12 results on '"Russo A.G."'
Search Results
2. P.0628 Found in translation: Cocaine craving drives connectivity alterations in fronto-striatal-thalamic-frontal network accompanied by accumbal glutamate disruptions
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Engeli, E., primary, Ponticorvo, S., additional, Russo, A.G., additional, Zoelch, N., additional, Hock, A., additional, Hulka, L.M., additional, Kirschner, M., additional, Preller, K.H., additional, Esposito, F., additional, and Herdener, M., additional
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- 2021
- Full Text
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3. Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy
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Zorzi, Manuel, primary, Dal Maso, Luigino, additional, Francisci, Silvia, additional, Buzzoni, Carlotta, additional, Rugge, Massimo, additional, Guzzinati, Stefano, additional, Mazzoleni, G., additional, Coviello, E., additional, Galasso, R., additional, Sampietro, G., additional, Magoni, M., additional, Ardizzone, A., additional, D‘Argenzio, A., additional, Sutera Sardo, A., additional, Giorno, A., additional, La Greca, G., additional, Ricci, P., additional, Ferretti, S., additional, Palma, F., additional, Serraino, D., additional, Iacovacci, S., additional, Melcarne, A., additional, Puppo, A., additional, Sciacca, S., additional, Russo, A.G., additional, Caruso, B., additional, Cavalieri d’Oro, L., additional, D‘Orsi, G., additional, Fusco, M., additional, Usala, M., additional, Vitale, F., additional, Cusimano, R., additional, Michiara, M., additional, Boschetti, L., additional, Chiaranda, G., additional, Rosso, S., additional, Tumino, R., additional, Mangone, L., additional, Falcini, F., additional, Caiazzo, A.L., additional, Cesaraccio, R., additional, Tisano, F., additional, Fanetti, A.C., additional, Minerba, S., additional, Caldarella, A., additional, Candela, G., additional, Piffer, S., additional, Cania, A., additional, Castelli, M., additional, Pisani, M., additional, Tagliabue, G., additional, Bovo, E., additional, and Brustolin, A., additional
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- 2019
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4. Cancer of the head and neck: a set of indicators based on register and administrative data
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ANDREANO, A., additional, ANSARIN, M., additional, ALTERIO, D., additional, BRUSCHINI, R., additional, VALSECCHI, M.G., additional, and RUSSO, A.G., additional
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- 2018
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5. Synthetic indicator of the impact of colorectal cancer screening programmes on incidence rates
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Zorzi M., Zappa M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R. A., Vitarelli S., Russo A. G., Carrozzi G., D'Orsi G., Fusco M., Sini G. M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A. L., Cesaraccio R., Madeddu A., Fanetti A. C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Rugge M., Brustolin A., Castelli M., Zorzi M., Zappa M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R.A., Vitarelli S., Russo A.G., Carrozzi G., D'Orsi G., Fusco M., Sini G.M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A.L., Cesaraccio R., Madeddu A., Fanetti A.C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Rugge M., Brustolin A., and Castelli M.
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Adenoma ,Male ,Colorectal cancer ,colorectal cancer ,Target population ,colorectal cancer screening ,NO ,Screening programme ,Single indicator ,medicine ,Humans ,Mass Screening ,National level ,Early Detection of Cancer ,Aged ,Potential impact ,business.industry ,Incidence ,Incidence (epidemiology) ,Gastroenterology ,Colonoscopy ,Colorectal Neoplasms ,Female ,Italy ,Middle Aged ,Occult Blood ,Patient Compliance ,Program Evaluation ,medicine.disease ,Colorectal cancer screening ,business ,Demography - Abstract
ObjectiveThe impact of a screening programme on colorectal cancer (CRC) incidence in its target population depends on several variables, including coverage with invitations, participation rate, positivity rate of the screening test, compliance with an invitation to second-level assessment and endoscopists’ sensitivity. We propose a synthetic indicator that may account for all the variables influencing the potential impact of a screening programme on CRC incidence.DesignWe defined the ‘rate of advanced adenoma on the target population’ (AA-TAP) as the rate of patients who received a diagnosis of advanced adenoma within a screening programme, divided by the programme target population. We computed the AA-TAP for the CRC Italian screening programmes (biennial faecal immunochemical test, target population 50–69 year olds) using the data of the Italian National Survey from 2003 to 2016, overall and by region, and assessed the association between AA-TAP and CRC incidence fitting a linear regression between the trend of regional CRC incidence rates in 50–74 year old subjects and the cumulative AA-TAP.ResultsIn 2016, the AA-TAP at a national level was 105×100 000, whereas significant differences were observed between the northern and central regions (respectively 126 and 149×100 000) and the South and Islands (36×100 000). The cumulative AA-TAP from 2004 to 2012 was significantly correlated with the difference between CRC incidence rates in 2013–2014 and those in 2003–2004 (p=0.009).ConclusionThe AA-TAP summarises into a single indicator the potential impact of a screening programme in reducing CRC incidence rates.
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- 2019
6. Risk of thyroid as a first or second primary cancer. A population-based study in Italy, 1998–2012
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Emanuele Crocetti, Veronica Mattioli, Carlotta Buzzoni, Silvia Franceschi, Diego Serraino, Salvatore Vaccarella, Stefano Ferretti, Susanna Busco, Ugo Fedeli, Massimo Varvarà, Fabio Falcini, Manuel Zorzi, Giuliano Carrozzi, Walter Mazzucco, Cinzia Gasparotti, Silvia Iacovacci, Federica Toffolutti, Rossella Cavallo, Fabrizio Stracci, Antonio G. Russo, Adele Caldarella, Stefano Rosso, Antonino Musolino, Lucia Mangone, Claudia Casella, Mario Fusco, Giovanna Tagliabue, Daniela Piras, Rosario Tumino, Linda Guarda, Ylenia M. Dinaro, Silvano Piffer, Pasquala Pinna, Guido Mazzoleni, Anna C. Fanetti, Luigino Dal Maso, for AIRTUM working group, Crocetti E., Mattioli V., Buzzoni C., Franceschi S., Serraino D., Vaccarella S., Ferretti S., Busco S., Fedeli U., Varvara M., Falcini F., Zorzi M., Carrozzi G., Mazzucco W., Gasparotti C., Iacovacci S., Toffolutti F., Cavallo R., Stracci F., Russo A.G., Caldarella A., Rosso S., Musolino A., Mangone L., Casella C., Fusco M., Tagliabue G., Piras D., Tumino R., Guarda L., Dinaro Y.M., Piffer S., Pinna P., Mazzoleni G., Fanetti A.C., and Dal Maso L.
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Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,population-based cancer registries ,Population ,Socio-culturale ,Settore MED/42 - Igiene Generale E Applicata ,History, 21st Century ,Cohort Studies ,Risk Factors ,Prostate ,Internal medicine ,population‐based cancer registries ,medicine ,thyroid cancer ,Humans ,cancer survivors ,Radiology, Nuclear Medicine and imaging ,Registries ,Thyroid Neoplasms ,Overdiagnosis ,education ,Thyroid cancer ,Research Articles ,RC254-282 ,Italy ,relative risk ,second primary cancer ,education.field_of_study ,cancer survivors, Italy, population-based cancer registries, relative risk, second primary cancer, thyroid cancer ,business.industry ,Incidence ,Incidence (epidemiology) ,Thyroid ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cancer ,Neoplasms, Second Primary ,History, 20th Century ,medicine.disease ,medicine.anatomical_structure ,Relative risk ,Female ,business ,Cancer Prevention ,Research Article - Abstract
Background The number of patients living after a cancer diagnosis is increasing, especially after thyroid cancer (TC). This study aims at evaluating both the risk of a second primary cancer (SPC) in TC patients and the risk of TC as a SPC. Methods We analyzed two population‐based cohorts of individuals with TC or other neoplasms diagnosed between 1998 and 2012, in 28 Italian areas covered by population‐based cancer registries. Standardized incidence ratios (SIRs) of SPC were stratified by sex, age, and time since first cancer. Results A total of 38,535 TC patients and 1,329,624 patients with other primary cancers were included. The overall SIR was 1.16 (95% CI: 1.12–1.21) for SPC in TC patients, though no increase was shown for people with follicular (1.06) and medullary (0.95) TC. SPC with significantly increased SIRs was bone/soft tissue (2.0), breast (1.2), prostate (1.4), kidney (2.2), and hemolymphopoietic (1.4) cancers. The overall SIR for TC as a SPC was 1.49 (95% CI: 1.42–1.55), similar for all TC subtypes, and it was significantly increased for people diagnosed with head and neck (2.1), colon–rectum (1.4), lung (1.8), melanoma (2.0), bone/soft tissue (2.8), breast (1.3), corpus uteri (1.4), prostate (1.5), kidney (3.2), central nervous system (2.3), and hemolymphopoietic (1.8) cancers. Conclusions The increased risk of TC after many other neoplasms and of few SPC after TC questions the best way to follow‐up cancer patients, avoiding overdiagnosis and overtreatment for TC and, possibly, for other malignancies., This is the first study able to calculate population‐based risk of thyroid cancers as a first or second tumor separately for different thyroid cancer histological types (i.e., follicular, medullary, and poorly differentiated). In a context of a large proportion of thyroid cancer cases due to overdiagnosis, the findings of the present study may help to more focused primary prevention and surveillance for side effects of treatments, thus avoiding overtreatment, particularly among younger women.
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- 2021
7. The economic impact of rectal cancer: A population-based study in Italy list of authors
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Gigli A., Francisci S., Capodaglio G., Pierannunzio D., Mallone S., Tavilla A., Lopez T., Zorzi M., Stracci F., Busco S., Mazzucco W., Lonardi S., Bianconi F., Russo A. G., Iacovacci S., Serraino D., Manneschi G., Fusco M., Cusimano R., Rugge M., Guzzinati S., Gigli A., Francisci S., Capodaglio G., Pierannunzio D., Mallone S., Tavilla A., Lopez T., Zorzi M., Stracci F., Busco S., Mazzucco W., Lonardi S., Bianconi F., Russo A.G., Iacovacci S., Serraino D., Manneschi G., Fusco M., Cusimano R., Rugge M., and Guzzinati S.
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Administrative databases ,Administrative databases, Cancer registry, Cost analysis, Patterns of care, Prevalence, Real-world data, Cross-Sectional Studies, Delivery of Health Care, Health Care Costs, Humans, Italy, Health Expenditures, Rectal Neoplasms ,lcsh:R ,Patterns of care ,Cost analysis ,Prevalence ,lcsh:Medicine ,Cancer registry ,Settore MED/42 - Igiene Generale E Applicata ,Real-world data - Abstract
Costs of cancer care are increasing worldwide, and sustainability of cancer burden is critical. In this study, the economic impact of rectal cancer on the Italian healthcare system, measured as public healthcare expenditure related to investigation and treatment of rectal cancer patients is estimated. A cross-sectional cohort of 9358 rectal cancer patients is linked, on an individual basis, to claims associated to rectal cancer diagnosis and treatments. Costs refer mainly to years 2010&ndash, 2011 and are estimated by phase of care, as healthcare needs vary along the care pathway: diagnostic procedures are mainly provided in the first year, surveillance procedures are addressed to chronically ill patients, and end-of-life procedures are given in the terminal status. Clinical approaches and corresponding costs are specific by cancer type and vary by phase of care, stage at diagnosis, and age. Surgery is undertaken by the great majority of patients. Thus, hospitalization is the main cost driver. The evidence produced can be used to improve planning and allocation of healthcare resources. In particular, early diagnosis of rectal cancer is a gain in healthcare budget. Policies raising spreading of and adherence to screening plans, above all when addressed to people living in Southern Italy, should be strongly encouraged.
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- 2021
8. Decline in the incidence of colorectal cancer and the associated mortality in young Italian adults
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Zorzi M., Cavestro G. M., Guzzinati S., Dal Maso L., Rugge M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R. A., Vitarelli S., Russo A. G., Carrozzi G., D'Orsi G., Fusco M., Sini G. M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A. L., Cesaraccio R., Madeddu A., Fanetti A. C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Tolin M., Brustolin A., Castelli M., Zorzi M., Cavestro G.M., Guzzinati S., Dal Maso L., Rugge M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R.A., Vitarelli S., Russo A.G., Carrozzi G., D'Orsi G., Fusco M., Sini G.M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A.L., Cesaraccio R., Madeddu A., Fanetti A.C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Tolin M., Brustolin A., Castelli M., Zorzi, M., Cavestro, G. M., Guzzinati, S., Dal Maso, L., and Rugge, M
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0301 basic medicine ,Colon ,Population ,Socio-culturale ,colorectal cancer ,colorectal cancer screening ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Epidemiology of cancer ,Medicine ,Humans ,Risk factor ,education ,education.field_of_study ,cancer epidemiology, Colorectal cancer, colorectal cancer screening ,business.industry ,Incidence (epidemiology) ,Mortality rate ,screening ,Incidence ,Gastroenterology ,Cancer ,medicine.disease ,Obesity ,Annual Percent Change ,Europe ,030104 developmental biology ,Italy ,030211 gastroenterology & hepatology ,epidemiology ,business ,Colorectal Neoplasms ,Demography ,cancer epidemiology ,SEER Program - Abstract
Objective The incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears among younger adults. In Europe, data on CRC incidence among younger adults are lacking. We therefore aimed to analyse European trends in CRC incidence and mortality in subjects younger than 50 years. Design Data on age-related CRC incidence and mortality between 1990 and 2016 were retrieved from national and regional cancer registries. Trends were analysed by Joinpoint regression and expressed as annual percent change. Results We retrieved data on 143.7 million people aged 20–49 years from 20 European countries. Of them, 187 918 (0.13%) were diagnosed with CRC. On average, CRC incidence increased with 7.9% per year among subjects aged 20–29 years from 2004 to 2016. The increase in the age group of 30–39 years was 4.9% per year from 2005 to 2016, the increase in the age group of 40–49 years was 1.6% per year from 2004 to 2016. This increase started earliest in subjects aged 20–29 years, and 10–20 years later in those aged 30–39 and 40–49 years. This is consistent with an age-cohort phenomenon. Although in most European countries the CRC incidence had risen, some heterogeneity was found between countries. CRC mortality did not significantly change among the youngest adults, but decreased with 1.1%per year between 1990 and 2016 and 2.4% per year between 1990 and 2009 among those aged 30–39 years and 40–49 years, respectively. Conclusion CRC incidence rises among young adults in Europe. The cause for this trend needs to be elucidated. Clinicians should be aware of this trend. If the trend continues, screening guidelines may need to be reconsidered.
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- 2020
9. Prognosis and cure of long-term cancer survivors: A population-based estimation
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Dal Maso, L., Panato, C., Guzzinati, S., Serraino, D., Francisci, S., Botta, L., Capocaccia, R., Tavilla, A., Gigli, A., Crocetti, E., Rugge, M., Tagliabue, G., Filiberti, R. A., Carrozzi, G., Michiara, M., Ferretti, S., Cesaraccio, R., Tumino, R., Falcini, F., Stracci, F., Torrisi, A., Mazzoleni, G., Fusco, M., Rosso, S., Tisano, F., Fanetti, A. C., Sini, G. M., Buzzoni, C., De Angelis, R., Virdone, S., Gatta, G., Zorzi, M., Mallone, S., Toffolutti, F., Russo, A. G., Caiazzo, A. L., Mangone, L., Mazzucco, W., Pannozzo, F., Ricci, P., Gola, G., Candela, G., Sutera Sardo, A., Dal Maso L., Panato C., Guzzinati S., Serraino D., Francisci S., Botta L., Capocaccia R., Tavilla A., Gigli A., Crocetti E., Rugge M., Tagliabue G., Filiberti R.A., Carrozzi G., Michiara M., Ferretti S., Cesaraccio R., Tumino R., Falcini F., Stracci F., Torrisi A., Mazzoleni G., Fusco M., Rosso S., Tisano F., Fanetti A.C., Sini G.M., Buzzoni C., De Angelis R., Virdone S., Gatta G., Zorzi M., Mallone S., Toffolutti F., Russo A.G., Caiazzo A.L., Mangone L., Mazzucco W., Pannozzo F., Ricci P., Gola G., Candela G., and Sutera Sardo A.
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0301 basic medicine ,Oncology ,Male ,Cancer Research ,Time Factors ,Settore MED/42 - Igiene Generale E Applicata ,0302 clinical medicine ,Cancer Survivors ,Prostate ,Neoplasms ,Thyroid cancer ,Original Research ,education.field_of_study ,Relative survival ,Mortality rate ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,population-based cancer registrie ,medicine.anatomical_structure ,Italy ,030220 oncology & carcinogenesis ,cancer cure, Italy, population-based cancer registries, prevalence, survival ,Female ,Cancer Prevention ,Adult ,medicine.medical_specialty ,population-based cancer registries ,Adolescent ,Population ,prevalence ,Socio-culturale ,lcsh:RC254-282 ,survival ,03 medical and health sciences ,Young Adult ,Life Expectancy ,Internal medicine ,medicine ,population‐based cancer registries ,Humans ,Radiology, Nuclear Medicine and imaging ,cancer cure ,education ,Aged ,Estimation ,business.industry ,Cancer ,Models, Theoretical ,medicine.disease ,030104 developmental biology ,Life expectancy ,business - Abstract
Background: Increasing evidence of cure for some neoplasms has emerged in recent years. The study aimed to estimate population-based indicators of cancer cure. Methods: Information on more than half a million cancer patients aged 15-74 years collected by population-based Italian cancer registries and mixture cure models were used to estimate the life expectancy of fatal tumors (LEFT), proportions of patients with similar death rates of the general population (cure fraction), and time to reach 5-year conditional relative survival (CRS) >90% or 95% (time to cure). Results: Between 1990 and 2000, the median LEFT increased >1 year for breast (from 8.1 to 9.4 years) and prostate cancers (from 5.2 to 7.4 years). Median LEFT in 1990 was >5 years for testicular cancers (5.8) and Hodgkin lymphoma (6.3) below 45 years of age. In both sexes, it was 95% was 90% was reached in 15 years. Conclusions: The study findings confirmed that several cancer types are curable. The awareness of the possibility of cancer cure has relevant clinical and social impacts. KEYWORDS cancer cure, Italy, population-based cancer registries, prevalence, survival
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- 2019
10. Cancer incidence and mortality trends from 2003 to 2014 in Italy
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Carlotta Buzzoni, Emanuele Crocetti, Stefano Guzzinati, Luigino Dal Maso, Silvia Francisci, G Mazzoleni, MA Ferrara, E Caputo, E Coviello, R Galasso, A Citarella, G Sampietro, M Magoni, A Ardizzone, A D’Argenzio, A Sutera Sardo, A Giorno, G La Greca, P Ricci, S Ferretti, F Palma, D Serraino, S Iacovacci, A Melcarne, A Puppo, S Sciacca, AG Russo, Bianca Caruso, L Cavalieri d’Oro, G D’Orsi, M Fusco, M Usala, F Vitale, R Cusimano, M Michiara, L Boschetti, G Chiaranda, S Rosso, R Tumino, L Mangone, S Valenti Clemente, F Falcini, AL Caiazzo, R Cesaraccio, F Tisano, AC Fanetti, S Minerba, A Caldarella, G Candela, S Piffer, A Cania, M Castelli, M Pisani, G Tagliabue, E Bovo, A Brustolin, Buzzoni C., Crocetti E., Guzzinati S., Dal Maso L., Francisci S., Mazzoleni G., Ferrara M.A., Caputo E., Coviello E., Galasso R., Citarella A., Sampietro G., Magoni M., Ardizzone A., D'Argenzio A., Sutera Sardo A., Giorno A., La Greca G., Ricci P., Ferretti S., Palma F., Serraino D., Iacovacci S., Melcarne A., Puppo A., Sciacca S., Russo A.G., Caruso B., Cavalieri d'Oro L., D'Orsi G., Fusco M., Usala M., Vitale F., Cusimano R., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A.L., Cesaraccio R., Tisano F., Fanetti A.C., Minerba S., Caldarella A., Candela G., Piffer S., Cania A., Castelli M., Pisani M., Tagliabue G., Bovo E., and Brustolin A.
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Registrie ,Adult ,Male ,Cancer Research ,Socio-culturale ,cancer, Epidemiology and prevention, incidence, Italy, mortality, time trend ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,cancer ,Medicine ,Humans ,030212 general & internal medicine ,Registries ,Sex Distribution ,Mortality trends ,Aged ,business.industry ,Incidence (epidemiology) ,Incidence ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,mortality ,time trend ,Oncology ,Cancer incidence ,Italy ,030220 oncology & carcinogenesis ,Neoplasm ,Epidemiology and prevention ,Female ,business ,Human ,Demography - Abstract
Objective: To evaluate short-term (2003–2014) cancer incidence and mortality trends in Italy. Methods: Italian Cancer Registries data, available in the AIRTUM database, from 17 out of 20 regions were used. The number of incident cases and deaths were estimated for those registries and those years with incomplete information. Age-standardized rates, overall and stratified by geographic area, region, sex, cancer site, and major age group, were computed. Time trends were expressed as annual percent change of rates. Results: In Italy, among males, incidence rates for all cancers showed during 2003–2014, a significant decrease (−0.9%/year), with stronger reductions in the northwest (−1.3%/year) and northeast (−2.0%/year since 2006) than in central (−0.7%/year) and southern (−0.4%/year) areas. Among females, a weak but significant overall reduction was detected (−0.1%/year), with a stronger decrease in the northwest (−0.5%/year). Incidence increased among women in the south (0.3%/year) of Italy. Mortality decreased in both sexes (−1.0%/year among males and −0.5%/year among females), but not in the south, where rates had a stable tendency. Conclusions: Incidence among males decreased, supported by trends for prostate, lung, colorectal, and urinary bladder cancers; among females the. The overall cancer incidence trend was stable, or even decreasing, in the northern and central areas and increasing in the southern areas, due to lung, thyroid, and melanoma rising trends. Study results provided information on the outcomes, in terms of cancer incidence and mortality, of primary and secondary prevention measures employed by regional health systems.
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- 2019
11. Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy
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Manuel Zorzi, Luigino Dal Maso, Silvia Francisci, Carlotta Buzzoni, Massimo Rugge, Stefano Guzzinati, G. Mazzoleni, E. Coviello, R. Galasso, G. Sampietro, M. Magoni, A. Ardizzone, A. D‘Argenzio, A. Sutera Sardo, A. Giorno, G. La Greca, P. Ricci, S. Ferretti, F. Palma, D. Serraino, S. Iacovacci, A. Melcarne, A. Puppo, S. Sciacca, A.G. Russo, B. Caruso, L. Cavalieri d’Oro, G. D‘Orsi, M. Fusco, M. Usala, F. Vitale, R. Cusimano, M. Michiara, L. Boschetti, G. Chiaranda, S. Rosso, R. Tumino, L. Mangone, F. Falcini, A.L. Caiazzo, R. Cesaraccio, F. Tisano, A.C. Fanetti, S. Minerba, A. Caldarella, G. Candela, S. Piffer, A. Cania, M. Castelli, M. Pisani, G. Tagliabue, E. Bovo, A. Brustolin, Zorzi M., Dal Maso L., Francisci S., Buzzoni C., Rugge M., Guzzinati S., Mazzoleni G., Coviello E., Galasso R., Sampietro G., Magoni M., Ardizzone A., D'Argenzio A., Sutera Sardo A., Giorno A., La Greca G., Ricci P., Ferretti S., Palma F., Serraino D., Iacovacci S., Melcarne A., Puppo A., Sciacca S., Russo A.G., Caruso B., Cavalieri d'Oro L., D'Orsi G., Fusco M., Usala M., Vitale F., Cusimano R., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Falcini F., Caiazzo A.L., Cesaraccio R., Tisano F., Fanetti A.C., Minerba S., Caldarella A., Candela G., Piffer S., Cania A., Castelli M., Pisani M., Tagliabue G., Bovo E., and Brustolin A.
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Male ,Registrie ,Cancer Research ,Colorectal cancer ,Socio-culturale ,Colorectal Neoplasm ,03 medical and health sciences ,0302 clinical medicine ,Age groups ,medicine ,Humans ,Age Factor ,Registries ,Aged ,Sex Characteristics ,incidence ,mortality ,screening ,business.industry ,Incidence (epidemiology) ,Mortality rate ,Age Factors ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Oncology ,Italy ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Colorectal Neoplasms ,business ,Demography ,Sex characteristics ,Human - Abstract
Objective: To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions. Methods: We used the data of 48 cancer registries from 17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (Results: Incidence rates decreased from 104.3 (2003) to 89.9 × 100,000 (2014) in men and from 64.3 to 58.4 × 100,000 in women. Among men, incidence decreased during 2007–2010 (APC −4.0, 95% CI −6.0 to −1.9) and 2010–2014 (APC −0.7, 95% CI −1.4 to 0.0), while in women it linearly decreased during the whole period (APC −1.1, 95% CI −1.4 to −0.8). Mortality rates showed a linear reduction both in men (APC −0.7, 95% CI −1.0 to −0.3) and women (APC −0.9, 95% CI −1.2 to −0.6) and decreased respectively from 41.1 to 39.2 × 100,000 and from 24.6 to 23.1 × 100,000. In the 50- to 69-year-old range (screening target age), incidence showed a prescreening increase, followed by a peak after screening started, and a decline thereafter. Incidence and mortality rates significantly decreased in all areas but in the south and islands, where incidence increased and mortality remained stable. Conclusions: A renewed commitment by all regional health systems to invest in primary (i.e., lifestyle) and secondary (i.e., screening programs) prevention is of utmost importance.
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- 2019
12. Impact of screening programme using the faecal immunochemical test on stage of colorectal cancer: Results from the IMPATTO study
- Author
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Vicentini, Massimo, Zorzi, Manuel, Bovo, Emanuela, Mancuso, Pamela, Zappa, Marco, Manneschi, Gianfranco, Mangone, Lucia, Rossi, Paolo Giorgi, Grazzini, Grazia, Mantellini, Paola, Caldarella, Adele, Intrieri, Teresa, Anghinoni, Emanuela, Senore, Carlo, Tisano, Francesco, Ziino, Antonio Colanino, Malignaggi, Sabina, Passanisi, Guido, Rugge, Massimo, Turrin, Anna, Piffer, Silvano, Gentilini, Maria, Rizzello, Roberto, Pertile, Riccardo, Sensi, Flavio, Cesaraccio, Rosaria, Interieri, Teresa, Ferretti, Stefano, Collina, Natalina, Petrucci, Chiara, Fanetti, Anna Clara, Cecconami, Lorella, Fusco, Mario, Vitale, Maria Francesca, Castaing, Marine, Ippolito, Antonella, Varvara, Massimo, Pesce, Paola, Filiberti, Rosa, Borciani, Elisabetta, Seghini, Pietro, Stracci, Fabrizio, Malaspina, Morena, Serraino, Diego, Falcini, Fabio, Giuliani, Orietta, Pannozzo, Fabio, Curatella, Simonetta, Calabretta, Francesca, Bellardini, Paola, Carrozzi, Giuliano, Bisanti, Luigi, Russo, Antonio Giampiero, Silvestri, Anna Rita, Tidone, Enrica, Giacomin, Adriano, Azzoni, Alberto, Mazzucco, Walter, Cusimano, Rosanna, Campari, Cinzia, Caroli, Stefania, Michiara, Maria, Sgargi, Paolo, De Togni, Aldo, Palmonari, Caterina, Casella, Claudia, Puppo, Antonella, Vicentini M., Zorzi M., Bovo E., Mancuso P., Zappa M., Manneschi G., Mangone L., Rossi P.G., Grazzini G., Mantellini P., Caldarella A., Intrieri T., Anghinoni E., Senore C., Tisano F., Ziino A.C., Malignaggi S., Passanisi G., Rugge M., Turrin A., Piffer S., Gentilini M., Rizzello R., Pertile R., Sensi F., Cesaraccio R., Interieri T., Ferretti S., De Togni A., Palmonari C., Collina N., Petrucci C., Fanetti A.C., Cecconami L., Fusco M., Vitale M.F., Castaing M., Ippolito A., VarvarA M., Pesce P., Filiberti R., Casella C., Puppo A., Borciani E., Seghini P., Stracci F., Malaspina M., Serraino D., Falcini F., Giuliani O., Pannozzo F., Curatella S., Calabretta F., Bellardini P., Carrozzi G., Bisanti L., Russo A.G., Silvestri A.R., Tidone E., Giacomin A., Azzoni A., Mazzucco W., Cusimano R., Campari C., Caroli S., Michiara M., and Sgargi P.
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Prevalence ,Socio-culturale ,Colonoscopy ,Colorectal Neoplasm ,Settore MED/42 - Igiene Generale E Applicata ,colorectal cancer screening ,Screening programme ,Feces ,03 medical and health sciences ,0302 clinical medicine ,colonoscopy ,Faecal immunochemical test, colonoscopy, colorectal cancer screening, epidemiology, cancer registries ,Internal medicine ,Epidemiology ,medicine ,Humans ,Stage (cooking) ,Early Detection of Cancer ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,cancer registrie ,medicine.diagnostic_test ,Faecal immunochemical test ,business.industry ,Incidence (epidemiology) ,Incidence ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Oncology ,Italy ,cancer registries ,030220 oncology & carcinogenesis ,Relative risk ,Occult Blood ,epidemiology ,Fece ,Female ,Neoplasm Grading ,Colorectal Neoplasms ,business ,Human - Abstract
To evaluate the impact of faecal immunochemical test (FIT) screening on stage distribution at diagnosis, and to estimate relative incidence rates by stage in screened at first and subsequent rounds vs. unscreened. We included all incident cases occurring in 2000-2008 in 50- to 71-year-olds residing in areas with an FIT-screening programme. Multinomial logistic models were computed to estimate the relative risk ratio (RRR) of stages I and IV, compared to stage II + III, adjusting for age, sex, geographical area, and incidence year. Proportions were then used to estimate incidence rate ratios (IRR) by stage for screened subjects at the first and at subsequent rounds vs. unscreened subjects, applying the expected changes in overall incidence during screening phases. 11,663 cancers were included: 5965 in not-invited and 5,698 in invited subjects, 3,425 of whom attendees. Compared to not-invited, invited subjects had RRR 2.04 (95% CI: 1.84; 2.46) of stage I and RRR 0.77 (95% CI: 0.69; 0.87) of stage IV. Differences were stronger comparing attendees vs. nonattendees. Interval cancers were more frequently stage I compared to non-invited (RRR 1.54; 95% CI: 1.15; 2.04), but there was no difference for stage IV. IRRs in screened at first round vs. unscreened were 4.6 (95% CI: 4.2; 5.1), 1.4 (95% CI: 1.3; 1.5) and 0.7 (95% CI: 0.6; 0.9) for stages I, II + III and IV, respectively; in the following rounds the IRRs of screened vs. unscreened were 1.4 (95% CI: 1.2; 1.6), 0.8 (95% CI: 0.7; 0.9) and 0.3 (95% CI: 0.1; 0.4) for stages I, II + III and IV, respectively. FIT screening reduces the incidence of metastatic cancers by about 70% after the first round.
- Published
- 2019
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