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17 results on '"Ryan Taft"'

4. O35: Feasibility of expanded newborn screening using genome sequencing for early actionable conditions in a diverse city

Author

Wendy Chung, Alban Ziegler, Carrie Koval-Burt, Denise Kay, Sharon Suchy, Amber Bergtrup, Katherine Langley, Laura Amendola, Brenna Boyd, Jennifer Bradley, Tracy Brandt, Lilian Cohen, Alison Coffey, Joseph Devaney, Beata Dygulska, Bethany Friedman, Ramsey Fuleihan, Awura Gyimah, Rebecca Hernan, Sean Hofherr, Kathleen Hruska, Zhanzhi Hu, Mederic Jeanne, Guanjun Jin, Aaron Johnson, Haluk Kavus, Rudolph Leibel, Kirsty McWalter, Kristin Monaghan, Nicole Pimentel Soler, Yeyson Quevedo, Samantha Ratner, Kyle Retterer, Natasha Shapiro, Robert Sicko, Samuel Storm, Rebecca Torene, Olatundun Williams, Julia Wynn, Ryan Taft, Paul Kruszka, and Michele Caggana

Subjects
Genetics, QH426-470, Medicine
Published
2024
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5. P624: Performance and impact of clinical genome sequencing in patients with suspected rare genetic diseases in Peru

Author

Erin Thorpe, Milagros Duenas-Roque, Mario Cornejo-Olivas, Jeny Bazalar-Montoya, Nelson Purizaca-Rosillo, Richard Rodriguez, Karina Milla-Neyra, Carlos De La Torre-Hernandez, Elison Sarapura-Castro, Carolina Galarreta Aima, Gioconda Manassero-Morales, Giulliana Chávez-Pasco, Luis Celis-García, Jorge La Serna, and Ryan Taft

Subjects
Genetics, QH426-470, Medicine
Published
2024
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9. O38: The impact of whole genome sequencing in a diverse global population of genetic disease patients

Author

Ryan Taft, Erin Thorpe, John Belmont, Taylor Williams, Chad Shaw, Jason Button, Julia Ortega, Keisha Robinson, Marilyn Jones, Diane Masser-Frye, Donald Basel, Chester Brown, Keith Vaux, Aime Lumaka, Fabio Sirchia, Milagros Dueñas Roque, Mario Cornejo-Olivas, Jeny Bazalar-Montoya, Nora Urraca, Alejandra Salguero, Samuel Wiafe, Romina Foster-Bonds, Erin Royer, Michelle Gallas, Pilar Magoulas, Adeline Vanderver, Marwan Shinawi, Alan Taylor, Kristen Fishler, Duncan Henry, Daria Salyakina, Kate Gibson, Melissa Lah, Alka Malhotra, James Avecilla, Andrew Warren, Denise Perry, and Max Arseneault

Subjects
Genetics, QH426-470, Medicine
Published
2023
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16. De novo missense variants in

Author

Alka, Malhotra, Alban, Ziegler, Li, Shu, Renee, Perrier, Louise, Amlie-Wolf, Elizabeth, Wohler, Nara, Lygia de Macena Sobreira, Estelle, Colin, Adeline, Vanderver, Omar, Sherbini, Katrien, Stouffs, Emmanuel, Scalais, Alessandro, Serretti, Magalie, Barth, Benjamin, Navet, Paul, Rollier, Hui, Xi, Hua, Wang, Hainan, Zhang, Denise L, Perry, Alessandra, Ferrarini, Roberto, Colombo, Alexander, Pepler, Adele, Schneider, Kiyotaka, Tomiwa, Nobuhiko, Okamoto, Naomichi, Matsumoto, Noriko, Miyake, Ryan, Taft, Xiao, Mao, and Dominique, Bonneau

Subjects
Cohort Studies, Motor Skills Disorders, Nucleocytoplasmic Transport Proteins, Phenotype, Amino Acid Substitution, Genotype, Developmental Disabilities, Mutation, Missense, Humans, Genetic Predisposition to Disease, Nervous System Malformations, Alleles
Abstract

To determine the potential disease association between variants inHere we describe a series of de novo missense variants inThese findings indicate that rare de novo variants in

Published
2020

17. Independent motile microplast formation correlates with glioma cell invasiveness.

Author

Garret Yount, Ryan Taft, Tri Luu, Kenneth Rachlin, and Wei Zhang

Abstract

Abstract??Diffuse brain invasion co ntributes to the poor prognosis for patients with gliomas. Analyzing glioma cell migration in vitro, we have demonstrated the spontaneous shedding of anucleate cell fragments that separate from glioma cell bodies and maintain viability from hours to days. Unlike previously described cell fragments that are released from cells as diffusible vectors, glioma cell fragments are independently motile. We used computerized time-lapse microscopy to characterize the formation of these independent motile microplasts (IMMPs) in human cell cultures derived from the most highly invasive glial tumor, glioblastoma. IMMPs were larger than previously described cell fragments, ranging in size from approximately 2% to nearly half of the area of their parent cells. Complex cell-like behaviors?including establishment of polarity, extension of lamellipodia and filopodia, and change in direction of movement?remained intact in IMMPs. The average direction and velocity of the IMMPs were indistinguishable from those of their parent cells. IMMPs formed at a significantly higher rate in glioma cell lines rendered more invasive by overexpression of invasion-related genes than in vector-transfected controls. The correlation with cell invasiveness indicates that IMMP formation may be related to the cell-invasive phenotype. Further investigation will determine whether IMMPs represent a novel addition to the growing list of viable cell fragments with biological relevance. [ABSTRACT FROM AUTHOR]

Published
2007

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