24 results on '"Sánchez Valiente S"'
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2. Temblor ortostático secundario al uso recreativo de disolventes
- Author
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Cruz Tabuenca, H., Camacho Velásquez, J.L., Rivero Sanz, E., Sánchez Valiente, S., and López del Val., J.
- Published
- 2017
- Full Text
- View/download PDF
3. Flunarizine is more effective than topiramate in patients with chronic migraine and medication overuse headache
- Author
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Gracia-Naya, M, Hernando-Quintana, N, García-Gomara, MJ, Sánchez-Valiente, S, Ríos, C, Santos-Lasaosa, S, Mauri, JA, Artal-Roy, J, and Latorre-Jimenez, AM
- Published
- 2013
- Full Text
- View/download PDF
4. Estudio de concordancia diagnóstica en cefalea entre neurología y atención primaria
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Sánchez-Valiente S, P R Vinueza-Buitron, C Iñiguez-Martínez, J L Millan-Morales, A Velazquez-Benito, Sonia Santos-Lasaosa, Larrodé-Pellicer P, L. J. Lopez Del Val, and Mauri-Llerda Ja
- Subjects
Gynecology ,medicine.medical_specialty ,Headache diagnosis ,business.industry ,Primary health care ,General Medicine ,Migraine Disorders ,Primary care ,03 medical and health sciences ,0302 clinical medicine ,medicine ,030212 general & internal medicine ,Neurology (clinical) ,Headaches ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Introduccion. La cefalea como sintoma es una patologia frecuente y uno de los principales motivos de consulta por parte de atencion primaria. Objetivo. Analizar las caracteristicas de los pacientes derivados desde atencion primaria a la consulta de neurologia general con cefalea o neuralgia como motivo de consulta, y la concordancia diagnostica. Pacientes y metodos. Estudio descriptivo transversal de todos los pacientes remitidos desde atencion primaria; se recogieron variables demograficas/clinicas y se compararon las hipotesis diagnosticas de atencion primaria y neurologia, determinando su concordancia. Resultados. Se remitieron desde atencion primaria 2.514 pacientes (588 de ellos con caracter preferente); en 378 casos el motivo de la consulta fue cefalea o neuralgia (42,46 anos de media; el 77,8%, mujeres). En 139 pacientes se establecio tan solo un diagnostico semiologico y en el resto predominaron la migrana episodica (49,79%), la cefalea tensional cronica (18,41%) y la neuralgia del trigemino (12,13%). Desde neurologia, los diagnosticos mas frecuentes fueron, respectivamente, 33,86%, 24,05% y 18,67%. Se obtuvo un coeficiente kappa de 0,543 (p < 0,05), compatible con una concordancia moderada al considerar solo los pacientes remitidos desde atencion primaria con un diagnostico concreto. Conclusiones. Las cefaleas constituyen un motivo de consulta desde atencion primaria muy frecuente (15%). La concordancia diagnostica es moderada en nuestro sector sanitario, por lo que es necesario disenar programas de formacion que ayuden a perfilar los criterios de derivacion al especialista y mejorar la atencion a nuestros pacientes.
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- 2016
5. [Topiramate in chronic daily headache due to migraine]
- Author
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Gracia-Naya M, Am, Latorre-Jiménez, Ríos-Gómez C, SANTOS LASAOSA, Ja, Mauri, Sánchez-Valiente S, and López E
- Subjects
Adult ,Male ,Topiramate ,Migraine Disorders ,Chronic Disease ,Headache ,Humans ,Anticonvulsants ,Female ,Fructose ,Middle Aged - Abstract
Chronic daily headache (CDH) includes primary headaches that last more than four hours with a frequency equal or superior to 15 days a month over the last three months. It has a prevalence of 4-5% in the general population and is a frequent reason for visiting the physician in headache units.To evaluate the effectiveness of topiramate, as the primary drug, in CDH due to probable chronic migraine with or without medication abuse.From the 447 patients with migraine in our database, we selected those: a) satisfying Silberstein criteria for CDH; b) that had not followed prior prophylactic treatment; and c) who were treated with topiramate as the primary drug. The mean number of days with headache and bouts of severe migraine in the fourth month of treatment using topiramate as compared to the month preceding treatment, as well as the percentage of responses and the rate of respondents in the fourth month were all analysed.Eighty-three patients (88% females) with a mean age of 38.0 +/- 14.13 years were selected. Medication abuse was reported in 44% of cases. At the fourth month of treatment, the mean number of days with headache dropped significantly from 20.8 to 7.9 (p0.0001) and the mean number of bouts of severe migraine diminished from 4.4 to 1.7 (p0.0001). The rate of respondents was 72%. Medication abuse continued in 14% of cases. Side effects were produced in 58% of patients and the dropout rate was 24%.Topiramate proved to be effective in the treatment of CDH due to probable chronic migraine and with probable medication abuse in de novo migraine patients.
- Published
- 2007
6. ¿El abuso de fármacos en pacientes con migraña crónica influye en la efectividad del tratamiento preventivo con topiramato?
- Author
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Sánchez-Valiente S, Latorre-Jiménez Am, Ríos C, Artal-Roy J, Hernando-Quintana N, García-Gomara Mj, Sonia Santos-Lasaosa, Gracia-Naya M, and Mauri-Llerda Ja
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Neurology (clinical) ,General Medicine - Abstract
Introduccion. Los pacientes con migrana cronica (MC) y abuso de medicacion son dificiles de tratar y tienen peor calidad de vida que otros pacientes con migranas. Objetivo. Valorar si la presencia de abuso de farmacos disminuye la efectividad del topiramato. Pacientes y metodos. Una serie de pacientes con MC fueron agrupados segun presentasen criterios de abuso o no abuso de farmacos. Se les aconsejo la supresion del farmaco del cual abusaban. Se ajusto el tratamiento de sus crisis y se inicio tratamiento preventivo desde el principio con topiramato. Se valoro el numero dias con cefalea y migranas intensas en el mes previo y al cuarto mes de tratamiento. Resultados. Fueron seleccionados 262 pacientes con criterios de MC, y de ellos 167 (63,7%) cumplieron criterios de abuso. En ambos grupos hubo una reduccion significativa del numero de dias con cefalea/mes y numero de crisis de migrana/mes al cuarto mes de tratamiento con topiramato. Porcentaje de reduccion de dias con cefalea/mes en MC sin abuso, 59,3 ± 36,1%; y con abuso, 48,7 ± 41,7% (p = 0,0574). Porcentaje de reduccion de migranas intensas/mes en MC sin abuso, 61,2%; y con abuso, 50% (p = 0,0224). Tasa de respondedores segun numero de dias con cefalea/mes en MC sin abuso, 69%; y con abuso, 57%. Tasa de respondedores segun numero de migranas intensas/mes en MC sin abuso, 76,8%; y en MC con abuso, 61% (p = 0,0097). Conclusiones. El topiramato fue efectivo en pacientes con MC sin y con abuso de farmacos, aunque con menor efectividad en estos ultimos.
- Published
- 2014
7. Estudio comparativo de la efectividad del topiramato y la flunaricina en series independientes de pacientes con migraña crónica sin abuso de medicación
- Author
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García-Gomara Mj, Ríos C, Sánchez-Valiente S, Latorre-Jiménez Am, Sonia Santos-Lasaosa, Gracia-Naya M, Mauri-Llerda Ja, and Artal-Roy J
- Subjects
Tratamiento farmacologico ,Chronic disease ,Medication abuse ,business.industry ,Treatment outcome ,Medicine ,Patient Dropouts ,Neurology (clinical) ,General Medicine ,Migraine Disorders ,business ,Humanities - Abstract
Introduccion. El topiramato y la onabotulinumtoxina A han mostrado ser eficaces en la migrana cronica con o sin abuso de farmacos segun los criterios recientes de la Clasificacion de Cefaleas de la Sociedad Internacional de Cefaleas. Objetivo. Demostrar que la flunaricina es tan efectiva como el topiramato en la migrana cronica sin abuso de farmacos. Pacientes y metodos. Estudio prospectivo, no aleatorizado, comparativo de dos grupos de pacientes con similar edad y sexo, con migrana cronica sin abuso, tratados preventivamente por primera vez con topiramato o flunaricina. Resultados. A 40 pacientes tratados con flunaricina se les asigno un paciente del mismo sexo y edad tratado con topiramato. La media de reduccion de las migranas intensas en el grupo del topiramato fue del 59% y en el grupo de la flunaricina, del 58,5% (p = 0,9444); la tasa de respondedores al cuarto mes de tratamiento tampoco mostro diferencias significativas, ya que fue del 75% para el topiramato y del 70% para la flunaricina (p = 0,6236). La media de reduccion de otras cefaleas en el grupo del topiramato fue del 57%, y en el grupo de la flunaricina, del 64% (p = 0,4261); la tasa de respondedores al cuarto mes de tratamiento fue del 76%, similar en ambos grupos. El porcentaje de abandonos del tratamiento fue mayor con el topiramato (19,5%) que con la flunaricina (10%) (p = 0,3493). En ninguno de los dos grupos hubo efectos adversos graves. Un 78,9% de los pacientes que tomo topiramato presento satisfaccion con el farmaco frente al 75% del grupo de la flunaricina (p = 0,7903). Conclusion. La flunaricina mostro ser tan efectiva como el topiramato en el tratamiento de la migrana cronica sin abuso de farmacos.
- Published
- 2013
8. Pacientes con cefalea y abuso de medicación. Indicadores de respuesta al tratamiento ambulatorio
- Author
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Gracia-Naya M, Mauri-Llerda Ja, Ríos-Gómez C, Sonia Santos-Lasaosa, Latorre-Jiménez Am, Sánchez-Valiente S, and García-Gomara Mj
- Subjects
Neurology (clinical) ,General Medicine - Abstract
Introduccion. Los pacientes con cefalea y abuso de medicacion (CAM) son dificiles de tratar, presentan mayor tendencia a la cronificacion y peor calidad de vida que los que cursan con otras cefaleas. Objetivo. Valorar los indicadores de respuesta de estos pacientes al tratamiento ambulatorio. Pacientes y metodos. De una serie de pacientes con migrana, seleccionamos aquellos con criterios de CAM segun el apendice de la International Classification of the Headache Disease (ICHD-2) de 2006 y que nunca habian llevado previamente tratamiento. Ambulatoriamente, se les aconsejo la supresion del farmaco del que abusaban. Se ajusto el tratamiento de sus crisis con los farmacos mas eficaces y se inicio tratamiento preventivo desde el principio, con topiramato o flunaricina. Se agrupo a los pacientes segun persistieran con CAM o no. Se valoro el numero dias con cefalea en el mes previo y al cuarto mes de tratamiento y la persistencia de abuso. Resultados. Cumplieron criterios de CAM 178 pacientes (edad media: 40,9 anos; 88,7% mujeres). El 68,5% (122 pacientes) respondio y dejo de cumplir criterios de CAM tras el tratamiento. En ambos grupos, los tratamientos de sus crisis (triptanes, antiinflamatorios no esteroideos, analgesicos) y preventivos utilizados (topiramato o flunaricina) fueron similares. La media de dias con cefalea previa al tratamiento fue de 18,52 en el grupo que respondio y de 20,87 (p = 0,0263) en el grupo que no respondio al tratamiento. Un 7,3% abandono el tratamiento preventivo en el grupo de respondedores frente al 35% (p = 0,0001) en los no respondedores. Conclusiones. El mayor numero de dias con cefalea en el mes previo al tratamiento y el abandono del tratamiento preventivo fueron indicadores de mala evolucion.
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- 2009
9. Estudio del síndrome de Rett en la población española
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Pineda Marfà, Mercè, primary, Aracil Martínez, Mª Asunción, additional, Vernet Bori, Ana María, additional, Espada, M., additional, Cobo, E., additional, Arteaga Morón, Rafael, additional, Artigas Pallarés, Josep, additional, Barrionuevo, C., additional, Bautista González, L., additional, Berenguer Molla, R., additional, Caballero, J., additional, Cabrera, J., additional, Campistol Plana, Jaume, additional, Campos Castelló, Jaime, additional, Casas Fernández, Carlos, additional, Castelló, M., additional, Castro Gago, Manuel, additional, Pascual Castroviejo, Ignacio, additional, Colomer Oferil, Jaume, additional, Delgado, P., additional, Pérez Fernández, Virginia, additional, Domínguez Jiménez, A., additional, Fernández Álvarez, Emilio, additional, García Aymerich, J., additional, García Campillo, A., additional, García Pérez, Asunción, additional, Jover, J., additional, Hernández, V., additional, Herranz Fernández, José Luis, additional, Herrera, M., additional, Mora López, Diego, additional, Mulas Delgado, Fernando, additional, Narbona García, Juan, additional, Nieto Barrera, Manuel, additional, Lartigau Fabregas, Mª Teresa, additional, López Martín, Valentín, additional, López Pisón, Javier, additional, Lorente Hurtado, Isabel, additional, Ortiz, A., additional, Palencia Luaces, Rafael, additional, Poo, P., additional, Prats Viñas, José María, additional, Domingo Jiménez, Rosario, additional, Rayo, C., additional, Rodríguez Barrionuevo, A. Carlos, additional, Rodríguez Costa, Trinidad, additional, Roig Quilis, Manel, additional, Sánchez Valiente, S., additional, Sans Fitó, Anna, additional, Santos Borbujo, José Ramiro, additional, Sanmartí Vilaplana, Francesc Xavier, additional, García Tena, Jesús, additional, Uganda, A., additional, and Vidal Sanahuja, Ramón, additional
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- 1999
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10. Flunarizine is more effective than topiramate in patients with chronic migraine and medication overuse headache
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Sonia Santos-Lasaosa, García-Gomara Mj, Gracia-Naya M, Artal-Roy J, Ríos C, J A Mauri, Hernando-Quintana N, Latorre-Jiménez Am, and Sánchez-Valiente S
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Drug ,Topiramate ,medicine.medical_specialty ,Pediatrics ,Neurology ,business.industry ,media_common.quotation_subject ,Clinical Neurology ,General Medicine ,Transformed migraine ,Chronic Migraine ,Anesthesiology and Pain Medicine ,Poster Presentation ,Medicine ,In patient ,Neurology (clinical) ,business ,Medication overuse ,Psychiatry ,Flunarizine ,media_common ,medicine.drug - Abstract
Medication overuse headache (MOH) implies secondary headache on a daily or near daily basis, for 15 days or more a month for 3 month and chronic migraine CM is the most common subtypes of MOH in speciality care [1]. Flunarizine and topiramate are considered as first-choice drugs in prophylactic treatment of episodic or transformed migraine(2). Topiramate is considered as first-choice drug in treatment of CM (3).
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11. Comparative study of the effectiveness of topiramate and nadolol in the preventive treatment of episodic migraine in independent series of patients,Estudio comparativo de la efectividad del topiramato y del nadolol en el tratamiento preventivo de la migraña episódica en series independientes de pacientes
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Gracia-Naya, M., Mariano Huerta Villanueva, Ríos-Gómez, C., Latorre-Jiménez, A. M., Sánchez-Valiente, S., Santos-Lasaosa, S., Mauri-Llerda, J. Á, García-Gómara, M. J., and Artal-Roy, J.
12. A study to compare independent groups of patients with episodic migraine who were treated preventively with flunarizine or nadolol,Estudio comparativo de grupos independientes de pacientes con migraña episódica tratados preventivamente con flunaricina o nadolol
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Gracia-Naya, M., Mariano Huerta Villanueva, Ríos, C., García-Gomara, M. J., Artal-Roy, J., Sánchez-Valiente, S., Santos-Lasaosa, S., Mauri-Llerda, J. A., and Latorre-Jiménez, A. M.
13. [Patients with headache and medication abuse. Indicators of response to ambulatory treatment]
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Gracia-Naya M, Sánchez-Valiente S, Am, Latorre-Jiménez, Ríos-Gómez C, SANTOS LASAOSA, Ja, Mauri-Llerda, and Mj, García-Gomara
- Subjects
Adult ,Male ,Treatment Outcome ,Migraine Disorders ,Ambulatory Care ,Headache ,Humans ,Female ,Self Medication - Abstract
Patients with headache and medication abuse (HMA) are difficult to treat, have a greater tendency towards chronification and a poorer quality of life than those with other types of headache. AIM. To evaluate the indicators showing that these patients are responding to ambulatory treatment.From a series of patients with migraine, we selected those who satisfied HMA criteria according to the appendix of the 2006 International Classification of the Headache Disease (ICHD-2) and who had never previously undergone treatment. As outpatients, they were advised to stop taking the drug that they were abusing. The treatment of their seizures was adjusted with the most efficient drugs and preventive treatment was started from the outset with topiramate or flunarizine. Patients were grouped according to whether they continued with HMA or not. Comparisons were made between the number of days with headache during the previous month and after four months of treatment and the persistence of abuse.HMA criteria were met by 178 patients (mean age 40.9; 88.7% females). Results showed that 68.5% (122 patients) responded and no longer met HMA criteria after treatment. The treatment used for their seizures (triptans, nonsteroidal antiinflammatory drugs, analgesics) and preventive treatment (topiramate or flunarizine) were similar in both groups. The average number of days with headache prior to treatment was 18.52 in the group that responded and 20.87 (p = 0.0263) in the group that did not respond to treatment. In the group of responders 7.3% dropped out of preventive treatment compared with 35% (p = 0.0001) in the group of non-responders.A higher number of days with headache during the previous month and withdrawing from preventive treatment were indicators of a bad progression.
14. Orthostatic tremor secondary to recreational use of solvents.
- Author
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Cruz Tabuenca H, Camacho Velásquez JL, Rivero Sanz E, Sánchez Valiente S, and López Del Val J
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- Adult, Brain diagnostic imaging, Brain drug effects, Dizziness diagnostic imaging, Humans, Inhalant Abuse diagnostic imaging, Male, Tremor diagnostic imaging, Dizziness chemically induced, Gasoline poisoning, Inhalant Abuse complications, Tremor chemically induced
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- 2017
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15. Rhombencephalitis due to Listeria monocytogenes: A Clinicopathologic Study of a Case.
- Author
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Giménez-Muñoz Á, Campello I, Pérez Trullén JM, Alfaro J, Sánchez Valiente S, and Sanz Moncasi P
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- Adult, Encephalitis microbiology, Fatal Outcome, Humans, Listeriosis microbiology, Male, Rhombencephalon microbiology, Encephalitis pathology, Listeriosis diagnosis, Rhombencephalon pathology
- Abstract
Introduction: Central nervous system infections caused by Listeria monocytogenes usually manifest in the form of meningitis or meningoencephalitis, and are more common among immunosuppressed patients. Brainstem encephalitis (rhombencephalitis) is less common and fatal if not recognized and treated early., Case Report: We describe the case of a 40-year-old, immunocompetent male patient, who presented with initial symptoms of high fever and productive cough. Signs of brainstem involvement appeared later. A magnetic resonance imaging of the brain revealed a lesion of inflammatory appearance in the right medulla oblongata, and the cerebrospinal fluid test showed mononuclear pleocytosis. Blood and cerebrospinal fluid cultures were negative. He presented with a significant improvement with the start of ceftriaxone and subsequent association of corticosteroids, until he developed respiratory failure and died. The third blood cultures grew after his death and they were positive for L. monocytogenes. An autopsy was carried out, which showed necrotizing inflammation, with gram-positive bacilli in the brainstem and the cerebellum., Conclusions: A fatal delay in the diagnosis occurred, mainly because of the favorable clinical response to ceftriaxone and corticosteroids. This case reminds us that a febrile clinical presentation with brainstem involvement must generate the suspicion of a Listeria infection, and therefore ampicillin must be a part of the empirical treatment.
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- 2015
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16. [A comparative study of the effectiveness of topiramate and flunarizine in independent series of chronic migraine patients without medication abuse].
- Author
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Gracia-Naya M, Ríos C, García-Gomara MJ, Sánchez-Valiente S, Mauri-Llerda JÁ, Santos-Lasaosa S, Artal-Roy J, and Latorre-Jiménez AM
- Subjects
- Adult, Calcium Channel Blockers adverse effects, Chronic Disease, Cognition Disorders chemically induced, Fatigue chemically induced, Female, Flunarizine adverse effects, Fructose administration & dosage, Fructose adverse effects, Fructose therapeutic use, Humans, Male, Middle Aged, Patient Dropouts, Patient Satisfaction, Prospective Studies, Topiramate, Treatment Outcome, Calcium Channel Blockers therapeutic use, Flunarizine therapeutic use, Fructose analogs & derivatives, Migraine Disorders drug therapy
- Abstract
Introduction: Topiramate and onabotulinumtoxin A have proven to be effective in chronic migraine with or without medication abuse according to recent criteria of the International Headache Society's Headache Classification., Aims: To show that flunarizine is as effective as topiramate in cases of chronic migraine without medication abuse., Patients and Methods: We conducted a prospective, non-randomised, comparative study of two groups of patients paired by age and sex, with chronic migraine without abuse, who had been treated preventively for the first time with topiramate or flunarizine., Results: Forty patients treated with flunarizine were assigned a patient of their same sex and age who was being treated with topiramate. The mean rate of reduction in intense migraines in the topiramate group was 59% and in the flunarizine group, 58.5% (p = 0.9444); the responder rate at four months of treatment did not show any significant differences either, the figures being 75% for topiramate and 70% for flunarizine (p = 0.6236). The mean reduction of other headaches in the topiramate group was 57% and in the flunarizine group, 64% (p = 0.4261); the responder rate at four months of treatment was similar in the two groups: 76%. The percentage of dropouts from treatment was higher with topiramate (19.5%) than with flunarizine (10%) (p = 0.3493). No serious side effects occurred in either of the groups. In all, 78.9% of the patients who took topiramate said they were satisfied with the drug versus 75% of those in the flunarizine group (p = 0.7903)., Conclusions: Flunarizine proved to be as effective as topiramate in the treatment of chronic migraine without medication abuse.
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- 2013
17. [Predisposing factors affecting drop-out rates in preventive treatment in a series of patients with migraine].
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Gracia-Naya M, Santos-Lasaosa S, Ríos-Gómez C, Sánchez-Valiente S, García-Gomara MJ, Latorre-Jiménez AM, Artal-Roy J, and Mauri-Llerda JA
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- Adrenergic beta-Antagonists therapeutic use, Adult, Anticonvulsants therapeutic use, Female, Flunarizine therapeutic use, Fructose analogs & derivatives, Fructose therapeutic use, Humans, Male, Middle Aged, Nadolol therapeutic use, Neuroprotective Agents therapeutic use, Patient Satisfaction, Prospective Studies, Risk Factors, Topiramate, Treatment Outcome, Young Adult, Migraine Disorders drug therapy, Migraine Disorders prevention & control, Patient Dropouts
- Abstract
Introduction: The drop-out rate among patients receiving preventive treatment for migraine is higher than 30%. This situation is not very widely known and the risk factors that lead patients to drop out from treatment have yet to be identified., Aim: To evaluate some of the factors that can predispose patients to drop out of preventive treatment., Patients and Methods: We conducted a prospective study of patients suffering from migraine who required preventive treatment for the first time with one of what are considered the top three first-choice drugs, i.e. a beta-blocker (nadolol), a neuromodulator (topiramate) or a calcium antagonist (flunarizine). Two groups were established according to whether patients dropped out of treatment or not. Different demographic and clinical variables were analysed and compared in the two groups., Results: Of 800 patients with migraine who required preventive treatment for the first time, the drop-out rate was 19.7%. In the drop-out group, the variables 'age', 'number of seizures', 'number of seizures prior to preventive treatment' and 'side effects' showed significant differences with those from the group of patients who did not drop out of preventive treatment., Conclusions: The drug used as preventive treatment, the side effects, a younger age and a lower number of seizures before starting the preventive treatment favoured higher drop-out rates. Whether the migraine was episodic or chronic, the presence of medication abuse and the drugs used to treat the seizures were not related with dropping out of preventive treatment., (© 2011 Revista de Neurología)
- Published
- 2011
18. [Comparative study of the effectiveness of topiramate and nadolol in the preventive treatment of episodic migraine in independent series of patients].
- Author
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Gracia-Naya M, Huerta-Villanueva M, Ríos-Gómez C, Latorre-Jiménez AM, Sánchez-Valiente S, Santos-Lasaosa S, Mauri-Llerda JA, García-Gómara MJ, and Artal-Roy J
- Subjects
- Adult, Female, Fructose therapeutic use, Humans, Male, Topiramate, Adrenergic beta-Antagonists therapeutic use, Fructose analogs & derivatives, Migraine Disorders prevention & control, Nadolol therapeutic use
- Abstract
Introduction: Topiramate and nadolol with levels A and C of scientific evidence, respectively, would be indicated as preventive treatments of migraine. To date only one study of satisfaction has been carried out to compare the two pharmaceuticals., Aim: To compare the effectiveness parameters in independent groups of patients treated preventively with one of the pharmaceuticals from the study., Patients and Methods: From a database of 700 patients with migraine, those with episodic migraine and who had followed a course of preventive treatment, for the first time, with topiramate or nadolol were selected for the study. The effectiveness variables (reduction in the number of crises at four months of preventive treatment and responder rates) were analysed., Results: Altogether 208 patients with were included for treatment: 140 with topiramate (77.8% females; mean age, 37.9) and 68 with nadolol (69% females; mean age, 36.9). The mean number of crises in the month prior to treatment was: topiramate group, 6.3 +/- 2.6; nadolol group 5.3 +/- 2.0 (p = 0.0066). At four months after starting treatment: topiramate group, 2.69 +/- 2.6; nadolol group 2.6 +/- 2.2 (NS). The percentage of reduction in the number of migraines was 56.6% with topiramate and 51.6% with nadolol (NS). The responder rate (reduction in the frequency of crises by at least 50%) was 71.3% with topiramate versus 69% with nadolol (NS). The excellent response rate (reduction in crises by at least 75%) was 53.3% with topiramate versus 32.2% with nadolol (p = 0.0077). Adverse side effects were reported by 54% of patients treated with topiramate versus 30.8% of those treated with nadolol (p = 0.0015). The rate of satisfaction was 61% for the topiramate group and 71% for the group with nadolol (NS)., Conclusions: Both topiramate and nadolol proved to be effective in the preventive treatment of episodic migraine. Topiramate was found to be more effective than nadolol, although it was used in patients with a higher frequency of crises, and was not tolerated so well.
- Published
- 2010
19. [Patients with headache and medication abuse. Indicators of response to ambulatory treatment].
- Author
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Gracia-Naya M, Sánchez-Valiente S, Latorre-Jiménez AM, Ríos-Gómez C, Santos-Lasaosa S, Mauri-Llerda JA, and García-Gomara MJ
- Subjects
- Adult, Ambulatory Care, Female, Humans, Male, Treatment Outcome, Headache chemically induced, Headache drug therapy, Migraine Disorders chemically induced, Migraine Disorders drug therapy, Self Medication adverse effects
- Abstract
Introduction: Patients with headache and medication abuse (HMA) are difficult to treat, have a greater tendency towards chronification and a poorer quality of life than those with other types of headache. AIM. To evaluate the indicators showing that these patients are responding to ambulatory treatment., Patients and Methods: From a series of patients with migraine, we selected those who satisfied HMA criteria according to the appendix of the 2006 International Classification of the Headache Disease (ICHD-2) and who had never previously undergone treatment. As outpatients, they were advised to stop taking the drug that they were abusing. The treatment of their seizures was adjusted with the most efficient drugs and preventive treatment was started from the outset with topiramate or flunarizine. Patients were grouped according to whether they continued with HMA or not. Comparisons were made between the number of days with headache during the previous month and after four months of treatment and the persistence of abuse., Results: HMA criteria were met by 178 patients (mean age 40.9; 88.7% females). Results showed that 68.5% (122 patients) responded and no longer met HMA criteria after treatment. The treatment used for their seizures (triptans, nonsteroidal antiinflammatory drugs, analgesics) and preventive treatment (topiramate or flunarizine) were similar in both groups. The average number of days with headache prior to treatment was 18.52 in the group that responded and 20.87 (p = 0.0263) in the group that did not respond to treatment. In the group of responders 7.3% dropped out of preventive treatment compared with 35% (p = 0.0001) in the group of non-responders., Conclusions: A higher number of days with headache during the previous month and withdrawing from preventive treatment were indicators of a bad progression.
- Published
- 2009
20. [Treatment of neuropathic pain with gabapentin ++].
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Sánchez-Valiente S
- Subjects
- Aged, Aged, 80 and over, Gabapentin, Humans, Male, Middle Aged, Acetates therapeutic use, Amines, Analgesics therapeutic use, Cyclohexanecarboxylic Acids, Neuralgia drug therapy, gamma-Aminobutyric Acid
- Abstract
Introduction: The antiepileptic drug gabapentin has begun to be used successfully in some cases of neuropathic pain. Its mechanism of action is still unknown, but seems to be related to a positive effect on the synthesis and liberation of the neurotransmitter GABA., Clinical Cases: Based on the observations of other authors, we used this drug in dosage varying between 900 and 1,200 mg/day, in three patients with neuropathic pain, of both central and peripheral origin, and in whom the usual treatments had been unsatisfactory or could not be tolerated because of side-effects. The patients had been diagnosed as having trigeminal neuralgia, post-herpetic neuralgia in the area of the first branch of the trigeminal nerve and a thalamic infarct which gave rise to a contralateral Déjerine-Roussy syndrome, respectively. In all three cases, administration of gabapentin was followed by such a striking improvement of the pain that co-adjuvant treatment could be reduced or stopped, with excellent tolerance and a minimal incidence of side-effects., Conclusions: Gabapentin should be borne in mind in the treatment of this type of pain, particularly when the usual treatment cannot be given or is insufficient to control pain, especially in elderly patients in whom there is often reduced tolerance of drugs.
- Published
- 1998
21. [Myoclonic encephalopathy induced by diclofenac treatment].
- Author
-
Sánchez Valiente S
- Subjects
- Aged, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Arthritis drug therapy, Arthritis physiopathology, Brain physiopathology, Diclofenac therapeutic use, Epilepsies, Myoclonic physiopathology, Female, Humans, Knee physiopathology, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Diclofenac adverse effects, Epilepsies, Myoclonic chemically induced
- Abstract
Some non-steroid anti-inflammatory drugs, and especially diclofenac, may, in some susceptible patients bring about the appearance of segmentary myoclonic symptoms, which in some cases where there is kidney failure may cause real myoclonic encephalopathy. We present the case of a patient admitted into the nephrology service suffering from prerenal kidney failure as a result of dehydration. Once her kidney problems had been overcome and analytical parameters normalized, during treatment with diclofenac for inflammation of the lower left extremity arthritic in origin, she showed generalized myoclonic symptoms of action and attitude especially in the upper extremities. Neurologic examination showed no abnormalities other than certain drowsiness. General analysis and kidney function were normal, as was brain CT scan, EEG showed only a general tendency towards slowing down. Myoclonic symptoms completely disappeared in the next 24 hours after giving diclofenac up, the patient remaining neurologically asymptomatic and not showing a similar clinical picture in any subsequent check-up.
- Published
- 1995
22. [Hypophyseal apoplexy].
- Author
-
Sánchez Valiente S
- Subjects
- Adenoma complications, Adenoma surgery, Cranial Nerves physiopathology, Humans, Male, Middle Aged, Paralysis physiopathology, Pituitary Apoplexy complications, Pituitary Gland surgery, Pituitary Neoplasms complications, Pituitary Neoplasms surgery, Adenoma pathology, Pituitary Apoplexy physiopathology, Pituitary Gland pathology, Pituitary Neoplasms pathology
- Published
- 1995
23. [Silent myocardial ischemia in patients with transient ischemic attacks].
- Author
-
Sánchez Valiente S, Mostacero E, del Río A, and Morales F
- Subjects
- Adult, Aged, Diabetes Complications, Electrocardiography, Exercise Test, Female, Humans, Hyperlipidemias complications, Ischemic Attack, Transient complications, Male, Middle Aged, Myocardial Ischemia complications, Myocardial Ischemia diagnosis
- Abstract
Given evidence that ischemic heart disease is the most frequent cause of death in patients with cerebrovascular disease, we used ergometrics to screen 80 patients with TIA for silent myocardial ischemia (SMI) at the neurological unit of Hospital Clínico Universitario in Zaragoza, Spain. The patients were compared with a control group of 80 with no signs of heart disease. Neither the patients nor the controls had ever shown clinical signs of coronary ischemia and their baseline electrocardiograms were normal. Stress test results were positive in 25 (31%) of the TIA patients, and in 4 (5%) (p < 0.001) of the controls, showing that the prevalence of SMI is significantly higher in TIA patients than in the general population. Hiperlipidemia (75% testing positive versus 43% negative, p < 0.01) and diabetes (31% testing positive versus 13% negative, p < 0.01) were the risk factors statistically related with a positive stress test.
- Published
- 1994
24. [Giant aneurysms of the basilar artery. Six cases].
- Author
-
Sánchez Valiente S, López del Val J, Mostacero Miguel E, Pascual Millán LF, Marta Moreno J, and Morales Asín F
- Subjects
- Adult, Aged, Arteriovenous Fistula surgery, Basilar Artery surgery, Cerebral Angiography, Diagnosis, Differential, Female, Humans, Ischemic Attack, Transient diagnosis, Ischemic Attack, Transient physiopathology, Magnetic Resonance Spectroscopy, Male, Middle Aged, Retrospective Studies, Subarachnoid Hemorrhage diagnosis, Subarachnoid Hemorrhage etiology, Subarachnoid Hemorrhage physiopathology, Tomography, X-Ray Computed, Arteriovenous Fistula diagnosis, Arteriovenous Fistula physiopathology, Basilar Artery physiopathology
- Abstract
The authors describe 6 cases of giant aneurysm of the basilar artery diagnosed in the Neurology Department of the Hospital Clínico Universitario of Zaragoza over the last 8 years by cerebral CT, arteriography and NMR with the clinical, diagnostic, and evolutive features of the same being reported. In 2 cases the clinical manifestations initiated as subarachnoid hemorrhage, in another two as AIT, in the fifth case as cerebral infarction and in the sixth case with pseudotumoral clinical manifestations with a necropsy study being available in the latter case. Three of the 6 patients died and of the remaining three only one was, successfully operated on. Anatomopathologic, clinical, therapeutic and diagnostic aspects of giant aneurysms of the basilar trunk are also reviewed with NMR being recommended as the technique of choice in diagnosis.
- Published
- 1993
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