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4 results on '"Run-Tai Lin"'

1. Multidisciplinary treatment of deep neck infection associated with descending necrotizing mediastinitis: a single-centre experience

Author

Chao Ma, Lian Zhou, Ji-Zhi Zhao, Run-Tai Lin, Tao Zhang, Li-Jiang Yu, Tian-Yin Shi, and Mu Wang

Subjects
Medicine (General), R5-920
Abstract

Objective Deep neck infection (DNI) associated with descending necrotizing mediastinitis (DNM) is a highly lethal condition. This retrospective review was performed to share our experience performing multidisciplinary management of DNI associated with DNM during a 7-year period. Methods We reviewed 16 patients who had been surgically treated for DNM at Peking Union Medical College Hospital from April 2010 to July 2017. The clinical outcomes were analysed to determine the most appropriate therapeutic strategy. Results Five women and 11 men were included in this study. Their mean age was 54.9 ± 14.3 years. DNM-associated infections most commonly occurred secondary to odontogenic infections (n = 10). Thirteen patients required tracheotomy because of tracheal compression. All patients underwent unilateral or bilateral cervicotomy. Six patients with DNM localized in the upper mediastinal space underwent transcervical mediastinal drainage, while 10 patients with DNM extending to the lower mediastinum were treated by cervicotomy and video-assisted thoracoscopic surgery. Three patients died of multiple organ failure. Conclusion Multidisciplinary treatment can achieve favourable outcomes in >80% of patients with DNM. Early diagnosis, proper airway management, and adequate surgical drainage are crucial for reducing mortality in patients with DNM, and minimally invasive procedures also play an important role.

Published
2019
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2. Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

Author

Man‑Man Liu, Lian Zhou, Ji‑Zhi Zhao, Mu Wang, Chao Ma, Li‑Jiang Yu, Run‑Tai Lin, Tao Zhang, Yong‑Ning Chen, Tian‑Yin Shi, and Yao‑Ran Liu

Subjects
0301 basic medicine, Cancer Research, Cluster of differentiation, biology, Oncogene, business.industry, Cadherin, CD44, Cancer, Articles, medicine.disease, Molecular medicine, Metastasis, 03 medical and health sciences, stomatognathic diseases, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Oncology, Cervical lymph nodes, 030220 oncology & carcinogenesis, medicine, Cancer research, biology.protein, business
Abstract

Oral squamous cell carcinoma (OSCC) is a highly invasive lesion that frequently metastasizes to the cervical lymph nodes and is associated with a poor prognosis. Several adhesion factors, including cadherin 6 (CDH6), cadherin 11 (CDH11) and cluster of differentiation 44 (CD44), have been reported to be involved in the invasion and metastasis of multiple types of cancer. Therefore, the aim of the present study was to determine the expression of CDH6, CDH11 and CD44 in tumor tissues from patients with OSCC, and whether this was associated with the metastasis and survival of OSCC. The mRNA expression of the human tumor metastasis-related cytokines was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in OSCC tumors with or without lymph node metastasis (n=10/group). The expression of CDH6, CDH11 and CD44 in 101 OSCC and 10 normal oral mucosa samples was examined by immunohistochemical staining. The association between overall and disease-specific survival times of patients with OSCC and the expression of these three proteins was evaluated using Kaplan-Meier curves and the log-rank test. RT-qPCR results indicated that the mRNA expression of CDH6, CDH11 and CD44 was increased in OSCC patients with lymph node metastasis (2.93-, 2.01- and 1.92-fold; P

Published
2018

4. Mesenchymal chondrosarcoma of the right buccal region: A case report and review of the literature

Author

Run-Tai Lin, Mingliang Li, Jizhi Zhao, Lijiang Yu, and Yue Mu

Subjects
Cancer Research, medicine.medical_specialty, Pathology, Soft Tissue Neoplasm, business.industry, medicine.medical_treatment, Cancer, Soft tissue, computed tomography, Articles, soft-tissue neoplasms, medicine.disease, Mesenchymal chondrosarcoma, Radiation therapy, calcification, Oncology, medicine, Right buccal region, Radiology, Radical surgery, mesenchymal chondrosarcoma, business, Calcification
Abstract

Extraskeletal mesenchymal chondrosarcoma (EMCS) is a rare malignant cartilaginous tumor arising from the soft tissues. The most common areas of extraskeletal origin are the lower extremities, the orbits and the central nervous system, among others. In this study, the case of primary EMCS arising from the right buccal region in a 26-year old female is presented. Histological and immunohistochemical analysis confirmed the diagnosis of EMCS. Subseqently, the patient was treated with radical surgery, but declined chemotherapy or radiotherapy, which was recommended. One year after surgery, no recurrence had been identified in the patient. To the best of our knowledge, only one case of primary EMCS of the buccal region has been reported previously. In the current study, a case of primary EMCS of the buccal region is presented.

Published
2014

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