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Introduction Post-Traumatic Stress Disorder (PTSD) is a psychiatric disorder that can occur after a traumatic event. It results in mental suffering and physical complications that profoundly alter personal, social, and professional life. One can develop PTSD after experiencing a frightening event, for example: rape, the death of a loved one, war veterans, or following a car accident. In Morocco, traffic accidents cause, on average, nearly 3,500 deaths and 12,000 serious injuries per year. Objectives Our main purpose is to evaluate the incidence of post-traumatic stress disorder in patients who are victims of traffic accidents and to identify key risk factors in the general population. Methods This is a descriptive cross-sectional study through a questionnaire shared on social networks including a socio-demographic description, a clinical description, and the “Peri-traumatic Distress Inventory (PDI)” Scale to evaluate the risk of developing PTSD. Results This study is based on 48 participants with 82.8% of females and 17.2% of men. The average age was 27.6. Most of the participants lived in urban areas (93%), a majority had higher education (93.1%), and 41.4% of the candidates had a physical impact of the accident. According to PDI scale, 65% showed PTSD and the average score was 20.3. A score of 15 and above indicates significant distress. Conclusions Our results confirm the presence of PTSD in victims of accidents. We propose a clinical reflection on the possible improvement of the care of people suffering from PTSD following a public road accident. Disclosure of Interest None Declared

Introduction Depression in psychosis has been more or less neglected as a field of study, due to its vague nosographic framework. Some studies have nevertheless focused on certain features of depression in psychosis, such as post-psychotic depression. This is a frequent phenomenon with a nosographic and etiopathogenic complexity that can lead to confusion. Objectives To study the characteristics of post-psychotic depression and compare results with those in the literature. Methods It is a prospective, descriptive, case series study conducted at the Ar-Razi psychiatric hospital in Salé. Inclusion criteria were patients diagnosed with a brief psychotic disorder, schizophreniform disorder or schizophrenia, in remission, who met the criteria for a DSM 5 characterized depressive episode. Data are collected during the psychiatric interview with the patient, using a questionnaire. Results Ongoing Conclusions Ongoing Disclosure of Interest None Declared

The neuroendocrine protein secretogranin II is the precursor of several neuropeptides, including secretoneurin and a novel 66-amino acid peptide, EM66, the sequence of which has been highly conserved across the vertebrae phylum. The presence of EM66 has been detected in the adult and fetal human adrenal gland, as well as the rat pituitary and adrenal glands. The present study aimed to explore a possible neuroendocrine role of EM66 by analysing its occurrence and distribution within the jerboa hypothalamus, and its potential implication in the control of feeding behaviour. High-performance liquid chromatography analysis of jerboa hypothalamic extracts combined with a radioimmunoassay of EM66 revealed a single peak of immunoreactive material exhibiting the same retention time as recombinant EM66. Immunocytochemical labelling showed that EM66-producing neurones are widely distributed in several hypothalamic regions, including the preoptic area, the suprachiasmatic, supraoptic, parvocellular paraventricular and arcuate nuclei, and the lateral hypothalamus. Food deprivation for 5 days induced a significant increase in the number of EM66-containing neurones within the arcuate nucleus (105% increase) and the parvocellular aspect of the paraventricular nucleus (115% increase), suggesting that EM66 could be involved in the control of feeding behaviour and/or the response to stress associated with fasting. Altogether, these data reveal the physiological plasticity of the EM66 system in the hypothalamus and implicate this novel peptide in the regulation of neuroendocrine functions.