardiology ,Risk factors ,Risk score ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: Although the early use of a risk stratification score in gastrointestinal bleeding (GIB) is recommended, so far there has been no risk score for GIB in patients admitted to the cardiology department. To describe the risk factors of GIB and develop a new risk score model in patients admitted to the cardiology department. Methods: A total of 633 inpatients with GIB from January 2014 to December 2018 were recruited, 4,231 inpatients with non-GIB were recruited as the control group. Multivariate logistic regression was used to describe the risk factors of GIB. A new risk score model was developed in the derivation cohort. Accuracy to predict GIB was assessed by the area under the receiver operating characteristic (AUROC) curve in the validation cohort. Results: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin, and alanine aminotransferase (ALT) were associated with GIB. The model had a high predictive accuracy (AUROC 0.816 and 95% CI, 0.792-0.839), which was supported by the validation cohort (AUROC 0.841 and 95% CI, 0.807~0.874). Besides, the prediction of the model was better than HAS-BLED score (AUROC 0.557; 95% CI, 0.513~0.602) and CRUSADE score (AUROC 0.791; 95%CI, 0.757~0.825), respectively. Among the inpatients with a score of 0-3, 4-7, and ≥8 points, the incidence of GIB, the proportion of inpatients requiring suspended red blood cells transfusion, length of stay, and in-hospital mortality all increased gradually (P< 0.001). Conclusions: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin, and ALT are associated with GIB. The new risk score model is an accurate risk score that predicts GIB in patients admitted to the cardiology department.
- Published
- 2021
- Full Text
- View/download PDF
8. The R-S difference index: A new electrocardiographic method for differentiating idiopathic premature ventricular contractions originating from the left and right ventricular outflow tracts presenting a left bundle branch block pattern
- Author
-
Lei Zhao, Ruibin Li, Jidong Zhang, Ruiqin Xie, Jingchao Lu, Jinming Liu, Chenglong Miao, and Wei Cui
- Subjects
electrocardiogram ,premature ventricular contractions ,septal right ventricular outflow tract ,diagnostic index ,aortic sinus cusp ,Physiology ,QP1-981 - Abstract
Introduction: Differentiating idiopathic premature ventricular contractions (PVCs) originating from the right and left ventricular outflow tracts with a left bundle branch block (LBBB) morphology is relevant to catheter ablation planning and important for lowering the risk of complications. This study established a novel electrocardiographic (ECG) criterion to discriminate PVCs originating from the septum of the right ventricular outflow tract (s-RVOT) and those originating from the aortic sinus cusp of the left ventricular outflow tract (LVOT-ASC).Methods: A total of 259 patients with idiopathic PVCs originating from ventricular outflow tract with a LBBB pattern who underwent successful catheter ablation were retrospectively included. Among them, the PVCs originated from the s-RVOT in 183 patients and from the LVOT-ASC in 76 patients. The surface ECGs of the PVCs and sinus beats were analyzed using an electronic caliper. The R-S difference index in the precordial leads was calculated as V2R + V3R + V4R − V1S.Results: PVCs originating from both the s-RVOT and LVOT-ASC displayed an inferior axis (dominant R waves in leads II, III, and aVF). Compared with the s-RVOT group, the R-wave amplitudes on leads II, III, and aVF were significantly larger in the LVOT-ASC group (p < 0.001, p < 0.003, and p < 0.001, respectively). Compared to the LVOT-ASC group, the s-RVOT group showed smaller R-wave amplitudes on leads V1–V6 (p = 0.021, p < 0.001, p < 0.001, p < 0.001, p < 0.001, and p < 0.001, respectively) and larger S-wave amplitudes on leads V1–V3 (p < 0.001, p < 0.001, and p < 0.001, respectively). Lead V3 was the most common transitional lead in both groups. Analysis of the receiver operating characteristic curve showed that the R-wave amplitude on lead V3 had the largest area under the curve (AUC) of 0.856 followed by the R-wave amplitudes on leads V4 (0.834) and V2 (0.806). The AUC of the R-S difference index was 0.867. An R-S difference index greater than 20.9 predicted an LVOT-ASC origin with 73.7% sensitivity and 86.3% specificity. This index is superior to previous criteria in differentiating PVCs with LBBB morphology and inferior axis originating from s-RVOT vs. LVOT-ASC.Conclusions: The R-S difference index in precordial leads is a useful new ECG criterion for distinguishing LVOT-PVCs from RVOT-PVCs with LBBB morphology.
- Published
- 2022
- Full Text
- View/download PDF
9. Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation
- Author
-
Yan Zhang, Jing Yang, Qian Liu, Jinglan Wu, Lei Yin, Jing Lv, Ling You, Yanan Zhang, Lianxia Wang, Yanlei Zhao, Qian Hou, Weilin Jing, and Ruiqin Xie
- Subjects
atrial fibrillation ,percutaneous left atrial appendage closure ,catheter ablation ,post-procedure adverse events ,multivariate analysis ,Medicine - Abstract
(1) Background: This study aimed to investigate the effect of an additional catheter ablation (CA) procedure on the risk of post-procedure adverse events during CA combined with left atrial appendage closure (LAAC). (2) Methods: From July 2017 to February 2022, data from 361 patients with atrial fibrillation who underwent LAAC at our center were analyzed retrospectively. The adverse events were compared between CA + LAAC and LAAC-only groups. (3) Results: The incidence of device-related thrombus (DRT) and embolic events was significantly lower in the CA + LAAC group than in the LAAC-only group (p = 0.01 and 0.04, respectively). A logistic regression analysis revealed that the combined procedure served as a protective factor for DRT (OR = 0.09; 95% confidence interval: 0.01–0.89; p = 0.04). Based on a Cox regression analysis, the risk of embolism marginally increased in patients aged ≥65 years (HR = 7.49, 95% CI: 0.85–66.22 p = 0.07), whereas the combined procedure was found to be a protective factor (HR = 0.25, 95% CI: 0.07–0.87 p = 0.03). Further subgroup and interaction analyses revealed similar results. (4) Conclusions: The combined procedure may be associated with a lower rate of post-procedure DRT and embolization without a higher occurrence of other adverse events after LAAC. A risk-score-based prediction model was conducted, showing a good prediction performance.
- Published
- 2023
- Full Text
- View/download PDF
10. Construction of a Clinical Predictive Model of Left Atrial and Left Atrial Appendage Thrombi in Patients with Nonvalvular Atrial Fibrillation
- Author
-
Lei Yin, Changjian He, Huixin Zheng, Jianshuai Ma, Jinting Liu, Xiaohong Zhang, and Ruiqin Xie
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background. The purpose of this study was to investigate the risk factors of left atrial (LA) or left atrial appendage (LAA) thrombi in patients with nonvalvular atrial fibrillation (NVAF) and to establish and validate relevant predictive models. It might improve thromboembolic risk stratification in patients with NVAF. Methods. This study retrospectively included 1210 consecutive patients with NVAF undergoing transesophageal echocardiography (TEE), of whom 139 patients had thrombi in LA or in LAA. Through literature review and the ten events per variable (10EPV) principle, 13 variables were finally identified for inclusion in multivariate analysis. Models were constructed by multivariate logistic stepwise regression and least absolute shrinkage and selection operator (lasso) regression. Results. After logistic regression, five variables (AF type, age, B-type natriuretic peptide, E/e’ ratio, and left atrial diameter) were finally screened out as model 1. After Lasso regression, AF type, age, gender, B-type natriuretic peptide, E/e’ ratio, left atrial diameter, and left ventricular ejection fraction were finally screened as model 2. After comparing the two models, the simpler model 1 was finally selected. The area under the ROC curve (AUC) of the model 1 was 0.865 (95% CI: 0.838–0.892), the Hosmer–Lemeshow test = 0.898, and the AUC = 0.861 after internal validation. The clinical decision curve showed that the new clinical prediction model could achieve a net clinical benefit when the expected threshold was between 0 and 0.6. Conclusion. This study constructed a new clinical prediction model of LA or LAA thrombi, with a higher discriminative degree than the CHADS2 and CHA2DS2-VASc scoring systems (AUC: 0.865 vs. 0.643; AUC: 0.865 vs 0.652).
- Published
- 2022
- Full Text
- View/download PDF
11. Impact of Left Atrial Appendage Closure Combined with Catheter Ablation on Endocrine and Mechanical Cardiac Function in Patients with Atrial Fibrillation
- Author
-
Jing Yang, Ling You, Mingqing Liu, Guangming Zhang, Liang Feng, Yue Liu, Xue Geng, Jinglan Wu, and Ruiqin Xie
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background. The combined procedure of left atrial appendage closure (LAAC) and catheter ablation (CA) is a safe and feasible therapy to treat patients with atrial fibrillation (AF). However, the effect of the combined procedure on cardiac function remains unclear. This study aimed to investigate the changes in endocrine and mechanical function of the heart following the combined procedure. Methods. This retrospective study included 62 consecutive patients who underwent the combined procedure of AF ablation and WATCHMAN LAAC and 62 sex and age-matched patients who only received AF ablation. During follow-up, patients were examined for brain natriuretic peptide (BNP) levels to represent endocrine cardiac function. Mechanical cardiac function was assessed during echocardiographic examination by means of the LA ejection fraction, LA strain (Ƹ), and LA strain rate (SR). Results. (1) The BNP levels decreased acutely after the procedure, rose at day 3 postoperation, but trended downwards at 3 months postoperation in both groups. No significant difference was observed between the two groups. (2) LA ejection fraction, LA Ƹ, and SR exhibited a continuous upward trend over a 3-month follow-up in both groups. There was no significant difference in LA ejection fractions, SRe (the parameter of LA conduit function), and SRa (the parameter of LA booster pump function) between the two groups. However, the Ƹ and SRs (the parameters of LA reservoir function) improved in patients treated with CA alone. Conclusions. The combined procedure of LAAC and CA significantly improved the endocrine and mechanical function of the heart. Compared to simple CA, based on CA with LAAC intervention, it does not significantly change LA endocrine function but may lead to a decline in the LA reservoir function.
- Published
- 2022
- Full Text
- View/download PDF
12. LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling
- Author
-
Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, and Ruiqin Xie
- Subjects
Pathology ,RB1-214 - Abstract
Objective. Long non-coding RNAs (lncRNAs) play many important roles in gene regulation and disease pathogenesis. Here, we sought to determine that mitochondrial dynamic related lncRNA (MDRL) modulates NLRP3 inflammasome activation and apoptosis of vascular smooth muscle cells (VSMCs) and protects arteries against atherosclerosis. Methods. In vivo experiments, we applied LDLR knockout (LDLR-/-) mice fed the high-fat diet to investigate the effects of MDRL on atherosclerosis. In vitro experiments, we applied mouse aortic smooth muscle cells to determine the mechanism of MDRL in abrogating NLRP3 inflammasome and inhibiting cell apoptosis through miR-361/sequentosome 1 (SQSTM1) by TUNEL staining, quantitative RT-PCR, western blot, microribonucleoprotein immunoprecipitation, and luciferase reporter assay. Results. Downregulated MDRL and increased NLRP3 were observed in mouse atherosclerotic plaques, accompanied with the increase of miR-361. The results showed that MDRL overexpression significantly attenuated the burden of atherosclerotic plaque and facilitated plaque stability through inhibiting NLRP3 inflammasome activation and cell apoptosis, and vice versa. Mechanically, MDRL suppressed NLRP3 inflammasome activation and VSMC apoptosis via suppressing miR-361. Furthermore, miR-361 directly bound to the 3’UTR of SQSTM1 and inhibited its translation, subsequently activating NLRP3 inflammasome. Systematic delivery of miR-361 partly counteracted the beneficial effects of MDRL overexpression on atherosclerotic development in LDLR-/- mice. Conclusions. In summary, MDRL alleviates NLRP3 inflammasome activation and apoptosis in VSMCs through miR-361/SQSTM1/NLRP3 pathway during atherogenesis. These data indicate that MDRL and inhibition of miR-361 represent potential therapeutic targets in atherosclerosis-related diseases.
- Published
- 2022
- Full Text
- View/download PDF
13. Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing
- Author
-
Xiaofei Li, Chunguang Qiu, Ruiqin Xie, Wentao Ma, Zhao Wang, Hui Li, Hao Wang, Wei Hua, Shu Zhang, Yan Yao, and Xiaohan Fan
- Subjects
Left bundle branch area pacing ,Cardiac resynchronization therapy ,Heart failure ,Left bundle branch block ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims This multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6‐month outcomes between LBBAP and biventricular pacing (BVP). Methods and results Consecutive patients with LBBB and left ventricular ejection fraction (LVEF) ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity score matching to minimize bias. Implant characteristics and echocardiographic parameters were assessed during the 6‐month follow‐up. LBBAP procedure succeeded in 81.1% (30/37) of patients, with selective LBBAP in 10 patients, and 3 of 20 patients combined non‐selective LBBAP and LV lead pacing for further QRS narrowing. LBBAP resulted in significant QRS narrowing (from 178.2 ± 18.8 to 121.8 ± 10.8 ms, P
- Published
- 2020
- Full Text
- View/download PDF
14. The Long-Term Results of Three Catheter Ablation Methods in Patients With Paroxysmal Atrial Fibrillation: A 4-Year Follow-Up Study
- Author
-
Ling You, Xiaohong Zhang, Jing Yang, Lianxia Wang, Yan Zhang, and Ruiqin Xie
- Subjects
catheter ablation ,paroxysmal atrial fibrillation ,recurrence ,cryoablation ,cryoablation plus radiofrequency ablation ,radiofrequency ablation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aims: Catheter ablation of paroxysmal atrial fibrillation (PAF) has been shown to be effective and safe. However, recurrence of PAF varies between 10 and 30% for radiofrequency ablation. There have been no reports comparing long-term recurrence rates following radiofrequency ablation, cryoablation, and three-dimensional guided cryoablation plus radiofrequency ablation. The aim of this study was to observe the long-term recurrence rate of PAF when treated by these three catheter ablation methods, and to explore clinical factors that can potentially predict PAF recurrence following catheter ablation.Methods: There were 238 patients involved in this study, including 106 radiofrequency (RF) ablation cases (RF group), 66 cryoablation cases (Freeze group), and 66 cases treated by three-dimensional guided cryoablation combined with radiofrequency ablation (Freeze-plus-RF group). All patients underwent standardized follow-up. The recurrence rate of atrial fibrillation (AF) in the three groups was calculated. Predictive factors for the recurrence of AF were also investigated.Results: At 48 months (the median follow-up period), the sinus rhythm maintenance rate was 77.4% in the RF group, 72.7% in the Freeze group, and 81.8% in the Freeze-plus-RF group. The maintenance rate of sinus rhythm was highest in the Freeze-plus-RF group, but differences among the three groups were not statistically significant. Further analysis found that the preoperative left atrial appendage emptying velocity (LAAEV) (recurrence vs. no recurrence, 56.58 ± 18.37 vs. 65.59 ± 18.83, respectively, p = 0.003), left atrial (LA) anteroposterior dimension (recurrence vs. no recurrence, 36.56 ± 4.65 vs. 35.00 ± 4.37, respectively; p = 0.028), and LA vertical dimension (recurrence vs. no recurrence, 56.31 ± 6.96 vs. 53.72 ± 6.52, respectively; p = 0.035) were related to postoperative recurrence. Multiple Cox regression analysis showed that only LAAEV was predictive of postoperative recurrence of PAF (hazard ratio: 0.979; 95% confidence interval: 0.961–0.997).Conclusion: Our study found that there was no statistically significant difference in long-term recurrence rates among the RF, Freeze, and Freeze-plus-RF groups. Preoperative LAAEV is an independent predictor of postoperative recurrence of PAF.
- Published
- 2021
- Full Text
- View/download PDF
15. Clinical Outcomes in Patients With Left Bundle Branch Area Pacing vs. Right Ventricular Pacing for Atrioventricular Block
- Author
-
Xiaofei Li, Junmeng Zhang, Chunguang Qiu, Zhao Wang, Hui Li, Kunjing Pang, Yan Yao, Zhimin Liu, Ruiqin Xie, Yangxin Chen, Yongquan Wu, and Xiaohan Fan
- Subjects
atrioventricular block ,left bundle branch area pacing ,heart failure hospitalization ,upgrade to biventricular pacing ,right ventricular pacing ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Left bundle branch area pacing (LBBAP) is a novel pacing modality with stable pacing parameters and a narrow-paced QRS duration. We compared heart failure (HF) hospitalization events and echocardiographic measures between LBBAP and right ventricular pacing (RVP) in patients with atrioventricular block (AVB).Methods and Results: This multicenter observational study prospectively recruited consecutive AVB patients requiring ventricular pacing in five centers if they received LBBAP or RVP and had left ventricular ejection fraction (LVEF) >50%. Data on electrocardiogram, pacing parameters, echocardiographic measurements, device complications, and clinical outcomes were collected at baseline and during follow-up. The primary outcome was first episode hospitalization for HF or upgrade to biventricular pacing. LBBAP was successful in 235 of 246 patients (95.5%), while 120 patients received RVP. During a mean of 11.4 ± 2.7 months of follow-up, the ventricular pacing burden was comparable (83.9 ± 35.1 vs. 85.7 ± 30.0%), while the mean LVEF differed significantly (62.6 ± 4.6 vs. 57.8 ± 11.4%) between the LBBAP and RVP groups. Patients with LBBAP had significantly lower occurrences of HF hospitalization and upgrading to biventricular pacing than patients with RVP (2.6 vs. 10.8%, P 40% or with baseline LVEF
- Published
- 2021
- Full Text
- View/download PDF
16. Effect of Left Atrial Appendage Closure in Combination With Catheter Ablation on Left Atrial Function for Persistent Atrial Fibrillation
- Author
-
Jing Yang, Yue Liu, Liang Feng, Mingqing Liu, Ling You, Yu Liu, Jinglan Wu, Guangming Zhang, Xue Geng, and Ruiqin Xie
- Subjects
left atrial appendage closure ,catheter ablation ,left atrial function ,left atrial volumes ,speckle tracking echocardiography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: A single procedure combining left atrial appendage closure (LAAC) plus catheter ablation (CA) has been proven to be safe and feasible for treating atrial fibrillation (AF). However, the influence of treatment modality on left atrial (LA) function is not thoroughly explained.Objective: We aimed to investigate the changes of LA function in persistent AF patients undergoing concomitant LAAC and CA.Methods: The study population comprised 65 patients who underwent combined AF ablation and Watchman LAAC (combined therapy group) in our center, and 65 participants of the AF simple ablation group who were matched based on sex, age, CHA2DS2-VASc score and HAS-BLED score using propensity score matching. During the 1-year follow-up period, two-dimensional echocardiography and speckle tracking echocardiography were performed to assess LA reservoir, conduit, and contractile function.Results: The combined therapy was associated with a significant improvement in the LA reservoir function with increased expansion index and strain indices, including strain and strain rate (SR) during ventricular systole. Conduit function with SR during early ventricular diastole was also improved, as was contractile function with active atrial emptying fraction and SR during atrial systole. Similarly, LA reservoir and contractile function indices all improved continuously during follow-up after catheter ablation alone. At 3 months follow-up LA reservoir and conduit function with strain indices had a tendency to improve only in the simple procedure group. At 1-year follow-up there was no significant difference in either LA volumes or strain indices between the two groups.Conclusion: Both the combined therapy group and the simple ablation group demonstrated significant improvement in LA function. Based upon the fact that LA function was improved in both groups it might be concluded that most of the effects appeared to result from ablation, not LAAC; furthermore the additional LAAC procedure did not affect the improvement of LA function after CA.
- Published
- 2021
- Full Text
- View/download PDF
17. The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models
- Author
-
Demin Liu, Jing Wang, Haijuan Hu, Guoqiang Gu, Rui Ding, Ruiqin Xie, and Wei Cui
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background. Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. Methods. Hypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar–Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized. Results. The two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis. Conclusion. RDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model.
- Published
- 2021
- Full Text
- View/download PDF
18. HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury
- Author
-
Yanan Zhang, Dawei Liu, Haijuan Hu, Puqiang Zhang, Ruiqin Xie, and Wei Cui
- Subjects
BNIP3 ,HIF-1α ,Autophagy ,Ischemia/reperfusion (I/R) ,Oxygen–glucose deprivation/recovery (OGD/R) injury ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: The study was established to inquire into the protective effect of the HIF-1α (Hypoxia-inducible factor-1α)/ BNIP3(Bcl-2/adenovirus E1B 19-kDa interacting protein) signal path-induced-autophagy during myocardial ischemia/ reperfusion (I/R) and oxygen–glucose deprivation/recovery (OGD/R) injury in heart-derived H9C2 cells as well as its potential underlying mechanism. Methods: Immediate myocardial I/R in SD (Spraque Dawley) rats and cytotoxicity of OGD/R injury on H9C2 cells with and without inhibitors or agonists of HIF-1α and BNIP3 were evaluated. Expression of mitochondrial autophagic protein were detected by Western blot and immunofluorescence. And the mitochondrial autophagosome were detected using Transmission Electron Microscope (TEM). Results: I/R and OGD/R injury increased the expression level of HIF-1α, activated the downstream BNIP3 and subsequently triggered mitochondria-dependent autophagy. Up-regulation the expression of HIF-1α and BNIP3 may promote the cardiac myocytes of SD rats of I/R injure and OGD/R injury-induced autophagy of H9C2 cells. Moreover, down-regulation the expression of HIF-1α or BNIP3-siRNA decreased H9C2 cells autophagy under OGD/R injury. Conclusions: Together, our studies indicated that HIF-1α synchronization regulate BNIP3 during OGD/R injury-induced autophagy in H9C2 cells, though BNIP3-induced autophagy acting as a survival mechanism.
- Published
- 2019
- Full Text
- View/download PDF
19. Relationship Between Parental Rejection and Problematic Mobile Phone Use in Chinese University Students: Mediating Roles of Perceived Discrimination and School Engagement
- Author
-
Jianjun Zhu, Ruiqin Xie, Yuanyuan Chen, and Wei Zhang
- Subjects
parental rejection ,perceived discrimination ,school engagement ,problematic mobile phone use ,sequential mediating effect ,Psychology ,BF1-990 - Abstract
In order to clarify the onset mechanism of problematic mobile phone use, and to develop better strategies to prevent and treat problematic mobile phone use, the current study tested the negative impact of parental rejection on problematic mobile phone use and the mediating roles of perceived discrimination and school engagement in this association. The sample consisted of 356 Chinese university students (36.3% male) ranging from 17 to 19 years of age. Participants completed self-report questionnaires assessing parental rejection, perceived discrimination, school engagement, and problematic mobile phone use. The results documented that parental rejection was a direct risk factor for problematic mobile phone use. This association was mediated by perceived discrimination, and there was also a sequential mediating effect in which perceived discrimination led in turn to low school engagement.
- Published
- 2019
- Full Text
- View/download PDF
20. Atorvastatin Protects Vascular Smooth Muscle Cells From TGF-β1-Stimulated Calcification by Inducing Autophagy via Suppression of the β-Catenin Pathway
- Author
-
Demin Liu, Wei Cui, Bin Liu, Haijuan Hu, Jing Liu, Ruiqin Xie, Xiaohong Yang, Guoqiang Gu, Jidong Zhang, and Hongmei Zheng
- Subjects
Atorvastatin ,autophagy ,β-catenin ,Calcification ,TGF-β1 ,VSMCs ,Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Abstract
Background: Arterial calcification is a major event in the progression of atherosclerosis. It is reported that statins exhibit various protective effects against vascular smooth muscle cell (VSMC) inflammation and proliferation in cardiovascular remodeling. Although statins counteract atherosclerosis, the molecular mechanisms of statins on the calcium release from VSMCs have not been clearly elucidated. Methods: Calcium content of VSMCs was measured using enzyme-linked immunosorbent assay (ELISA). The expression of proteins involved in cellular transdifferentiation was analyzed by western blot. Cell autophagy was measured by fluorescence microscopic analysis for acridine orange staining and transmission electron microscopy analysis. The autophagic inhibitors (3-MA, chloroquine, NH4Cl and bafilomycin A1) and β-catenin inhibitor JW74 were used to assess the effects of atorvastatin on autophagy and the involvement of β-catenin on cell calcification respectively. Furthermore, cell transfection was performed to overexpress β-catenin. Results: In VSMCs, atorvastatin significantly suppressed transforming growth factor-β1 (TGF-β1)-stimulated calcification, accompanied by the induction of autophagy. Downregulation of autophagy with autophagic inhibitors significantly suppressed the inhibitory effect of atorvastatin on cell calcification. Moreover, the beneficial effect of atorvastatin on calcification and autophagy was reversed by β-catenin overexpression. Conversely, JW74 supplement enhanced this effect. Conclusion: These data demonstrated that atorvastatin protect VSMC from TGF-β1-stimulated calcification by inducing autophagy through suppression of the β-catenin pathway, identifying autophagy induction might be a therapeutic strategy for use in vascular calcification.
- Published
- 2014
- Full Text
- View/download PDF
21. New-onset atrial fibrillation following left bundle branch area pacing vs. right ventricular pacing: a two-centre prospective cohort study
- Author
-
Haojie Zhu, Xiaofei Li, Zhao Wang, Qian Liu, Bingqian Chu, Yan Yao, Zhimin Liu, Ruiqin Xie, and Xiaohan Fan
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Aims To investigate whether left bundle branch area pacing (LBBAP) can reduce the risk of new-onset atrial fibrillation (AF) compared with right ventricular pacing (RVP). Methods and results Patients with indications for dual-chamber pacemaker implant and no history of AF were prospectively enrolled if they underwent successful LBBAP or RVP. The primary endpoint was time to the first occurrence of AF detected by pacemaker programming or surface electrocardiogram. Follow-up at clinic visit was performed and multivariate Cox regression models were applied to evaluate the effect of LBBAP on new-onset AF. The final analysis included 527 patients (mean age 65.3 ± 12.6, male 47.3%), with 257 in the LBBAP and 270 in the RVP groups. During a mean follow-up of 11.1 months, LBBAP resulted in significantly lower incidence of new-onset AF (7.4 vs. 17.0%, P < 0.001) and AF burden (3.7 ± 1.9 vs. 9.3 ± 2.2%, P < 0.001) than RVP. After adjusting for confounding factors, LBBAP demonstrated a lower hazard ratio for new-onset AF compared with RVP {hazard ratio (HR) [95% confidence interval (CI)]: 0.278 (0.156, 0.496), P < 0.001}. A significant interaction existed between pacing modalities and the percentage of ventricular pacing (VP%) (P for interaction = 0.020). In patients with VP ≥ 20%, LBBAP was associated with decreased risk of new-onset AF compared with RVP [HR (95% CI): 0.199 (0.105, 0.378), P < 0.001]. The effect of pacing modalities was not pronounced in patients with VP < 20% [HR (95% CI): 0.751 (0.309, 1.823), P = 0.316]. Conclusion Left bundle branch area pacing demonstrated a reduced risk of new-onset AF compared with RVP. Patients with a high ventricular pacing burden might benefit from LBBAP.
- Published
- 2022
22. <scp>JMJD5</scp> attenuates oxygen–glucose deprivation and reperfusion‐induced injury in cardiomyocytes through regulation of <scp>HIF‐1α‐BNIP3</scp>
- Author
-
Haijuan Hu, Ya-Nan Zhang, Wei Cui, Ya-Xiang Pang, Da-Wei Liu, and Ruiqin Xie
- Subjects
Jumonji Domain-Containing Histone Demethylases ,Medicine (General) ,BNIP3 ,Cell Survival ,ATG5 ,Myocardial Reperfusion Injury ,JMJD5 ,Protective Agents ,Mitochondrial Proteins ,chemistry.chemical_compound ,R5-920 ,Western blot ,Downregulation and upregulation ,Lactate dehydrogenase ,Mitophagy ,Animals ,Medicine ,Myocytes, Cardiac ,Secretion ,Gene knockdown ,medicine.diagnostic_test ,business.industry ,apoptosis ,Membrane Proteins ,General Medicine ,Hypoxia-Inducible Factor 1, alpha Subunit ,OGD/R ,Rats ,Cell biology ,Oxygen ,Disease Models, Animal ,Glucose ,mitophagy ,chemistry ,Apoptosis ,business - Abstract
Proteins in Jumonji family function as histone demethylases and participate in cardiac development. Jumonji domain containing 5 (JMJD5) is responsible for the embryonic development through removing methyl moieties from H3K36me2 histone, and has pro‐proliferative effect on heart and eye development. However, the protective role of JMJD5 against oxygen–glucose deprivation and reperfusion (OGD/R)‐induced injury in cardiomyocytes has not been fully understood. Firstly, myocardial ischemia/reperfusion (I/R) rat model was established by ligation of left coronary artery. OGD/R was performed in non‐transfected H9C2 or H9C2 transfected with pcDNA‐JMJD5 plasmid to induce cell cytotoxicity. Data from qRT‐PCR and western blot showed that JMJD5 was reduced in the heart tissues of myocardial I/R rat model and OGD/R‐induced H9C2. Secondly, JMJD5 over‐expression attenuated OGD/R‐induced decrease in cell viability and increase in lactate dehydrogenase secretion and cell apoptosis in H9C2. Mitophagy was promoted by pcDNA‐mediated over‐expression of JMJD5 with enhanced protein expression of LC3‐I, LC3‐II, Atg5, and Beclin 1. Thirdly, knockdown of JMJD5 aggravated OGD/R‐induced decrease in hypoxia‐inducible factor‐1α (HIF‐1α), whereas JMJD5 over‐expression enhanced BNIP3 (Bcl‐2/adenovirus E1B 19‐kDa interacting protein) through upregulation of HIF‐1α. Lastly, BNIP3 silencing promoted cell apoptosis, suppressed mitophagy, and attenuated the protective effects of JMJD5 over‐expression against OGD/R‐induced injury in H9C2. In conclusion, JMJD5 exerted protective effects against OGD/R‐induced injury in cardiomyocytes through upregulation of HIF‐1α‐BNIP3.
- Published
- 2021
23. A model of increasing predictability of atrial fibrillation related stroke in patients with non-valvular atrial fibrillation
- Author
-
Ling You, Webin He, Yanjie Zhen, Jing Yang, Lianxia Wang, Yanlei Zhao, and Ruiqin Xie
- Abstract
Objective: Our aim for this study was to develop a model using clinical, laboratory and echocardiographic factors, in addition to CHA2DS2-VASC score, to increase predictability of AF related stroke in patients with non-valvular atrial fibrillation (NVAF).Methods: We retrospectively analyzed the medical history, clinical characteristics, laboratory and echocardiographic data of 373 patients with NVAF.Results: In multiple logistic regression, CHA2DAS2 VASC score (OR 1.22 (95%CI 1.04-1.43), P=0.016), anion gap (OR 1.19 (95%CI 1.08-1.30), P < 0.001), e-peak deceleration time (EDT) (OR 1.01 (95%CI 1.00-1.01), P=0.001) and the left atrial appendage emptying rate (LAAEV) (OR 0.99 (95%CI 0.97-0.99), P=0.013) were risk factors for predicting stroke in NVAF patients. For patients with low CHA2DAS2 VASC score, anion gap (OR 1.35 (95%CI 1.03-1.77), P=0.028) and EDT (OR 1.01 (95%CI 1.00-1.02), P=0.043) were associated with stroke.Receiver operating characteristic (ROC) curve showed that area under curve (AUC) is 11% higher in the model including anion gap, EDT, LAAEV and CHA2DS2-VASc score, compared to only using CHA2DS2-VASc score as predictor (0.70 (95%CI 0.64-0.75) vs 0.59 (95%CI 0.54-0.65)).Conclusions: Our study showed that incorporating anion gap, EDT and LAAEV into CHA2DS2-VASC score increases the ability to predict atrial fibrillation related stroke.
- Published
- 2022
24. Clinical Characteristics of Patients with Arrhythmias of the Idiopathic Outflow Tract Ventricular: Age, Gender, Comorbidities, Laboratory Test Results, and Echocardiographic Parameters
- Author
-
Lei, Zhao, Ruibin, Li, Jidong, Zhang, Ruiqin, Xie, Jingchao, Lu, Jinming, Liu, Chenglong, Miao, Suyun, Liu, and Wei, Cui
- Subjects
Adult ,Male ,Stroke Volume ,Middle Aged ,Ventricular Premature Complexes ,Ventricular Function, Left ,Young Adult ,Echocardiography ,Creatinine ,Tachycardia, Ventricular ,Humans ,Female ,Aged ,Retrospective Studies - Abstract
Idiopathic ventricular arrhythmias (IVAs) are a spectrum of ventricular arrhythmia (VA) without structural heart disease (SHD), that includes premature ventricular contractions (PVCs) and ventricular tachycardia (VT). The clinical characteristics of patients with PVCs or VT remain unclear, including distribution of the origin of arrhythmias, age and gender differences, comorbidities, laboratory tests, and electrocardiographic parameters.The study intended to compare the clinical characteristics of the right ventricular outflow tract (RVOT)- and left ventricular outflow tract (LVOT)-VT of a large group of consecutive patients, to investigate the distribution of the origin of the arrhythmias, age and gender differences, comorbidities, laboratory-examination results, and echocardiographic parameters.The research team designed a retrospective study to collect data on the above-mentioned variables.The study occurred at the Second Hospital of Hebei Medical University in Shijiazhuang, China.Participants were 774 patients with symptomatic ventricular arrhythmias, 328 males and 446 females with the mean age of 48.6 ± 15.7 years, who underwent catheter ablation between January 2015 and January 2019. Participants were divided into the right ventricular outflow tract (RVOT) group and left ventricular outflow tract (LVOT) group, according to the different origins of their arrhythmias, with 428 participants in the RVOT group and 180 in the LVOT group.The research team collected and analyzed the data for the original sites of the IVAs; ages; genders; comorbidities; laboratory examinations, including routine blood tests, liver function, kidney function, blood lipid and potassium; and echocardiographic parameters.Among the 774 participants, 76 had experienced VTs and 698 PVCs. The original site of IVAs was 2.38 times more likely to be in the RVOT than the LVOT, with the ratio for RVOT/LVOT = 2.38. IVAs usually occurred in participants between 50 and 70 years old and exhibited a decreasing incidence after 70 years of age. IVAs derived from the His bundle were more common in older participants, with a mean age of 60.4 ± 10.4 years, while IVAs derived from the fascicular were more common in younger patients, with a mean age of 36.08 ± 16.01 years. Compared with the LVOT group, the RVOT group was younger, 51.91 ± 14.65 years vs 46.95 ± 14.95 years, respectively (P.001). PVCs in the RVOT group were more common in women, with the ratio of females/males = 2.10, and no gender difference existed in the overall incidence of IVAs in the LVOT group (P.05). The most common cardiovascular comorbidities of outflow tract ventricular arrhythmias (OTVAs) were hypertension, coronary heart disease, and hyperlipidemia, while the most common noncardiovascular comorbidities were diabetes, ischemic stroke, and thyroid disease. The red-blood-cell counts, hemoglobin, creatinine, and gamma-glutamyl transpeptidase (GGT) of the LVOT group were higher than those from the RVOT, with P = .008, P = .009, P = .001, and P.001, respectively. The left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), interventricular septal thickness (IVS), and left ventricular posterior wall thickness (LVPWT) in the LVOT group were larger than those in the RVOT group (P.001), while the LVOT group's left ventricular ejection fraction (LVEF%) was lower than that of the RVOT group.The outflow tract served as the major original site of IVAs, and significant differences existed between participants in the LVOT and RVOT groups in age; gender; comorbidities; results of laboratory examinations, including red-blood-cell counts, hemoglobin, creatinine, and GGT; and echocardiographic parameters, including LVEF%, LAD, LVEDD, IVS, and LVPWT.
- Published
- 2022
25. Periprocedural Outcomes Associated With Use of a Left Atrial Appendage Occlusion Device in China
- Author
-
Fangju Su, Chao Gao, Jianzheng Liu, Zhongping Ning, Beng He, Yi Liu, Yawei Xu, Bing Yang, Yuechun Li, Junfeng Zhang, Xianxian Zhao, Yushun Zhang, Hao Hu, Xianfeng Du, Ruiqin Xie, Ling Zhou, Jie Zeng, Zhongbao Ruan, Haitao Liu, Jun Guo, Rutao Wang, Scot Garg, Osama Soliman, David R. Holmes, Patrick W. Serruys, and Ling Tao
- Subjects
Male ,China ,Embolism ,Hemorrhage ,General Medicine ,Cohort Studies ,Stroke ,Treatment Outcome ,Atrial Fibrillation ,Humans ,Atrial Appendage ,Female ,Aged ,Retrospective Studies - Abstract
Left atrial appendage occlusion (LAAO) has emerged as an alternative to anticoagulation for patients with atrial fibrillation. However, the performance of LAAO among East Asian patients is unknown.To document the procedural success rate and configurations, major adverse event rates, and antithrombotic medication regimens during and after LAAO procedures among patients in China.In this cohort study, consecutive patients from 39 Chinese centers undergoing LAAO were prospectively enrolled between April 1, 2019, and October 31, 2020. Periprocedural and intraprocedural techniques and postprocedural medications were left to the surgeon's discretion. Data were analyzed from July 1 to November 1, 2021.LAAO for patients with atrial fibrillation.The main outcomes were procedural success and complication rates periprocedure and major adverse event rates of death, stroke, systemic embolism, and bleeding events at 30 days postprocedure; the composite end point of death, stroke, and systemic embolism was also analyzed. Unadjusted and multivariable-adjusted logistic regression analyses were performed to assess the associations of periprocedural techniques (types of anesthesia, intraprocedural imaging modalities, and combined ablation procedure) with 30-day adverse events.Among 3096 enrolled participants, 1782 participants (57.6%) were men, and the mean (SD) age was 69 (9) years. Participants had a high risk of stroke (mean [SD] cardiovascular risk score, 4.0 [1.8]) and a moderate-to-high risk of bleeding (mean [SD] bleeding risk score, 2.4 [1.2]). A total of 1287 procedures (41.6%) were performed under local anesthesia, while 493 procedures (15.9%) used only fluoroscopy guidance. In 1297 procedures (41.9%), LAAO implantation was combined with radiofrequency ablation or cryoablation for atrial fibrillation. Procedural success was achieved in 3032 patients (97.9%). At 30-day follow-up, the rate of the composite end point of death, stroke, or systemic embolism was 0.52% (95% CI, 0.32%-0.84%), and the rate of any life-threatening or major bleeding was 1.23% (95% CI, 0.90%-1.68%). No significant associations were observed between the procedural success or 30-day adverse events and the types of anesthesia (general or local), intraprocedural imaging (transesophageal echocardiography, fluoroscopy, or intracardiac echocardiography), or whether a combined ablation procedure was performed or not. In centers performing at least 40 procedures per year, compared with those performing fewer than 40 procedures per year, procedural success was significantly higher (adjusted odd ratio [aOR], 1.97; 95% CI, 1.01-3.53; P = .02) and risk of life-threatening or major bleeding was significantly lower (aOR, 0.42; 95% CI, 0.21-0.87; P = .02).These findings suggest that patients with a high risk of stroke and moderate to high risk of bleeding who underwent implantation of a LAAO device in Chinese centers had high rates of procedural success and low rates of short-term ischemic and bleeding events.
- Published
- 2022
26. Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing
- Author
-
Shu Zhang, Ruiqin Xie, Hao Wang, Xiaofei Li, Wei Hua, Xiaohan Fan, Chunguang Qiu, Yan Yao, Hui Li, Wentao Ma, and Zhao Wang
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Heart failure ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,QRS complex ,Electrocardiography ,0302 clinical medicine ,Internal medicine ,Original Research Articles ,Left bundle branch ,medicine ,Humans ,030212 general & internal medicine ,Original Research Article ,Retrospective Studies ,Ejection fraction ,Left bundle branch block ,business.industry ,Stroke Volume ,medicine.disease ,Left bundle branch area pacing ,Treatment Outcome ,lcsh:RC666-701 ,Propensity score matching ,Cardiology ,Implant ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims This multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6‐month outcomes between LBBAP and biventricular pacing (BVP). Methods and results Consecutive patients with LBBB and left ventricular ejection fraction (LVEF) ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity score matching to minimize bias. Implant characteristics and echocardiographic parameters were assessed during the 6‐month follow‐up. LBBAP procedure succeeded in 81.1% (30/37) of patients, with selective LBBAP in 10 patients, and 3 of 20 patients combined non‐selective LBBAP and LV lead pacing for further QRS narrowing. LBBAP resulted in significant QRS narrowing (from 178.2 ± 18.8 to 121.8 ± 10.8 ms, P
- Published
- 2020
27. Impact of Left Atrial Appendage Closure Combined with Catheter Ablation on Endocrine and Mechanical Cardiac Function in Patients with Atrial Fibrillation
- Author
-
Jing Yang, Ling You, Mingqing Liu, Guangming Zhang, Liang Feng, Yue Liu, Xue Geng, Jinglan Wu, and Ruiqin Xie
- Subjects
Treatment Outcome ,Article Subject ,Atrial Fibrillation ,Catheter Ablation ,Humans ,Radiology, Nuclear Medicine and imaging ,Atrial Appendage ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Background. The combined procedure of left atrial appendage closure (LAAC) and catheter ablation (CA) is a safe and feasible therapy to treat patients with atrial fibrillation (AF). However, the effect of the combined procedure on cardiac function remains unclear. This study aimed to investigate the changes in endocrine and mechanical function of the heart following the combined procedure. Methods. This retrospective study included 62 consecutive patients who underwent the combined procedure of AF ablation and WATCHMAN LAAC and 62 sex and age-matched patients who only received AF ablation. During follow-up, patients were examined for brain natriuretic peptide (BNP) levels to represent endocrine cardiac function. Mechanical cardiac function was assessed during echocardiographic examination by means of the LA ejection fraction, LA strain (Ƹ), and LA strain rate (SR). Results. (1) The BNP levels decreased acutely after the procedure, rose at day 3 postoperation, but trended downwards at 3 months postoperation in both groups. No significant difference was observed between the two groups. (2) LA ejection fraction, LA Ƹ, and SR exhibited a continuous upward trend over a 3-month follow-up in both groups. There was no significant difference in LA ejection fractions, SRe (the parameter of LA conduit function), and SRa (the parameter of LA booster pump function) between the two groups. However, the Ƹ and SRs (the parameters of LA reservoir function) improved in patients treated with CA alone. Conclusions. The combined procedure of LAAC and CA significantly improved the endocrine and mechanical function of the heart. Compared to simple CA, based on CA with LAAC intervention, it does not significantly change LA endocrine function but may lead to a decline in the LA reservoir function.
- Published
- 2021
28. Relationship among atrial fibrillation, the CHA2DS2-VASc score and ischaemic stroke in patients with coronary artery disease: a propensity score matching study in Hebei, China
- Author
-
Demin Liu, Wei Cui, Guoqiang Gu, Qian Hou, Xue Geng, Ruiqin Xie, Boqun Shi, and Qian Wang
- Subjects
medicine.medical_specialty ,CHA2DS2-VASc score ,business.industry ,Subgroup analysis ,Atrial fibrillation ,medicine.disease ,Coronary artery disease ,Cardiac surgery ,RC666-701 ,Internal medicine ,CHA2DS2–VASc score ,Propensity score matching ,medicine ,Cardiology ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Ischaemic stroke ,Body mass index ,Angiology - Abstract
Background Recent evidence has shown that the pathogenesis of ischaemic stroke associated with atrial fibrillation (AF) is complex and involves other factors in addition to arrhythmias. The purpose of this study was to investigate the relationship among AF, CHA2DS2-VASc score and ischaemic stroke in patients with coronary artery disease (CAD) in Hebei, China. Methods A total of 2,335 patients with CAD from September 2016 to May 2019 at the Second Hospital of Hebei Medical University were included (mean age 62.73 ± 10.35 years, range 26–92 years; 41.58% female). This was a cross-sectional study, and participants were divided into non-stroke (n = 1997) and ischaemic stroke groups (n = 338). Propensity score matching (PSM) was performed to match ischaemic stroke patients with non-stroke patients in a 1:4 ratio. The relationship among AF, the CHA2DS2-VASc score and ischaemic stroke was evaluated using univariable generalized linear models for different sex, age, body mass index (BMI), CAD and CHA2DS2-VASc score subgroups. Univariable and multivariable generalized linear models were used to evaluate the relationship between AF and ischaemic stroke in the different models. Results Compared with that in the non-stroke group, the prevalence of AF (8.81% vs. 14.20%, P = 0.002) in the ischaemic stroke group was higher. The proportion of patients with ischaemic stroke was significantly different between the AF group and the non-AF group (28.74% vs. 19.04%, P = 0.003). An increasing CHA2DS2-VASc score was associated with a gradual increase in the prevalence of AF (P for trend P = 0.087). Conclusion In our cross-sectional study, after adjustment for confounding factors, there was no association between AF and ischaemic stroke. The increased risk of ischaemic stroke associated with AF was attenuated by atherosclerotic factors. Our study supports the current view that enhanced control of modifiable cardiovascular risk factors in patients with AF is essential.
- Published
- 2021
29. The Long-Term Results of Three Catheter Ablation Methods in Patients With Paroxysmal Atrial Fibrillation: A 4-Year Follow-Up Study
- Author
-
Xiaohong Zhang, Lianxia Wang, Ruiqin Xie, Ling You, Yan Zhang, and Jing Yang
- Subjects
medicine.medical_specialty ,recurrence ,Radiofrequency ablation ,medicine.medical_treatment ,Catheter ablation ,Cardiovascular Medicine ,law.invention ,cryoablation plus radiofrequency ablation ,law ,Internal medicine ,catheter ablation ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Sinus rhythm ,paroxysmal atrial fibrillation ,Original Research ,business.industry ,Hazard ratio ,Cryoablation ,Atrial fibrillation ,Ablation ,medicine.disease ,Confidence interval ,cryoablation ,RC666-701 ,Cardiology ,radiofrequency ablation ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims: Catheter ablation of paroxysmal atrial fibrillation (PAF) has been shown to be effective and safe. However, recurrence of PAF varies between 10 and 30% for radiofrequency ablation. There have been no reports comparing long-term recurrence rates following radiofrequency ablation, cryoablation, and three-dimensional guided cryoablation plus radiofrequency ablation. The aim of this study was to observe the long-term recurrence rate of PAF when treated by these three catheter ablation methods, and to explore clinical factors that can potentially predict PAF recurrence following catheter ablation.Methods: There were 238 patients involved in this study, including 106 radiofrequency (RF) ablation cases (RF group), 66 cryoablation cases (Freeze group), and 66 cases treated by three-dimensional guided cryoablation combined with radiofrequency ablation (Freeze-plus-RF group). All patients underwent standardized follow-up. The recurrence rate of atrial fibrillation (AF) in the three groups was calculated. Predictive factors for the recurrence of AF were also investigated.Results: At 48 months (the median follow-up period), the sinus rhythm maintenance rate was 77.4% in the RF group, 72.7% in the Freeze group, and 81.8% in the Freeze-plus-RF group. The maintenance rate of sinus rhythm was highest in the Freeze-plus-RF group, but differences among the three groups were not statistically significant. Further analysis found that the preoperative left atrial appendage emptying velocity (LAAEV) (recurrence vs. no recurrence, 56.58 ± 18.37 vs. 65.59 ± 18.83, respectively, p = 0.003), left atrial (LA) anteroposterior dimension (recurrence vs. no recurrence, 36.56 ± 4.65 vs. 35.00 ± 4.37, respectively; p = 0.028), and LA vertical dimension (recurrence vs. no recurrence, 56.31 ± 6.96 vs. 53.72 ± 6.52, respectively; p = 0.035) were related to postoperative recurrence. Multiple Cox regression analysis showed that only LAAEV was predictive of postoperative recurrence of PAF (hazard ratio: 0.979; 95% confidence interval: 0.961–0.997).Conclusion: Our study found that there was no statistically significant difference in long-term recurrence rates among the RF, Freeze, and Freeze-plus-RF groups. Preoperative LAAEV is an independent predictor of postoperative recurrence of PAF.
- Published
- 2021
30. S-R index in V1/V3 serves as a novel criterion to discriminate idiopathic premature ventricular contractions originating from posteroseptal right ventricular outflow tract versus right coronary cusp
- Author
-
Wei Cui, Jidong Zhang, Ruiqin Xie, Suyun Liu, Rui-Bin Li, Lei Zhao, Jingchao Lu, Jinming Liu, and Chenglong Miao
- Subjects
medicine.medical_specialty ,Receiver operating characteristic ,business.industry ,medicine.medical_treatment ,Heart Ventricles ,Subtraction ,Curve analysis ,Ablation ,Ventricular Premature Complexes ,QRS complex ,Electrocardiography ,Internal medicine ,Cardiology ,Catheter Ablation ,Tachycardia, Ventricular ,Medicine ,Ventricular outflow tract ,Humans ,Cardiology and Cardiovascular Medicine ,business ,Lead (electronics) ,Right coronary cusp ,Retrospective Studies - Abstract
Aim The current study aimed to establish a novel electrocardiographic (ECG) criterion for discrimination of idiopathic premature ventricular contractions (PVCs) originating from posteroseptal right ventricular outflow tract (sRVOT-p) versus right coronary cusp (RCC). Methods A total of 76 patients with idiopathic PVCs who underwent mapping and successful ablation were retrospectively included. Among them, 37 patients had PVCs from sRVOT-p origin and 39 patients from RCC origin. The surface ECGs during PVCs were recorded. S-R different index in V1/V3 was calculated with the following formula of 0.134*V3R-0.133*V1S. Results ECG characteristics showed wider total QRS duration, smaller R-wave amplitude on lead V2-V5, and larger S-wave amplitude on lead V1-V3 in sRVOT-p origin than RCC origin. Lead V3 was the most common transitional lead in two groups. Receiver operating characteristic (ROC) curve analysis showed that S-wave amplitude on lead V1 exhibited the largest AUC of 0.772, followed by the AUC of R-wave amplitude on lead V3 of 0.771. Subsequently, 0.134*V3R-0.133*V1S index was obtained by multiplication, subtraction, sum, and division of these ECG measurements, which exhibited the largest AUC of 0.808. The optimal cut-off value was −0.26 for differentiating RCC from sRVOT-p origin, with the sensitivity of 78.4% and specificity of 77.8%. Moreover, 0.134*V3R-0.133*V1S index was superior to previous criteria in analysis of PVCs originating from sRVOT-p and RCC. Conclusions 0.134*V3R-0.133*V1S is a novel ECG criterion to discriminate sRVOT-p from RCC origin in patients with idiopathic PVCs, which may provide guidance for approach of radiofrequency catheter ablation.
- Published
- 2021
31. Clinical Outcomes in Patients With Left Bundle Branch Area Pacing vs. Right Ventricular Pacing for Atrioventricular Block
- Author
-
Yongquan Wu, Ruiqin Xie, Zhimin Liu, Kunjing Pang, Hui Li, Yan Yao, Zhao Wang, Chunguang Qiu, Junmeng Zhang, Xiaohan Fan, Yangxin Chen, and Xiaofei Li
- Subjects
medicine.medical_specialty ,Cardiovascular Medicine ,030204 cardiovascular system & hematology ,right ventricular pacing ,03 medical and health sciences ,QRS complex ,0302 clinical medicine ,Internal medicine ,atrioventricular block ,Left bundle branch ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,First episode ,upgrade to biventricular pacing ,Ejection fraction ,business.industry ,left bundle branch area pacing ,heart failure hospitalization ,medicine.disease ,Clinical Trial ,Clinical trial ,RC666-701 ,Heart failure ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Atrioventricular block - Abstract
Background: Left bundle branch area pacing (LBBAP) is a novel pacing modality with stable pacing parameters and a narrow-paced QRS duration. We compared heart failure (HF) hospitalization events and echocardiographic measures between LBBAP and right ventricular pacing (RVP) in patients with atrioventricular block (AVB).Methods and Results: This multicenter observational study prospectively recruited consecutive AVB patients requiring ventricular pacing in five centers if they received LBBAP or RVP and had left ventricular ejection fraction (LVEF) >50%. Data on electrocardiogram, pacing parameters, echocardiographic measurements, device complications, and clinical outcomes were collected at baseline and during follow-up. The primary outcome was first episode hospitalization for HF or upgrade to biventricular pacing. LBBAP was successful in 235 of 246 patients (95.5%), while 120 patients received RVP. During a mean of 11.4 ± 2.7 months of follow-up, the ventricular pacing burden was comparable (83.9 ± 35.1 vs. 85.7 ± 30.0%), while the mean LVEF differed significantly (62.6 ± 4.6 vs. 57.8 ± 11.4%) between the LBBAP and RVP groups. Patients with LBBAP had significantly lower occurrences of HF hospitalization and upgrading to biventricular pacing than patients with RVP (2.6 vs. 10.8%, P 40% or with baseline LVEF Conclusion: Permanent LBBAP might reduce the risk of HF hospitalization or upgrade to biventricular pacing compared with RVP in AVB patients requiring a high burden of ventricular pacing.Clinical Trial Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03851315; URL: http://www.chictr.org.cn; Unique Identifier: ChiCTR2100043296.
- Published
- 2021
32. The immediate trends in atrial electrical remodeling for paroxysmal atrial fibrillation across different modes of catheter ablation
- Author
-
Qian Hou, Liang Feng, Jing Yang, Qian Liu, Ling You, Yue Liu, Yuliang Zhao, Ruiqin Xie, Lianxia Wang, and Yan Zhang
- Subjects
medicine.medical_specialty ,Radiofrequency ablation ,Paroxysmal atrial fibrillation ,medicine.medical_treatment ,Clinical Investigations ,Catheter ablation ,immediate trends ,030204 cardiovascular system & hematology ,law.invention ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,law ,Internal medicine ,catheter ablation ,Atrial Fibrillation ,medicine ,Humans ,Electrical Remodeling ,Heart Atria ,030212 general & internal medicine ,paroxysmal atrial fibrillation ,Coronary sinus ,medicine.diagnostic_test ,business.industry ,Cryoablation ,Atrial Remodeling ,General Medicine ,Ablation ,Treatment Outcome ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,atrial electrical remodeling - Abstract
Background Catheter ablation has emerged as a major strategy for paroxysmal atrial fibrillation (PAF). Atrial electrical remodeling (AER) plays a critical role in the recurrence of PAF after ablation. Hypothesis To characterize the immediate trends of AER during ablations in patients with PAF, and assess the relationship between immediate trends and recurrence. Methods We performed this prospective observational study of 135 patients to investigate AER following three ablation modes: radiofrequency ablation (RFA), cryoablation (CA) and 3D mapping‐guided cryoablation (3D‐CA). The atrial effective refractory period (AERP) and atrial conduction time (ACT) were measured via electrophysiology before and immediately after ablation, and P‐wave indices were measured via electrocardiography before and within 24 h after ablation. Follow‐up visits were conducted for at least 1 year or until relapse. Results Different approaches of ablation caused a fairly significant increase in the shortest P‐wave duration and AERP in both the proximal coronary sinus (PCS) and distal coronary sinus (DCS) but caused a shortened P‐wave dispersion. No different effect was found at the AERP among the three modes. Compared to patients who received CA, among patients who received RFA, a significant reduction in total ACT and right ACT was seen. Statistically, there was a weakly positive association between changes in total ACT and early recurrence. Conclusions Injury during ablation for PAF was associated with an increase in the AERP but not in the ACT. Total ACT and right ACT were shorter after RFA than after CA. The increase in total ACT were slightly predictive of early recurrence.
- Published
- 2021
33. Effect of Left Atrial Appendage Closure in Combination With Catheter Ablation on Left Atrial Function for Persistent Atrial Fibrillation
- Author
-
Ruiqin Xie, Mingqing Liu, Jing Yang, Liang Feng, Yu Liu, Guangming Zhang, Jinglan Wu, Yue Liu, Ling You, and Xue Geng
- Subjects
left atrial volumes ,medicine.medical_specialty ,medicine.medical_treatment ,Diastole ,Catheter ablation ,Speckle tracking echocardiography ,Cardiovascular Medicine ,030204 cardiovascular system & hematology ,left atrial appendage closure ,03 medical and health sciences ,0302 clinical medicine ,Left atrial ,Internal medicine ,catheter ablation ,medicine ,Diseases of the circulatory (Cardiovascular) system ,030212 general & internal medicine ,speckle tracking echocardiography ,Original Research ,Cardiac cycle ,business.industry ,Atrial fibrillation ,medicine.disease ,Ablation ,RC666-701 ,Concomitant ,Cardiology ,left atrial function ,business ,Cardiology and Cardiovascular Medicine - Abstract
Background: A single procedure combining left atrial appendage closure (LAAC) plus catheter ablation (CA) has been proven to be safe and feasible for treating atrial fibrillation (AF). However, the influence of treatment modality on left atrial (LA) function is not thoroughly explained.Objective: We aimed to investigate the changes of LA function in persistent AF patients undergoing concomitant LAAC and CA.Methods: The study population comprised 65 patients who underwent combined AF ablation and Watchman LAAC (combined therapy group) in our center, and 65 participants of the AF simple ablation group who were matched based on sex, age, CHA2DS2-VASc score and HAS-BLED score using propensity score matching. During the 1-year follow-up period, two-dimensional echocardiography and speckle tracking echocardiography were performed to assess LA reservoir, conduit, and contractile function.Results: The combined therapy was associated with a significant improvement in the LA reservoir function with increased expansion index and strain indices, including strain and strain rate (SR) during ventricular systole. Conduit function with SR during early ventricular diastole was also improved, as was contractile function with active atrial emptying fraction and SR during atrial systole. Similarly, LA reservoir and contractile function indices all improved continuously during follow-up after catheter ablation alone. At 3 months follow-up LA reservoir and conduit function with strain indices had a tendency to improve only in the simple procedure group. At 1-year follow-up there was no significant difference in either LA volumes or strain indices between the two groups.Conclusion: Both the combined therapy group and the simple ablation group demonstrated significant improvement in LA function. Based upon the fact that LA function was improved in both groups it might be concluded that most of the effects appeared to result from ablation, not LAAC; furthermore the additional LAAC procedure did not affect the improvement of LA function after CA.
- Published
- 2021
- Full Text
- View/download PDF
34. Relationship Among Atrial Fibrillation, CHADS2 Score and Ischaemic Stroke in Patients With Coronary Artery Disease: A Propensity Score Matching Study
- Author
-
Boqun Shi, Demin Liu, Qian Wang, Xue Geng, Qian Hou, Guoqiang Gu, Ruiqin Xie, and Wei Cui
- Abstract
Objective: The purpose of this study was to investigate the relationship among atrial fibrillation (AF), CHADS2 score and ischaemic stroke in patients with coronary artery disease.Methods: A total of 2335 patients with coronary artery disease were included. They were divided into a nonischaemic stroke group (n=1997) and an ischaemic stroke group (n=388). Propensity score matching (PSM) was used to match ischaemic stroke patients with nonischaemic stroke patients in a 1:4 ratio. The relationship between AF, CHADS2 score and ischaemic stroke was evaluated using a univariate generalized linear model in different age, body mass index, and coronary artery disease subgroups. Univariate and multivariate generalized linear models were used to evaluate the relationship between AF and ischaemic stroke in different models.Results: Compared with the nonischaemic stroke group, the rate of AF (8.81% vs. 14.20%, P=0.002) in the ischaemic stroke group was higher. The proportion of patients with ischaemic stroke was significantly different between the AF group and the non-AF group (19.04% vs. 28.74%, P=0.003). With increasing CHADS2 score, the incidence of AF gradually increased (P for trend Conclusion: After adjusting for confounding factors, the correlation between AF and ischaemic stroke decreased. Atherosclerotic factors may play an important role in ischaemic stroke in patients with coronary heart disease.
- Published
- 2020
35. Relationship among atrial fibrillation, the CHA
- Author
-
Boqun, Shi, Demin, Liu, Qian, Wang, Xue, Geng, Qian, Hou, Guoqiang, Gu, Ruiqin, Xie, and Wei, Cui
- Subjects
Adult ,Aged, 80 and over ,Male ,China ,CHA2DS2-VASc score ,Coronary Artery Disease ,Middle Aged ,Prognosis ,Risk Assessment ,Atrial fibrillation ,Decision Support Techniques ,Cross-Sectional Studies ,Predictive Value of Tests ,Risk Factors ,Prevalence ,Humans ,Female ,cardiovascular diseases ,Propensity Score ,Ischaemic stroke ,Aged ,Ischemic Stroke ,Research Article - Abstract
Background Recent evidence has shown that the pathogenesis of ischaemic stroke associated with atrial fibrillation (AF) is complex and involves other factors in addition to arrhythmias. The purpose of this study was to investigate the relationship among AF, CHA2DS2-VASc score and ischaemic stroke in patients with coronary artery disease (CAD) in Hebei, China. Methods A total of 2,335 patients with CAD from September 2016 to May 2019 at the Second Hospital of Hebei Medical University were included (mean age 62.73 ± 10.35 years, range 26–92 years; 41.58% female). This was a cross-sectional study, and participants were divided into non-stroke (n = 1997) and ischaemic stroke groups (n = 338). Propensity score matching (PSM) was performed to match ischaemic stroke patients with non-stroke patients in a 1:4 ratio. The relationship among AF, the CHA2DS2-VASc score and ischaemic stroke was evaluated using univariable generalized linear models for different sex, age, body mass index (BMI), CAD and CHA2DS2-VASc score subgroups. Univariable and multivariable generalized linear models were used to evaluate the relationship between AF and ischaemic stroke in the different models. Results Compared with that in the non-stroke group, the prevalence of AF (8.81% vs. 14.20%, P = 0.002) in the ischaemic stroke group was higher. The proportion of patients with ischaemic stroke was significantly different between the AF group and the non-AF group (28.74% vs. 19.04%, P = 0.003). An increasing CHA2DS2-VASc score was associated with a gradual increase in the prevalence of AF (P for trend
- Published
- 2020
36. Electromagnetic interference effect of dental equipment on cardiac implantable electrical devices: A systematic review
- Author
-
Yuting Niu, Xuliang Deng, Wenjing Li, Yufei Chen, and Ruiqin Xie
- Subjects
Dental practice ,medicine.medical_specialty ,Pacemaker, Artificial ,business.industry ,Dental Equipment ,MEDLINE ,General Medicine ,030204 cardiovascular system & hematology ,Electrical devices ,Cochrane Library ,Dental instruments ,Electromagnetic interference ,Defibrillators, Implantable ,stomatognathic diseases ,03 medical and health sciences ,0302 clinical medicine ,Electromagnetic Fields ,stomatognathic system ,medicine ,Humans ,Medical physics ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The electromagnet interference (EMI) effect resulting from using dental equipment near cardiovascular implantable electronic devices (CIEDs) is controversial based on in vitro and in vivo studies. We aimed to summarize the available evidence to investigate the safety of using dental equipment on patients with CIEDs. Methods An electronic search was performed in PubMed, Embase, MEDLINE Ovid, and the Cochrane Library for relevant studies published between January 2000 and May 2020. The search strategy centered on terms related to dental devices and CIEDs. Two independent reviewers determined the final inclusion of the studies in the systematic review. The EMI effect was summarized based on different dental instruments detected in in vitro or in vivo studies. Results The primary search identified 84 articles, and 18 studies were finally included in this systematic review after exclusions. Most in vitro studies (n = 12) reported background noise or severe EMI affecting CIED function at a close distance from the lead tip or at a high sensitivity setting of CIEDs. In in vivo studies (n = 6), EMI that altered CIED function was not detected at clinical distance and sensitivity settings. The summary, based on electronic apex locators, ultrasonic devices, and electric pulp testers, demonstrated the compatibility of these common dental devices with CIEDs. Conclusions This systematic review indicates that most dental instruments can be used safely in routine dental practice. The EMI effect of dental equipment depends on the exposure distance and lead-related parameters of the CIEDs.
- Published
- 2020
37. Inflammatory Response after Different Ablation Strategies for Paroxysmal Atrial Fibrillation
- Author
-
Guangli Yin, Bofei Ma, Bolun Zhou, Ling You, Jinglan Wu, and Ruiqin Xie
- Subjects
Male ,medicine.medical_specialty ,Paroxysmal atrial fibrillation ,Inflammatory response ,medicine.medical_treatment ,Inflammation ,Catheter ablation ,Electrocardiography ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,Medicine ,Humans ,In patient ,Tachycardia, Paroxysmal ,Retrospective Studies ,business.industry ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Ablation ,Cardiology ,Catheter Ablation ,Surgery ,Female ,medicine.symptom ,Postoperative inflammation ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Catheter ablation for atrial fibrillation (AF) has been gaining popularity; however, the trend of inflammatory response markers in patients treated with different catheter ablation strategies over time and their predictability of AF recurrence remain unknown. Methods: A total of 210 patients with AF were enrolled and grouped according to surgical mode as follows: freeze group, RF group, and freeze3D group. The subjects were tested for related indexes before and after surgery. To determine AF recurrence during follow up, 24-h ambulatory electrocardiography was performed at two, three, six, and 12 months after surgery. Results: The inflammation indexes of the three groups peaked between one and three days after surgery but fell at different time points (P < .05). The recurrence rate of paroxysmal atrial fibrillation (PAF) was positively correlated with the increase in the percentage of white blood cells and neutrophils after surgery (P < .05). Conclusions: The postoperative inflammation indices peaked and fell at different time points after different catheter ablation methods. In addition, the recurrence rate of AF in patients treated with freeze3D is lower.
- Published
- 2020
38. The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models
- Author
-
Demin Liu, Ruiqin Xie, Wei Cui, Haijuan Hu, Jing Wang, Guoqiang Gu, and Rui Ding
- Subjects
Denervation ,Sympathetic nervous system ,medicine.medical_specialty ,Article Subject ,business.industry ,Rat model ,Urology ,Secondary hypertension ,030204 cardiovascular system & hematology ,medicine.disease ,Angiotensin II ,Norepinephrine (medication) ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Blood pressure ,RC666-701 ,Internal Medicine ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,030212 general & internal medicine ,business ,Target organ ,medicine.drug ,Research Article - Abstract
Background. Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. Methods. Hypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar–Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized. Results. The two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis. Conclusion. RDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model.
- Published
- 2020
39. Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score
- Author
-
Ming Zhang, Xue Geng, Demin Liu, Qian Hou, Qian Wang, Guoqiang Gu, Ruiqin Xie, and Wei Cui
- Subjects
Male ,Gastrointestinal bleeding ,medicine.medical_specialty ,Cardiology ,030204 cardiovascular system & hematology ,Hematocrit ,Logistic regression ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,Humans ,Gastrointestinal Bleeding ,030212 general & internal medicine ,Stroke ,Retrospective Studies ,Framingham Risk Score ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,medicine.disease ,Hospitalization ,Blood pressure ,RC666-701 ,Risk score ,Cardiology and Cardiovascular Medicine ,business ,Gastrointestinal Hemorrhage - Abstract
Background: Although the early use of a risk stratification score in gastrointestinal bleeding(GIB) is recommended, there has been no risk score for GIB in patients admitted to cardiology so far.Objective:To describe the risk factors of GIB and develop a new risk score model in patients admitted to cardiology. Methods: A total of 633 inpatients with GIB from January 2014 to December 2018 were recruited, 4,231 inpatients with non-GIB recruited as the control group. Multivariate logistic regression was used to describe the risk factors of GIB,A new risk score model was developed in the derivation cohort. Accuracy to predict GIB was assessed by the area under the receiver operating characteristic (AUROC) curve in the validation cohort.Results: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin and alanine aminotransferase(ALT) were associated with GIB . The model had a high predictive accuracy (AUROC 0.816; 95%CI, 0.792-0.839), which was supported by the validation cohort (AUROC 0.841; 95% CI, 0.807~0.874). Besides,the prediction of the model better than HAS-BLED score(AUROC 0.557; 95%CI, 0.513~0.602) and CRUSADE score(AUROC 0.791; 95%CI, 0.757~0.825), respectively. Among the inpatients with a score 0-3, 4-7, and ≥8 points, the incidence of GIB, the proportion of inpatients requiring suspended red blood cells transfusion, length of stay and in-hospital mortality all increased gradually(P< 0.001). Conclusions: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin and ALT are associated with GIB. The new risk score model is an accurate risk score that predicts GIB in patients admitted to cardiology.
- Published
- 2020
40. The influence of iatrogenic atrial septal defect on the prognosis of patients with atrial fibrillation between cryoablation and radiofrequency ablation
- Author
-
Ling You, Ruiqin Xie, Yue Liu, Jing Yang, Ying Yang, Lixia Yao, Jinglan Wu, and Chenfeng Zhang
- Subjects
Male ,Time Factors ,Radiofrequency ablation ,medicine.medical_treatment ,Iatrogenic Disease ,030204 cardiovascular system & hematology ,Cryosurgery ,Biochemistry ,law.invention ,0302 clinical medicine ,Recurrence ,Risk Factors ,law ,Atrial Fibrillation ,030212 general & internal medicine ,Research Articles ,Ejection fraction ,Incidence ,Cryoablation ,Atrial fibrillation ,Middle Aged ,Treatment Outcome ,cryoablation ,Catheter Ablation ,cardiovascular system ,Cardiology ,Atrial Function, Left ,Female ,radiofrequency ablation ,Adult ,Cardiac function curve ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Biophysics ,Diastole ,Risk Assessment ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Systole ,Molecular Biology ,Aged ,Atrial Septum ,business.industry ,Cell Biology ,medicine.disease ,Heart Injuries ,Cardiovascular System & Vascular Biology ,prognosis ,cardiac function ,iatrogenic atrial septal defect ,business - Abstract
Objective: The present study was to compare the incidence of septal defect (SD) in patients with atrial fibrillation (AF) who received radiofrequency ablation or cryoablation. Methods: A total of 293 AF patients were performed with radiofrequency ablation and cryoablation. Cardiac ultrasonography was performed to calculate left atrial diameter (LAD), left atrial ejection fraction (LAEF%), strain rate (SR), left ventricular systolic (SRs), left ventricular diastolic (SRe), and left atrial systole (SRa) before surgery, 3 months and 1 year after surgery. The patients were followed up to observe statin and angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) medication, AF recurrence, 6-min walk test, stroke, any symptoms caused by arrhythmia, and re-hospitalization. Results: The levels of LAD and SD were higher, while SRe and SRa were lower in the cryoablation group in the comparison with the radiofrequency ablation group after surgery (P
- Published
- 2020
41. Early intervention of long-acting nifedipine GITS reduces brachial–ankle pulse wave velocity and improves arterial stiffness in Chinese patients with mild hypertension: a 24-week, single-arm, open-label, prospective study
- Author
-
Xiaohong Yang, Zejun Tian, Hongmei Zheng, Yan Wang, Ruiqin Xie, Demin Liu, Jidong Zhang, Wei Cui, Guoqiang Gu, and Haijuan Hu
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,hypertension ,Time Factors ,Adolescent ,Nifedipine ,Diastole ,Pharmaceutical Science ,Blood Pressure ,Pulse Wave Analysis ,Angina ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Vascular Stiffness ,Internal medicine ,Drug Discovery ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Adverse effect ,Pulse wave velocity ,Antihypertensive Agents ,Original Research ,Aged ,Pharmacology ,gastrointestinal therapeutic system ,calcium channel blockers ,Drug Design, Development and Therapy ,business.industry ,Middle Aged ,medicine.disease ,030104 developmental biology ,Blood pressure ,030220 oncology & carcinogenesis ,Arterial stiffness ,Cardiology ,Female ,business ,brachial–ankle pulse wave velocity ,medicine.drug - Abstract
Jidong Zhang, Yan Wang, Haijuan Hu, Xiaohong Yang, Zejun Tian, Demin Liu, Guoqiang Gu, Hongmei Zheng, Ruiqin Xie, Wei Cui Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China Background: Nifedipine gastrointestinal therapeutic system (GITS) is used to treat angina and hypertension. The authors aimed to study the early intervention impact on arterial stiffness and pulse wave velocity (PWV) independent of its blood-pressure-(BP) lowering effect in mild hypertensive patients.Methods: This single-center, single-arm, open-label, prospective, Phase IV study recruited patients with mild hypertension and increased PWV from December 2013 to December 2014 (N=138; age, 18–75 years; systolic blood pressure, 140–160 mmHg; diastolic BP, 90–100 mmHg; increased brachial–ankle pulse wave velocity [baPWV, ≥12 m/s]). Nifedipine GITS (30 mg/d) was administered for 24 weeks to achieve target BP of 0.05). There were no other drug-related serious adverse events.Conclusion: Nifedipine GITS was considerably effective in reducing baPWV and BP, indicating improvement in arterial stiffness as early as 4 weeks. Keywords: nifedipine, gastrointestinal therapeutic system, calcium channel blockers, brachial–ankle pulse wave velocity, hypertension
- Published
- 2016
42. LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis
- Author
-
Ruiqin Xie, Lixia Yao, Bolun Zhou, Haijuan Hu, and Ling You
- Subjects
0301 basic medicine ,Male ,China ,medicine.medical_treatment ,Myocardial Infarction ,Apoptosis ,Small hairpin RNA ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,microRNA ,Atrial Fibrillation ,Genetics ,medicine ,Animals ,Humans ,Molecular Biology ,Gene knockdown ,business.industry ,Growth factor ,Myocardium ,Atrial fibrillation ,General Medicine ,medicine.disease ,Endomyocardial Fibrosis ,Fibrosis ,Rats ,CTGF ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Myocardial fibrosis ,Female ,RNA, Long Noncoding ,business ,Cardiomyopathies ,Signal Transduction - Abstract
Atrial fibrillation (AF) is a commonly encountered heart arrhythmia and a risk factor for cardiovascular system. The purpose of the present study was to explore the role of long non-coding RNA myocardial infarction-associated transcript (MIAT) in AF and AF-induced myocardial fibrosis and the possible mechanisms involved in this process. We successfully induced an AF rat model. Expression of MIAT presented a dramatic increase, while microRNA (miR)-133a-3p presented a dramatic decrease in atrium tissues of rats with AF induction. In addition, we also found that MIAT was highly expressed and miR-133a-3p was significantly reduced in peripheral blood leukocyte of AF patients. For biological function exploration of MIAT/miR-133a-3p axis, MIAT was knocked down using small hairpin RNA (shRNA) lentivirus injection and the rescue experiments were performed simultaneously by inhibiting miR-133a-3p using anti-miR-133a-3p lentivirus injection in rats with AF. MIAT downregulation significantly alleviated AF, increased atrial effective refractory period (AERP), and reduced the duration of AF as well as cardiomyocytes apoptosis. Whereas these effects of MIAT downregulation on AF were reversed by anti-miR-133a-3p administration. Luciferase reporter revealed that miR-133a-3p was directly regulated by MIAT. Moreover, MIAT knockdown effectively reduced AF-induced atrial fibrosis by detecting reduced collagen in the right atria and inhibited expression of fibrosis-related gene expression of collagen I, collagen III, connective tissue growth factor (CTGF) and transforming growth factor-β1 (TGF-β1) in rats with AF, these findings were in contrast with the findings for rats with inhibition of miR-133a-3p. In conclusion, our study demonstrated the role of MIAT downregulation in alleviating AF and AF-induced myocardial fibrosis, and the functional regulatory pathway of MIAT targeting miR-133a-3p.
- Published
- 2019
43. Effects of different ablation strategies on long-term left atrial function in patients with paroxysmal atrial fibrillation: a single-blind randomized controlled trial
- Author
-
Jinglan Wu, Ying Yang, Chenfeng Zhang, Ling You, Lixia Yao, Guangli Yin, Bolun Zhou, Honglin Yin, Ruiqin Xie, Li-Li Jin, and Yue Liu
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Systole ,medicine.medical_treatment ,Diastole ,lcsh:Medicine ,Cryosurgery ,Article ,Pulmonary vein ,law.invention ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Randomized controlled trial ,Recurrence ,law ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Single-Blind Method ,Sinus rhythm ,lcsh:Science ,Aged ,Multidisciplinary ,business.industry ,lcsh:R ,Atrial fibrillation ,Cryoablation ,Middle Aged ,medicine.disease ,Ablation ,Treatment Outcome ,030104 developmental biology ,Surgery, Computer-Assisted ,Echocardiography ,Pulmonary Veins ,Outcomes research ,Catheter Ablation ,Cardiology ,Female ,lcsh:Q ,business ,Interventional cardiology ,030217 neurology & neurosurgery - Abstract
Restoration of sinus rhythm in atrial fibrillation (AF) by radiofrequency catheter ablation (RFCA) is associated with a transient stunning of left atrial (LA) function. However, the long-term effects of different ablation strategies on LA function remain undetermined. We performed randomized controlled trial to evaluate the effects of RFCA, cryoablation, and 3D mapping-guided cryoablation on LA function of proximal AF patients within 1 year. The 3D mapping-guided cryoablation was defined as a maximum of two cryoablation procedures for each pulmonary vein accompanied by RFCA for additional points until complete pulmonary vein isolation was achieved. Conventional and speckle tracking echocardiographic analyses were performed to evaluate LA function. Among the 210 patients (70 in each group) included, a trend of decreasing LA systolic and diastolic function was observed in all groups, as evidenced by decreases in peak A-wave velocity, the global LA peak systolic strain, the peak strain rate, the peak early diastolic strain rate, and the peak late diastolic strain rate within 7 days to 3 months after ablation followed by gradual recovery thereafter. However, the temporal changes in the above four strain parameters among the three groups did not differ significantly within 1 year after ablation (all p > 0.05). Parameters of the LA emptying fraction and LA dimensions were not significantly affected. These results suggested that stunning of LA function occurred within 7 days to 3 months after ablation, and different strategies of AF ablation did not differentially affect the temporal changes in LA function up to 1 year after ablation.
- Published
- 2019
44. Relationship Between Parental Rejection and Problematic Mobile Phone Use in Chinese University Students: Mediating Roles of Perceived Discrimination and School Engagement
- Author
-
Yuanyuan Chen, Jianjun Zhu, Wei Zhang, and Ruiqin Xie
- Subjects
05 social sciences ,lcsh:BF1-990 ,school engagement ,Risk factor (computing) ,050105 experimental psychology ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Psychology ,Mobile phone ,problematic mobile phone use ,Psychology ,0501 psychology and cognitive sciences ,perceived discrimination ,School engagement ,parental rejection ,Association (psychology) ,sequential mediating effect ,030217 neurology & neurosurgery ,General Psychology ,Original Research - Abstract
In order to clarify the onset mechanism of problematic mobile phone use, and to develop better strategies to prevent and treat problematic mobile phone use, the current study tested the negative impact of parental rejection on problematic mobile phone use and the mediating roles of perceived discrimination and school engagement in this association. The sample consisted of 356 Chinese university students (36.3% male) ranging from 17 to 19 years of age. Participants completed self-report questionnaires assessing parental rejection, perceived discrimination, school engagement, and problematic mobile phone use. The results documented that parental rejection was a direct risk factor for problematic mobile phone use. This association was mediated by perceived discrimination, and there was also a sequential mediating effect in which perceived discrimination led in turn to low school engagement.
- Published
- 2019
45. HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury
- Author
-
Wei Cui, Puqiang Zhang, Ya-Nan Zhang, Da‑Wei Liu, Ruiqin Xie, and Haijuan Hu
- Subjects
Male ,0301 basic medicine ,Autophagosome ,Indazoles ,BNIP3 ,HIF-1α ,Apoptosis ,Myocardial Reperfusion Injury ,RM1-950 ,Immunofluorescence ,Cell Line ,Mitochondrial Proteins ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Western blot ,Autophagy ,medicine ,Animals ,Myocyte ,Myocytes, Cardiac ,Cytotoxicity ,Pharmacology ,medicine.diagnostic_test ,Chemistry ,Membrane Proteins ,General Medicine ,Hypoxia-Inducible Factor 1, alpha Subunit ,medicine.disease ,Ischemia/reperfusion (I/R) ,Oxygen–glucose deprivation/recovery (OGD/R) injury ,Cell Hypoxia ,Amino Acids, Dicarboxylic ,Mitochondria ,Rats ,Cell biology ,030104 developmental biology ,030220 oncology & carcinogenesis ,Models, Animal ,Beclin-1 ,Therapeutics. Pharmacology ,Signal transduction ,Microtubule-Associated Proteins ,Reperfusion injury ,Signal Transduction - Abstract
Objective The study was established to inquire into the protective effect of the HIF-1α (Hypoxia-inducible factor-1α)/ BNIP3(Bcl-2/adenovirus E1B 19-kDa interacting protein) signal path-induced-autophagy during myocardial ischemia/ reperfusion (I/R) and oxygen–glucose deprivation/recovery (OGD/R) injury in heart-derived H9C2 cells as well as its potential underlying mechanism. Methods Immediate myocardial I/R in SD (Spraque Dawley) rats and cytotoxicity of OGD/R injury on H9C2 cells with and without inhibitors or agonists of HIF-1α and BNIP3 were evaluated. Expression of mitochondrial autophagic protein were detected by Western blot and immunofluorescence. And the mitochondrial autophagosome were detected using Transmission Electron Microscope (TEM). Results I/R and OGD/R injury increased the expression level of HIF-1α, activated the downstream BNIP3 and subsequently triggered mitochondria-dependent autophagy. Up-regulation the expression of HIF-1α and BNIP3 may promote the cardiac myocytes of SD rats of I/R injure and OGD/R injury-induced autophagy of H9C2 cells. Moreover, down-regulation the expression of HIF-1α or BNIP3-siRNA decreased H9C2 cells autophagy under OGD/R injury. Conclusions Together, our studies indicated that HIF-1α synchronization regulate BNIP3 during OGD/R injury-induced autophagy in H9C2 cells, though BNIP3-induced autophagy acting as a survival mechanism.
- Published
- 2019
46. Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle
- Author
-
Zejun Tian, Yan Wang, Jidong Zhang, Ruiqin Xie, Demin Liu, Guoqiang Gu, Hongmei Zheng, Wei Cui, Haijuan Hu, and Guangming Zhang
- Subjects
China ,hypertension ,Nifedipine ,Diastole ,Pharmaceutical Science ,Blood Pressure ,030204 cardiovascular system & hematology ,Essential hypertension ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Drug Discovery ,Heart rate ,medicine ,Humans ,In patient ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Antihypertensive Agents ,Original Research ,Pharmacology ,Drug Design, Development and Therapy ,Dose-Response Relationship, Drug ,nifedipine gastrointestinal therapeutic system ,Chemistry ,baseline blood pressure ,medicine.disease ,Blood pressure ,Anesthesia ,Blood pressure lowering ,medicine.drug - Abstract
Haijuan Hu, Jidong Zhang, Yan Wang, Zejun Tian, Demin Liu, Guangming Zhang, Guoqiang Gu, Hongmei Zheng, Ruiqin Xie, Wei Cui Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China Background: The objective of the study was to investigate the relationship between baseline blood pressure (BP) and the magnitude of BP reduction in patients with essential hypertension treated with nifedipine gastrointestinal therapeutic system (NGTS).Methods and patients: One hundred and thirty-eight patients with essential hypertension were enrolled in this prospective, single-arm, open-label study. NGTS was administered for 24 weeks to achieve target BP of 140/90 mmHg. The dose could be uptitrated to 60 mg/d in case of unsatisfactory BP reduction after 4-week treatment. Home blood pressure measurement was recorded through the initial 1–14 days, and office BP and heart rate were evaluated at 2, 4, 8, 12, and 24 weeks.Results: One hundred and seventeen patients (84.8%) completed the study, and their average BP decreased by 19.0/11.3 mmHg after 24 weeks. The reduction of either systolic or diastolic BP was positively correlated with baseline BP at weeks 2, 4, or 24 after treatment (r=0.603–0.762, all p
- Published
- 2017
47. Cardioprotective effects of single oral dose of nicorandil before selective percutaneous coronary intervention
- Author
-
Jidong Zhang, Xue Geng, Fan Liu, Hongmei Zheng, Qian Wang, Jingchao Lu, Wei Cui, Xiuchun Yang, Jing Yang, Xiaohong Yang, Guangming Zhang, Guoqiang Gu, and Ruiqin Xie
- Subjects
Male ,medicine.medical_specialty ,Acute coronary syndrome ,Cardiotonic Agents ,Vasodilator Agents ,medicine.medical_treatment ,Administration, Oral ,Angina ,Coronary artery disease ,preconditioning ,Internal medicine ,Humans ,Medicine ,myocardial injury ,Postoperative Period ,cardiovascular diseases ,Myocardial infarction ,coronary heart disease ,Acute Coronary Syndrome ,Nicorandil ,Original Investigation ,Ejection fraction ,Dose-Response Relationship, Drug ,business.industry ,percutaneous coronary intervention ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,nicorandil ,Treatment Outcome ,Anesthesia ,Conventional PCI ,cardiovascular system ,Cardiology ,Female ,Vascular Resistance ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Objective Nicorandil, an opener of ATP-sensitive K+ channels, was used to treat angina in patients with coronary artery disease. In this study, we aim to investigate the cardioprotective effects of single oral dose of nicorandil in patients undergoing selective percutaneous coronary intervention (PCI). Methods One hundred and thirty-eight patients with acute coronary syndrome undergoing PCI from July 2011 to October 2012 were randomly divided into control group (group 1, n = 47), 10 mg oral nicorandil group (group 2, n = 45), and 20 mg oral nicorandil group (group 3, n = 46) about 2 hours before procedure, respectively. Cardiac troponin I (cTnI) levels were determined at 20 ~ 24 hours after PCI. Results There was a significant difference in the rate of any cTnI elevation among the three groups (group 1: 36.17%, group 2: 20.00%, group 3: 15.22%, p = 0.0176). With respect to the frequency of cTnI elevation ≥ 3 and 5 × the upper limit of normal (ULN), there also had statistical difference among the three groups (17.02% in group 1, 8.89% in group 2, and 4.35% in group 3, respectively for cTnI elevation ≥ 3 × ULN, p = 0.0428; 12.77% in group 1, 6.67% in group 2, and 2.17% in group 3, respectively, for cTnI elevation ≥ 5 × ULN, p = 0.0487). Logistic regression analysis showed that LVEF (OR = 0.915, 95% CI = 0.853-0.981) and the use of nicorandil (OR = 0.516, 95% CI = 0.267-0.996) before PCI were independent protective factors of myocardial injury. Conclusion Single oral dose of nicorandil (10 mg, 20 mg) 2 hours before the PCI procedure could decrease the incidence of peri-procedure myocardial injury and PCI-related myocardial infarction.
- Published
- 2015
48. Left atrial function, inflammation, and prothrombotic response after radiofrequency ablation for atrial fibrillation
- Author
-
Jinglan Wu, Yansha Zhao, Ruiqin Xie, Hongning Yin, Yucui Sun, Yanan Zhang, Xue Geng, Guangli Yin, and Ling You
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,Radiofrequency ablation ,medicine.medical_treatment ,Catheter ablation ,030204 cardiovascular system & hematology ,Doppler echocardiography ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,medicine ,Humans ,Sinus rhythm ,030212 general & internal medicine ,Aged ,Inflammation ,lcsh:R5-920 ,Radiofrequency Ablation ,medicine.diagnostic_test ,business.industry ,Anticoagulant ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Ablation ,Thrombosis ,C-Reactive Protein ,Cardiology ,Atrial Function, Left ,Female ,business ,lcsh:Medicine (General) - Abstract
Background: The conversion of atrial fibrillation (AF) to sinus rhythm is associated with transient dysfunction of the left atrium (LA). This study aimed to investigate the time course of LA function and inflammation after radiofrequency (RF) ablation for paroxysmal AF. Methods: Fifty-three patients with paroxysmal AF undergoing RF ablation were recruited. White blood cells were counted and high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and D-dimer levels were measured. LA emptying fraction, strain, and strain rate were evaluated before RF ablation and at 1, 2, 3, and 4 weeks and 2 and 3 months after ablation using conventional Doppler echocardiography and two-dimensional speckle-tracking echocardiography. Results: LA emptying fraction sharply decreased at day 7 after ablation and then slowly increased (p
- Published
- 2017
49. Atorvastatin can ameliorate left atrial stunning induced by radiofrequency ablation for atrial fibrillation
- Author
-
Ruiqin Xie, Wei Cui, Yingtao Yang, Jidong Zhang, Hongmei Zheng, Hongning Yin, and Ling You
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,Radiofrequency ablation ,Systole ,Atorvastatin ,Left atrium ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Left atrial ,law ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Heart Atria ,Aged ,Pharmacology ,Myocardial Stunning ,business.industry ,Therapeutic effect ,Stunning ,nutritional and metabolic diseases ,Atrial fibrillation ,Stroke Volume ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,cardiovascular system ,Cardiology ,Catheter Ablation ,lipids (amino acids, peptides, and proteins) ,Female ,business ,medicine.drug - Abstract
The objective of this study was to study the functional changes of the left atrium after radiofrequency ablation treatment for atrial fibrillation and the therapeutic effect of atorvastatin. Fifty-eight patients undergoing radiofrequency ablation for atrial fibrillation were randomly divided into non-atorvastatin group and atorvastatin group. Patients in the atorvastatin group were treated with atorvastatin 20 mg p.o. per night in addition to the conventional treatment of atrial fibrillation; patients in the non-atorvastatin group received conventional treatment of atrial fibrillation only. Echocardiography was performed before radiofrequency ablation operation and 1 week, 2 weeks, 3 weeks, and 4 weeks after operation. Two-dimensional ultrasound speckle tracking imaging system was used to measure the structural indexes of the left atrium. Results indicated that there was no significant change for indexes representing the structural status of the left atrium within a month after radiofrequency ablation (P > 0.05); however, there were significant changes for indexes representing the functional status of the left atrium. There were also significant changes in indexes reflecting left atrial strain status: the S and SRs of atorvastatin group were higher than those of non-atorvastatin group (P < 0.05). In summary, atorvastatin could improve left atrial function and shorten the duration of atrial stunning after radiofrequency ablation of atrial fibrillation.
- Published
- 2017
50. High levels of serum β2-microglobulin predict severity of coronary artery disease
- Author
-
Haijuan Hu, Ruiqin Xie, Wei Cui, Ximiao He, Hongmei Zheng, Jidong Zhang, Guoqiang Gu, Xiaohong Yang, and Ling You
- Subjects
Male ,China ,medicine.medical_specialty ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Severity of Illness Index ,Severity ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Severity of illness ,Prevalence ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Risk factor ,β2-Microglobulin ,Aged ,Framingham Risk Score ,Receiver operating characteristic ,business.industry ,Case-control study ,Odds ratio ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,Up-Regulation ,ROC Curve ,Area Under Curve ,Case-Control Studies ,Cardiology ,Female ,beta 2-Microglobulin ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Research Article - Abstract
Background The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardiovascular disease remains under-researched. This study evaluated the effects of B2M on CAD without renal dysfunction. Methods One thousand seven hundred sixty-two subjects (403 non-CAD subjects and 1,359 CAD subjects) were investigated. Fasting samples were collected to determine B2M level. The Gensini and SYNTAX scores were used to assess the severity of CAD. Results CAD subjects were significantly higher in serum B2M level comparing with non-CAD subjects (1.25 ± 0.46 vs 1.14 ± 0.28 mg/L, p
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.