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Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February–June 2020; n = 769 (66%)) and later (July 2020–February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11–0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01–3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22–0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81–1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis., Fundación Madrileña de Hematología y Hemoterapia, Fundación Leucemia y Linfoma, Asociación Madrileña de Hematología y Hemoterapia, Depto. de Medicina, Fac. de Medicina, TRUE, pub

Uno de los objetivos principales en Antropología Forense es determinar el sexo de los restos que están bajo estudio. No siempre es posible recuperar aquellos restos a partir de los cuales se puede determinar el sexo con una alta fiabilidad, como es el caso de la pelvis o el cráneo, con lo que son necesarios nuevos estudios sobre huesos del esqueleto postcraneal para conocer su poder discriminante. Debido a las diferencias encontradas entre poblaciones, es necesario realizar estudios específicos sobre las diferentes poblaciones con lo cual es necesario conocer la variabilidad en población española. Diferencias en el desarrollo muscular, en el nivel cantidad-calidad ósea y en el nivel de actividad física explicarían parte de las diferencias entre varones y mujeres, existiendo un dimorfismo sexual en la especie humana que permite determinar el sexo a partir de restos óseos, siendo unos huesos másdisciminantes que otros. En cuanto a los métodos existentes para determinar el sexo a partirde un resto óseo principalmente se encontrarían dos: el morfológico y el métrico. En el cráneo y en la pelvis son más utilizados los morfológicos y en el resto de los huesos del esqueleto postcraneal los métricos. El estudio del volumen óseo para determinar el sexo noparece haber despertado un gran interés ya que pocos estudios se encuentran que hayan descrito el poder discriminante de esta variable. Quizás esto sea debido a la falta de técnicas fiables para poder calcularlo más que a considerarla una variable que no fuera a discriminar bien el sexo. En los estudios publicados se calculaba el volumen utilizando la técnica de desplazamiento de fluido, presentando el inconveniente de tener que sumergir el hueso en agua, con lo que siendo el hueso poroso parte de ese agua era absorbida por el mismo, no siendo preciso el cálculo de su volumen. Actualmente con los nuevos avances basados en tecnología 3D es posible reproducir el hueso digitalmente y calcular su volumen de forma fiable utilizan, One of the main objectives in Forensic Anthropology is to determine the sex of the remains under study. It is not always possible to recover the remains which determine the sex with a high fiability, as pelvis or cranium, so new studies over the postcraneal skeleton are necessary to discover its discriminant power. Due to the differences found between populations it is necessary to perform specific studies over them, so the variability of the Spanish population also need to be studied. Differences in the muscular development, the quantitly-quality bone levels and the physical activity level could explain the differences found between males and females, existing a sexual dimorphism on the human specie that makes possible to determine sex from its bones, being one bones more discriminant than others. Regarding the existing methods to determine sex from an skeletal remain there are mainly two: the morphologic and metric methods. The morphologic method is commonly used on the cranium and pelvis and the metric method on the rest of the postcranial skeleton. The bone volume study to determine sex seems not having aroused a big interest because few studies are found that have described the discriminant power of this variable. This could be due to the lack of reliable techniques to calculate it, not for thinking that the variable volume was not going to discriminate sex well. On the published studies the researchers calculated the volume using the displacement fluid technique, showing the inconvenience of immersing the bone in water and being part of the liquid absorbed by the bone because of its porosity, not being accurate the volume calculation. Nowadays the new advancements on 3D technology make possible to digitalize the bone and calculate its volume in a reliable manner using informatic tools. Four bones of the postcraneal skeleton were selected to perform the present study, considering its morfology, size and easy manipulation to be digitalized correctly, and also co