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5 results on '"S, Salditt"'

1. Synthese tumoraffiner Yb-169- und Y-90-Porphyrin-Komplexe und tierexperimentelle Untersuchung verschiedener Yb-169-Porphyrine

Author

T. Fischer, V. D. Rumyantseva, H. Lohr, K. Schomäcker, S. Liebenhoff, Harald Schicha, S. Salditt, and M. I. Gaidouk

Subjects
Animal model, Chemistry, Radiology, Nuclear Medicine and imaging, General Medicine, Molecular biology
Abstract

ZusammenfassungZiel: Es wurde untersucht, ob eine Einführung radioaktiver Isotope von Yb und Y in ausgewählte Porphyrine möglich ist. Außerdem sollten erste Daten zur Bioverteilung von radioaktiven Yb-169-Porphyrin-Komplexen gewonnen werden. Methoden: Die Synthesen der Metall-Porphyrin-Komplexe erfolgten mit geträgerten Radiometallen. Erste Tierversuche wurden an Mammakarzinom-tragenden Mäusen durchgeführt. Die Organe wurden 5 und 24 h nach i.v.-lnjektion im Bohrlochdetektor gemessen. Ergebnisse: Es konnten vier Yb-169-Porphyrin-Komplexe und Y-90-Porphyrin-Komplexe in nicht trägerfreier Form synthetisiert werden. Dies wurde anhand der Absorptionsspektren sowie mittels DC und HPLC bewiesen. Je nach Komplex lagen die Tumor/Untergrund-Verhältnisse im Durchschnitt zwischen 2 und 20. Schlußfolgerung: Die synthetisierten radioaktiven Metall-Porphyrin-Komplexe zeigen eine deutliche Tumoraffinität, die bei weiterer Verbesserung der Synthese (Ziel: Trägerreduzierung, andere Radionuklide) eine Tumorszintigraphie und vielleicht -therapie ermöglichen könnte.

Published
1999
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3. [Synthesis of tumor affinity label Yb-169- and Y-90- porphyrin complexes and animal experimental investigations with various Yb-169-porphyrins]

Author

K, Schomäcker, M I, Gaidouk, V D, Rumyantseva, T, Fischer, H, Löhr, S, Salditt, S, Liebenhoff, and H, Schicha

Subjects
Radioisotopes, Mice, Structure-Activity Relationship, Porphyrins, Animals, Tissue Distribution, Yttrium Radioisotopes, Radiopharmaceuticals, Ytterbium, Radionuclide Imaging, Bone and Bones, Chromatography, High Pressure Liquid
Abstract

It should be shown, that it is possible to insert radioactive isotopes of Yb and Y into some selected porphyrins. Besides, first informations about the biodistribution of Yb-169-por-phyrin-complexes should be obtained.Carrier added radioactive isotopes were used for the synthesis of the metal porphyrin complexes. The animal experiments were done with mamma carcinoma bearing mice. The activity of the organs was determined 5 and 24 h after i.v. injection in a well counter.Four Yb-169-porphyrin complexes and Y-90-porphyrin complexes could be synthesized in non-carrier-free form. This was verified by absorption spectra, TLC and HPLC. Depending on the complex, the average tumour/background ratios were between 2 and 20.The synthesized radioactive metal-porphyrin complexes showed a clear tumour-affinity which could be used for tumour scintigraphy or perhaps therapy if the synthesis is improved (goal: reduction of carrier, other radionuclides).

Published
1999

4. Implantation of scleral fixated sutured posterior chamber lenses: a retrospective analysis of 119 cases.

Author

Krause L, Bechrakis NE, Heimann H, Salditt S, and Foerster MH

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Aphakia surgery, Contact Lenses adverse effects, Corneal Diseases etiology, Device Removal, Female, Follow-Up Studies, Foreign-Body Migration, Glaucoma etiology, Humans, Lenses, Intraocular adverse effects, Male, Middle Aged, Postoperative Period, Retrospective Studies, Visual Acuity, Young Adult, Intraoperative Complications, Lens Capsule, Crystalline surgery, Lens Implantation, Intraocular methods, Postoperative Complications, Sclera surgery, Suture Techniques adverse effects
Abstract

Background: The implantation of scleral fixated sutured posterior chamber lenses enables lens implantation in the absence of adequate lens capsule support. Anterior chamber lenses and their side effects can also be avoided, particularly in cases of unilateral aphakia and contact lens incompatibility., Methods: This study is a retrospective analysis of 119 scleral fixated sutured posterior chamber lenses implanted in 115 patients. Seventy-nine cases of damaged zonula or damaged lens capsule and 17 cases of corneal decompensation secondary to anterior chamber lenses were the main indications for the suture fixation. The mean follow-up was 23 months (6-83 months)., Results: In 50% of all cases, improved visual acuity was achieved. Twenty-four percent of patients showed unchanged visual acuity, while 26% had poorer vision postoperatively, mainly because of corneal decompensation following anterior chamber lens explantation. The main postoperative complication was transient rise of intraocular pressure, occurring in 44% of the cases., Conclusions: In most cases improved or comparable postoperative visual acuity was achieved. The main complication observed was postoperative glaucoma, especially in patients with pre-existing glaucoma.

Published
2009
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5. [Synthesis of tumor affinity label Yb-169- and Y-90- porphyrin complexes and animal experimental investigations with various Yb-169-porphyrins].

Author

Schomäcker K, Gaidouk MI, Rumyantseva VD, Fischer T, Löhr H, Salditt S, Liebenhoff S, and Schicha H

Subjects
Animals, Bone and Bones diagnostic imaging, Bone and Bones metabolism, Chromatography, High Pressure Liquid, Mice, Porphyrins pharmacokinetics, Radioisotopes pharmacokinetics, Radionuclide Imaging, Structure-Activity Relationship, Tissue Distribution, Porphyrins chemical synthesis, Radiopharmaceuticals chemical synthesis, Radiopharmaceuticals pharmacokinetics, Ytterbium pharmacokinetics, Yttrium Radioisotopes pharmacokinetics
Abstract

Aim: It should be shown, that it is possible to insert radioactive isotopes of Yb and Y into some selected porphyrins. Besides, first informations about the biodistribution of Yb-169-por-phyrin-complexes should be obtained., Methods: Carrier added radioactive isotopes were used for the synthesis of the metal porphyrin complexes. The animal experiments were done with mamma carcinoma bearing mice. The activity of the organs was determined 5 and 24 h after i.v. injection in a well counter., Results: Four Yb-169-porphyrin complexes and Y-90-porphyrin complexes could be synthesized in non-carrier-free form. This was verified by absorption spectra, TLC and HPLC. Depending on the complex, the average tumour/background ratios were between 2 and 20., Conclusion: The synthesized radioactive metal-porphyrin complexes showed a clear tumour-affinity which could be used for tumour scintigraphy or perhaps therapy if the synthesis is improved (goal: reduction of carrier, other radionuclides).

Published
1999

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