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15 results on '"Sánchez-Ramon S"'

3. Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies

Author

Ochoa-Grullón, J., Benavente Cuesta, C., Pérez López, C., Peña Cortijo, A., Rodríguez de la Peña, A., Álvarez Carmona, A., Mateo Morales, M., Llano-Hernández, K., Williams, L.J., Rodríguez de Frías, E., Guevara-Hoyer, K., Cordero Torres, G., Orte, C., Fernández-Arquero, M., Fernández-Paredes, L., Serrano-García, I., Recio, M.J., Pérez de Diego, R., Martínez, R., and Sánchez-Ramón, S.

Published
2020
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4. Multicenter study for the evaluation of the antibody response against salmonella typhi Vi vaccination (EMPATHY) for the diagnosis of Anti-polysaccharide antibody production deficiency in patients with primary immunodeficiency

Author

Sánchez-Ramón, S., de Gracia, J., García-Alonso, AM., Rodríguez Molina, J.J., Melero, J., de Andrés, A., García Ruiz de Morales, J.M., Ferreira, A., Ocejo-Vinyals, J.G., Cid, J.J., García Martínez, J.M., Lasheras, T., Vargas, M.L., Gil-Herrera, J., García Rodríguez, M.C., Castañer, J.L., González Granado, L.I., Allende, L.M., Soler-Palacin, P., Herráiz, L., López Hoyos, M., Bellón, J.M., Silva, G., Gurbindo, D.M., Carbone, J., Rodríguez-Sáinz, C., Matamoros, N., Parker, A.R., and Fernández-Cruz, E.

Published
2016
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15. Targeting of Non-Classical Human Leukocyte Antigens as Novel Therapeutic Strategies in Cancer.

Author

Benitez Fuentes JD, Bartolome Arcilla J, Mohamed Mohamed K, Lopez de Sa A, de Luna Aguilar A, Guevara-Hoyer K, Ballestin Martinez P, Lazaro Sanchez AD, Carosella ED, Ocaña A, and Sánchez-Ramon S

Abstract

Human leukocyte antigens (HLAs) are essential regulators of immune responses against cancer, with classical HLAs well-documented for their role in tumor recognition and immune surveillance. In recent years, non-classical HLAs-including HLA-E, HLA-F, HLA-G, and HLA-H-have emerged as critical players in the immune landscape of cancer due to their diverse and less conventional functions in immune modulation. These molecules exhibit unique mechanisms that enable tumors to escape immune detection, promote tumor progression, and contribute to therapeutic resistance. This review provides a comprehensive examination of the current understanding of non-classical HLAs in solid cancers, focusing on their specific roles in shaping the tumor microenvironment and influencing immune responses. By analyzing how HLA-E, HLA-F, HLA-G, and HLA-H modulate interactions with immune cells, such as T cells, natural killer cells, and antigen-presenting cells, we highlight key pathways through which these molecules contribute to immune evasion and metastasis. Additionally, we review promising therapeutic strategies aimed at targeting non-classical HLAs, including emerging immunotherapies that could potentially enhance cancer treatment outcomes by reversing immune suppression within tumors. Understanding the influence of these non-classical HLAs in solid cancers may offer new insights into cancer immunology and may lead to the development of innovative and more effective immunotherapeutic approaches. This review underscores the importance of non-classical HLAs as potential therapeutic targets, providing a necessary foundation for future studies in the evolving field of cancer immunotherapy.

Published
2024
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