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The differential cross sections of the Σ^{-}p→Λn reaction were measured accurately for the Σ^{-} momentum (p_{Σ}) ranging from 470 to 650 MeV/c at the J-PARC Hadron Experimental Facility. Precise angular information about the Σ^{-}p→Λn reaction was obtained for the first time by detecting approximately 100 reaction events at each angular step of Δcosθ=0.1. The obtained differential cross sections show a slightly forward-peaking structure in the measured momentum regions. The cross sections integrated for -0.7≤cosθ≤1.0 were obtained as 22.5±0.68 [statistical error(stat.)] ±0.65 [systematic error(syst.)] mb and 15.8±0.83(stat)±0.52(syst) mb for 470p_{Σ}(MeV/c)550 and 550p_{Σ}(MeV/c)650, respectively. These results show a drastic improvement compared with past measurements of the hyperon-proton scattering experiments. They will play essential roles in updating the theoretical models of the baryon-baryon interactions.

In an emulsion-counter hybrid experiment performed at J-PARC, a Ξ^{-} absorption event was observed which decayed into twin single-Λ hypernuclei. Kinematic calculations enabled a unique identification of the reaction process as Ξ^{-}+^{14}N→_{Λ}^{10}Be+_{Λ}^{5}He. For the binding energy of the Ξ^{-} hyperon in the Ξ^{-}-^{14}N system a value of 1.27±0.21 MeV was deduced. The energy level of Ξ^{-} is likely a nuclear 1p state which indicates a weak ΞN-ΛΛ coupling.

In an emulsion-counter hybrid experiment performed at J-PARC, a Ξ^{-} absorption event was observed which decayed into twin single-Λ hypernuclei. Kinematic calculations enabled a unique identification of the reaction process as Ξ^{-}+^{14}N→_{Λ}^{10}Be+_{Λ}^{5}He. For the binding energy of the Ξ^{-} hyperon in the Ξ^{-}-^{14}N system a value of 1.27±0.21 MeV was deduced. The energy level of Ξ^{-} is likely a nuclear 1p state which indicates a weak ΞN-ΛΛ coupling.

Charge changing cross sections (\(\sigma _{\text{CC}}\)) for ^40–48K and ^42–51Ca have been measured using BigRIPS at RIBF, RIKEN. The \(\sigma _{\text{CC}}\) obtained along the long isotopic chain of K and Ca revealed the fact that \(\sigma _{\text{CC}}\) have strong proton separation energy () dependence. The data are compared with the calculation based on the Glauber model and also with the proton evaporation model. It is found that the \(\sigma _{\text{CC}}\) data are well reproduced when the proton evaporation effect is taken into account.

Interaction cross sections for ^{42-51}Ca on a carbon target at 280 MeV/nucleon have been measured for the first time. The neutron number dependence of derived root-mean-square matter radii shows a significant increase beyond the neutron magic number N=28. Furthermore, this enhancement of matter radii is much larger than that of the previously measured charge radii, indicating a novel growth in neutron skin thickness. A simple examination based on the Fermi-type distribution, and mean field calculations point out that this anomalous enhancement of the nuclear size beyond N=28 results from an enlargement of the core by a sudden increase in the surface diffuseness of the neutron density distribution, which implies the swelling of the bare ^{48}Ca core in Ca isotopes beyond N=28.

A new hyperon-proton scattering experiment, dubbed J-PARC E40, was performed to measure differential cross sections of the Σ+p, Σ−p elastic scatterings and the Σ−p → Λn scattering by identifying a lot of Σ particles in the momentum ranging from 0.4 to 0.8 GeV/c produced by the π±p → K+Σ± reactions. We successfully measured the differential cross sections of these three channels with a drastically improved accuracy with a fine angular step. These new data will become important experimental constraints to improve the theories of the two-body baryon-baryon interactions. Following this success, we proposed a new experiment to measure the differential cross sections and spin observables by using a highly polarized Λ beam for providing quantitative information on the ΛN interaction. The results of three Σp channels and future prospects of the Λp scattering experiment are described.

International audience; A part of the experiment was performed in 2018 and 2019 in J-PARC. As a result of analyzing the collected data, the \(\Sigma ^{ - }\) production and the \(\Sigma ^{ - }p\) scattering reaction have been identified. It means that our new measurement and analysis method are successfully working well. Analysis for deriving the differential cross section of the \(\Sigma p\) scattering is on going.

International audience; The \(\pi ^{ - }p \to K^{0}\Lambda \) reaction is an important elementary process to produce \(\Lambda \) from a proton target and is a key for a \(\Lambda p\) scattering experiment where the momentum of \(\Lambda \) should be tagged from the missing momentum of the \((\pi ^{ - },K^{0})\) reaction. However, the \((\pi ^{ - },K^{0})\) spectroscopy method has not been established yet due to the difficulty of the K^0 detection. Therefore, we have proposed a new K^0 detection method where \(\pi ^{ + }\) and \(i^{ - }\) from the K^0 decay are measured by a forward magnetic spectrometer and a detector cluster surrounding the target, respectively. The feasibility of the K^0 detection method was confirmed by analyzing the J-PARC E40 data taken with such a detector system. In the analysis, \(\Lambda \)’s were successfully identified in the missing mass spectrum of the \(\pi ^{ - }p \to K^{0}X\) reaction.

J-PARC E07 is the most complex emulsion experiment to date investigating double hypernuclei with a hybrid emulsion method. This experiment aims to detect 104 Ξ− stop events, ten times more events than the past experiments. Thus, an unequivocal identification of several new double hypernuclei is expected. The beam exposure has been completed at the K1.8 beam line of the J-PARC hadron facility in June 2017. The photographic development of all emulsion sheets has also been completed in February 2018. The emulsion sheets are presently being analyzed with dedicated optical microscopes. Current statistics is comparable to that of E373 and so far 10 events of 3-vertices topology have been detected. A typical event of double Λ hypernucleus and a twin Λ hypernucleus are introduced. We plan to complete the main part of the emulsion scanning within a year.

A high statistics ∑p scattering experiment has been performed at the K1.8 beamline in the J-PARC Hadron Experimental Facility. Data for momentum-tagged ∑− beam running in a liquid hydrogen target were accumulated by detecting the π − p → K + ∑ − reaction with a high intensity π− beam of 20 M/spill. The number of the Σ− beam was about 1.7 × 107 in total. The ∑−ρ elastic scattering and the ∑−p → Λn inelastic scattering events were successfully observed with about 100 times larger statistics than that in past experiments.

Over these decades, tourism industry has developed very rapidly. Tourism evidently improves sustainability especially in rural by prosperity enhancement. Japan is nominated as the decade’s fastest-growing major destination with a 334% rise of arrival from 2010-2017. Moreover, Japan pulls out a tourism goal, aiming 40 million arrivals with JPY 8 trillion receipts by the year 2020. Rural areas are promoted to be tourist destination as an effort for sustaining rural landscape. But, it is not the case for Kita Village. Kita Village is one of famous rural heritage destinations located in Kyoto Prefecture with excellent Satoyama landscape. Residents of Kita Village agreed to preserve the Satoyama landscape through tourism. Maintaining a heritage site is not easy nor cheap. Economic needs couldn’t be denied to sustain the area. Tourists’ visitation is increasing each year, yet the tourism income is low. Therefore, increasing tourism income became an important issue in Miyama to sustain the Satoyama landscape. Literature have shown domestic and international tourists are different. With the increasing international tourists in Kita Village, this study aimed to explore each group and compare their consumption behavior. Tourists’ consumption behavior is studied to understand the tourism demands to increase tourism income in Kita Village, aiming for local revitalization and Satoyama landscape preservation. Data collected through a questionnaire survey in Spring. Results showed that expenditure between domestic and international tourists in Kita Village is not significantly different, JPY1954 for domestic tourists and JPY1994 for international tourists, yet the tourism attitudes between the two groups were different. Domestic and international tourists are significantly different in age, companion, transportation, times visited Miyama, duration, motivation, activity preference, and price preference. Expenditure is affected by marital status, age, duration, satisfaction, motivation, product preference, and price preference. This study managed to discover that the low tourism receipt from international tourists is mainly due to the incompatibility of the type of program. While for domestic tourists, the low tourism receipt is mainly due to the high price offered. It is suggested to make tourism program development as priority for tourism development.

International audience; Although more detailed analysis for deriving the cross section of \(\Sigma p\) scattering is necessary to derive the cross section of \(\Sigma p\) scattering, we have confirmed that CFT has enough angular resolution of tracking and energy resolution in order for the identification of the scattering events and particles.

International audience; J-PARC E40 aims to measure the differential cross sections of the Σ^±p elastic scatterings and the Σ^−p → Λn conversion. A clear peak of Σ^− was observed in a missing mass spectrum of the π^−p → K^+X reaction and recoil protons from the πp elastic scattering were successfully observed in the data taken in the summer 2018. The rest of data taking is coming in the spring 2019.

A double-$\Lambda$ hypernucleus, ${}_{\Lambda\Lambda}\mathrm{Be}$, was observed by the J-PARC E07 collaboration in nuclear emulsions tagged by the $(K^{-},K^{+})$ reaction. This event was interpreted as a production and decay of $ {}_{\Lambda\Lambda}^{\;10}\mathrm{Be}$, ${}_{\Lambda\Lambda}^{\;11}\mathrm{Be}$, or ${}_{\Lambda\Lambda}^{\;12}\mathrm{Be}^{*}$ via $\Xi^{-}$ capture in ${}^{16}\mathrm{O}$. By assuming the capture in the atomic 3D state, the binding energy of two $\Lambda$ hyperons$\,$($B_{\Lambda\Lambda}$) of these double-$\Lambda$ hypernuclei are obtained to be $15.05 \pm 0.11\,\mathrm{MeV}$, $19.07 \pm 0.11\,\mathrm{MeV}$, and $13.68 \pm 0.11\,\mathrm{MeV}$, respectively. Based on the kinematic fitting, ${}_{\Lambda\Lambda}^{\;11}\mathrm{Be}$ is the most likely explanation for the observed event., Comment: 11 pages, 3 figures

Background The incidence of Kawasaki disease has been increasing since it was first reported by Tomisaku Kawsasaki in 1967. Among complications of the condition, the formation of coronary artery aneurysms is the most important. In particular, giant aneurysms with diameters that exceed 8 mm are likely to not regress and result in serious complications, such as acute myocardial infarction. Objectives To understand the long-term course of patients with giant aneurysms and Kawasaki disease as well as to consider the cause of aneurysm formation and its appropriate treatment. Methods We retrospectively studied the long-term course of 12 cases of giant coronary artery aneurysms accompanied with Kawasaki disease, which were being followed at Shiga University of Medical Science Hospital, Omihachiman Community Medical Center, and Nagahama Red Cross Hospital. These are three major facilities in Shiga prefecture of Japan, whose population is 1.4 million, comprising 200,000 children. Results Ten male and two female patients were included. The average current age was 16.8 years, the median age was 14.3 (10.7–18.9) years, and 5 cases were of adults. The average age at the time of onset was 3.5 years, the median age was 3.7 years (1.8 - 4.4), and all experienced onset between 1 and 5 years of age. The mean period from onset to treatment start was 6.7 days (median 5.0 (4.3–8.3)), but the average period until fever declined was 16.0 days and only three patients9 temperature was reduced in 10 days. Aneurysm formation occurred at 14.1 days on average (median 12 (10–17)). The average size of the maximum coronary artery aneurysm at onset was 11.3 mm, and the median size was 9.5 mm (8.8 mm – 13.8 mm).The average and median follow-up periods were 13.2 years and 11.7 years (5.4–13.4), respectively. The number of patients received steroid therapy was four, and all their onset was after 2006. None received infliximab or underwent plasmapheresis. During the course of the condition, all patients underwent multiple centripetal echocardiography. Among all cases, 7 underwent coronary angiography CT, 10 underwent myocardial scintigraphy. All 12 patients underwent cardiac catheterization and the total number of underwent cardiac catheterization for them was thirty-one. Two adult patients had a history of acute myocardial infarction and had undergone cardiac bypass surgery. Through this survey, we found that 9 cases developed giant coronary artery aneurysm between 1983 and 2007, and 3 cases between 2012 and 2015 used prednisolone. Conclusions All patients are currently receiving anticoagulant therapy and undergoing diagnostic imaging. In our prefecture, the incidence of giant coronary artery aneurysm accompanied with Kawasaki disease has been decreasing gradually. From 2007 to 2012, in which high dose gamma globulin therapy (2g/kg) has become commonly underwent for Kawasaki disease in Japan, there were no giant aneurysm formation in our hospitals. Three patients in whom giant aneurysms developed between 2012 and 2015 were taking oral prednisolone, thereby suggesting a relationship between prednisolone and giant aneurysm formation. Disclosure of Interest None declared

The spatial dispersal patterns ofTomato yellow leaf curl virus (TYLCV) disease vectored by the B and Q biotypes of the whiteflyBemisia tabaci in tomato glasshouses were compared. Tomato plants were arranged in glasshouses and TYLCV-infected plants were placed in the center of each plot. Adult whiteflies of each biotype were released onto TYLCV-infected plants and the insects were then freely dispersed in the glasshouses under high or moderate temperature conditions. The abundance and spatial distribution of dispersed whiteflies did not differ between the B and Q biotypes in tomato glasshouses. The disease incidence and dispersion of TYLCV as a result of short-distance movement of the whiteflies were also similar between the two biotypes, although on several investigation dates there was a tendency for the disease incidence caused by the B biotype to be slightly greater than that caused by the Q biotype. These results demonstrated that the aspects of spatial spread of TYLCV vectored by the B and Q biotypes ofB. tabaci in tomato glasshouses are similar.

Summary The aim of this study was to examine the pharmacokinetics of clinically applied benzoporphyrin derivative monoacid ring-A (BPD-MA; Verteporfin®), a second-generation photosensitizer, during a trial of photodynamic therapy (PDT) in nine dogs having naturally occurring neoplasms. After injecting BPD-MA at 0.5 mg/kg intravenously, its mean half-life (t1/2) was found to be 8.14 ± 5.34 h, mean clearance (Cl) 35.13 ± 9.62 ml/(h kg), the mean value of the volume of distribution (Vc) 0.08 ± 0.01 l/kg and the mean steady state volume of distribution (Vss) 0.38 ± 0.31 l/kg respectively. With the exception of a transitional increase in serum alkaline phosphatase activity, no other clinical abnormalities were observed. The t1/2 in dogs with naturally occurring tumours was longer than that in humans, but similar to that in rats. The values of Cl and Vss in dogs having naturally occurring neoplasms were lower than those in humans. It is suggested that the pharmacokinetics of BPD-MA in tumour-bearing dogs would be helpful in determining the protocol of a short drug-light interval PDT with BPD-MA that mainly targets the tumour vasculature.

The isotopic ratio of molecules often provides valuable information about past or presently occurring processes in the atmosphere because chemical and physical processes may give rise to isotope fractionation of molecular species. However, there are so far no published satellite measurements on the spatial and temporal variations of ozone isotopes in the stratosphere. Spectroscopic remote sensing methods can theoretically be used to observe ozone isotope fractionation on a global scale, but sufficient accuracy has not yet been achieved. A new generation of submillimeter-wave receivers employing sensitive superconductor-insulator-superconductor (SIS) detector technology will provide new opportunities for precise remote sensing measurements of ozone isotopes on a global scale. We have estimated the observation capabilities of two different SIS instruments, namely the space-station-borne Japanese Experimental Module/Sub-Millimeter-wave Limb Emission Sounder (JEM/SMILES) instrument, currently planned for launch in 2008, as well as the airborne Submillimeter wave Atmospheric Sounder/Airborne Submillimeter SIS Radiometer (SUMAS/ASUR) sensor. Measurements of the airborne sensor, conducted in 1996, are presented in order to demonstrate the detection of normal-O/sub 3/ and asymmetric-18-O/sub 3/ in the SMILES frequency bands. In the ideal case, JEM/SMILES has the capability to measure the ozone isotope enrichment (/spl delta//sup M/O/sub 3/) in the middle stratosphere with a precision of /spl sim/12/sup 0///sub 00/, /spl sim/11/sup 0///sub 00/, and /spl sim/9/sup 0///sub 00/, for asymmetric-18-O/sub 3/, symmetric-17-O/sub 3/, asymmetric-17-O/sub 3/, respectively, for a daily zonal mean product with resolution of 10/spl deg/ in latitude. The systematic error, including contributions of all instrumental and spectroscopic uncertainties, is estimated to be of the order of 100/sup 0///sub 00/ to 200/sup 0///sub 00/ and should be reduced by prelaunch laboratory measurements and in-flight calibrations. A remaining bias in the SMILES measurements will have to be quantified by dedicated validation campaigns. JEM/SMILES should then be capable to provide valuable information on the global distribution and seasonal variation of ozone isotope fractionation in the stratosphere. This new technology will allow us to shed new light on this still open issue in atmospheric sciences.

Of 875 idiopathic carpal tunnel syndrome (CTS) cases, 101 (11.5%) required trigger digit release operations within three years before and/or after carpal tunnel release (CTR); these 101 cases were investigated, retrospectively. Trigger digit release (TDR) was performed most often after the CTR, especially within three months. Next most common was at the same time as the CTR. The TDR performance rate after CTR was 5.9%. The nerve conduction study (NCS) comparison between trigger digits-associated CTS and isolated CTS showed that pre-operative distal motor latency was significantly more delayed in trigger digits-associated CTS, while there was no evidence of any difference due to age or gender. The difference of operative method (open or endoscopic procedure) did not influence the incidence rate of trigger digits after the CTR. This study suggested that trigger digits-associated CTS has a previously developed wide-ranging narrowing of the flexor tendon sheath.

To establish a method for investigating hidden radiation sources and their mechanisms in a printed circuit board, we performed preliminary measurements of one-dimensional magnetic near-field distribution over pins of a large-scale integrated circuit (LSI) package by means of an optical method: the fiber-edge magnetooptic (FEMO) probing technique. The FEMO probe consists of fiber optics and a magnetooptic crystal glued at a fiber edge. Its planar spatial resolution is approximately 100 /spl mu/m. It was found that a magnetic field generated from each LSI pin could be distinguished and some radiation was generated from ground and power supply lines. We compared the measured results with corresponding radiated electric field strength that was separately measured. The frequency of interest was the tenth harmonic of the output signal. We observed a strong correlation between those two experimental results, which suggests the effectiveness of our proposed method for near-field investigation. One of the beneficial features of the FEMO probe is its small probe head, due to which one can perform detailed near-field evaluations in a microscopic region. Furthermore, we tried to specify a major electromagnetic interference source by additional measurements of near-field distributions and frequency dependence of magnetooptic signals. It was suggested that the short-through current flowing in the power-supply system of the input/output circuits caused high-level radiated emission.

Helminth antigens were investigated in the search for accessible heterologous antigens capable to discriminate different helminthiases, by the enzyme linked immunosorbent assay (ELISA) and the immunoblot assay (IB). Antigens used were: Taenia solium cysticercus total saline (Tso); Taenia crassiceps cysticercus vesicular fluid (Tcra-VF); T. crassiceps cysticercus glycoproteins (Tcra-GP and Tcra-(18-14)-GP); Toxocara canis larva excretory-secretory (TES); Schistosoma mansoni adult total saline (Sm) and Echinococcus granulosus hydatid fluid (Eg). The assayed sera were from patients with: cysticercosis (n = 18); toxocariasis (n = 40); schistosomiasis (n = 19) and hydatidosis (n = 50) with proven clinical and laboratory diagnosis, and sera from rabbits immunized with Tso, Tcra-VF, TES and Eg. Cross-reactivity occurred mostly between infections caused by Taenia and Echinococcus or in immunized rabbits, by ELISA. Moreover, the cross-reactivity among helminthiases was found with the use of antigens belonging to phylogenetically related parasite species, Eg, Tso and Tcra-VF, by sharing same antigenic components. Lower cross-reactivities were obtained by IB technique, when only peptides were considered as antigens, and the use of T. crassiceps purified glycoproteins demonstrated high sensitivity and specificity in the diagnosis of human cysticercosis, similarly to that using homologous antigen (Tso) by the same technique.

The performance (bandwidth, sensitivity, and spatial resolution) of a fiber edge magnetooptic (FEMO) probe developed for observing three-dimensional magnetic-field distributions was evaluated. A gigahertz bandwidth was achieved without any magnetic bias by using the magnetization rotation in a magnetooptic crystal. The ferromagnetic resonance restricted the observation bandwidth to around 10 GHz. Precise adjustment of the polarization and efficient use of the optical amplifier enhanced the magnetic field sensitivity, enabling an electric current of less than 0.05 mA to be detected. The concept of "sensitive volume" was used to measure the spatial resolution in three-dimensional space; reducing the sensitive volume improved the spatial resolution. Magnetic fields above a microwave patch antenna and around a 10-/spl mu/m-class circuit board were observed using FEMO probes. The FEMO probe should thus be effective for evaluating microwave and miniature circuits.

Brazilian purpuric fever (BPF) is an acute disease caused by Haemophilus influenzae biogroup aegyptius; it is characterized by fever, purpura, and hypotensive shock and is usually fatal. The factors responsible for bacterial virulence and pathogenesis are poorly known. Hemagglutinins have been frequently associated with bacterial virulence, and, in the present study, hemagglutinating activity was detected in extracellular products from H. influenzae biogroup aegyptius strains isolated from patients with BPF. A 60-kilodalton (kDa) molecule absorbable by human O-type erythrocytes was identified by an immunoblot assay; a corresponding fraction was chromatographically purified, and its pathogenic effect was evaluated. Rabbits injected intravenously with either the whole bacterial extracellular product or the 60-kDa fraction showed reactions similar to those seen in patients with BPF: purpura, congestion, and fibrin thrombi in the inner organs. We suggest that this hemagglutinating factor is one of the major pathogenic components of BPF.

Recent measles outbreaks in different countries led to an increase of laboratory measles diagnosis. Thus, we developed the IgM-Measles ELISA IAL, using measles virus antigens obtained from cell cultured in microcarriers in order to supply reagent kits to Brazilian public health laboratories. A batch of antigenic reagent was produced and evaluated in the enzyme immunoassay in comparison with clinical diagnosis and with as reference assay (IgM Capture ELISA CDC) data. This study was performed in a positive panel with 70 serum samples from patients with measles, and a negative panel with 132 samples from patients with unrelated diseases and without recent measles or vaccination history. In relation to other diagnostic methods, the IgM ELISA IAL presented sensitivity higher than 97.1%, specificity and precision of 97%, and agreement kappa (k) index higher than 0.94 (P < 0.05). Moreover, the IgM antibody profile from measles acute phase revealed by the assay was similar to the reference assay. A practical analysis system for checking the quality of new reagent batches was proposed based on the diagnostic features and agreement kappa index. Our findings suggest that measles antigenic reagents can be produced with reliable quality control system, and supplied to public health laboratories for routine serodiagnosis or population surveys.

The expression of p53 and PCNA on deparaffinized sections of tumor was assessed in relation to the International Index and response to chemotherapy. Thirty-five non-Hodgkin's lymphoma (NHL) patients were divided into three groups: aggressive NHL, mantle cell lymphoma (MCL), and low-grade NHL. None of the expressions correlated with the International Index or early response to chemotherapy in any group. In low-grade NHL, none of the patients expressed p53. Only one of three patients with overexpression of p53 showed conformational change and alteration of sequence in exon 7 by PCR-SSCP and DNA sequencing. The results showed that p53 and PCNA staining were not useful for predicting early response to chemotherapy, and that their expressions had no correlation with the International Index.