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Objective: To analyze the changes in land-use and vegetation (LUV), from 1985 to 2014, in the sites in northern Mexico where 16 pine trees listed in the NOM-059-SEMARNAT-2010 are collected. Design/Methodology/Approach: Based on consultations in botanical collections, a georeferenced database of the species under study was developed. A point coverage was created to which LUV vector information from Series I (1985) and VI (2014) was added. Subsequently, LUV class changes were identified during the evaluation period through spatial analysis and geoprocessing. Results: A total of 2,242 georeferenced records of pine species were obtained. Fifty percent of the pine records consulted in collections with Series I information belong to other non-primary forest categories of LUV, while with Series VI information with this condition rose to 58.7%. Consequently, in the study period major changes occurred in the conversion of primary forests to agricultural lands, pasture, secondary vegetation in coniferous and oak forests, and mainly urban areas. Limitations/Implications: The availability of larger-scale cartographic material limited the generation of a risk analysis study about the changes and threats to forest conservation. Findings/Conclusions: The number of collection sites registered in coniferous forest, scrubland, and primary oak forest in Series I —which are now agricultural lands, water bodies, pastures, and urban areas— was significantly lower than in Series VI. [ABSTRACT FROM AUTHOR] more...

Defects in myelin homeostasis have been reported in many neuropathological conditions. Cannabinoid compounds have been shown to efficiently promote myelin regeneration in animal models of demyelination. However, it is still unknown whether this action relies mostly on a cell autonomous effect on oligodendroglial-lineage-NG2 cells. By using conditional genetic mouse models, here we found that cannabinoid CB 1 receptors located on NG2 cells are required for oligodendroglial differentiation and myelin regeneration after demyelination. Selective CB 1 receptor gene depletion in NG2 cells following toxin-induced demyelination disrupted oligodendrocyte regeneration and functional remyelination and exacerbated axonal damage. These deficits were rescued by pharmacological blockade of the RhoA/ROCK/Cofilin pathway. Conversely, tetrahydrocannabinol administration promoted oligodendrocyte regeneration and functional remyelination in wild-type but not Ng2-CB 1 -deficient mice. Overall, this study identifies CB 1 receptors as essential modulators of remyelination and support the therapeutic potential of cannabinoids for promoting remyelination in neurological disorders., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.) more...

Introduction: Teledermatology is the practice of dermatology through communication technologies. The aim of this study is to analyze its implementation in a Spanish health area during its first two years., Methods: Cross-sectional descriptive study. It included interconsultations between dermatologists and family physicians in the Salamanca Health Area (Spain) after the implementation of the non-face-to-face modality over a period of two consecutive years. A total of 25,424 consultations were performed (20,912 face-to-face and 4,512 non-face-to-face); 1000 were selected by random sampling, half of each modality., Main Measures: referral rate, response time and resolution time, type of pathology, diagnostic concordance, and quality of consultation., Results: The annual referral rate was 42.9/1000 inhabitants (35.3 face-to-face and 7.6 non-face- to-face). The rate of face-to-face referrals was higher in urban areas (37.1) and the rate of non- face-to-face referrals in rural areas (10.4). The response time for non-face-to-face consultations was 2.4 ± 12.7 days and 56 ± 34.8 days for face-to-face consultations (p < 0.001). The resolution rate for non-face-to-face consultations was 44%. Diagnostic concordance, assessed by the kappa index, was 0.527 for face-to-face consultations and 0.564 for non-face-to-face consultations. Greater compliance with the quality criteria in the non-attendance consultations., Conclusions: Teledermatology appears to be an efficient tool in the resolution of dermatological problems, with a rapid, effective, and higher quality response for attention to skin pathologies., Registry: ClinicalTrials.gov Identifier: NCT05625295. Registered on 21 November 2022 ( https://clinicaltrials.gov/ct2/show/ NCT05625295)., (© 2024. The Author(s).) more...