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Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of the Institute of Science & Technology / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi is the property of Igdir University, Institute of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives: Pirfenidone is a non-peptide synthetic low molecular weight substance with anti-inflammatory, antioxidant and antifibrotic effects. Its positive effects have been shown on ischemia-reperfusion injury in various tissues such as testis, kidney, liver, lung and small intestine. Our aim is to investigate the effects of Pirfenidone on ischemia-reperfusion injury in skin flaps. Materials and Methods: Eighteen Wistar male rats were divided randomly into three groups: Sham, IschemiaReperfusion (IR) and Pirfenidone plus Ischemia-Reperfusion (IR+Pirf). The epigastric island flap was elevated and returned to its place in the Sham group. In the second group (IR), the flap was elevated, and flap perfusion was interrupted with an avascular clamp for eight hours. In the third group (IR+Pirf), 300 mg/kg Pirfenidone was given orally before ischemia. Tissue samples were taken to evaluate biochemical substances (1st day) and histopathologic examination (7th day). On the seventh day, standardized photographs were taken to calculate the viable areas of the flap and all animals were sacrificed. Results: Tissue MPO levels were statistically higher in the IR+Pirf group than in the Sham and IR groups (p=0.006). Tissue MDA levels were statistically higher in the IR+Pirf group than in the IR group (p=0.026). The lymphocyte count was lower in the Sham group than in the IR and IR+Pirf groups (p=0.002). The reepithelization ratio was higher in the IR+Pirf group than in the IR and Sham groups p=0.010). Flap survival areas showed no significant difference between groups (p=0.194). Conclusion: As a conclusion, single dose treatment of Pirfenidone in rat skin flap ischemia-reperfusion model enhanced significantly re-epithelization and has no significant effect on flap survival. [ABSTRACT FROM AUTHOR]

Copyright of SDU Journal of Engineering Sciences & Design / Mühendislik Bilimleri ve Tasarım Dergisi is the property of Journal of Engineering Sciences & Design and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)