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22. MicroRNA-135b-5p Is a Pathologic Biomarker in the Endothelial Cells of Arteriovenous Malformations.

Author

Lee, Joon Seok, Kim, Gyeonghwa, Lee, Jong Ho, Ryu, Jeong Yeop, Oh, Eun Jung, Kim, Hyun Mi, Kwak, Suin, Hur, Keun, and Chung, Ho Yun

Subjects
ARTERIOVENOUS malformation, ENDOTHELIAL cells, BIOMARKERS, VASCULAR endothelial growth factors
Abstract

Arteriovenous malformations (AVMs) are congenital vascular anomalies with a poor prognosis. AVMs are considered intractable diseases, as there is no established approach for early diagnosis and treatment. Therefore, this study aimed to provide new evidence by analyzing microRNAs (miRNAs) associated with AVM. We present fundamental evidence for the early diagnosis and treatment of AVM by analyzing miRNAs in the endothelial cells of AVMs. This study performed sequencing and validation of miRNAs in endothelial cells from normal and AVM tissues. Five upregulated and two downregulated miRNAs were subsequently analyzed under hypoxia and vascular endothelial growth factor (VEGF) treatment by one-way analysis of variance (ANOVA). Under hypoxic conditions, miR-135b-5p was significantly upregulated in the AVM compared to that under normal conditions, corresponding to increased endothelial activity (p-value = 0.0238). VEGF treatment showed no significant increase in miR-135b-5p under normal conditions, however, a surge in AVM was observed. Under both hypoxia and VEGF treatment, comparison indicated a downregulation of miR-135b-5p in AVM. Therefore, miR-135b-5p was assumed to affect the pathophysiological process of AVM and might play a vital role as a potential biomarker of AVMs for application related to diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Catastrophic rhabdomyolysis following breast reconstruction operation using an abdominal flap: a case report

Author

Kang, Myeong Jae, primary, Cho, Hyun Geun, additional, Lim, Jeong-Hoon, additional, Byun, Sung-Hye, additional, Lee, Su-Hyun, additional, Kang, Byeongju, additional, Lee, Jeeyeon, additional, Park, Ho Yong, additional, Ryu, Jeong Yeop, additional, Choi, Kang Young, additional, Yang, Jung Dug, additional, Chung, Ho Yun, additional, Cho, Byung Chae, additional, and Lee, Joon Seok, additional

Published
2023
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29. Technical approach and clinical outcomes of delayed two-stage tissue expander/implant breast reconstruction: a single-institution experience

Author

Kang, Myeong Jae, primary, Lee, Jung Ho, additional, Jeon, Hyeon Jun, additional, Ryu, Jeong Yeop, additional, Lee, Joon Seok, additional, Choi, Kang Young, additional, Chung, Ho Yun, additional, Cho, Byung Chae, additional, Lee, Jeeyeon, additional, Park, Ho Yong, additional, and Yang, Jung Dug, additional

Published
2023
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34. Anatomical View of Thoracodorsal Artery Variants Using Computed Tomography Angiography.

Author

Cho, Hyun Geun, Kang, Byeongju, Ryu, Jeong Yeop, Choi, Kang Young, Yang, Jung Dug, Chung, Ho Yun, Cho, Byung Chae, Lee, Jeeyeon, Park, Ho Yong, and Lee, Joon Seok

Subjects
COMPUTED tomography, MAMMAPLASTY, ANGIOGRAPHY, PLASTIC surgery, PERFORATOR flaps (Surgery), BLOOD circulation, ARTERIES
Abstract

Background The latissimus dorsi (LD) muscle has a dominant pedicle with one thoracodorsal artery and receives sufficient blood by segmental circulation through several perforators. Thus, it is widely used in various reconstructive surgeries. We are reporting on the patterns of the thoracodorsal artery analyzed by chest computed tomography (CT) angiography. Methods We analyzed the preoperative chest CT angiography results of 350 patients scheduled to undergo LD flap breast reconstruction following complete mastectomy for breast cancer between October 2011 and October 2020. Results A total of 700 blood vessels were classified according to the Kyungpook National University Plastic Surgery-Thoracodorsal Artery (KNUPS-TDA) classification: 388 (185 right and 203 left), 126 (64 right and 62 left), 91 (49 right and 42 left), 57 (27 right and 30 left), and 38 (25 right and 13 left) vessels were classified as type I, type II, type III, type IV, and type V, respectively. Among 350 patients, 205 patients showed matching types for left and right vessels, whereas 145 patients showed mismatching types. For 205 patients with matching types, the distribution by type was 134, 30, 30, 7, and 4 patients with type I, type II, type III, type IV, and type V, respectively. For 145 patients with mismatching types, the distribution by different combinations was 48, 25, 28, 19, 2, 9, 7, 3, 1, and 3 patients with type I + type II, type I + type III, type I + type IV, type I + type V, type II + type III, type II + type IV, type II + type V, type III + type IV, type III + type V, and type IV + type V, respectively. Conclusion While there is some diversity in the vascular anatomical structures of the LD flap, the dominant vessel can be found in a similar location in almost all cases and no flap had absence of a dominant vessel. Therefore, in surgical procedures using the thoracodorsal artery as the pedicle, preoperative radiological confirmation is not absolutely necessary; however, due to variants, performing the surgery with an understanding of this aspect should lead to good outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Clinical assessment and management of auricular arteriovenous malformation: retrospective study

Author

Kim, Do Gon, Cho, Hyun Geun, Ryu, Jeong Yeop, Lee, Joon Seok, Lee, Seok Jong, Lee, Jong Min, Lee, Sang Yub, Huh, Seung, Kim, Ji Yoon, and Chung, Ho Yun

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Arteriovenous malformation, Retrospective cohort study, Stage ii, Multidisciplinary communications, medicine.disease, Lower half, Surgery, Lesion, Plastic surgery, Otorhinolaryngology, Sclerotherapy, AVM protocol, Medicine, Original Article, Stage (cooking), medicine.symptom, business
Abstract

Background Arteriovenous malformation (AVM) which is a high-blood-flow lesion with connections between arteries and veins without an intervening capillary bed, is difficult to manage. The ear is the second most common site of extracranial AVM. However, studies regarding the management of this condition remain lacking. The purpose of this study was to share managing experiences in our center and to investigate the treatment effect through a retrospective analysis of cases. Methods Among 265 patients with AVM treated in our vascular anomalies center between January 2008 and January 2021, 10 patients with auricular AVM were included in the study to investigate the lesion distribution, clinical stage, and treatment methods by performing a retrospective evaluation. Results Among 10 patients, five patients had AVMs distributed in the upper half of the ear, one patient in the lower half of the ear, and four patients in whole ear, respectively. Seven patients had Schobinger stage II, and three had stage III. One patient received surgical treatment only, four patients received sclerotherapy only, and five patients received both surgical treatment and sclerotherapy. The posttreatment status was checked as controlled in two patients, improved in seven patients, persistent in one patient. There were no worsening patients. Conclusion Auricular AVM is a disease that is difficult to manage by one specific department, thus requiring a collaborative management effort from multidisciplinary team.

Published
2021
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39. Oscillatory shear stress promotes angiogenic effects in arteriovenous malformations endothelial cells

Author

Ryu, Jeong Yeop, Kim, Yun Hyun, Lee, Joon Seok, Lee, Jeong Woo, Oh, Eun Jung, Kim, Hyun Mi, Lee, Seok-Jong, Lee, Jongmin, Lee, Sang Yub, Huh, Seung, Kim, Ji Yoon, Im, Saewon, and Chung, Ho Yun

Subjects
Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Adolescent, Angiogenesis, Endothelial cells, Receptor, Transforming Growth Factor-beta Type I, Gene Expression, Transforming growth factor-beta type I, Stress (mechanics), Angiopoietin-2, lcsh:Biochemistry, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Shear strength (soil), Arteriovenous malformations, Genetics, Shear stress, medicine, Humans, lcsh:QD415-436, Child, Molecular Biology, Genetics (clinical), Shearing (physics), Neovascularization, Pathologic, Aquaporin 1, Chemistry, lcsh:RM1-950, Arteriovenous malformation, Arteries, medicine.disease, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Shear strength, Molecular Medicine, Female, Stress, Mechanical, Shear flow, 030217 neurology & neurosurgery, Research Article, Receptor
Abstract

Background Vascular endothelial cells (ECs) are subject to continuous shear stress due to blood circulation. Mechanical stress due to high shear flow can also cause arteriovenous malformation (AVM) when ECs respond hyper-sensitively to shear flow. This study was conducted to test the hypothesis that angiogenesis could be promoted in response to mechanical stress via regulation of pro-angiogenic factors in AVM cells. Methods ECs were extracted from the tissue samples from six AVM patients and six normal patients. Shear stress at 7 dynes/cm2 were applied for 24 h. Before and after application of shear stress to each group, RT-PCR was performed to access the expression levels of angiopoietin2(AGP2), aquaporin1(AQP1) and TGFβR1. Immunofluorescences was also performed to evaluate the level of protein expressions. Results In both normal and AVM tissues, AGP2 and TGFβR1 under the shear stress showed increased expression in the ECs compared to the non-sheared samples. When AVMs and normal arterial vasculature were compared, the expression levels of both AGP2 and TGFβR1 in AVMs were higher when compared to normal arterial vasculature with or without shear stress. Immunofluorescence-based protein analysis also confirmed shear-induced AGP2 and TGFβR1 in both samples of normal and AVM patients. Conclusions AVMs exhibited higher sensitivity to shear stress by producing higher expressions of some marked genes and proteins that regulate the endothelial functions upon exposure to shear stress. While the physiological mechanism for AVMs remain elusive, our study shows the plausibility of physical stress imposed by the shearing flow can cause the occurrence of AVMs.

Published
2021

48. An Experimental Study in the Canine Mandible

Author

Lee, Joon Seok, Park, Tae Hyun, Ryu, Jeong Yeop, Kim, Dong Kyu, Oh, Eun Jung, Kim, Hyun Mi, Shim, Jin-Hyung, Yun, Won-Soo, Huh, Jung Bo, Moon, Sung Hwan, Kang, Seong Soo, and Chung, Ho Yun

Subjects
aggregate, adipose-derived stem cells, osteogenesis, 3D-printed PCL/TCP/bdECM scaffold
Abstract

Three-dimensional (3D) printing is perceived as an innovative tool for change in tissue engineering and regenerative medicine based on research outcomes on the development of artificial organs and tissues. With advances in such technology, research is underway into 3D-printed artificial scaffolds for tissue recovery and regeneration. In this study, we fabricated artificial scaffolds by coating bone demineralized and decellularized extracellular matrix (bdECM) onto existing 3D-printed polycaprolactone/tricalcium phosphate (PCL/TCP) to enhance osteoconductivity and osteoinductivity. After injecting adipose-derived stem cells (ADSCs) in an aggregate form found to be effective in previous studies, we examined the effects of the scaffold on ossification during mandibular reconstruction in beagle dogs. Ten beagles were divided into two groups: group A (PCL/TCP/bdECM + ADSC injection, n = 5) and group B (PCL/TCP/bdECM, n = 5). The results were analyzed four and eight weeks after intervention. Computed tomography (CT) findings showed that group A had more diffuse osteoblast tissue than group B. Evidence of infection or immune rejection was not detected following histological examination. Goldner trichrome (G/T) staining revealed rich ossification in scaffold pores. ColI, Osteocalcin, and Runx2 gene expressions were determined using real-time polymerase chain reaction. Group A showed greater expression of these genes. Through Western blotting, group A showed a greater expression of genes that encode ColI, Osteocalcin, and Runx2 proteins. In conclusion, intervention group A, in which the beagles received the additional ADSC injection together with the 3D-printed PCL/TCP coated with bdECM, showed improved mandibular ossification in and around the pores of the scaffold.

Published
2021
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