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7. Alzheimer's Disease Pharmacotherapy in Relation to Cholinergic System Involvement.

Author

Stanciu, Gabriela Dumitrita, Luca, Andrei, Rusu, Razvan Nicolae, Bild, Veronica, Chiriac, Sorin Ioan Beschea, Solcan, Carmen, Bild, Walther, and Ababei, Daniela Carmen

Subjects
ALZHEIMER'S disease, DRUG therapy, ETIOLOGY of diseases, CHOLINESTERASE inhibitors, ACETYLCHOLINESTERASE
Abstract

Alzheimer's disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning. The etiology of this disease is not completely understood, and no safe and e ective anti-Alzheimer's disease drug to prevent, stop, or reverse its evolution is currently available. Current pharmacotherapy concentrated on drugs that aimed to improve the cerebral acetylcholine levels by facilitating cholinergic neurotransmission through inhibiting cholinesterase. These compounds, recognized as cholinesterase inhibitors, o er a viable target across key sign domains of Alzheimer's disease, but have a modest influence on improving the progression of this condition. In this paper, we sought to highlight the current understanding of the cholinergic system involvement in Alzheimer's disease progression in relation to the recent status of the available cholinesterase inhibitors as e ective therapeutics. [ABSTRACT FROM AUTHOR]

Published
2020
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