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21 results on '"Russo, Sebastiano"'

5. Lung recruitment in patients with the acute respiratory distress syndrome

Author

Gattinoni, Luciano, Caironi, Pietro, Cressoi, Massimo, Chiumello, Davide, Ranieri, V. Marco, Quintel, Michael, Russo, Sebastiano, Patroniti, Nicolo, Cornejo, Rodrigo, and Bugedo, Guillermo

Subjects
Acute respiratory distress syndrome -- Diagnosis, CT imaging -- Usage
Abstract

A study was conducted to examine the relationship between the percentage of potentially recruitable lung, in the acute respiratory distress syndrome (ARDS) as indicated by computed tomography (CT) and effects of positive end-expiratory pressure (PEEP). In ARDS, the percentage of potentially recruitable lung is extremely variable and is strongly associated with the response to PEEP.

Published
2006

11. Motor Overvoltage Mitigation on SiC MOSFET Drives Exploiting an Open-End Winding Configuration.

Author

De Caro, Salvatore, Foti, Salvatore, Scimone, Tommaso, Testa, Antonio, Scelba, Giacomo, Pulvirenti, Mario, and Russo, Sebastiano

Subjects
OVERVOLTAGE, ALTERNATING current electric motors, METAL oxide semiconductor field-effect transistors, VARIABLE speed drives, SILICON carbide, BIPOLAR transistors, WINDS
Abstract

Voltage wave reflection phenomena along power cables are particularly threatening on ac motor drives equipped with silicon carbide power mosfets due to very short switching times and high switching frequency. Overvoltage suppression resistance inductance capacitance (RLC) networks are usually added but leading to extra cost and a lower efficiency. A completely different overvoltage mitigation approach is presented in this paper exploiting an open-end winding motor configuration. Overvoltage occurring on the terminals of motor phase windings are, in fact, mitigated by simply coordinating the operations of the two inverters; thus, no passive RLC networks are required. The proposed approach is intended as a mean to provide a further valuable feature to open-winding systems at no extra cost, but it can be also valued as an alternative to conventional bridge inverters equipped with overvoltage mitigation devices. [ABSTRACT FROM AUTHOR]

Published
2019
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13. Analysis of RBFOX1 gene expression in lymphoblastoid cell lines of Italian discordant autism spectrum disorders sib-pairs

Author

Prandini, Paola, Zusi, Chiara, Malerba, Giovanni, Itan, Null, Pignatti, Pier Franco, Trabetti, Elisabetta, Allibrio, Giovanni, Amato, Maria Cristina, Anchisi, Laura, Andruccioli, Milena, Battistella, PIER ANTONIO, Benedetti, Sveva, Benvenuto, Arianna, Boscaini, Flavio, Canetta, Elisabetta, Cangini, Alessandra, Conti, Sara, Curatolo, Paolo, Bernardina, Bernardo Dalla, Da Ros, Lucio, De Giacomo, Andrea, Distefano, Grazia, Di Stefano, Maria Letizia, Di Vita, Giuseppa, Elia, Maurizio, Gitti, Filippo, Grittani, Serenella, Lafortezza, Mariaelena, Lamanna, Anna Linda, Mani, Elisa, Manzi, Barbara, Margari, Lucia, Marino, Maria, Masi, Gabriele, Molteni, Massimo, Muglia, Pierandrea, Nardocci, Franco, Parmeggiani, Antonia, Pascotto, Antonio, Patrini, Mara, Pias, Paola, Piroddi, Tiziana, Poledri, Sara, Polizzi, Miriam, Porfirio, Maria Cristina, Posar, Annio, Riccio, Maria Pia, Russo, Sebastiano, Santocchi, Elisa, Santucci, Margherita, Scifo, Renato, Tancredi, Raffaella, Tedde, Maria Rita, Tiberti, Alessandra, Valli, Angela, Dri, Valeria Vianello, Zanni, Roberta, Zoccante, Leonardo, Zuddas, Alessandro, Paola Prandini, Chiara Zusi, Giovanni Malerba, ITAN […, Parmeggiani Antonia, Posar Annio, Santucci Margherita, …], Pier Franco Pignatti, and Elisabetta Trabetti

Subjects
Male, Autismo, Child Development Disorders, Adolescent, Autism, Cells, Gene Expression, RBFOX1, Biology, Cell Line, Cohort Studies, Transcription (biology), Gene expression, mental disorders, medicine, Humans, Genetic Predisposition to Disease, Lymphocytes, Child, Preschool, Molecular Biology, Cells, Cultured, Pervasive, Genetics, Cultured, Reverse Transcriptase Polymerase Chain Reaction, Siblings, Medicine (all), RNA-Binding Proteins, Cell Biology, medicine.disease, Lymphoblastoid cell lines, Italy, Child Development Disorders, Pervasive, Cell culture, Autism spectrum disorder, Child, Preschool, RBFOX1 gene, RNA splicing, RBFOX1 Gene, Lymphocyte, Female, RNA Splicing Factors
Abstract

Several lines of evidence suggest that RBFOX1 is a key regulator of transcriptional and splicing programs in neural cells during development, and that it is expressed in a neuronal module enriched for known autism susceptibility genes. We have investigated its expression by semiquantitative RT-PCR in accessible nonbrain resources in eighteen autism spectrum disorder sib-pairs belonging to the Italian Autism Network cohort. RBFOX1 gene expression was detected in lymphoblastoid cell lines but not in lymphocytes. No significant differences between autism spectrum disorders and non-affected brothers were found. We were not able to replicate in lymphoblastoid cell lines the previously reported RBFOX1 gene downregulation in autism, even if a trend was observed. This might be due to less pronounced transcription level differences in RBFOX1 gene expression in lymphoblastoid cell lines than in brain samples.

Published
2014

18. Against Le Packing: A Consensus Statement

Author

Amaral, David, Rogers, Sally J., Baron-Cohen, Simon, Bourgeron, Thomas, Caffo, Ernesto, Fombonne, Eric, Fuentes, Joaquin, Howlin, Patricia, Rutter, Michael, Klin, Ami, Volkmar, Fred, Lord, Catherine, Minshew, Nancy, Nardocci, Franco, Rizzolatti, Giacomo, Russo, Sebastiano, Scifo, Renato, and van der Gaag, Rutger Jan

Published
2011
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20. Multchip SiC-based compact module for automotive applications: A high speed thermal study

Author

Anoldo Laura, Malta Giuliana, Mazza Bruna, Piccione Giuseppe Gabriele, Calabretta Michele, Russo Sebastiano, Russo Alfio, Sitta Alessandro, Messina Angelo, Lionetto Antonio, and Patanè Salvatore

Subjects
Thermal mapping, Automotive, Power electronic device, Silicon carbide, Electrical and Electronic Engineering, Safety, Risk, Reliability and Quality, Condensed Matter Physics, Reliability, Atomic and Molecular Physics, and Optics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Abstract

Nowadays the increasing demand of high-efficiency power devices for automotive framework, forced the scientific community to develop new technologies capable to operate under intense power loads. Among the broad scenario SiC-based substrates represent a promising solution. This study focuses on a high-speed thermal characterization of a power module designed by STMicroelectronics (ACEPACK DRIVE) with the aim to provide a map of the temperature values reached at the surface upon current-pulse stresses. Thermal images collected on one leg show a symmetrical temperature distribution, with a maximum of around 60 ◦C on the device metals and ensures that any reliability issues due to the thermo-mechanical stress are avoided.

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21. The Italian autism network (ITAN): a resource for molecular genetics and biomarker investigations

Author

Muglia, P., Filosi, M., Ros, Da, Kam-Thong, T., Nardocci, F., Trabetti, E., Ratti, E., Rizzini, P., Zuddas, A., Bernardina, B. D., Domenici, Enrico, Alibrio, G., Anchisi, L., Andruccioli, M., Benvenuto, A., Battistella, P. A., Boscaini, F., Bravaccio, C., Ceppi, E., Cosentino, D., Curatolo, P., De Giacomo, A., Di Vita, G., Elia, M., Gitti, F., Grittani, S., Lamanna, A. L., Mani, E., Manzi, B., Margari, L., Masi, G., Molteni, M., Pascotto, A., Parmeggiani, A., Pignatti, P. F., Piroddi, T., Prandini, P., Russo, S., Scifo, R., Tancredi, R., Tiberti, A., Zoccante, L., Pierandrea Muglia, Michele Filosi, Lucio Da Ros, Tony Kam-Thong, Franco Nardocci, Elisabetta Trabetti, Emiliangelo Ratti, Paolo Rizzini, Alessandro Zuddas, Bernardo Dalla Bernardina, Enrico Domenici,..Antonia Parmeggiani, Muglia, Pierandrea, Filosi, Michele, Da Ros, Lucio, Kam-Thong, Tony, Nardocci, Franco, Trabetti, Elisabetta, Ratti, Emiliangelo, Rizzini, Paolo, Zuddas, Alessandro, Bernardina, Bernardo Dalla, Domenici, Enrico, Alibrio, Giovanni, Anchisi, Laura, Andruccioli, Milena, Benvenuto, Arianna, Battistella, Pier Antonio, Boscaini, Flavio, Bravaccio, Carmela, Ceppi, Elisa, Cosentino, Diego, Curatolo, Paolo, De Giacomo, Andrea, Di Vita, Giuseppa, Elia, Massimo, Gitti, Filippo, Grittani, Serenella, Lamanna, Anna Linda, Mani, Elisa, Manzi, Barbara, Margari, Lucia, Masi, Gabriele, Molteni, Massimo, Pascotto, Antonio, Parmeggiani, Antonia, Pignatti, Pier Franco, Piroddi, Tiziana, Prandini, Paola, Russo, Sebastiano, Scifo, Renato, Tancredi, Raffaella, Tiberti, Alessandra, and Zoccante, Leonardo

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Adolescent, lcsh:RC435-571, Autism Spectrum Disorder, Medical Records, Autism Spectrum disorders, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Genetic, Language assessment, lcsh:Psychiatry, medicine, Pervasive developmental disorder, Child and adolescent psychiatry, Genetics, Humans, Biorepository, Asperger Syndrome, Child, Biomarkers, Wechsler Intelligence Scale for Children, Biological Specimen Banks, business.industry, Leiter International Performance Scale, Medical record, Autism Spectrum disorders, Biomarkers, Biorepository, Genetics, Biomarker, medicine.disease, Settore MED/39 - Neuropsichiatria Infantile, Psychiatry and Mental health, 030104 developmental biology, Databases as Topic, Italy, Psychiatry and Mental Health, Child Development Disorders, Pervasive, Child, Preschool, Autism, Health Resources, Female, business, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundA substantial genetic component accounts for Autism Spectrum Disorders (ASD) aetiology, with some rare and common genetic risk factors recently identified. Large collections of DNAs from thoroughly characterized ASD families are an essential step to confirm genetic risk factors, identify new variants and investigate genotype-phenotype correlations. The Italian Autism Network aimed at constituting a clinical database and a biorepository of samples derived from ASD subjects and first-degree relatives extensively and consistently characterized by child psychiatry centers in Italy.MethodsThe study was approved by the ethical committee of the University of Verona, the coordinating site, and by the local ethical committees of each recruiting site. Certified staff was specifically trained at each site for the overall study conduct, for clinical protocol administration and handling of biological material. A centralized database was developed to collect clinical assessment and medical records from each recruiting site. Children were eligible for recruitment based on the following inclusion criteria: age 4–18 years, at least one parent or legal guardian giving voluntary written consent, meeting DSM-IV criteria for Autistic Disorder or Asperger’s Disorder or Pervasive Developmental Disorder NOS. Affected individuals were assessed by full psychiatric, neurological and physical examination, evaluation with ADI-R and ADOS scales, cognitive assessment with Wechsler Intelligence Scale for Children or Preschool and Primary, Leiter International Performance Scale or Griffiths Mental Developmental Scale. Additional evaluations included language assessment, the Krug Asperger’s Disorder Index, and instrumental examination such as EEG and structural MRI. DNA, RNA and plasma were collected from eligible individuals and relatives. A central laboratory was established to host the biorepository, perform DNA and RNA extraction and lymphocytes immortalisation. DiscussionThe study has led to an extensive collection of biological samples associated with standardised clinical assessments from a network of expert clinicians and psychologists. Eighteen sites have received ADI/ADOS training, thirteen of which have been actively recruiting. The clinical database currently includes information on 812 individuals from 249 families, and the biorepository has samples for 98% of the subjects. This effort has generated a highly valuable resource for conducting clinical and genetic research of ASD, amenable to further expansion.

Published
2018

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