1. Non-Small-Cell Lung Cancer Promotion by Air Pollutants
- Author
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Charles Swanton, William Hill, Emilia Lim, Claudia Lee, Clare Weeden, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward Evans, David Moore, Felipe Rodrigues, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Deborah Caswell, Ai Nagano, Min Hyung Ryu, Ryan Huff, Shijia Li, Alastair Magness, Alejandro Suarez-Bonnet, Simon Priestnall, Margreet Lüchtenborg, Katrina Lavelle, Joanna Pethick, Steven Hardy, Fiona McRonald, Meng-Hung Lin, Clara Troccoli, Moumita Ghosh, York Miller, Daniel Merrick, Robert Keith, Maise Al Bakir, Chris Bailey, Lao Saal, Yilun Chen, Anthony George, Chris Abbosh, Nnennaya Kanu, Se-Hoon Lee, Nicholas McGranahan, Chistine Berg, Eva Grönroos, Julian Downward, Tyler Jacks, Christopher Carlsten, Ilaria Malanchi, Allan Hackshaw, Kevin Litchfield, Mariam Jamal-Hanjani, and James DeGregori
- Abstract
Environmental carcinogenic exposures are major contributors to global disease burden yet how they promote cancer is unclear. Over 70 years ago, the concept of tumour promoting agents driving latent clones to expand was first proposed. In support of this model, recent evidence suggests that human tissue contains a patchwork of mutant clones, some of which harbour oncogenic mutations, and many environmental carcinogens lack a clear mutational signature. We hypothesised that the environmental carcinogen
- Published
- 2022
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