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5. Association Between Orthostatic Hypertension and Frailty Among Older Patients With Hypertension.

Author

Choi, Jung-Yeon, Ryu, Dong Ryeol, Lee, Hae-Young, Lee, Ju-Hee, Hong, Youjin, Park, Sue K., Lee, Jang Hoon, Hwang, Seok-Jae, Kim, Kye Hun, Lee, Sun Hwa, Kim, Song Yi, Park, Jae-Hyeong, Kim, Sang-Hyun, Kim, Hack-Lyoung, Choi, Jung Hyun, Kim, Cheol-Ho, Cho, Myeong-Chan, and Kim, Kwang-il

Abstract

BACKGROUND: Frailty frequently coexists with hypertension in older patients. We aimed to evaluate the association between frailty and positional change in blood pressure, especially orthostatic hypertension. METHODS: Participants were recruited from 12 University hospitals in South Korea. Using a digital device, trained research nurses measured blood pressure in the supine and standing positions. Physical frailty was evaluated using the Korean version of the FRAIL questionnaire, gait speed, and handgrip strength. Orthostatic hypertension was defined as a ≥20-mm Hg increase in systolic blood pressure within 3 minutes of standing and upright systolic blood pressure of ≥140 mm Hg. RESULTS: We analyzed the data of 2065 participants who had been enrolled until December 31, 2022. The mean age was 73.2±5.6 years, and 52.0% were female. The mean blood pressure was 137.1±14.9/75.1±9.7 mm Hg. Among the participants, 1886 (91.3%) showed normal response after standing, but 94 (4.6%) had orthostatic hypertension, and 85 (4.1%) had orthostatic hypotension. Orthostatic hypertension was associated with female sex, obesity, cognitive function, physical frailty, and lower quality of life. In the multivariable analysis, body mass index and frailty status were independently associated with orthostatic hypertension. CONCLUSIONS: Orthostatic hypertension is associated with physical frailty, cognitive impairment, and low quality of life in older patients with hypertension. Therefore, evaluation of orthostatic blood pressure changes to confirm orthostatic hypertension or hypotension in frail older adults will serve as an important diagnostic procedure in vulnerable patients. Further studies are required to identify the underlying mechanisms of this association. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After Contrast-Enhanced Computed Tomography

Author

Park, Sehoon, Kim, Dong Ki, Jung, Hee-Yeon, Kim, Chan-Duck, Cho, Jang-Hee, Cha, Ran-hui, Jeong, Jong Cheol, Kim, Sejoong, Kim, Hyung-Jong, Ban, Tae Hyun, Chung, Byung Ha, Lee, Jung Pyo, Park, Jung Tak, Han, Seung Hyeok, Yoo, Tae-Hyun, Ryu, Dong-Ryeol, Moon, Sung Jin, Lee, Jung Eun, Huh, Wooseong, Kang, Ea Wha, Chang, Tae Ik, and Joo, Kwon Wook

Published
2020
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10. Efficacy of the HLA-B∗58:01 Screening Test in Preventing Allopurinol-Induced Severe Cutaneous Adverse Reactions in Patients with Chronic Renal Insufficiency—A Prospective Study

Author

Park, Heung-Woo, Kim, Dong Ki, Kim, Sae-Hoon, Kim, Sejoong, Chae, Dong-Wan, Yang, Min-Suk, Oh, Yun Kyu, Lee, Jung Pyo, Jung, Jae-Woo, Shin, Jungho, Hwang, Jin Ho, Kang, Min-Gyu, Kim, Sun Moon, Kwon, Soon Kil, Kim, Hye-Young, Kim, Min-Hye, Kim, Seung-Jung, Ryu, Dong-Ryeol, Cho, Young-Joo, Jee, Young-Koo, Kim, So Mi, Lee, Eun Kyoung, Kim, Ju-Young, Cho, Hyun Seop, Jeong, Yi Yeong, Kim, Sang-Heon, Jun, Jae-Bum, Park, Joon-Sung, Kim, Gheun-Ho, Kim, Sujeong, Jung, Hee-Yeon, and Lee, Jong-Myung

Published
2019
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15. A Randomized, Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and the Tolerability of a Triple Combination of Amlodipine/Losartan/Rosuvastatin in Patients With Comorbid Essential Hypertension and Hyperlipidemia

Author

Lee, Hae-Young, Kim, Seok-Yeon, Choi, Kee-Joon, Yoo, Byung-Su, Cha, Dong-Hun, Jung, Hae Ok, Ryu, Dong-Ryeol, Choi, Joon Hyouk, Lee, Kwang Je, Park, Tae Ho, Oh, Ju Hyeon, Kim, Sang Min, Choi, Ji-Yong, Kim, Kye Hun, Shim, Jaemin, Kim, Woo-Shik, Choi, Si-Wan, Park, Dae-Gyun, Song, Pil-Sang, Hong, Taek-Jong, Rhee, Moo-Yong, Rha, Seung-Woon, and Park, Seung Woo

Published
2017
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18. Occupational radiation exposure in femoral artery approach is higher than radial artery approach during coronary angiography or percutaneous coronary intervention

Author

Kim, Jung-Su, Lee, Bong-Ki, Ryu, Dong-Ryeol, Chun, Kwangjin, Kwon, Ho-Seok, Nam, So-Ra, Kim, Doo-il, Lee, Sung-Yun, Jeong, Jin-Ok, Bae, Jang-Whan, Park, Jong-Seon, Ahn, Youngkeun, Chae, Je-Keon, Yoon, Myeong-Ho, Lee, Seung-Hwan, Yoon, Jeonghan, Gwon, Hyeon-Cheol, Choi, Donghoon, Kwon, Soon-Mu, Roh, Young-Hoon, and Cho, Byung-Ryul

Published
2020
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34. Metformin use and cardiovascular outcomes in patients with diabetes and chronic kidney disease: a nationwide cohort study

Author

Kim, Min-Ho, Oh, Hyung Jung, Kwon, Soon Hyo, Jeon, Jin Seok, Noh, Hyunjin, Han, Dong Cheol, Kim, Hyoungnae, and Ryu, Dong-Ryeol

Subjects
medicine.medical_specialty, endocrine system diseases, business.industry, General Medicine, urologic and male genital diseases, medicine.disease, Metformin, Chronic kidney disease, Internal medicine, Diabetes mellitus, Medicine, Original Article, In patient, Mortality, Renal insufficiency, business, Cardiovascular outcomes, Cohort study, medicine.drug, Kidney disease
Abstract

Background Metformin has recently been shown not to increase the risk of lactic acidosis in patients with chronic kidney disease (CKD). Thus, the criteria for metformin use in this population has expanded. However, the relationship between metformin use and clinical outcomes in CKD remains controversial. Methods This study considered data from 97,713 diabetes patients with an estimated glomerular filtration rate of

Published
2021

35. Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury

Author

Li, Lilin, An, Jung Nam, Lee, Jeonghwan, Shin, Dong Jin, Zhu, Shi Mao, Kim, Jin Hyuk, Kim, Dong Ki, Ryu, Dong-Ryeol, Kim, Sejoong, and Lee, Jung Pyo

Subjects
Hepatocyte growth factor, Continuous renal replacement therapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, Hazard ratio, Acute kidney injury, Soluble c-Met, General Medicine, medicine.disease, Gastroenterology, Confidence interval, Internal medicine, Charlson comorbidity index, medicine, Original Article, In patient, Renal replacement therapy, business, Body mass index, Biomarkers, medicine.drug
Abstract

Background Hepatocyte growth factor (HGF)/cMet pathway is necessary for repair and regeneration following acute kidney injury (AKI). We evaluated the clinical potential of plasma HGF and soluble cMet as prognostic biomarkers for severe AKI requiring continuous renal replacement therapy (CRRT). Methods One hundred thirty-six patients with severe AKI who participated in the VENUS (volume management under body composition monitoring in critically ill patients on CRRT) trial between 2017 and 2019 were enrolled in this study. We investigated associations between plasma HGF and cMet concentrations and all-cause mortality. Results Plasma HGF and soluble cMet levels were positively correlated. Patients were divided into three groups based on their HGF and soluble cMet concentrations. The day D 0, D2, and D7 highest concentration HGF groups had significantly higher in-hospital mortality after adjusting for sex, body mass index, Acute Physiology and Chronic Health Evaluation II, and age-adjusted Charlson comorbidity index score, especially on D7 (hazard ratio, 4.26; 95% confidence interval, 1.71-10.62; p = 0.002). D7 soluble cMet level was also associated with mortality. Receiver operating characteristic curve analysis indicated that D7 HGF and soluble cMet levels were best at predicting mortality. Addition of plasma HGF and soluble cMet to conventional prognostic indices significantly improved the predictive value for mortality on D7. However, plasma HGF and soluble cMet were not associated with fluid status. Conclusion Plasma HGF and soluble cMet levels were significant predictors of the outcomes of severe AKI patients undergoing CRRT. There was no correlation between plasma HGF and soluble cMet levels and fluid balance.

Published
2021

36. Optimal blood pressure target in the elderly: rationale and design of the HOW to Optimize eLDerly systolic Blood Pressure (HOWOLD-BP) trial

Author

Lee, Dong-Hwa, primary, Lee, Ju-Hee, additional, Kim, So Young, additional, Lee, Hae-Young, additional, Choi, Jung-Yeon, additional, Hong, Youjin, additional, Park, Sue K., additional, Ryu, Dong Ryeol, additional, Yang, Dong Heon, additional, Hwang, Seok-Jae, additional, Choi, Jung Hyun, additional, Kim, Kye Hun, additional, Lee, Sun Hwa, additional, Joo, Seung Jae, additional, Park, Jae-Hyeong, additional, Kim, Sang-Hyun, additional, Kim, Hack-Lyong, additional, Kim, Kwang-il, additional, and Cho, Myeong-Chan, additional

Published
2022
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48. Optimal target blood pressure for major adverse cardiovascular and cerebrovascular events in hypertensive patients

Author

Kim, Seon-Mi, primary, Kim, Do-Hyang, additional, Ryu, Dong-Ryeol, additional, Lee, Soojin, additional, Kim, Yaerim, additional, Park, Sehoon, additional, Cho, Semin, additional, huh, Hyuk, additional, Hwang, Jinseub, additional, Lee, Jung-Pyo, additional, Han, Seung-Seok, additional, Lee, Hajeong, additional, Kim, Dong-Ki, additional, Joo, Kwon-Wook, additional, Lim, Chun-Soo, additional, Kim, Yon-Su, additional, and Oh, Hyung-Jung, additional

Published
2021
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49. GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study

Author

Lim, Jeong-Hoon, primary, Jeon, Yena, additional, Ahn, Ji-Sun, additional, Kim, Sejoong, additional, Kim, Dong Ki, additional, Lee, Jung Pyo, additional, Ryu, Dong-Ryeol, additional, Seong, Eun Young, additional, Ahn, Shin Young, additional, Baek, Seon Ha, additional, Jung, Hee-Yeon, additional, Choi, Ji-Young, additional, Park, Sun-Hee, additional, Kim, Chan-Duck, additional, Kim, Yong-Lim, additional, and Cho, Jang-Hee, additional

Published
2021
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