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3. Neurochemical alterations of intrinsic cardiac ganglionated nerve plexus caused by arterial hypertension developed during ageing in spontaneously hypertensive and Wistar Kyoto rats

Author

Pauziene, Neringa, primary, Ranceviene, Dalia, additional, Rysevaite‐Kyguoliene, Kristina, additional, Ragauskas, Tomas, additional, Inokaitis, Hermanas, additional, Sabeckis, Ignas, additional, Plekhanova, Khrystyna, additional, Khmel, Olena, additional, and Pauza, Dainius H., additional

Published
2023
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6. Contributors

Author

Aagaard, Philip, primary, Abrams, Dominic James, additional, Abriel, Hugues, additional, Adkisson, Wayne O., additional, Agullo-Pascual, Esperanza, additional, Alvarado, Francisco J., additional, Amin, Ahmad S., additional, Antzelevitch, Charles, additional, Anumonwo, Justus M.B., additional, Armaganijan, Luciana, additional, Arya, Arash, additional, Asirvatham, Samuel, additional, Atienza, Felipe, additional, Backx, Peter H., additional, Ballou, Lisa M., additional, Balse, Elise, additional, Balulad, Sujata, additional, Barbuti, Andrea, additional, Bardy, Gust H., additional, Bassil, Guillaume, additional, Benditt, David G., additional, Berenfeld, Omer, additional, Bers, Donald M., additional, Binah, Ofer, additional, Bogun, Frank, additional, Bongianino, Rossana, additional, Boyle, Noel G., additional, Boyle, Patrick M., additional, Breithardt, Günter, additional, Brini, Marisa, additional, Brink, Peter R., additional, Brugada, Pedro, additional, Buch, Eric, additional, Bukauskas, Feliksas F., additional, Calkins, Hugh, additional, Callans, David J., additional, Caples, Sean M., additional, Carafoli, Ernesto, additional, Catterall, William A., additional, Cerrone, Marina, additional, Chaumeil, Arnaud, additional, Chen, Caressa, additional, Chen, Lan S., additional, Chen, Peng-Sheng, additional, Cheng, Jianding, additional, Chiamvimonvat, Nipavan, additional, Christini, David J., additional, Chugh, Aman, additional, Climent, Andreu M., additional, Cohen, Ira S., additional, Connolly, Stuart J., additional, Cooper, Lebron, additional, Crespo, Eric M., additional, Crotti, Lia, additional, Csepe, Thomas A., additional, Cuoco, Frank, additional, Curtis, Anne B., additional, Damiano, Ralph J., additional, Darbar, Dawood, additional, Das, Mithilesh K., additional, d’Avila, Andre, additional, Delmar, Mario, additional, Delpón, Eva, additional, Denegri, Marco, additional, Denis, Arnaud, additional, Derval, Nicolas, additional, Deschênes, Isabelle, additional, Deshmukh, Abhishek, additional, Di Biase, Luigi, additional, Dickfeld, Timm M., additional, Dierckx, Hans, additional, Dinov, Borislav, additional, Dixit, Sanjay, additional, Dobrev, Dobromir, additional, Dubois, Remi, additional, Eckardt, Lars, additional, Edwards, Andrew G., additional, Ellenbogen, Kenneth A., additional, Ellinor, Patrick T., additional, Estes, N.A. Mark, additional, Fabritz, Larissa, additional, Fedorov, Vadim V., additional, Fernandez, Antonio B., additional, Teijeira Fernández, Elvis, additional, Filgueiras-Rama, David, additional, Fishbein, Michael C., additional, Fishman, Glenn I., additional, Frankel, David S., additional, Friedman, Paul, additional, Frontera, Antonio, additional, Gami, Apoor S., additional, Garabelli, Paul, additional, George, Alfred L., additional, Gerstenfeld, Edward P., additional, Gizurarson, Sigfus, additional, Gold, Michael R., additional, Goldberger, Jeffrey J., additional, Grace, Andrew, additional, Grassi, Guido, additional, Greenfield, Ruth Ann, additional, Gross, Wendy L., additional, Grubb, Blair P., additional, Guillem, María S., additional, Györke, Sándor, additional, Haïssaguerre, Michel, additional, Hake, Johan, additional, Halperin, Henry R., additional, Hansen, Brian J., additional, Hatem, Stéphane, additional, Hayes, David L., additional, Heijman, Jordi, additional, Herron, Todd J., additional, Hindricks, Gerhard, additional, Hocini, Mélèze, additional, Hohnloser, Stefan H., additional, Holmes, David R., additional, Hoshijima, Masahiko, additional, Hund, Thomas J., additional, Hutchinson, Mathew D., additional, Ilkhanoff, Leonard, additional, Ingles, Jodie, additional, Ip, James E., additional, Jackman, Warren M., additional, Jackson, Nicholas, additional, Jaïs, Pierre, additional, Jalife, José, additional, Jhun, Bong Sook, additional, John, Roy M., additional, Jongbloed, Monique, additional, Jordaens, Luc, additional, Kalman, Jonathan M., additional, Kamp, Timothy J., additional, Kanj, Mohamed H., additional, Kapa, Suraj, additional, Karabin, Beverly, additional, Karakikes, Ioannis, additional, Katritsis, Demosthenes G., additional, Kaur, Kuljeet, additional, Kirchhof, Paulus, additional, Kléber, André G., additional, Klein, George J., additional, Kohl, Peter, additional, Koneru, Jayanthi N., additional, Koruth, Jacob S., additional, Krahn, Andrew D., additional, Krogh-Madsen, Trine, additional, Kuck, Karl Heinz, additional, Kumar, Saurabh, additional, Kushnir, Alexander, additional, Lakdawala, Neal K., additional, Laksman, Zachary W.M., additional, Latchamsetty, Rakesh, additional, Lau, Dennis H., additional, Lerman, Bruce B., additional, Lin, Richard Z., additional, Lin, Shien-Fong, additional, Link, Mark S., additional, Liu, Bin, additional, Liu, Christopher F., additional, Lockwood, Deborah J., additional, Lopatin, Anatoli N., additional, Lubitz, Steven A., additional, Mahajan, Rajiv, additional, Makielski, Jonathan C., additional, Malik, Marek, additional, Marchlinski, Francis E., additional, Markowitz, Steven M., additional, Maron, Barry J., additional, Maron, Martin S., additional, Marx, Steven O., additional, Massé, Stéphane, additional, McCulloch, Andrew D., additional, McKelvie-Sebileau, Pippa, additional, Melby, Spencer J., additional, Metzner, Andreas, additional, Michailova, Anushka P., additional, Michaud, Gregory F., additional, Miller, John M., additional, Mishra, Jyotsna, additional, Mitrani, Raul D., additional, Mohler, Peter J., additional, Morady, Fred, additional, Myerburg, Robert J., additional, Nakagawa, Hiroshi, additional, Nalliah, Chrishan Joseph, additional, Nanthakumar, Kumaraswamy, additional, Napolitano, Carlo, additional, Narayan, Sanjiv M., additional, Natale, Andrea, additional, Nattel, Stanley, additional, Nazarian, Saman, additional, Nguyen, Thao P., additional, Nogami, Akihiko, additional, Noujaim, Sami F., additional, Nubret Le Coniat, Karine, additional, Olshansky, Brian, additional, O-Uchi, Jin, additional, Oudit, Gavin Y., additional, Ouyang, Feifan, additional, Ozcan, Cevher, additional, Packer, Douglas L., additional, Pandit, Sandeep V., additional, Panfilov, Alexander V., additional, Park, David S., additional, Patocskai, Bence, additional, Pauza, Dainius H., additional, Pauziene, Neringa, additional, Piccini, Jonathan P., additional, Pitt, Geoffrey S., additional, Po, Sunny S., additional, Prasad, Abhiram, additional, Priori, Silvia G., additional, Radwański, Przemysław B., additional, Rappel, Wouter-Jan, additional, Reiser, Michelle, additional, Restrepo, Alejandro Jimenez, additional, Robinson, Richard B., additional, Roden, Dan M., additional, Rosen, Michael R., additional, Rosso, Raphael, additional, Rudy, Yoram, additional, Rysevaite-Kyguoliene, Kristina, additional, Sabbah, Hani N., additional, Sacher, Frederic, additional, Sachse, Frank B., additional, Saguner, Ardan M., additional, Sanders, Prashanthan, additional, Sanguinetti, Michael C., additional, Santangeli, Pasquale, additional, Sarraf, Mohammad, additional, Satin, Jonathan, additional, Schalij, Martin Jan, additional, Scherlag, Benjamin J., additional, Schill, Matthew R., additional, Schleifer, J. William, additional, Schuessler, Richard B., additional, Schwartz, Peter J., additional, Seeger, Timon, additional, Semsarian, Christopher, additional, Seravalle, Gino, additional, Shah, Ashok J., additional, Shaw, Robin M., additional, Shen, Mark J., additional, Shen, Win–Kuang, additional, Sheu, Shey-Shing, additional, Shivkumar, Kalyanam, additional, Silva, Jennifer N.A., additional, Skanes, Allan C., additional, Soejima, Kyoko, additional, Somers, Virend K., additional, Sorajja, Dan, additional, Stavrakis, Stavros, additional, Steinberg, Christian, additional, Stevenson, Lynne Warner, additional, Stevenson, William G., additional, Sweeney, Michael O., additional, Swerdlow, Charles, additional, Takigawa, Masateru, additional, Tamargo, Juan, additional, Tandri, Harikrishna, additional, Tedrow, Usha B., additional, Thompson, Nathaniel, additional, Thompson, Paul D., additional, Tomaselli, Gordon F., additional, Towbin, Jeffrey A., additional, Trayanova, Natalia A., additional, Tristani-Firouzi, Martin, additional, Tseng, Zian H., additional, Ueda, Akiko, additional, Valdivia, Héctor H., additional, Valiunas, Virginijus, additional, van der Werf, Christian, additional, Van Hare, George F., additional, Vidmar, David, additional, Viskin, Sami, additional, Voigt, Niels, additional, Walsh, Edward P., additional, Wang, Paul J., additional, Wehrens, Xander H.T., additional, Weiss, Mark S., additional, Wilde, Arthur A.M., additional, Wilkoff, Bruce L., additional, Woo, Y. Joseph, additional, Wu, Joseph C., additional, Yee, Raymond, additional, Zaman, Junaid A.B., additional, Zarzoso, Manuel, additional, Zeitler, Emily P., additional, Zeppenfeld, Katja, additional, Zghaib, Tarek, additional, Zhang, Xiao-Dong, additional, and Zipes, Douglas P., additional

Published
2018
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11. Comparative analysis of intracardiac neural structures in the aged rats with essential hypertension

Author

Pauziene, Neringa, primary, Ranceviene, Dalia, additional, Rysevaite‐Kyguoliene, Kristina, additional, Inokaitis, Hermanas, additional, Saburkina, Inga, additional, Plekhanova, Khrystyna, additional, Sabeckiene, Deimante, additional, Sabeckis, Ignas, additional, Martinaityte, Rugile, additional, Pilnikovaite, Ernesta, additional, and Pauza, Dainius H., additional

Published
2022
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14. GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

Author

Pauza, Audrys G., primary, Thakkar, Pratik, additional, Tasic, Tatjana, additional, Felippe, Igor, additional, Bishop, Paul, additional, Greenwood, Michael P., additional, Rysevaite-Kyguoliene, Kristina, additional, Ast, Julia, additional, Broichhagen, Johannes, additional, Hodson, David J., additional, Salgado, Helio C., additional, Pauza, Dainius H., additional, Japundzic-Zigon, Nina, additional, Paton, Julian F.R., additional, and Murphy, David, additional

Published
2022
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16. Innervation of the rabbit cardiac ventricles

Author

Pauziene, Neringa, Alaburda, Paulius, Rysevaite-Kyguoliene, Kristina, Pauza, Audrys G., Inokaitis, Hermanas, Masaityte, Aiste, Rudokaite, Gabriele, Saburkina, Inga, Plisiene, Jurgita, and Pauza, Dainius H.

Published
2016
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17. Saturation of visual responses explains size tuning in rat collicular neurons.

Author

Baranauskas, Gytis, Rysevaite‐Kyguoliene, Kristina, Sabeckis, Ignas, and Pauza, Dainius H.

Subjects
*SUPERIOR colliculus, *VISUAL perception, *VISUAL fields, *NEURONS, *RATS, *SQUARE root
Abstract

The receptive field of many visual neurons is composed of a central responsive area, the classical receptive field, and a non‐classical receptive field, also called the "suppressive surround." A visual stimulus placed in the suppressive surround does not induce any response but modulates visual responses to stimuli within the classical receptive field, usually by suppressing them. Therefore, visual responses become smaller when stimuli exceed the classical receptive field size. The stimulus size inducing the maximal response is called the preferred stimulus size. In cortex, there is good correspondence between the sizes of the classical receptive field and the preferred stimulus. In contrast, in the rodent superior colliculus, the preferred size is often several fold smaller than the classical receptive field size. Here, we show that in the rat superior colliculus, the preferred stimulus size changes as a square root of the contrast inverse and the classical receptive field size is independent of contrast. In addition, responses to annulus were largely independent of the inner hole size. To explain these data, three models were tested: the divisive modulation of the gain by the suppressive surround (the "normalization" model), the difference of the Gaussians, and a divisive model that incorporates saturation to light flux. Despite the same number of free parameters, the model incorporating saturation to light performed the best. Thus, our data indicate that in rats, the saturation to light can be a dominant phenomenon even at relatively low illumination levels defining visual responses in the collicular neurons. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Intrinsic cardiac neurons of the adult pigs: chemical types, abundance, parameters and distribution within ganglionated plexus

Author

Ragauskas, Tomas, Rysevaite-Kyguoliene, Kristina, Pauziene, Neringa, Inokaitis, Hermanas, and Pauza H, Dainius

Subjects
Neurons, Adrenergic Agents, Swine, Calcitonin Gene-Related Peptide, Cholinergic Agents, Animals, Heart Atria, General Medicine, Anatomy, Developmental Biology
Abstract

Intracardiac neurons (ICNs) have a pivotal role in the regulation of heart rhythm and myocardial contractility. However, comparative data about the precise distribution of the chemically phenotypically distinct ICNs in the heart as well as their interrelations within intracardiac ganglia (ICG) are limited. In this study, we employed the whole-mount approach to characterise immunohistochemically the porcine atrial ICG. We found that almost all, 99%, of ICNs express cholinergic neuronal marker in the adult pig. Some cholinergic ICNs were simultaneously positive for adrenergic (3.6%) or nitrergic (3.3%) neuronal markers as well. These biphenotypic adrenergic ICNs were more abundant within the right atrial ganglionated subplexi (sGPi), while the biphenotypic nitrergic ICNs were more numerous in the dorsal sGPi compared with the ventral sGPi. Non-cholinergic as well as entirely adrenergic and nitrergic ICNs were seldom and compiled respectively 0.1% and 0.4% of all intracardiac neuronal population. In contrast to neuronal somata, nerve fibres observed in the adult pig atrial sGPi were also positive for vesicular glutamate transporter 2 and calcitonin gene-related peptide (CGRP). Receptor protein for CGRP, CRLR, was found on cholinergic neuronal somata within ICG as well as the putative neuro-somatic contact sites with peptidergic and adrenergic nerve fibres. Morphological analysis of neuronal somata disclosed that the largest somata were nitrergic. This study demonstrates the scanty chemical variety of ICNs in the adult porcine atrial ICG that possess mainly cholinergic neuronal somata with the few adrenergic and nitrergic ones which are patchily distributed within sGPi. Inside the ICG, cholinergic ICNs are wrapped by a complex network of chemically diverse nerve terminals, some of which contain varicosities with probable passage type synapses.

Published
2022

22. Contributors

Author

Abrams, Dominic, Abriel, Hugues, Adkisson, Wayne O., Ajijola, Olujimi A., Alvarado, Francisco J., Amin, Ahmad S., André, Clémentine, Anter, Elad, Antzelevitch, Charles, Ariga, Rina, Arora, Rishi, Arya, Arash, Asirvatham, Samuel, Atienza, Felipe, Atluri, Pavan, Balse, Elise, Basso, Cristina, Benditt, David G., Bennett, Richard, Berenfeld, Omer, Berruezo, Antonio, Bers, Donald M., Bhaskaran, Ashwin, Bogun, Frank, Bose, Rupan, Botzer, Lior, Boyle, Patrick M., Bradfield, Jason S., Brini, Marisa, Brugada, Pedro, Caldwell, Jessica L., Calkins, Hugh, Poindexter, Catherine Ellen, Callans, David J., Carafoli, Ernesto, Catterall, William A., Cerrone, Marina, Chandler, Stephanie, Chauvel, Remi, Chen, Lan S., Chen, Peng-Sheng, Cheniti, Ghassen, Cheung, Christopher C., Chiamvimonvat, Nipavan, Chiang, David Y., Chorin, Ehud, Christini, David J., Christoffels, Vincent M., Christoph, Jan, Clancy, Colleen E., Climent, Andreu M., Cochet, Hubert, Coetzee, William A., Crossley, George H., Crotti, Lia, Cuculich, Phillip S., Curtis, Anne B., Dagradi, Federica, Damiano, Ralph J., Jr, Darbar, Dawood, Das, Mithilesh K., Delmar, Mario, Delpón, Eva, Derval, Nicolas, Deshmukh, Abhishek, Dherange, Parinita, Dickfeld, Timm M., Dierckx, Hans, Dinov, Borislav, Divakaran, Sanjay, Dixit, Sanjay, Dubois, Rémi, Duchateau, Josselin, Edwards, Andrew G., Ellenbogen, Kenneth A., Ellinor, Patrick T., Ellis, Christopher R., Enriquez, Andres, Estes III, N.A. Mark, Etheridge, Susan P., Everett, Thomas H., Fedorov, Vadim V., Filgueiras-Rama, David, Fishbein, Michael, Fishman, Glenn I., Fradley, Michael, Gami, Apoor S., Gando, Ivan, Garabelli, Paul James, Garcia, Fermin, George, Alfred L., Jr, Gerstenfeld, Edward P., Goldberger, Jeffrey J., Gourdie, Robert G., Grace, Andrew, Grubb, Blair P., Guerrier, Karine, Guillem, María S., Györke, Sándor, Haines, David E., Halperin, Henry R., Hatem, Stéphane, Haïssaguerre, Michel, Herron, Todd J., Hindricks, Gerhard, Hocini, Mélèze, Hoffman, Jacob, Hund, Thomas J., Hutchinson, Mathew D., Iliceto, Sabino, Ilkhanoff, Leonard, Ingles, Jodie, Ip, James E., Jackman, Warren M., Jalife, Jose, Jaïs, Pierre, Jhun, Bong Sook, Restrepo, Alejandro Jimenez, John, Roy M., Johnson, Jason, Jongbloed, Monique, Jáuregui, Beatriz, Kalman, Jonathan M., Kalyanasundaram, Anuradha, Kamp, Timothy J., Kanagasundram, Arvindh N., Kang, Po Wei, Kanj, Mohamed H., Kapa, Suraj, Kapur, Sunil, Karabin, Beverly, Kernik, Divya C., Klein, George J., Kléber, André G., Knight, Bradley P., Koenig, Sara N., Kohl, Peter, Konecny, Thomas, Koneru, Jayanthi N., Krahn, Andrew D., Krishnappa, Darshan, Krogh-Madsen, Trine, Kumar, Saurabh, Kusayama, Takashi, Kushnir, Alexander, Kwak, Brenda R., Lador, Adi, Lakatta, Edward G., Laksman, Zachary W.M., Latchamsetty, Rakesh, Lau, Dennis H., Lee, Byron K., Lenaeus, Michael J., Lerman, Bruce B., Li, Ning, Lin, Shien-Fong, Link, Mark S., Liu, Bin, Liu, Christopher F., Lockwood, Deborah J., Loeys, Bart, Lubitz, Steven A., Prof-Dr, Stefan Luther, Lyon, Aurore, MacGregor, Robert M., MacRae, Calum A., Maher, Timothy, Maltsev, Victor, Man, Joyce C.K., Marchlinski, Francis E., Markowitz, Steven M., Maron, Barry J., Maron, Martin S., Marra, Martina Perazzolo, Marx, Steven O., Mazzanti, Andrea, McCulloch, Andrew D., Mehta, Nishaki K., Melby, Spencer J., Mellor, Greg, Michaud, Gregory F., Miles, William M., Miller, Jennifer C., Miller, John M., Mitrani, Raul D., Mohler, Peter J., Montgomery, Jay A., Moreno, Jonathan D., Murray, Katherine T., Myerburg, Robert J., Nakagawa, Hiroshi, Naksuk, Niyada, Nalliah, Chrishan Joseph, Napolitano, Carlo, Narayan, Sanjiv M., Nazarian, Saman, Nerbonne, Jeanne M., Nery, Pablo B., Nguyen, Thao P., Nichols, Colin G., Nielsen, Morten S., Nogami, Akihiko, Noujaim, Sami F., Nubret, Karine, O-Uchi, Jin, Olgin, Jeffrey E., Olshansky, Brian, Ozcan, Cevher, Pambrun, Thomas, Panfilov, Alexander V., Pang, Paul D., Park, David S., Parlitz, Ulrich, Patocskai, Bence, Pauziene, Neringa, Pauža, Dainius H., Penela, Diego, Peyronnet, Rémi, Pfenniger, Anna, Phillips, S. Tyler, Picard, François, Ploux, Sylvain, Po, Sunny S., Poelzing, Steven, Polina, Iuliia, Porta-Sánchez, Andreu, Prasad, Abhiram, Priori, Silvia G., Pérez-Hernández, Marta, Qian, Pierre C., Quintanilla, MScEng, Jorge G., Radwański, Przemysław B., Ramirez, F. Daniel, Rappel, Wouter-Jan, Richardson, Travis D., Ripplinger, Crystal M., Robinson, Clifford G., Roden, Dan M., Rodrigo, Miguel, Rodriguez, Blanca, Rosso, Raphael, Rowin, Ethan J., Rudy, Yoram, Rysevaite-Kyguoliene, Kristina, Sacher, Frédéric, Sadek, Mouhannad M., Sanders, Prashanthan, Satin, Jonathan, Sauer, William H., Saxon, Leslie A., Schalij, Martin Jan, Schepers, Dorien, Scherlag, Benjamin J., Schleifer, J. William, Schmidt, Ehud J., Schröder-Schetelig, Johannes, Schuessler, Richard B., Schwartz, Peter J., Semsarian, Christopher, Shaw, Robin M., Shen, Win-Kuang, Sheu, Shey-Shing, Shivkumar, Kalyanam, Sieliwonczyk, Ewa, Silva, Jonathan R., Skanes, Allan C., Smyth, James W., Sobie, Eric A., Soejima, Kyoko, Somers, Virend K., Sorajja, Dan, Sroubek, Jakub, Stavrakis, Stavros, Steinberg, Christian, Stevenson, William G., Supple, Gregory E., Swerdlow, Charles, Tandri, Harikrishna, Tedrow, Usha, Thai, Phung N., Thiene, Gaetano, Tixier, Romain, Tomaselli, Gordon F., Towbin, Jeffrey A., Trayanova, Natalia A., Tristani-Firouzi, Martin, Tseng, Zian H., Tung, Roderick, Ueda, Akiko, Upadhyay, Gaurav A., Valderrábano, Miguel, Valdivia, Héctor H., van den Brink, Jonas, van der Werf, Christian, van Opbergen, Chantal J.M., Vaseghi, Marmar, Vautier, R. Ashton, Vera Pedrosa, Maria Linarejos, Verma, Nishant, Vermij, Sarah H., Virk, Sohaib, Viskin, Sami, Vlachos, Konstantinos, Walsh, Edward P., Wang, Paul J., Welte, Nicolas, Wilde, Arthur A.M., Wilkoff, Bruce L., Wu, Joseph C., Yang, Hua-Qian, Yee, Raymond, Zaman, Junaid A.B., Zeppenfeld, Katja, Zghaib, Tarek, Zhang, Jianhua, Zhang, Xiao-Dong, and Zimetbaum, Peter

Published
2022
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23. Neuroanatomy of the Pig Cardiac Ventricles. A Stereomicroscopic, Confocal and Electron Microscope Study

Author

Pauziene, Neringa, primary, Rysevaite-Kyguoliene, Kristina, additional, Alaburda, Paulius, additional, Pauza, Audrys G., additional, Skukauskaite, Monika, additional, Masaityte, Aiste, additional, Laucaityte, Goda, additional, Saburkina, Inga, additional, Inokaitis, Hermanas, additional, Plisiene, Jurgita, additional, and Pauza, Dainius H., additional

Published
2017
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25. Innervation of the rabbit cardiac ventricles

Author

Pauziene, Neringa, primary, Alaburda, Paulius, additional, Rysevaite‐Kyguoliene, Kristina, additional, Pauza, Audrys G., additional, Inokaitis, Hermanas, additional, Masaityte, Aiste, additional, Rudokaite, Gabriele, additional, Saburkina, Inga, additional, Plisiene, Jurgita, additional, and Pauza, Dainius H., additional

Published
2015
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26. Section’s osseous slice biopsy during major amputation of lower extremity: preliminary results of prospective cohort study

Author

Vaznaisiene, Danguole, primary, Sulcaite, Rita, additional, Vitkauskiene, Astra, additional, Spucis, Arturas, additional, Reingardas, Anatolijus, additional, Kymantas, Vytautas, additional, Balanaska, Kestutis, additional, Sleivys, Rolandas, additional, Velicka, Linas, additional, Belickas, Juozas, additional, Rysevaite-Kyguoliene, Kristina, additional, Pauza, Dainius H., additional, Mickiene, Aukse, additional, and Senneville, Eric, additional

Published
2015
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27. Comparative analysis of intracardiac neural structures in the aged rats with essential hypertension.

Author

Pauziene N, Ranceviene D, Rysevaite-Kyguoliene K, Inokaitis H, Saburkina I, Plekhanova K, Sabeckiene D, Sabeckis I, Martinaityte R, Pilnikovaite E, and Pauza DH

Subjects
Rats, Animals, Rats, Inbred WKY, Rats, Inbred SHR, Essential Hypertension, Nerve Fibers, Myelinated, Axons, Hypertension
Abstract

Persistent arterial hypertension initiates cardiac autonomic imbalance and alters cardiac tissues. Previous studies have shown that neural component contributes to arterial hypertension etiology, maintenance, and progression and leads to brain damage, peripheral neuropathy, and remodeling of intrinsic cardiac neural plexus. Recently, significant structural changes of the intracardiac neural plexus were demonstrated in young prehypertensive and adult hypertensive spontaneously hypertensive rats (SHR), yet structural alterations of intracardiac neural plexus that occur in the aged SHR remain undetermined. Thus, we analyzed the impact of uncontrolled arterial hypertension in old (48-52 weeks) SHR and the age-matched Wistar-Kyoto rats (WKY). Intrinsic cardiac neural plexus was examined using a combination of immunofluorescence confocal microscopy and transmission electron microscopy in cardiac sections and whole-mount preparations. Our findings demonstrate that structural changes of intrinsic cardiac neural plexus caused by arterial hypertension are heterogeneous and may support recent physiological implications about cardiac denervation occurring together with the hyperinnervation of the SHR heart. We conclude that arterial hypertension leads to (i) the decrease of the neuronal body area, the thickness of atrial nerves, the number of myelinated nerve fibers, unmyelinated axon area and cumulative axon area in the nerve, and the density of myocardial nerve fibers, and (ii) the increase in myelinated nerve fiber area and density of neuronal bodies within epicardiac ganglia. Despite neuropathic alterations of myelinated fibers were exposed within intracardiac nerves of both groups, SHR and WKY, we consider that the determined significant changes in structure of intrinsic cardiac neural plexus were predisposed by arterial hypertension., (© 2022 American Association for Anatomy.)

Published
2023
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28. Comparative gross anatomy of epicardiac ganglionated nerve plexi on the human and sheep cardiac ventricles.

Author

Saburkina I, Pauziene N, Solomon OI, Rysevaite-Kyguoliene K, and Pauza DH

Subjects
Humans, Animals, Infant, Newborn, Sheep, Heart physiology, Ganglia anatomy & histology, Neurons, Heart Ventricles innervation, Acetylcholinesterase
Abstract

This study aimed to examine the distribution and quantitative parameters of the epicardiac ventricular neural ganglionated plexus in the hearts of humans and sheep, highlighting the differences of this plexus in humans and large models. Five non-sectioned pressure distended whole hearts of the human newborns and 10 hearts of newborn German black-faced lambs were investigated applying a histochemical method for acetylcholinesterase to stain epicardiac neural structures with their subsequent stereomicroscopic examination. In humans, the ventricular nerves are spread by four epicardiac nerve subplexuses, that is, the left and right coronary as well as the left and middle dorsal. In sheep, the ventricular nerves are spread by five epicardiac nerve subplexuses, that is, the left and right coronary, the left and middle dorsal and the right ventral ones. The ventricular epicardium involved up to 129 ganglia in humans and up to 198-in sheep. The largest number of the ventricular ganglionic cells in humans were located on the ventral side, in front of the conus arteriosus, while on sheep ventricles, the most numerous neurons distributed on the dorsal wall of the left ventricle. This comparative study of the morphological patterns of the human and sheep ventricles demonstrates that the sheep heart is neuroanatomically distinct from the human one and this must be taking into consideration using the sheep model for the heart physiology experiments., (© 2022 American Association for Anatomy.)

Published
2023
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29. Early structural alterations of intrinsic cardiac ganglionated plexus in spontaneously hypertensive rats.

Author

Ranceviene D, Rysevaite-Kyguoliene K, Inokaitis H, Saburkina I, Plekhanova K, Sabeckiene D, Sabeckis I, Azukaite J, Pauza DH, and Pauziene N

Subjects
Rats, Humans, Dogs, Animals, Rats, Inbred SHR, Rats, Inbred WKY, Heart, Hypertension, Heart Failure
Abstract

Persistent arterial hypertension leads to structural and functional remodeling of the heart resulting in myocardial ischemia, fibrosis, hypertrophy, and eventually heart failure. Previous studies have shown that individual neurons composing the intracardiac ganglia are hypertrophied in the failing human, dog, and rat hearts, indicating that this process involves changes in cardiac innervation. However, despite a wealth of data on changes in intrinsic cardiac ganglionated plexus (GP) in late-stage disease models, little is known about the effects of hypertension on cardiac innervation during the early onset of heart failure development. Thus, we examined the impact of early hypertension on the structural organization of the intrinsic cardiac ganglionated plexus in juvenile (8-9 weeks) and adult (12-18 weeks) spontaneously hypertensive (SH) and age-matched Wistar-Kyoto (WKY) rats. GP was studied using a combination of immunofluorescence confocal microscopy and transmission electron microscopy in whole-mount preparations and tissue sections. Here, we report intrinsic cardiac GP of SH rats to display multiple structural alterations: (i) a decrease in the intracardiac neuronal number, (ii) a marked reduction in axonal diameters and their proportion within intracardiac nerves, (iii) an increased density of myocardial nerve fibers, and (iv) neuropathic abnormalities in cardiac glial cells. These findings represent early neurological changes of the intrinsic ganglionated plexus of the heart introduced by early-onset arterial hypertension in young adult SH rats., (©The Author(s) 2022. Open Access. This article is licensed under a Creative Commons CC-BY International License.)

Published
2022
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30. Ultrastructural changes of the human enteric nervous system and interstitial cells of Cajal in diverticular disease.

Author

Alaburda P, Lukosiene JI, Pauza AG, Rysevaite-Kyguoliene K, Kupcinskas J, Saladzinskas Z, Tamelis A, and Pauziene N

Subjects
Adult, Aged, Female, Humans, Male, Microscopy, Electron, Transmission, Middle Aged, Diverticular Diseases pathology, Enteric Nervous System pathology, Enteric Nervous System ultrastructure, Interstitial Cells of Cajal pathology, Interstitial Cells of Cajal ultrastructure
Abstract

Background: In spite of numerous advances in understanding diverticular disease, its pathogenesis remains one of the main problems to be solved. We aimed to investigate the ultrastructural changes of the enteric nervous system in unaffected individuals, in asymptomatic patients with diverticulosis and in patients with diverticular disease., Methods: Transmission electron microscopy was used to analyse samples of the myenteric, outer submucosal and inner submucosal plexuses from patients without diverticula (n=9), asymptomatic patients with diverticulosis (n=7) and in patients with complicated diverticular disease (n=9). We described the structure of ganglia, interstitial cells of Cajal and enteric nerves, as well as their relationship with each other. The distribution and size of nerve processes were analysed quantitatively., Results: In complicated diverticular disease, neurons exhibited larger lipofuscin-like inclusions, their membranous organelles had larger cisterns and the nucleus showed deeper indentations. Nerve remodeling occurred in every plexus, characterised by an increased percentage of swollen and fine neurites. Interstitial cells of Cajal had looser contacts with the surrounding cells and showed cytoplasmic depletion and proliferation of the rough endoplasmic reticulum. In asymptomatic patients with diverticulosis, alterations of enteric nerves and ICC were less pronounced., Conclusions: In conclusion, the present findings suggest that most ultrastructural changes of the enteric nervous system occur in complicated diverticular disease. The changes are compatible with damage to the enteric nervous system and reactive remodeling of enteric ganglia, nerves and interstitial cells of Cajal. Disrupted architecture of enteric plexuses might explain clinical and pathophysiological changes associated with diverticular disease.

Published
2020
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