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17 results on '"Ruiz-Miyazawa, Kenji W."'

3. Quercetin attenuates zymosan-induced arthritis in mice

Author

Guazelli, Carla F.S., Staurengo-Ferrari, Larissa, Zarpelon, Ana C., Pinho-Ribeiro, Felipe A., Ruiz-Miyazawa, Kenji W., Vicentini, Fabiana T.M.C., Vignoli, Josiane A., Camilios-Neto, Doumit, Georgetti, Sandra R., Baracat, Marcela M., Casagrande, Rubia, and Verri, Waldiceu A., Jr

Published
2018
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4. The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells

Author

Bussmann, Allan J. C., Borghi, Sergio M., Zaninelli, Tiago H., dos Santos, Telma S., Guazelli, Carla F. S., Fattori, Victor, Domiciano, Talita P., Pinho-Ribeiro, Felipe A., Ruiz-Miyazawa, Kenji W., Casella, Antonio M. B., Vignoli, Josiane A., Camilios-Neto, Doumit, Casagrande, Rubia, and Verri, Jr., Waldiceu A.

Published
2019
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11. 15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

Author

Ruiz-Miyazawa, Kenji W., Staurengo-Ferrari, Larissa, Pinho-Ribeiro, Felipe A., Fattori, Victor, Zaninelli, Tiago H., Badaro-Garcia, Stephanie, Borghi, Sergio M., Andrade, Ketlem C., Clemente-Napimoga, Juliana T., Alves-Filho, Jose C., Cunha, Thiago M., Fraceto, Leonardo F., Cunha, Fernando Q., Napimoga, Marcelo H., Casagrande, Rubia, and Verri, Jr., Waldiceu A.

Published
2018
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13. Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

Author

Staurengo-Ferrari, Larissa, primary, Ruiz-Miyazawa, Kenji W., additional, Pinho-Ribeiro, Felipe A., additional, Fattori, Victor, additional, Zaninelli, Tiago H., additional, Badaro-Garcia, Stephanie, additional, Borghi, Sergio M., additional, Carvalho, Thacyana T., additional, Alves-Filho, Jose C., additional, Cunha, Thiago M., additional, Cunha, Fernando Q., additional, Casagrande, Rubia, additional, and Verri, Waldiceu A., additional

Published
2018
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14. Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

Author

Ruiz-Miyazawa, Kenji W., primary, Pinho-Ribeiro, Felipe A., additional, Borghi, Sergio M., additional, Staurengo-Ferrari, Larissa, additional, Fattori, Victor, additional, Amaral, Flavio A., additional, Teixeira, Mauro M., additional, Alves-Filho, Jose C., additional, Cunha, Thiago M., additional, Cunha, Fernando Q., additional, Casagrande, Rubia, additional, and Verri, Waldiceu A., additional

Published
2018
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15. The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells.

Author

Bussmann, Allan J. C., Borghi, Sergio M., Zaninelli, Tiago H., dos Santos, Telma S., Guazelli, Carla F. S., Fattori, Victor, Domiciano, Talita P., Pinho-Ribeiro, Felipe A., Ruiz-Miyazawa, Kenji W., Casella, Antonio M. B., Vignoli, Josiane A., Camilios-Neto, Doumit, Casagrande, Rubia, and Verri, Waldiceu A.

Subjects
NARINGENIN, LEUCOCYTES, INTRA-articular injections, CITRUS, OXIDATIVE stress, INFLAMMATION, FLAVONOIDS
Abstract

Background: Naringenin is a biologically active analgesic, anti-inflammatory, and antioxidant flavonoid. Naringenin targets in inflammation-induced articular pain remain poorly explored. Methods: The present study investigated the cellular and molecular mechanisms involved in the analgesic/anti-inflammatory effects of naringenin in zymosan-induced arthritis. Mice were pre-treated orally with naringenin (16.7–150 mg/kg), followed by intra-articular injection of zymosan. Articular mechanical hyperalgesia and oedema, leucocyte recruitment to synovial cavity, histopathology, expression/production of pro- and anti-inflammatory mediators and NFκB activation, inflammasome component expression, and oxidative stress were evaluated. Results: Naringenin inhibited articular pain and oedema in a dose-dependent manner. The dose of 50 mg/kg inhibited leucocyte recruitment, histopathological alterations, NFκB activation, and NFκB-dependent pro-inflammatory cytokines (TNF-α, IL-1β, and IL-33), and preproET-1 mRNA expression, but increased anti-inflammatory IL-10. Naringenin also inhibited inflammasome upregulation (reduced Nlrp3, ASC, caspase-1, and pro-IL-1β mRNA expression) and oxidative stress (reduced gp91phox mRNA expression and superoxide anion production, increased GSH levels, induced Nrf2 protein in CD45+ hematopoietic recruited cells, and induced Nrf2 and HO-1 mRNA expression). Conclusions: Naringenin presents analgesic and anti-inflammatory effects in zymosan-induced arthritis by targeting its main physiopathological mechanisms. These data highlight this flavonoid as an interesting therapeutic compound to treat joint inflammation, deserving additional pre-clinical and clinical studies. [ABSTRACT FROM AUTHOR]

Published
2019
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16. 15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice.

Author

Ruiz-Miyazawa, Kenji W., Staurengo-Ferrari, Larissa, Pinho-Ribeiro, Felipe A., Fattori, Victor, Zaninelli, Tiago H., Badaro-Garcia, Stephanie, Borghi, Sergio M., Andrade, Ketlem C., Clemente-Napimoga, Juliana T., Alves-Filho, Jose C., Cunha, Thiago M., Fraceto, Leonardo F., Cunha, Fernando Q., Napimoga, Marcelo H., Casagrande, Rubia, and Verri, Waldiceu A.

Abstract

Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals in the joints. 15deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed to evaluate the effect and mechanisms of action of 15d-PGJ2 nanocapsules (NC) in the model of GA in mice, since a reduction of 33-fold in the dose of 15d-PGJ2 has been reported. Mice were treated with 15d-PGJ2-loaded NC, inert NC, free 15d-PGJ2 (without NC), or 15d-PGJ2-loaded NC+ GW9662, a PPAR-γ inhibitor. We show that 15d-PGJ2-loaded NC provided analgesic effect in a dose that the free 15d-PGJ2 failed to inhibiting pain and inflammation. Hence, 15d-PGJ2-loaded NC reduced MSU-induced IL-1β, TNF-α, IL-6, IL-17, and IL-33 release and oxidative stress. Also, 15d-PGJ2-loaded NC decreased the maturation of IL-1β in LPS-primed BMDM triggered by MSU. Further, 15d-PGJ2-loaded NC decreased the expression of the components of the inflammasome Nlrp3, Asc, and Pro-caspase-1, as consequence of inhibiting NF-κB activation. All effects were PPAR-γ-sensitive. Therefore, we demonstrated that 15d-PGJ2-loaded NC present analgesic and anti-inflammatory properties in a PPAR-γ-dependent manner inhibiting IL-1β release and NF-κB activation in GA. Concluding, 15d-PGJ2-loaded NC ameliorates MSU-induced GA in a PPAR-γ-sensitive manner. [ABSTRACT FROM AUTHOR]

Published
2018
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