4 results on '"Ryskal, O. V."'
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2. Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia
- Author
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Rumyantseva, Y. V., Karachunsky, A. I., Aleinikova, O. V., Fechina, L. G., Shamardinal, A. V., Litvinov, D. V., Ponomareva, N. I., Boichenko, E. G., Dudkin, S. A., Streneva, O. V., Kondratchik, K. L., Mansurova, E. G., Minkina, L. M., Lapotentova, E. S., Inyushkina, E. V., Yudina, N. B., Pavlova, G. P., Zhukovskaya, E. V., Khlebnikova, O. P., Lagoiko, S. N., Basharova, E. V., Denisov, R. E., Zlobina, V. D., Banshchikova, E. S., Aslanyan, K. S., Kondakova, E. V., Tselousova, Myakova, N. V., Turobova, T. V., Ryskal, O. V., Chipsanova, N. F., Varfolomeyeva, S. R., and Rumyantsev, A. G.
- Subjects
Male ,Adolescent ,Dose-Response Relationship, Drug ,lcsh:R ,Age Factors ,Infant ,lcsh:Medicine ,acute lymphoblastic leukemia ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Disease-Free Survival ,Drug Administration Schedule ,Russia ,efficiency of therapy ,children ,Recurrence ,Child, Preschool ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Female ,Child - Abstract
Aim. To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children. Subjects and methods. A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008. Results. With the median observation of 4.12 years, 7-year event-free survival (EFS) was 73±13%; overall survival (OS) 78±2%; relapse-free survival 82±1%. The rates of EFS and OS were equal and amounted to 76±2 and 80±2% in the standard-risk group (SRG) and intermediate-risk group (ImRG), respectively. In the high-risk group (HRG) patients, EFS and OS were as high as 30±6 and 37±6%, respectively. The frequency of relapses with central nervous system lesion was as much as 4.7% in all the patients, 6-year cumulative risk for isolated neurorecurrences being 2.5% in the SRG patients. Adolescents, patients with the baseline leukocytosis (more than 100109/l), and those with a splenic size of over 4 cm or more from the costal arch margin had substantially worse survival rates. A poor early response to therapy (on induction days 8 and 15) was also associated with its lower efficiency. Conclusion. Despite a considerable rise in the number of centers and a slight increase in the intensity of therapy, the results of the new ALL-MB-2002 protocol are as minimum equivalents obtained in the use of the previous ALL-MB-91 protocol. A significant improvement in the overall results of therapy and a reduction in the cumulative risk for isolated neurorecurrences were noted in the ImRG patients.
- Published
- 2010
3. Treatment of B-cells non-Hodgkin lymphomas with combined immunochemotherapy: ability to treatment optimization
- Author
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Smirnova, N. V., primary, Myakova, N. V., additional, Belogurova, M. B., additional, Ryskal, O. V., additional, Nikonova, O. E., additional, Sharapova, G. R., additional, Fedorova, A. S., additional, Grigorieva, N. A., additional, Shamardina, A. V., additional, Ponomareva, N. I., additional, Abramov, D. S., additional, Konovalov, D. M., additional, Dubrovina, M. E., additional, Maschan, A. A., additional, and Samochatova, E. V., additional
- Published
- 2015
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4. [Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia].
- Author
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Rumiantseva IuV, Karachunskiĭ AI, Aleĭnikova OV, Fechina LG, Shamardina AV, Litvinov DV, Ponomareva NI, Boĭchenko EG, Dudkin SA, Streneva OV, Kondratchik KL, Mansurova EG, Minkina LM, Lapotentova ES, Iniushkina EV, Iudina NB, Pavlova GP, Zhukovskaia EV, Khlebnikova OP, Lagoĭko SN, Basharova EV, Denisov RE, Zlobina VD, Banshchikova ES, Aslanian KS, Kondakova EV, Tselousova EV, Miakova NV, Turobova TV, Ryskal' OV, Chipsanova NF, Varfolomeeva SR, and Rumiantsev AG
- Subjects
- Adolescent, Age Factors, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Child, Child, Preschool, Disease-Free Survival, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Infant, Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma mortality, Precursor Cell Lymphoblastic Leukemia-Lymphoma prevention & control, Recurrence, Russia, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
- Abstract
Aim: To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children., Subjects and Methods: A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008., Results: With the median observation of 4.12 years, 7-year event-free survival (EFS) was 73 +/- 13%; overall survival (OS) 78 +/- 2%; relapse-free survival 82 +/- 1%. The rates of EFS and OS were equal and amounted to 76 +/- 2 and 80 +/- 2% in the standard-risk group (SRG) and intermediate-risk group (ImRG), respectively. In the high-risk group (HRG) patients, EFS and OS were as high as 30 +/- 6 and 37 +/- 6%, respectively. The frequency of relapses with central nervous system lesion was as much as 4.7% in all the patients, 6-year cumulative risk for isolated neurorecurrences being 2.5% in the SRG patients. Adolescents, patients with the baseline leukocytosis (more than 100 x 10(9)/l), and those with a splenic size of over 4 cm or more from the costal arch margin had substantially worse survival rates. A poor early response to therapy (on induction days 8 and 15) was also associated with its lower efficiency., Conclusion: Despite a considerable rise in the number of centers and a slight increase in the intensity of therapy, the results of the new ALL-MB-2002 protocol are as minimum equivalents obtained in the use of the previous ALL-MB-91 protocol. A significant improvement in the overall results of therapy and a reduction in the cumulative risk for isolated neurorecurrences were noted in the ImRG patients.
- Published
- 2010
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