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5 results on '"Ryan Gallo"'

1. An Elderly Man with Atypical Multiple Evanescent White Dot Syndrome

Author

Liang Wang, Polina Lankry, David Rabinovitch, Ryan Gallo, Rita Laiginhas, Prashanth Iyer, Shiri Shulman, and Omer Trivizki

Subjects
multiple evanescent white dot syndrome, fluorescein angiography, fundus autofluorescence, indocyanine green angiography, optical coherence tomography, Ophthalmology, RE1-994
Abstract

A rare occurrence of an atypical case of multiple evanescent white dot syndrome (MEWDS) in a 75-year-old man without viral prodrome or white dots on fundus that presented with acute, severe left eye visual loss, which returned to baseline without treatment in several weeks. Multimodal imaging, including fluorescein angiography (FA), fundus autofluorescence (FAF), indocyanine green angiography (ICG), and optical coherence tomography (OCT) demonstrated classical presentation of MEWDS with wreath-like lesions and inflammatory foci in the retinal pigment epithelium that correlated among modalities. Possible underlying systemic disorders were ruled out through extended work up. To the best of our knowledge, this is the first report to show atypical MEWDS in an elderly man with classic changes on FA, FAF, ICG, and OCT.

Published
2022
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3. N-cadherin suppression enhances inner limiting membrane permeability for intravitreal cellular transplantation

Author

Daniel Pelaez, Ryan Gallo, Galina Dvoriantchikova, Acadia Moeyersoms, Hua Wang, Chloe Moulin, Zenith Acosta Torres, Steven Lang, and Dmitry Ivanov

Abstract

The efficient migration, survival, and engraftment of transplanted cells are important initial steps toward effective cellular therapies for retinal degenerative diseases. The inner limiting membrane (ILM), which separates the retina from the vitreous cavity, is a major barrier for intravitreally transplanted cells. Focusing on the cellular components of the ILM, we found that the cell adhesion molecule N-cadherin (NCAD) at Müller glia (MG) endfeet helps maintain this barrier. To increase ILM cellular permeability, we modulated NCAD expression via two approaches: an inducible MG-specific knockout animal model and with intravitreal self-deliverable siRNA injections. We show that NCAD suppression enhances retinal migration of multiple cell types after intravitreal transplantation, including mouse MG, human induced pluripotent stem cell-derived retinal ganglion cells, and human dental pulp stem cells. Our study may contribute to the development of targeted approaches for recipient tissue modulation to improve cellular therapies for retinal disease.

Published
2022

4. List of contributors

Author

Matthew C. Abramowitz, Prasanna Alluri, Tahira Alyas, Waleed Arafat, Rukset Attar, Seda Avnioglu, Ravi Pratap Barnwal, Filippo Bellati, Pierluigi Benedetti Panici, Rossana Berardi, Alka Bhatia, Cigir Biray Avci, Adrian L. Breto, Giuseppe Caruso, Donatella Caserta, Laura C. Ceafalan, Selin Cesmeli, Rosa Corcoy, Gabrielle Di Bartolomeo, Violante Di Donato, Rosa Di Micco, Joan Carles Escolà-Gil, Maham Fakhar, Madeline Farmer, Ammad Ahmad Farooqi, Victoria Fuste, Ryan Gallo, Maria Luisa Gasparri, Oreste D. Gentilini, Mihaela Gherghiceanu, Sumit Goel, Bakiye Goker Bagca, Daiki Hara, Mihail E. Hinescu, Xiaoyu Hu, Octavian Ioghen, Muhammad Javed Iqbal, Srishti Jain, Josep Julve, Lazzat Karasholakova, Indu Pal Kaur, Yomna Khamis, Oleksandr N. Kryvenko, Alican Kusoglu, Enrique Lerma, Naila Nasir Mahmood, Durr-e-shahwar Malik, Naila Malkani, Chiara Martinelli, Eugènia Mato, Iqra Mobeen, Antonio Moral, Sidra Mumtaz, Ludovico Muzii, Humaira Naureen, Andrei M. Niculae, Ulku Ozbey, Enma Veronica Paez Espinosa, Innocenza Palaia, Chitvan Pandit, Andrea Papadia, José Ignacio Pérez, Giorgia Perniola, Tatiana Colombo Pimentel, Alan Pollack, Alan Dal Pra, Sanoj Punnen, Muhammad Usman Rashid, Kristina Redd, Giovanna Revilla, Silvia Rinaldi, Tinsley Roberson, Ilary Ruscito, Junwei Shi, Arianna Siconolfi, Aagamjit Singh, Gurpal Singh, Joga Singh, Metta Smith, Muhammad Imran Sohail, Udit Soni, Tania Cristina Leite de Sampaio e Spohr, Kayla Lewis Steed, Radka Stoyanova, Gamze Tanriover, Wensi Tao, Yusuf Tutar, Ilhan Yaylim, Seher Yilmaz, Lara Youssef, Ishmuratova Margarita Yulaevna, and Veronica Zuber

Published
2022

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