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91 results on '"Sánchez-Toril"'

1. Red flags for clinical suspicion of eosinophilic granulomatosis with polyangiitis (EGPA)

Author: Solans-Laqué, R., Rúa-Figueroa, I., Blanco Aparicio, M., García Moguel, I., Blanco, R., Pérez Grimaldi, F., Noblejas Mozo, A., Labrador Horrillo, M., Álvaro-Gracia, J.M., Domingo Ribas, C., Espigol-Frigolé, G., Sánchez-Toril López, F., Ortiz Sanjuán, F.M., Arismendi, E., and Cid, M.C.
Published: 2024
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2. Achieving clinical outcomes with benralizumab in severe eosinophilic asthma patients in a real-world setting: ORBE II study

Author: Padilla-Galo, Alicia, Moya Carmona, Isabel, Ausín, Pilar, Carazo Fernández, Luis, García-Moguel, Ismael, Velasco-Garrido, José Luis, Andújar-Espinosa, Rubén, Casas-Maldonado, Francisco, Martínez-Moragón, Eva, Martínez Rivera, Carlos, Vera Solsona, Elisabet, Sánchez-Toril López, Fernando, Trisán Alonso, Andrea, Blanco Aparicio, Marina, Valverde-Monge, Marcela, Valencia Azcona, Borja, Palop Cervera, Marta, Nuevo, Javier, Sánchez Tena, Jesús, Resler, Gustavo, Luzón, Elisa, and Levy Naon, Alberto
Published: 2023
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3. Achieving clinical outcomes with benralizumab in severe eosinophilic asthma patients in a real-world setting: ORBE II study

Author: Alicia Padilla-Galo, Isabel Moya Carmona, Pilar Ausín, Luis Carazo Fernández, Ismael García-Moguel, José Luis Velasco-Garrido, Rubén Andújar-Espinosa, Francisco Casas-Maldonado, Eva Martínez-Moragón, Carlos Martínez Rivera, Elisabet Vera Solsona, Fernando Sánchez-Toril López, Andrea Trisán Alonso, Marina Blanco Aparicio, Marcela Valverde-Monge, Borja Valencia Azcona, Marta Palop Cervera, Javier Nuevo, Jesús Sánchez Tena, Gustavo Resler, Elisa Luzón, and Alberto Levy Naon
Subjects: Benralizumab, Severe eosinophilic asthma, ORBE II, Real world evidence, Biologics, Chronic rhinosinusitis with nasal polyps, Diseases of the respiratory system, RC705-779
Abstract: Abstract Background The ORBE II study aimed to describe the characteristics and clinical outcomes of adult patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-world setting in Spain. Methods ORBE II (NCT04648839) was an observational, retrospective cohort study in adult SEA patients who had been prescribed benralizumab. Demographic and clinical data of 204 SEA patients were collected 12 months prior to benralizumab initiation (baseline) and at follow-up. Exacerbation rate, asthma symptoms, maintenance oral corticosteroid (OCS) use and lung function were evaluated, among other variables. Results A total of 204 SEA patients were evaluated. Mean (standard deviation, SD) age of the study population was 56.4 (12.4) years, 62.3% were women and mean (SD) duration of asthma was 15.1 (12.7) years. Median (Q1–Q3) follow-up duration was 19.5 (14.2–24.2) months. At baseline, 72.6% of the overall population (OP) presented blood eosinophil counts ≥ 300 cells/µL; 36.8% had comorbid chronic rhinosinusitis with nasal polyps (CRSwNP); 84.8% reported at least one severe exacerbation, and 29.1% were OCS-dependent. At 1 year of follow-up, patients receiving benralizumab treatment had a 85.6% mean reduction in exacerbations from baseline, and 81.4% of patients achieved zero exacerbations. We also found a clinically relevant mean (SD) increase in pre-bronchodilator (BD) FEV1 of 331 (413) mL, with 66.7% of patients achieving a pre-BD FEV1 increase ≥ 100 mL, and 46.3% of patients achieving a pre-BD FEV1 ≥ 80% of predicted. Regarding symptom control, 73.8% of the OP obtained an ACT score ≥ 20 points. After 1 year of follow-up, mean reduction in the daily OCS dose was 70.5%, and complete OCS withdrawal was achieved by 52.8% of the OCS-dependent patients. Almost half (43.7%) of the OP on benralizumab met all four criteria for clinical remission. Patients with concomitant CRSwNP obtained similar or enhanced outcomes. Conclusions These data support the real-world benefits of benralizumab in SEA patients, and particularly in those with concomitant CRSwNP. Trial registration NCT04648839.
Published: 2023
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4. Clinical characteristics and risk of exacerbations associated with different diagnostic criteria of asthma-COPD overlap

Author: Soler-Cataluña, Juan José, Novella, Laura, Soler, Cristina, Nieto, María Luisa, Esteban, Violeta, Sánchez-Toril, Fernando, and Miravitlles, Marc
Published: 2020
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5. Características clínicas y riesgo de agudizaciones asociados con diferentes criterios diagnósticos del solapamiento asma-EPOC

Author: Soler-Cataluña, Juan José, Novella, Laura, Soler, Cristina, Nieto, María Luisa, Esteban, Violeta, Sánchez-Toril, Fernando, and Miravitlles, Marc
Published: 2020
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6. Utilidad clínica de la determinación de pepsina en saliva en pacientes con tos crónica asociada a refujo

Author: Nieto-Cabrera, María Luisa, Soler-Cataluña, Juan José, Rodrigo-Nieto, Clara, Capella Soriano, Begoña, Sánchez-Toril, Fernando, and Lorenzo Dus, María José
Published: 2020
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7. Utilidad clínica de la determinación de pepsina en saliva en pacientes con tos crónica asociada a refujo

Author: María Luisa Nieto-Cabrera, Juan José Soler-Cataluña, Clara Rodrigo-Nieto, Begoña Capella Soriano, Fernando Sánchez-Toril, and María José Lorenzo Dus
Subjects: Chronic cough, Reflux associated with chronic cough, Pepsin, Diseases of the respiratory system, RC705-779
Abstract: Resumen: Introducción: La tos crónica (TC) asociada a reflujo es muy frecuente en la práctica clínica, pero su diagnóstico no siempre es sencillo. La determinación de pepsina en saliva es un método novedoso, sencillo y no invasivo para el estudio de reflujo. Objetivo: Analizar rentabilidad diagnóstica de la determinación de pepsina en saliva en paciente con TC. Método: Estudio prospectivo sobre una cohorte consecutiva de pacientes con TC. Los pacientes se diagnostican de tos asociada a reflujo según 3 criterios: 1) presencia de síntomas típicos de reflujo gastroesofágico; 2) Reflux Symptom Index > 13, Reflux Findings Score ≥ 5, y 3) tránsito gastroesofágico, endoscopia digestiva o pHmetría-impedanciometría positiva. A todos los pacientes se les realizaron 2 determinaciones de pepsina en saliva, mediante la aplicación del Peptest®. Resultados: Se incluyó a 99 pacientes, de los cuales 64 (64,6%) fueron diagnosticados de TC asociada a reflujo, 9 (14,1%) como única causa y 55 (85,9%) asociada a otros diagnósticos. Cincuenta y seis tenían un Peptest® positivo, con una sensibilidad de la prueba del 87,5%, una especificidad del 65,7% y los valores predictivo positivo (VPP) y negativo (VPN) del 82 y el 74%, respectivamente. En pacientes sin síntomas digestivos, el VPP de la pepsina fue del 64% y el VPN del 88%. Conclusiones: El reflujo es una causa importante de TC y generalmente forma parte de una etiología multifactorial. La determinación de pepsina en saliva tiene una alta sensibilidad para reflujo, aunque con baja especificidad que a día de hoy limita su uso sistemático. Abstract: Introduction: Chronic cough (CC) associated with reflux is very common in clinical practice, but it is not always easy to diagnose. The determination of pepsin in saliva is a novel, simple and non-invasive method for the study of reflux. Objective: To analyze the diagnostic yield of the determination of pepsin in saliva in a patient with CC. Method: This was a prospective study conducted in a consecutive cohort of patients with CC. Patients were diagnosed with cough associated with reflux according to 3 criteria: 1) Presence of typical symptoms of gastroesophageal reflux disease (GERD), 2) Reflux Symptom Index > 13, Reflux Findings Score ≥ 5 and 3) gastroesophageal transit, gastrointestinal endoscopy, and/or positive impedance pH monitoring. All patients underwent 2 determinations of pepsin in saliva, using the Peptest®. Results: We included 99 patients, of which 64 (64.6%) were diagnosed with CC associated with reflux, 9 (14.1%) as the sole cause and 85.9% (55) associated with other diagnoses. Fifty-six had a positive Peptest®, with a sensitivity of 87.5%, specificity of 65.7%, and positive (PPV) and negative (NPV) predictive values of 82% and 74%, respectively. In patients without digestive symptoms, the PPV of pepsin was 64% and the NPV was 88%. Conclusions: Reflux is an important cause of chronic cough and usually forms part of a multifactorial etiology. The determination of pepsin in saliva has a high sensitivity for reflux, but a low specificity that currently limits its routine use.
Published: 2020
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8. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author: Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, Sabine, Rolke, Mathias, Korn, Stephanie, Pabel, Helmut, Hoffmann, Martin, Feimer, Jan, Rabe, Klaus, Deckelmann, Regina, Welte, Tobias, Ohbayashi, Hiroyuki, Hozawa, Soichiro, Shimoda, Terufumi, Yoshida, Makoto, Nagakura, Toshikazu, Kamei, Tadashi, Sano, Yasuyuki, Kagami, Shinichiro, Takahashi, Hisaho, Haida, Michiko, Kimura, Goro, Nakamura, Hiroyuki, To, Yasuo, Shinkai, Masaharu, Shimokawaji, Tadasuke, Kudo, Makoto, Shijyubo, Noriharu, Tochigi, Takao, Kato, Motokazu, Tanaka, Akihiko, Gon, Yasuhiro, Sasaki, Norihisa, Ohdaira, Tetsuro, Omori, Chiharu, Takahashi, Toshiki, Takeuchi, Satomi, Nakajima, Kiyotaka, Makita, Hironi, Kaneko, Masahiro, Furuta, Kenjiro, Taniguchi, Masami, Inobe, Yoshito, Miki, Hiroshi, Nakamura, Yoichi, Miyazawa, Naoki, Yano, Shuichi, Iijima, Masayuki, Yamato, Tsuyoshi, Diaz, Javier, Matsuno, Alberto, Felix, Efrain, Guerreros, Alfredo, Daly, Alejandro, Rodriguez Chariarse, Fernando, Salazar, Danilo, Castro, Socorro, Chavez, William, Estrella, Rolando, Aquino, Teresita, Atienza, Tito, Samoro, Ronnie, Isidro, Marie Grace Dawn, Kuna, Piotr, Antczak, Adam, Bednarek, Michał, Mądra-Rogacka, Danuta, Hofman, Teresa, Jutel, Marek, Pisarczyk-Bogacka, Ewa, Kot, Agata, Mróz, Robert, Czupryńska-Borkowska, Małgorzata, Żurowska-Gębala, Małgorzata, Dyczek, Andrzej, Jasieniak-Pinis, Grażyna, Wojnowski, Piotr, Trębas-Pietraś, Ewa, Dobryniewska, Małgorzata, Stobiecki, Marcin, Tarnowska-Matusiak, Marzenna, Magner, Alina, Kolczyński, Andrzej, Kachel, Tomasz, Bartuzi, Zbigniew, Majorek-Olechowska, Bernadetta, Śliwiński, Paweł, Balicka, Violetta, Hajoł, Elżbieta, Stachera, Jacek, Rachel, Marta, Michnar, Marek, Tałałaj, Jarosław, Springer, Ewa, Napora, Piotr, Grzelewski, Tomasz, Bijata-Bronisz, Renata, Świderska, Anna, Mincewicz, Grzegorz, Sankowski, Zbigniew, Fijołek, Tomasz, Kwaśniewski, Artur, Jerzyńska, Joanna, Cygler, Jerzy, Olesiejuk, Ryszard, Von Steiner, Iwona, Machowiak, Wojciech, Filipek, Krzysztof, Piskorz, Piotr, Uhryn, Ewa, Nittner-Marszalska, Marita, Rybicka-Liszewska, Elżbieta, Bodzenta-Łukaszyk, Anna, Chełmińska, Marta, Krupa-Borek, Izabella, Skucha, Wojciech, Płoszczuk, Anna, Mihaescu, Traian, Petrui, Ioan Dorin, Savu, Angelica, Apti, Ghiulten, Toma, Claudia, Trailescu, Ana, Sokurenko, Sergei, Trofimov, Vasiliy, Leshchenko, Igor, Shaporova, Natalia, Ilyashevich, Inna, Stitsenko, Irina, Vizel, Alexander, Ilkovich, Yulia, Tikhanov, Dmitrii, Goncharova, Svetlana, Ezhov, Andrey, Ignatova, Galina, Izmozherova, Nadezhda, Berdnikova, Nadezhda, Goryachkina, Ludmila, Popova, Veronika, Bolieva, Laura, Rebrov, Andrey, Nosov, Vladimir, Magnitskaya, Olga, Nedogoda, Sergey, Abrosimov, Vladimir, Molotkov, Artem, Reshedko, Galina, Smirnov, Mikhail, Osipenko, Marina, Pavlysh, Elena, Myasoedova, Svetlana, Lenskaya, Liudmila, Chistyakov, Valery, Vishneva, Elena, Uon, Liliya, Zateyschikova, Anna, Laleko, Svetlana, Pak, Tatiana, Bruning, Axel, Naidoo, Visvakuren, Reddy, Jeevren, Van Zyl Smit, Richard, Park, Hae-Sim, Cho, Young Joo, Cho, Sang-Heon, Lee, Sang Haak, Lee, Byung Jae, Kim, Ju Sang, Cho, You Sook, Park, Choon-Sik, Kim, Mi-Kyeong, Koh, Young-Il, Kim, Joo-Hee, Lee, Sook Young, Lee, Sang Pyo, Park, Jung Won, Yoo, Kwang Ha, Yoon, Hyoungkyu, Lee, Jaechun, Hur, Gyu-Young, Lee, Soo Keol, Kim, HeeKyoo, Ramos Barbón, David, Laffond Yges, Elena, Martínez Moragón, Eva, Arias Guillen, Miguel, Saura Vinuesa, Alberto, Sánchez-Toril López, Fernando, Velasco Garrido, José Luis, García-Cosio Piqueras, Borja, Pérez de Llano, Luis, Valero Santiago, Antonio Luis, Rubio, Myriam Calle, Bjermer, Leif, Lundbäck, Bo, Gemicioglu, Bilun, Bavbek, Sevim, Ediger, Dane, Erdinc, Munevver, Hanta, Ismail, Nayci, Sibel, Arinc, Sibel, Iashyna, Liudmyla, Mostovoy, Yuriy, Ostrovskyy, Mykola, Kuryk, Lesia, Lemko, Ivan, Ospanova, Tetyana, Moskalenko, Liubov, Korzh, Oleksii, Blazhko, Viktor, Krakhmalova, Olena, Romaniuk, Liliia, Dytyatkovs'ka, Yevgeniya, Yakovenko, Oleh, Gavrysyuk, Volodymyr, Burhan, Hassan, Saralaya, Dinesh, Scott, Stephen, Morice, Alyn, Jackson-Voyzey, Ewart, Win, Thida, Nasser, Shuab, Harrison, Richard, Chaudhuri, Rekha, Nordstrom, Monica, De, Pradip, Masoli, Matthew, Mansur, Adel, Gunstone, Anthony, Niven, Robert, Harrison, Timothy, Babu, Suresh, Bhuchar, Subodh, Kureishy, Shahrukh, Zwetchkenbaum, John, Kaplan, Lawrence, Bleecker, Eugene, Reyes, Santiago, Fakih, Faisal, Heuer, Marvin, Klein, Ryan, Marcus, Michael, Hussain, Iftikhar, Tanus, Tonny, Raissy, Hengameh, Alpizar, Sady, Rodriguez, Hector, Gleich, Gerald, Bridges, Tracy, Pouzar, Joe, Steven, Gary, Matz, Jonathan, Krstevska, Shana, Ziworitin, Dama, Kaplan, Adolfo, Sublett, James, DeAngelo, James, Darter, Amy, Agaiby, John, Hagan, John, Davis, Enrique, Siri, Dareen, Mcevoy, Charlene, Dharma, Chrisette, Karimjee, Najmuddin, Kelsen, Steven, Frade, Manuel, Silverthorn, Amy, Kline, Joel, Averill, Francis, Ruiz, Jose, Robinette, Emory, Shaikh, Zeeshan, Aguilar, Carlos, Nish, William, Alvarez, German, Ismail, Younus, Parikh, Purvi, Leong, Mila, Murphy, Dennis, Garcia, Francisco, Goldsobel, Alan, Blanco, Antonio, Campbell, Edward, Perez, Guido, Chupp, Geoffrey, Bates, Toby, Perez, Vandely, Wenzel, Sally, Shenoy, Kartik, Katial, Rohit, Bernstein, David, Parikh, Neil, Sims, William, Ferguson, Gary, Pham, David, George, Anu, Beasley, Richard, Perez, Gilberto, Garver, Robert, Garcia-Portela, Miriam, Wong, Stephen, Soong, Weily, Guillot, Richard, Hudes, Golda, Arif, Ahmed, Binker, Josefa, Villareal, Manuel, Ziegner, Ulrike, Ojile, Joseph, Goswami, Sanjeev, Piniella, Carlos, Segal, Ilia, Zafra, Heidi, Lee, Mitchell, Tarpay, Martha, Panuto, John, Merchant, Rajan, Springsteen, Peter, Scialla, Timothy, Shapero, Paul, Allen, Karen, Moss, Mark, Cruz, Humberto, Rumbyrt, Jeffrey, Boyd, Amy, Nathan, Robert, Bernstein, Jonathan, Jacobs, Joshua, Ginchansky, Elliot, Johnston, Janice, Baxter, Barbara, Johnson II, Thomas, Apaliski, Stephen, Corder, Clinton, Fuentes, David, Diaz, Joseph, Ngo, Chau, Le, Lan, Busse, William W, Bleecker, Eugene R, Ferguson, Gary T, Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell
Published: 2019
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9. ORBE II study: Is rapid response to benralizumab associated with positive long term clinical outcomes?

Author: Ausin Herrero, Pilar, primary, Navarrete, Eugenia, additional, Velasco, Jose Luis, additional, Martinez, Álvaro, additional, Cañete, Carmen, additional, Sánchez Toril, Fernando, additional, Santin, Mónica, additional, Gonzalez, Marta, additional, Nuevo, Javier, additional, Luzón, Elisa, additional, and Padillo, Alicia, additional
Published: 2023
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10. Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

Author: González, F. Callejas, López, J. Jiménez, Riaza, M. Martínez, Orenes, M. Moscardó, Montaño, P. Prieto, Toro, M. Torrecillas, Balaguer, C. Andreu, Girones, M. Antón, Martinez, C. Baeza, Martín, I. Flores, Delgado, P. Gonzalez, Calahorro, M. Martos, Carrasco, G. Mediero, Pacheco, R. Rodríguez, Tomás, V. Vilella, Godoy, M. Mota, Yébenes, J. Zapata, Balza De Vallejo, O. Villarreal, Fernandez, J. Alvarez, Gonzalez, T. Bazus, De Las Pozas, G. Castaño, Donado, C. Diaz, Angulo, S. Díaz, Ortiz, G. Gala, Mañana, B. Requejo, Gonzalez, R. Blanco, Nieves, E. Gómez, Torrado, J. Marin, Culla, M. Dordal, Pla, J. Juanola, Bellfill, R. Lleonart, Velasco, J. Martos, Nogues, E. Pinto, Ortun, M. Rivera, Aguñin, P. Rubinstein, Farre, N. Subira, Combas, J. Valldeperas, Zubeldia, I. Ansotegui, Hortigüela, G. Bernaola, Ayuso, J. Ciruelos, Álvarez, G. González, Peña, M. Herrerias, Castro, A. Lahuerta, Llorente, P. Losada, Martinez, P. Marin, Malanda, N. Marina, Gonzalez, F. Garcia, Miguel, T. Peña, Hernandez, M., Timon, S. Jimenez, Carreño, S. Porcel, Olbah, M. Alwakil, Muñoz, A. Arnedillo, Mohedad, J. Chamorro, Fernandez, D. Gutierrez, Camacho, A. Letran, Lopez, C. Merinas, Gonzalez, M. Millan, Bernal, S. Niño, Pellon, L. Fernandez, Miguel, E. Morchon, Portal, F. Ortiz, Rodríguez, A. Suárez, Alapont, M. Modesto, Raducan, I., Segarra, M. Salvador, Bonilla, P. Galindo, Calderon, P. Mata, Rodriguez, M. Mena, Martinez, R. Lama, Pérez, M. Martín, Villarejo, M. Morales, Aparicio, M. Blanco, Muíño Joga, M. Do, Garcia-Boente, L. Fontan, Paz, V. García, Barcala, F. Gonzalez, Orjales, R. Nuñez, Castedo, C. Rabade, Diaz, M. Rico, Fernandez, A. Moreno, Español, S. Aparicio, San Francisco, A. Ruiz, Navarrete, B. Alcázar, Gomez De Cadiz, L. Cassini, Rodriguez, M. Escribano, Lopez, J. Florido, Jiménez, M. Lara, Caballero, J. Lopez, Ceres, M. Martínez, Costoya, R. Mayorgas, García, C. Morales, Vilchez, M. Rojas, Ortiz, A. Romero, Mazuecos, J. Beitia, Castro, A. Vega, Arenaza, B. Labeguerie, Mendizabal, S. Lizarza, Sampedro, I. Perez, Vazquez, L. Valverde, De Sus, J. Cegoñino, Villa, J. Compaired, Pargada, D. Ferrer, Jarque, J. Herrero, Patiño, M. Chacon, Gomila, A. Fuster, Pastrie, F. Nicolau, Lopez, J. Almagro, Martinez, P. Benito, Ruiz De Lobera, A. Velez, Gonzalez, F. Carballada, Carral, C. Perez, Racamonde, A. Veres, Del Pino, M. Cervera, Sacanell, J. Rozadilla, García, I. Ali, Mejias, Y. Anta, Bausela, B. Añíbarro, Cozar, M. Arroyo, Sanz, P. Barranco, Bobolea, I., Fernandez, A. Bueso, De Santiago Delgado, E., Campos, R. Diaz, Uña, J. Donado, Vila, A. Feliu, Cano, M. Gandolfo, De Pedro, J. Garcia, Galicia, M. Garcimartin, De Olano, D. González, Barbudo, B. Huertas, Viña, A. López, Peña, A. Losada, Martin, G. Minguez, De Francisco, A. Montoro, Borque, R. Moreno, Moro, M., Prieto, M. Ramirez, Frutos, M. Reche, Jimenez, B. Rodriguez, Rodríguez, M., Ribate, D. Romero, Perez, F. Ruano, Hornillos, J. Ruiz, López, P. Sánchez, Martinez, F. Sola, Garrido-Lestache, J. Subiza, Gambasica, Z. Vasquez, Albelda, C. Vila, Ramirez, J. Alcazar, De Luiz Martínez, G., Núñez, I. García, De Luna, F. Linde, Sáenz De Tejada, E. Ortega, Galo, A. Padilla, Martinez, R. Rodriguez, Esojo, M. Soria, Espinosa, R. Andujar, Inglés, M. Avilés, Mora, R. Bernabeu, Campos, M. Franco, Arellano, M. Peña, Puebla, M. Alvarez, Figueroa, B. García, Fernández, S. Garrido, Rivera, J. Olaguibel, Purroy, A. Tabar, Garazo, B. Presedo, Losada, S. Varela, Villamuza, Y. García, Bonny, J. Cumplido, Sintes, R. Alvarez, Landin, J. Castro, Paz, A. Cobas, Abelaira, M. Corbacho, Rio, F. Iglesias, Sanmartín, A. Pallarés, Picans, I., Moreira, A. Regueiro, Romera, R. Tejedor, Aznar, J. Igea, Bellido, F. Muñoz, Hernandez, M. Rodriguez, Perez, R. González, Flores, H. Izaguirre, Gutierrez, F. Alvarez, Cimbollek, S., De Luque Piñana, V., Gallardo, J. Medina, Garcia, V. Moreno, Cuevas, J. Orta, Crespo, Y. Puente, Enriquez, J. Quiralte, Dominguez, P. Serrano, Elias, Ò. Sotorra, Pamplona, M. Muñoz, Lara, M. Jimenez, De Gregorio, A. Moral, Martin, M. Alvariño, Canelles, M. Ballester, Baixauli, E. Burches, Serra, P. Catalán, Gregori, M. Climent, Rodriguez, P. Cordero, De Las Marinas Alvarez, M., Palacios, M. Díaz, El-Qutob López, D., Giner, J. Greses, Lara, S. Herrera, Martínez, G. Jorro, Santafé, J. Liñana, Bayo, A. Lloris, Moragon, E. Martinez, Sancho, I. Molero, Lacomba, J. Montoro, Sendra, E. Naval, Seisdedos, L. Navarro, Bertol, B. Orosa, Iniesta, A. Robles, Cubillan, J. Ruiz, Sánchez-Toril López, F., Vinuesa, A. Saura, Gomez, A. Alonso, De Frutos Arribas, J., Fernandez, E. Macias, Alonso, A. Sanchez, Sanz, C. Colás, Fuentes, M. Domínguez, Sotillos, M. Garcés, Arazuri, N. Segura, Sastre, Joaquín, Crespo, Astrid, Fernandez-Sanchez, Antonio, Rial, Manuel, and Plaza, Vicente
Published: 2018
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11. The Role of Pulmonology in the National Health System Chronicity Strategy

Author: Soler-Cataluña, Juan José, Sánchez Toril, Fernando, and Aguar Benito, M. Carmen
Published: 2015
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12. El papel de la neumología ante la Estrategia de cronicidad del Sistema Nacional de Salud

Author: Soler-Cataluña, Juan José, Sánchez Toril, Fernando, and Aguar Benito, M. Carmen
Published: 2015
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13. Clinical characteristics and risk of exacerbations associated with different diagnostic criteria of asthma-COPD overlap

Author: Violeta Esteban, Cristina Soler, María Luisa Nieto, Laura Novella, Fernando Sánchez-Toril, Juan José Soler-Cataluña, and Marc Miravitlles
Subjects: Male, medicine.medical_specialty, Exacerbation, Population, Cohort Studies, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Eosinophilia, Prevalence, Humans, Medicine, Asthma copd overlap, education, Asthma, education.field_of_study, COPD, business.industry, General Medicine, medicine.disease, respiratory tract diseases, 030228 respiratory system, Cohort, Female, Observational study, medicine.symptom, business
Abstract: Introduction There is currently no universally accepted definition of asthma−COPD overlap (ACO). Objective To compare the prevalence of ACO in patients with asthma or COPD, and to assess their clinical characteristics and the capacity of the different definitions to predict the risk of exacerbation. Method Prospective observational study with a 12-month follow-up in an asthma cohort and a COPD cohort. Four diagnostic criteria were compared: A) the Spanish 2012 consensus; B) the 2016 international consensus; C) the 2017 consensus between the Spanish COPD guidelines (GesEPOC) and GEMA asthma guidelines; and D) the single criterion of ≥300 eosinophils/μL, proposed by GOLD 2019. The risk of exacerbations was evaluated in each group. Results A total of 345 patients were included, 233 (67.5%) with COPD and 112 (32.5%) with asthma, aged 63 ± 14 years, 70.4% men. Fifteen (4.3%) patients met the criteria for ACO according to the criteria described under A above; 30 (8.7%) with the criteria of B; 118 (34.2%) with the criteria of C; and 97 (28.1%), with the D criterion. The ACO-COPD subtype were older, had worse lung function, and an increased risk of exacerbation compared with the ACO-asthma group. Of all the definitions evaluated, those which distinguished a higher risk of exacerbations were the GesEPOC-GEMA consensus and the GOLD proposal. Conclusions The prevalence of ACO varies enormously depending on the diagnostic criteria used. The ACO population is heterogeneous, and the ACO-COPD subtype is very different from the ACO-asthma subtype. The definitions that include eosinophilia identify ACO patients with a greater risk of exacerbation.
Published: 2020

14. Características clínicas y riesgo de agudizaciones asociados con diferentes criterios diagnósticos del solapamiento asma-EPOC

Author: Juan José Soler-Cataluña, Fernando Sánchez-Toril, Violeta Esteban, Cristina Soler, María Luisa Nieto, Laura Novella, and Marc Miravitlles
Subjects: Pulmonary and Respiratory Medicine, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, business.industry, Medicine, business, Humanities
Abstract: Resumen Introduccion En la actualidad no disponemos de una definicion de solapamiento asma-EPOC (ACO) universalmente aceptada. Objetivo Comparar la prevalencia del ACO en pacientes con asma o EPOC, valorar sus caracteristicas clinicas y la capacidad predictiva de riesgo de agudizacion de las diferentes definiciones. Metodo Estudio prospectivo observacional con seguimiento de 12 meses sobre una cohorte de asma y otra con EPOC. Se comparan 4 criterios diagnosticos: A) el consenso espanol del 2012; B) el consenso internacional del 2016; C) el consenso entre la guia espanola de la EPOC (GesEPOC) y la del asma (GEMA) del 2017; y D) el criterio unico de ≥ 300 eosinofilos/μl, propuesto por GOLD 2019. En cada grupo se evaluo el riesgo de agudizaciones. Resultados Se incluyeron 345 pacientes, 233 (67,5%) con EPOC y 112 (32,5%) con asma, con una edad de 63 ± 14 anos; el 70,4% eran hombres. Quince (4,3%) pacientes cumplian criterios de ACO con criterios A; 30 (8,7%) con los B; 118 (34,2%) con los C; y 97 (28,1%) con el criterio D. El subtipo ACO-EPOC presento mas edad, peor funcion pulmonar y mayor riesgo de agudizacion que los ACO-asma. De todas las definiciones evaluadas, las que presentaron mayor riesgo de agudizaciones fueron la del consenso GesEPOC-GEMA y la propuesta de GOLD. Conclusiones La prevalencia de ACO varia enormemente en funcion del criterio diagnostico utilizado. La poblacion de ACO es heterogenea, con un subtipo ACO-EPOC muy diferente al ACO-asma. Las definiciones que incluyen la eosinofilia identifican a los ACO de mas riesgo de agudizacion.
Published: 2020

15. The Importance of Small Airway Dysfunction in Asthma: The GEMA-FORUM III Task Force

Author: Vicente Plaza, J.A. Trigueros, Gemaforum Task Force, Javier Domínguez-Ortega, Isabel Urrutia, J Hernández, S. Cimbollek, S Fernández, Iñigo Ojanguren, C Cisneros, Santiago Quirce, F J Sánchez-Toril, A Torrego, A Padilla, A Pallarés, and J D López
Subjects: medicine.medical_specialty, business.industry, Task force, Immunology, Respiratory System, medicine.disease, Asthma, Physical medicine and rehabilitation, Impulse Oscillometry, Spirometry, medicine, Immunology and Allergy, Humans, business, Airway
Published: 2021

16. Estructura motorizada para soporte de paneles solares, con seguimiento solar y medida de temperatura

Author: Capilla Lladró, Roberto, Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny, Sánchez-Toril Mora, Jorge, Capilla Lladró, Roberto, Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny, and Sánchez-Toril Mora, Jorge
Abstract: [ES] La motivación que ha llevado a realizar este proyecto es el diseño de un seguidor solar para Valencia con la instalación de módulos solares fotovoltaicos y la producción eficiente de energía eléctrica. Esto lleva implícito la mejora del rendimiento respecto a un sistema fijo convencional. Para el diseño del seguidor solar tendremos en cuenta: • Los conocimientos sobre el comportamiento del sol, para poder optimizar y aprovechar de manera eficiente la radiación recibida. • La robustez del seguidor para prevenir fallos y averías que perjudiquen a la producción ya que la se encuentra expuesto a las inclemencias del tiempo que pueden deteriorar las características de los materiales. • El diseño del producto para conseguir un buen precio en relación a su potencia y así competir con los sistemas fijos.
Published: 2021

17. Benralizumab for the Prevention of COPD Exacerbations

Author: Criner, G. J., Celli, B. R., Brightling, C. E., Agusti, A., Papi, A., Singh, D., Sin, D. D., Vogelmeier, C. F., Sciurba, F. C., Bafadhel, M., Backer, V., Kato, M., Ramirez-Venegas, A., Wei, Y. -F., Bjermer, L., Shih, V. H., Jison, M., O'Quinn, S., Makulova, N., Newbold, P., Goldman, M., Martin, U. J., GALATHEA Study Investigators, TERRANOVA Study Investigators, Otto, Burghuber, Bernhard, Forstner, Gerhard, Köberl, Bernd, Lamprecht, Judith, Löffler-Ragg, Horst, Olschewski, Michael, Studnicka, Francois, Beaucage, Guy, Chouinard, Anthony, Dechant, Anthony, Dowell, Jacques, Hebert, Sohail, Khattak, Kieran, Killian, William, Killorn, Andy, Lam, Francois, Maltais, Darcy, Marciniuk, Lyle, Melenka, Bonavuth, Pek, Jeremy, Road, Donald, Sin, Alain, Vaugeois, Brandie, Walker, Tomas, Dvorak, Stanislav, Holub, Otakar, Hokynar, Vitezslav, Kolek, Daniela, Kopecka, Jan, Krepelka, Jaroslav, Mares, Josef, Veverka, Vladimir, Zindr, Sabine, Ballenberger, Rolf, Dichmann, Christian, Geßner, Margret, Jandl, Claus, Keller, Joachim, Kirschner, Marc, Kornmann, Petra, Mikloweit, Ingomar, Naudts, Axel, Overlack, Isabelle, Schenkenberger, Volker, Schlegel, Lutz Von Versen, Claus Franz Vogelmeier, Stefan, Zielen, István, Albert, Beatrix, Bálint, Mária Csilla Hangonyi, Teréz, Kecskés, Anikó, Kurucz, Balázs, Medgyasszay, Lajos, Molnár, János, Mucsi, Márta, Papp, Magdolna, Póczi, Éva, Radeczky, Zsolt Pápai Székely, Csilla, Szabó, Gyöngyi, Szabó, Melinda, Szabó, Alfredo Antonio Chetta, Giuseppe Di Maria, Giulio, Donazzan, Federica, Meloni, Elisabetta, Pace, Pierluigi, Paggiaro, Alberto, Papi, Ricciardolo, Fabio Luigi Massimo, Antonio, Spanevello, Fumiaki, Aoki, Ryosuke, Eda, Takeo, Endo, Yasushi, Fukushima, Kenichi, Gemba, Naoki, Hagimoto, Hiromasa, Harada, Yasuko, Harada, Norihiko, Hata, Osamu, Hataji, Nobuo, Hatakeyama, Takahiko, Horiguchi, Gen, Ideura, Motoyasu, Iikura, Azusa, Ikegami, Shirou, Imokawa, Yoshikazu, Inoue, Takeshi, Isobe, Ryoji, Ito, Susumu, Iwata, Tadashi, Kamei, Motokazu, Kato, Hideki, Katsura, Yuji, Kawarada, Norio, Kihara, Masaharu, Kinoshita, Takashi, Kinoshita, Tomoo, Kishaba, Hideo, Kita, Arihiro, Kiyosue, Shigeru, Komatsu, Kazuki, Konishi, Sekiya, Koyama, Makoto, Kudo, Kazuhiko, Machida, Hironi, Makita, Hiroto, Matsuse, Naoki, Miyazawa, Hiroyuki, Nakamura, Yuji, Nakatani, Kazuyuki, Nishimura, Takashi, Nishimura, Junichi, Ogawa, Hiroyuki, Ohbayashi, Tetsuro, Ohdaira, Tsukasa, Ohnishi, Kazuhiko, Oki, Masahiko, Saito, Kenji, Sakamoto, Osamu, Sakamoto, Hisakuni, Sekino, Noriharu, Shijubo, Masaharu, Shinkai, Hideo, Soto, Yoshitaka, Sugawara, Noriaki, Suko, Hisaho, Takahashi, Masamitsu, Takahashi, Tsuneyuki, Takahashi, Hiroshi, Tanaka, Hiroyuki, Taniguchi, Tadayuki, Terada, Takao, Tochigi, Kazuyo, Tohyama, Hirokazu, Tokuyasu, Keisuke, Tomii, Tomomasa, Tsuboi, Mitsuyoshi, Utsugi, Katsumaru, Yamamoto, Michiko, Yamamoto, Shuichi, Yano, Makoto, Yoshida, Frank, Custers, Richard, Dekhuijzen, Remco, Djamin, Jan Willem Van Dan Berg, Lowie, Vanfleteren, Pascal, Wielders, Bogusława, Cimoszko, Anna, Doboszyńska, Andrzej, Dyczek, Andrzej, Fal, Krystyna, Folcik, Łukasz, Goliński, Marek, Jutel, Andrzej, Kolczyński, Piotr, Kuna, Ewa, Łączyńska, Wojciech, Machowiak, Maciej, Marczak, Joanna, Markiewicz, Janusz, Milanowski, Grzegorz, Mincewicz, Maria, Nittner-Marszalska, Wojciech, Papiewski, Małgorzata, Pawlukiewicz, Witold, Pomiećko, Barbara, Rewerska, Cezary, Rybacki, Wojciech, Skucha, Ewa, Trębas-Pietraś, Ewa, Uhryn, Małgorzata, Żurowska-Gębala, Laurentia, Andrei, Traian, Mihaescu, Stefan, Mihaicuta, Eniko Vera Pall, Ioan, Petrui, Angelica, Savu, Claudia, Toma, Ana, Trailescu, Vladimir, Abrosimov, Nataliya, Astafyeva, Evgenyi, Bazdyrev, Nadezhda, Berdnikova, Laura, Bolieva, Ekaterina, Bukreeva, Valery, Chistyakov, Anna, Galustyan, Halida, Gantseva, Svetlana, Goncharova, Sergey, Grigoriev, Galina, Ignatova, Inna, Ilyashevich, Nadezhda, Izmozherova, Magomed, Kamalov, Yaroslava, Khovaeva, Natalia, Kuzubova, Lyudmila, Kvitkova, Liudmila, Lenskaya, Igor, Leshchenko, Olga, Magnitskaya, Boris, Molotilov, Artem, Molotkov, Svetlana, Myasoedova, Sergey, Nedogoda, Vladimir, Nosov, Marina, Osipenko, Andrey, Peskov, Veronika, Popova, Oksana, Ratushnay, Irina, Ryzhova, Olga, Shangina, Natalia, Shaporova, Evgeny, Shmelev, Lybov, Shpagina, Alexander, Shutkin, Yuri, Shvarts, Mikhail, Smirnov, Irina, Stitsenko, Maksim, Vasilev, Arkadiy, Vertkin, Elena, Vishneva, Alexander, Vizel, Anna, Zateyschikova, Mohamed, Abdool-Gaffar, Ismail, Abdullah, Axel, Bruning, Nyda, Fourie, Michael, Greenblatt, Mohammed, Tayob, Venter, K, An Soo Jang, Kwan Ho Lee, Sang Haak Lee, Sook Young Lee, Suk Joong Yong, Kwang Ha Yoo, Soo Taek Uh, Ramón Agüero Balbín, David Ramos Barbón, Álvar Agustí García-Navarro, José Luis Velasco Garrido, Sergi Pascual Guardia, Eduard Monso Molas, Luis De Teresa Parreño, Borja García-Cosio Piqueras, German Peces-Barba Romero, Myriam Calle Rubio, Fernando Sánchez-Toril López, Alicia Marín Tapia, Heidi Martin Braschler, Martin, Brutsche, Michael, Grob, Jörg, Leuppi, Daiana, Stolz, Alexander, Turk, Nawar, Bakerley, Mona, Bafadhel, Christopher, Brightling, Rekha, Chaudhuri, Gourab, Choudhury, Graham, Devereux, Imran, Hussain, Kai, Lee, William, Macnee, Ravindran, Mahadeva, Matthew, Masoli, Monica, Nordstrom, Manish, Patel, Allan, Reid, Dinesh, Saralaya, Tariq, Sethi, Sukh Dave Singh, Anthony, G de Soyza, Tom, Wilkinson, Alice, Turner, Helen, Ward, Chandar, Abboy, Ivan, Ackerman, Idalia, Acosta, Arun, Adlakha, Bassil, Aish, Mohamed, Ali, Charles, Andrews, Robby, Ayoub, Anil, Badhwar, Dennis, Bassetti, Sherif El Bayadi, Richard, Beasley, Shashi, Bellam, Jonathan, Bernstein, Maria, Blahey, Scott, Bloom, Eugene, Bleecker, Wesley, Bray, Johnathan, Brewer, Robert, Buynak, William, Calhoun, Edward, Campbell, Anthony, Captain, Birjis, Chinoy, Kenneth, Chinsky, Geoffrey, Chupp, Arsenio, Columbie, Clinton, Corder, Gerard, Criner, Humberto, Cruz, Edward, Cullen, Kevin, Deboer, Michael, Denenberg, Mark, Dransfield, Leonard, Dunn, Miles, Elmore, David, Erb, Faisal, Fakih, Gary, Ferguson, Charles, Fogarty, Mark, Freed, Stephen, Fritz, David, Fuentes, Shariar, Cohen-Gadol, Robert, Garver, John, Given, Luis Ramos Gonez, Raul Ebran Gonzalez, Robert, Gordon, Gregory, Gottschlich, Donald, Graham, David, Grant, Gary, Greenwald, James, Greenwald, Kenneth, Haft, Gregory, Hammond, Nadia, Hansel, Jeffrey, Harris, Humberto, Hernandez, Marvin, Heuer, Albrecht, Heyder, David, Hill, Willis, Holloway, Octavian, Ioachimescu, Richard, Jackson, Ajay, Jain, Nan, Jiang, Thomas, Kaelin, Adolfo, Kaplan, Mitchell, Kaye, Akram, Khan, Yekaterina, Khronusova, Ryan, Klein, Joel, Kline, Firas, Koura, Ritsu, Kuno, Ware, Kuschner, Jean Claude Labissiere, David Laman Jr, John, Lee, Mitchell, Lee, Lawrence, Levinson, Njira, Lugogo, Mador, M, Nathaniel, Marchetti, Rafael, Martinez, Richard, Martinez, Peter, Mattar, David, Maybee, Dennis, Mcgraw, Michael, Mcguire, Curtis, Mello, Aaron, Milstone, John, Mitchell, Wendy, Moore, Timothy, Moriarty, Cheta, Nand, Brooke, Nevins, Ikeadi, Ndukwu, Rachel, Nisbet, David, Nyanjom, Maria, Nualart, Thomas, O'Brien, Mikhail, Palatnik, Gnyandev, Patel, Amit, Patel, Guido, Perez, Christopher, Perry, Michael, Pfeffer, Krishna, Pudi, Marina, Raikhel, Murali, Ramaswamy, Joe, Ramsdell, Donato, Ricci, Gary, Richmond, Eugene, Ryan, Fadi, Saba, Boris, Sagalovich, C Andrew Schroeder, Timothy, Scialla, Frank, Sciurba, Amit, Shah, Nirav, Shah, Zeeshan, Shaikh, Akhtar, Siddiqui, Barry, Sigal, Thomas, Siler, Howard, Silverboard, William, Sims, Clyde, Southwell, Selwyn, Spangenthal, Peruvemba, Sriram, James, Stocks, Tony, Su, John, Suen, Robert, Sussman, Horia, Tatu, Antonio, Terrelonge, Alan, Thomas, Mario, Torres, Rodolfo, Trejo, Miguel, Trevino, Banks, Turner, Manuel, Villareal, Janine, Vintch, Neal, Warshoff, Jan, Westerman, Philip, Wexler, Thomas, Yunger, Amir, Zeki, Mariano Fernandez Acquier, Norma, Aramayo, German, Arce, Juan, Belloni, Víctor, Cambursano, Carlos De La Vega, Fernando Rodriguez Chariarse, Pedro, Elias, Marcelo, Fernández, Ana, Lopez, Andrea, Medina, María, Otaola, Maria Salazan Saez, Maria De Salvo, Fernando, Scherbovsky, Ana, Stok, Jorge, Taborda, Alberto, Tolcachier, Fernando, Verra, Carlos, Victorio, Rita Gisela Delgado Vizcarra, Philip, Bardin, Peter, Bremner, Martin, Phillips, John, Upham, Peter, Wark, Antoine, Bolly, Alain, Delobbe, Peter, Driesen, Eduard, Janssens, Wim, Janssens, Olivier, Michel, Bernard, Vandooren, Martti, Antila, Jussara, Fiterman, Carlos, Fritscher, Jorge, Hetzel, Jose, Jardim, Waldo De Mattos, Rafael, Martins, Maria Eunice De Oliveira, Andreia, Pez, Maria, Sales, Rafael, Stelmach, Priscila, Wolff, Svetla, Andreeva, Reneta, Antonova, Ana, Dancheva, Yuliya, Ivanova, Slavcho, Ivanov, Hristo, Metev, Iveta, Naydenova, Tatyana, Petkova, Galina, Petrova, Kostadinka, Sotirova, Mariyana, Stoyanova, Rumen, Tiholov, Iliyana, Valkanova, Oleg, Yakov, Rosa, Feijoo, Juana, Pavie, Patricia, Schönffeldt, Absalon, Silva, Victor, Martinez, David, Espinosa, Alejandro, Londono, Dora, Molina, Gonzalo, Prada, Andrés, Rico, Gregorio Sanchez Vallejo, Alvaro, Urbina, Ana, Vanegas, Maria, Villegas, Josip, Aralica, Gordana, Stjepanovic, Vibeke, Backer, Uffe, Bødtger, Christian, Meyer, Læge Sven Nielsen, Anders Loekke Ottesen, Ingrid, Titlestad, Nathalie, Bautin, Arnaud, Bourdin, Pascal, Chanez, Francis, Couturaud, Antoine, Cuvelier, Gilles, Devouassoux, Pierre-Olivier, Girodet, Jean-François, Muir, Jean-Louis, Pépin, Alain, Proust, Azzedine, Yaici, Yochai, Adir, Gershon, Fink, Zvi, Fridlender, Gabriel, Izbicki, Mordechai, Kramer, Yehuda, Schwartz, Juan Moreno Hoyos Abril, Ricardo Campos Cerda, Efraín Montaño Gonzalez, Ricardo Ramirez Terrones, Rodolfo Posadas Valay, Alejandra, Ramirez-Venegas, Paul, Dawkins, Syed, Hussain, Benedict, Brockway, John, Richmond, Colin, Helm, Catherina, Chang, Jørn, Ahlqvist, Terje, Tollåli, Tadeusz, Tomala, Socorro, Castro, William, Chavez, Octavio, Cubas, Rolando, Estrella, Efrain, Felix, Ronal, Gamarra, Alfredo, Guerreros, Alberto, Matsuno, Danilo, Salazar, Miguel, Tsukayama, Albert Albay Jr, Teresita, Aquino, Tito, Atienza, Joven Roque Gonong, Ronnie, Samoro, Joel, Santiaguel, Beata, Asankowicz-Bargiel, Ewa, Pisarczyk-Bogacka, Renata, Bijata-Bronisz, Marta, Chełmińska, Małgorzata, Dobryniewska, Anna, Olech-Cudzik, Tomasz, Fijołek, Krzysztof, Filipek, Agata, Kot, Bożena, Kucińska, Krzysztof, Lis, Elżbieta, Rybicka-Liszewska, Marzenna, Tarnowska-Matusiak, Robert, Mróz, Piotr, Napora, Wojciech, Naumnik, Artur, Niemiec, Władysław, Pierzchała, Grzegorz, Przybylski, Katarzyna, Styka, Danuta, Wrońska, Branislava, Milenkovic, Dobrivoje, Novkovic, Matijaz, Flezar, Niksa, Segota, Snezana Ulcar Kostic, Albert, Klobucar, Leif, Bjermer, Dan, Curiac, Christer, Janson, Pekka, Koskinen, Lundback, Bo, Åke, Olsson, Shih-Lung, Cheng, Ming-Lin, Ho, Jeng-Yuan, Hsu, Wu-Huei, Hsu, Ping-Hung, Kuo, Chin-Chou, Wang, Yu-Feng, Wei, Kuang-Yao, Yang, Watchara, Boonsawat, Somchai, Chantarothorn, Warangkana, Keeratichananont, Kittipong, Maneechotesuwan, Kanok, Pipatvech, Piamlarp, Sangsayunh, Sibel, Arinc, Sermin, Borekci, Arzu Kaner Erturk, Filiz, Kosar, Hakan, Gunen, Ismail, Hanta, Pinar Akin Kabalak, Tunc Alp Demir, Sibel, Nayci, Serir Aktogu Ozkan, Abdullah, Sayiner, Esra, Uzaslan, Viktor, Blazhko, Volodymyr, Gavrysyuk, Olena, Golub, Liudmyla, Iashyna, Tetiana, Ilashchuk, Volodymyr, Koshlia, Olena, Krakhmalova, Vitali, Kryvenko, Lesia, Kuryk, Olena, Levchenko, Yuriy, Mostovoy, Mykola, Ostrovskyy, Tetyana, Pertseva, Olena, Piura, Nadiya, Rudnytska, Ganna, Stupnytska, Nataliia, Velychko, Oleh, Yakovenko, Lilia Rodriguez Ables, Roger, Abrahams, Jose, Alvarez, Fernando, Arencibia, Chander, Arora, Samir, Arora, Francis, Averill, Kwabena, Ayesu, Stephen, Basheda, Steven, Bauer, Jose, Bautista, Matthew, Beacom, Hernando, Bernal, Subodh, Bhuchar, J'Cinda, Bitters, John, Burk, Elizabeth, Burkett, James, Cain, Robert, Call, Christopher, Chappel, Bartolome, Celli, Tom, Christensen, Jeremy, Cole, Jerome, Daniel, Nguyen, Dang, Enrique, Davis, Samuel, Deleon, Robert, Deluca, Ernesto, Diaz, Anthony, Dimarco, Calvin, Dixon, Ankur, Doshi, Hugh, Durrence, Alain, Eid, John, Elsen, Herbon, Fleming, May, Flores, Scott, Franczek, Gregory, Funk, Stuart, Garay, Bernard, Garcia, Joseph, Graif, Carl, Griffin, Yamirka Duardo Guerra, David, Headley, Mitzie, Hewitt, Susan, Hole, Robert, Holladay, Ira, Horowitz, Yu-Luen, Hsu, Jonathan, Ilowite, Stephen, Jones, Ravindra, Kashyap, Edward, Kerwin, Ahtaram, Khan, Nicole, Kimzey, James, Krainson, Flory, Kreutter, Kannappan, Krishnaswamy, Shahrukh, Kureishy, Albert, Lai, Alex, Lechin, Daria, Lee, Marcus, Lee, Williams, Leeds, Joseph, Lillo, Edward, Lisberg, Lawrence, Madoff, Narendra, Maheskwari, Mujibur, Majumder, Sashi, Makam, Douglas, Mapel, Matthew, Mardiney, Jennifer, Martin, Isaac, Melamed, Elvin, Mendez, Stuart, Millstone, Joseph, Montes, Lee, Morrow, Frank, Murphy, Dany, Obeid, France, Occy, Godson, Oguchi, Juan, Ortiz, Francisco, Padron, Ward, Paine, James, Pearle, Enrique, Pelayo, Vandely, Perez, David, Pham, Carlos, Piniella, Kevin, Pritchett, Padmashri, Rastogi, Stephen, Ryan, Syed, Rehman, Jackson, Rhudy, Eustace, Riley, James, Riser, Clifford, Risk, Emory, Robinette, Christopher, Roney, Gary, Ruoff, David, Russian, Mercedes, Samson, Jay, Sandberg, Jose, Santiago, William, Sargeant, Alan, Schecter, Jeffrey, Scott, Ilia, Segal, Sudhir, Sehgal, Frederic, Seifer, Sudhir, Sekhsaria, Richard, Sellman, Paul, Shapero, Jeffrey, Shea, Lawrence, Sher, John, Sibille, Jawed, Siddiqui, Toniya, Singh, Deren, Sinkowitz, Denise, Smyth, Daniel, Soteres, Daniel, Sousa, Ralph, Steele, Thomas, Stern, Jose, Suarez, Sever, Surdulescu, Ricardo, Tan, Tonny, Tanus, Raymond, Tidman, Aurelio, Torres-Consuegra, Barry, Troyan, John, Updegrove, Sanjay, Vadgama, Armando, Pineda-Velez, Eduardo, Viera, Andrew, Wachtel, Ralph, Wade, Jimin, Wang, Dave, Webster, Paul, Weinberg, Terry, Wells, Jeffrey, White, Bram, Wieskopf, Hugh, Windom, Patrick, Wright, David, Wyatt, Bassam, Yousef, Zahid, Zafar, Chau, Ngo, Huong, Le, Lan, Nguyen, Thanh, Nguyen, Nhung, Nguyen, SALAS, Danielle, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Harvard Medical School [Boston] (HMS), University of Leicester, University of Barcelona, Università degli Studi di Ferrara = University of Ferrara (UniFE), University of Manchester [Manchester], St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada] (SPH-UBC), Philipps Universität Marburg = Philipps University of Marburg, University of Pittsburgh School of Medicine, University of Oxford, Bispebjerg University Hospital [Copenhagen, Denmark] (BUH), Kishiwada City Hospital [Osaka, Japan] (KCH), Instituto Nacional de Enfermedades Respiratorias [México, Mexico], I-Shou University [Kaohsiung, Taiwan] (ISU), Lund University [Lund], AstraZeneca [Gaithersburg, MD, USA] (AZ), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), and Otto Burghuber, Bernhard Forstner, Gerhard Köberl, Bernd Lamprecht, Judith Löffler-Ragg, Horst Olschewski, Michael Studnicka, Francois Beaucage, Guy Chouinard, Anthony Dechant, Anthony Dowell, Jacques Hebert, Sohail Khattak, Kieran Killian, William Killorn, Andy Lam, Francois Maltais, Darcy Marciniuk, Lyle Melenka, Bonavuth Pek, Jeremy Road, Donald Sin, Alain Vaugeois, Brandie Walker, Tomas Dvorak, Stanislav Holub, Otakar Hokynar, Vitezslav Kolek, Daniela Kopecka, Jan Krepelka, Jaroslav Mares, Josef Veverka, Vladimir Zindr, Sabine Ballenberger, Rolf Dichmann, Christian Geßner, Margret Jandl, Claus Keller, Joachim Kirschner, Marc Kornmann, Petra Mikloweit, Ingomar Naudts, Axel Overlack, Isabelle Schenkenberger, Volker Schlegel, Lutz Von Versen, Claus Franz Vogelmeier, Stefan Zielen, István Albert, Beatrix Bálint, Mária Csilla Hangonyi, Teréz Kecskés, Anikó Kurucz, Balázs Medgyasszay, Lajos Molnár, János Mucsi, Márta Papp, Magdolna Póczi, Éva Radeczky, Zsolt Pápai Székely, Csilla Szabó, Gyöngyi Szabó, Melinda Szabó, Alfredo Antonio Chetta, Giuseppe Di Maria, Giulio Donazzan, Federica Meloni, Elisabetta Pace, Pierluigi Paggiaro, Alberto Papi, Fabio Luigi, Massimo Ricciardolo, Antonio Spanevello, Fumiaki Aoki, Ryosuke Eda, Takeo Endo, Yasushi Fukushima, Kenichi Gemba, Naoki Hagimoto, Hiromasa Harada, Yasuko Harada, Norihiko Hata, Osamu Hataji, Nobuo Hatakeyama, Takahiko Horiguchi, Gen Ideura, Motoyasu Iikura, Azusa Ikegami, Shirou Imokawa, Yoshikazu Inoue, Takeshi Isobe, Ryoji Ito, Susumu Iwata, Tadashi Kamei, Motokazu Kato, Hideki Katsura, Yuji Kawarada, Norio Kihara, Masaharu Kinoshita, Takashi Kinoshita, Tomoo Kishaba, Hideo Kita, Arihiro Kiyosue, Shigeru Komatsu, Kazuki Konishi, Sekiya Koyama, Makoto Kudo, Kazuhiko Machida, Hironi Makita, Hiroto Matsuse, Naoki Miyazawa, Hiroyuki Nakamura, Yuji Nakatani, Kazuyuki Nishimura, Takashi Nishimura, Junichi Ogawa, Hiroyuki Ohbayashi, Tetsuro Ohdaira, Tsukasa Ohnishi, Kazuhiko Oki, Masahiko Saito, Kenji Sakamoto, Osamu Sakamoto, Hisakuni Sekino, Noriharu Shijubo, Masaharu Shinkai, Hideo Soto, Yoshitaka Sugawara, Noriaki Suko, Hisaho Takahashi, Masamitsu Takahashi, Tsuneyuki Takahashi, Hiroshi Tanaka, Hiroyuki Taniguchi, Tadayuki Terada, Takao Tochigi, Kazuyo Tohyama, Hirokazu Tokuyasu, Keisuke Tomii, Tomomasa Tsuboi, Mitsuyoshi Utsugi, Katsumaru Yamamoto, Michiko Yamamoto, Shuichi Yano, Makoto Yoshida, Frank Custers, Richard Dekhuijzen, Remco Djamin, Jan Willem Van Dan Berg, Lowie Vanfleteren, Pascal Wielders, Bogusława Cimoszko, Anna Doboszyńska, Andrzej Dyczek, Andrzej Fal, Krystyna Folcik, Łukasz Goliński, Marek Jutel, Andrzej Kolczyński, Piotr Kuna, Ewa Łączyńska, Wojciech Machowiak, Maciej Marczak, Joanna Markiewicz, Janusz Milanowski, Grzegorz Mincewicz, Maria Nittner-Marszalska, Wojciech Papiewski, Małgorzata Pawlukiewicz, Witold Pomiećko, Barbara Rewerska, Cezary Rybacki, Wojciech Skucha, Ewa Trębas-Pietraś, Ewa Uhryn, Małgorzata Żurowska-Gębala, Laurentia Andrei, Traian Mihaescu, Stefan Mihaicuta, Eniko Vera Pall, Ioan Petrui, Angelica Savu, Claudia Toma, Ana Trailescu, Vladimir Abrosimov, Nataliya Astafyeva, Evgenyi Bazdyrev, Nadezhda Berdnikova, Laura Bolieva, Ekaterina Bukreeva, Valery Chistyakov, Anna Galustyan, Halida Gantseva, Svetlana Goncharova, Sergey Grigoriev, Galina Ignatova, Inna Ilyashevich, Nadezhda Izmozherova, Magomed Kamalov, Yaroslava Khovaeva, Natalia Kuzubova, Lyudmila Kvitkova, Liudmila Lenskaya, Igor Leshchenko, Olga Magnitskaya, Boris Molotilov, Artem Molotkov, Svetlana Myasoedova, Sergey Nedogoda, Vladimir Nosov, Marina Osipenko, Andrey Peskov, Veronika Popova, Oksana Ratushnay, Irina Ryzhova, Olga Shangina, Natalia Shaporova, Evgeny Shmelev, Lybov Shpagina, Alexander Shutkin, Yuri Shvarts, Mikhail Smirnov, Irina Stitsenko, Maksim Vasilev, Arkadiy Vertkin, Elena Vishneva, Alexander Vizel, Anna Zateyschikova, Mohamed Abdool-Gaffar, Ismail Abdullah, Axel Bruning, Nyda Fourie, Michael Greenblatt, Mohammed Tayob, K Venter, An Soo Jang, Kwan Ho Lee, Sang Haak Lee, Sook Young Lee, Suk Joong Yong, Kwang Ha Yoo, Soo Taek Uh, Ramón Agüero Balbín, David Ramos Barbón, Álvar Agustí García-Navarro, José Luis Velasco Garrido, Sergi Pascual Guardia, Eduard Monso Molas, Luis De Teresa Parreño, Borja García-Cosio Piqueras, German Peces-Barba Romero, Myriam Calle Rubio, Fernando Sánchez-Toril López, Alicia Marín Tapia, Heidi Martin Braschler, Martin Brutsche, Michael Grob, Jörg Leuppi, Daiana Stolz, Alexander Turk, Nawar Bakerley, Mona Bafadhel, Christopher Brightling, Rekha Chaudhuri, Gourab Choudhury, Graham Devereux, Imran Hussain, Kai Lee, William MacNee, Ravindran Mahadeva, Matthew Masoli, Monica Nordstrom, Manish Patel, Allan Reid, Dinesh Saralaya, Tariq Sethi, Sukh Dave Singh, Anthony G de Soyza, Tom Wilkinson, Alice Turner, Helen Ward, Chandar Abboy, Ivan Ackerman, Idalia Acosta, Arun Adlakha, Bassil Aish, Mohamed Ali, Charles Andrews, Robby Ayoub, Anil Badhwar, Dennis Bassetti, Sherif El Bayadi, Richard Beasley, Shashi Bellam, Jonathan Bernstein, Maria Blahey, Scott Bloom, Eugene Bleecker, Wesley Bray, Johnathan Brewer, Robert Buynak, William Calhoun, Edward Campbell, Anthony Captain, Birjis Chinoy, Kenneth Chinsky, Geoffrey Chupp, Arsenio Columbie, Clinton Corder, Gerard Criner, Humberto Cruz, Edward Cullen, Kevin Deboer, Michael Denenberg, Mark Dransfield, Leonard Dunn, Miles Elmore, David Erb, Faisal Fakih, Gary Ferguson, Charles Fogarty, Mark Freed, Stephen Fritz, David Fuentes, Shariar Cohen-Gadol, Robert Garver, John Given, Luis Ramos Gonez, Raul Ebran Gonzalez, Robert Gordon, Gregory Gottschlich, Donald Graham, David Grant, Gary Greenwald, James Greenwald, Kenneth Haft, Gregory Hammond, Nadia Hansel, Jeffrey Harris, Humberto Hernandez, Marvin Heuer, Albrecht Heyder, David Hill, Willis Holloway, Octavian Ioachimescu, Richard Jackson, Ajay Jain, Nan Jiang, Thomas Kaelin, Adolfo Kaplan, Mitchell Kaye, Akram Khan, Yekaterina Khronusova, Ryan Klein, Joel Kline, Firas Koura, Ritsu Kuno, Ware Kuschner, Jean Claude Labissiere, David Laman Jr, John Lee, Mitchell Lee, Lawrence Levinson, Njira Lugogo, M Mador, Nathaniel Marchetti, Rafael Martinez, Richard Martinez, Peter Mattar, David Maybee, Dennis McGraw, Michael McGuire, Curtis Mello, Aaron Milstone, John Mitchell, Wendy Moore, Timothy Moriarty, Cheta Nand, Brooke Nevins, Ikeadi Ndukwu, Rachel Nisbet, David Nyanjom, Maria Nualart, Thomas O'Brien, Mikhail Palatnik, Gnyandev Patel, Amit Patel, Guido Perez, Christopher Perry, Michael Pfeffer, Krishna Pudi, Marina Raikhel, Murali Ramaswamy, Joe Ramsdell, Donato Ricci, Gary Richmond, Eugene Ryan, Fadi Saba, Boris Sagalovich, C Andrew Schroeder, Timothy Scialla, Frank Sciurba, Amit Shah, Nirav Shah, Zeeshan Shaikh, Akhtar Siddiqui, Barry Sigal, Thomas Siler, Howard Silverboard, William Sims, Clyde Southwell, Selwyn Spangenthal, Peruvemba Sriram, James Stocks, Tony Su, John Suen, Robert Sussman, Horia Tatu, Antonio Terrelonge, Alan Thomas, Mario Torres, Rodolfo Trejo, Miguel Trevino, Banks Turner, Manuel Villareal, Janine Vintch, Neal Warshoff, Jan Westerman, Philip Wexler, Thomas Yunger, Amir Zeki, Mariano Fernandez Acquier, Norma Aramayo, German Arce, Juan Belloni, Víctor Cambursano, Carlos De La Vega, Fernando Rodriguez Chariarse, Pedro Elias, Marcelo Fernández, Ana Lopez, Andrea Medina, María Otaola, Maria Salazan Saez, Maria De Salvo, Fernando Scherbovsky, Ana Stok, Jorge Taborda, Alberto Tolcachier, Fernando Verra, Carlos Victorio, Rita Gisela Delgado Vizcarra, Philip Bardin, Peter Bremner, Martin Phillips, John Upham, Peter Wark, Antoine Bolly, Alain Delobbe, Peter Driesen, Eduard Janssens, Wim Janssens, Olivier Michel, Bernard Vandooren, Martti Antila, Jussara Fiterman, Carlos Fritscher, Jorge Hetzel, Jose Jardim, Waldo De Mattos, Rafael Martins, Maria Eunice De Oliveira, Andreia Pez, Maria Sales, Rafael Stelmach, Priscila Wolff, Svetla Andreeva, Reneta Antonova, Ana Dancheva, Yuliya Ivanova, Slavcho Ivanov, Hristo Metev, Iveta Naydenova, Tatyana Petkova, Galina Petrova, Kostadinka Sotirova, Mariyana Stoyanova, Rumen Tiholov, Iliyana Valkanova, Oleg Yakov, Rosa Feijoo, Juana Pavie, Patricia Schönffeldt, Absalon Silva, Victor Martinez, David Espinosa, Alejandro Londono, Dora Molina, Gonzalo Prada, Andrés Rico, Gregorio Sanchez Vallejo, Alvaro Urbina, Ana Vanegas, Maria Villegas, Josip Aralica, Gordana Stjepanovic, Vibeke Backer, Uffe Bødtger, Christian Meyer, Læge Sven Nielsen, Anders Loekke Ottesen, Ingrid Titlestad, Nathalie Bautin, Arnaud Bourdin, Pascal Chanez, Francis Couturaud, Antoine Cuvelier, Gilles Devouassoux, Pierre-Olivier Girodet, Jean-François Muir, Jean-Louis Pépin, Alain Proust, Azzedine Yaici, Yochai Adir, Gershon Fink, Zvi Fridlender, Gabriel Izbicki, Mordechai Kramer, Yehuda Schwartz, Juan Moreno Hoyos Abril, Ricardo Campos Cerda, Efraín Montaño Gonzalez, Ricardo Ramirez Terrones, Rodolfo Posadas Valay, Alejandra Ramirez-Venegas, Paul Dawkins, Syed Hussain, Benedict Brockway, John Richmond, Colin Helm, Catherina Chang, Jørn Ahlqvist, Terje Tollåli, Tadeusz Tomala, Socorro Castro, William Chavez, Octavio Cubas, Rolando Estrella, Efrain Felix, Ronal Gamarra, Alfredo Guerreros, Alberto Matsuno, Danilo Salazar, Miguel Tsukayama, Albert Albay Jr, Teresita Aquino, Tito Atienza, Joven Roque Gonong, Ronnie Samoro, Joel Santiaguel, Beata Asankowicz-Bargiel, Ewa Pisarczyk-Bogacka, Renata Bijata-Bronisz, Marta Chełmińska, Małgorzata Dobryniewska, Anna Olech-Cudzik, Tomasz Fijołek, Krzysztof Filipek, Agata Kot, Bożena Kucińska, Krzysztof Lis, Elżbieta Rybicka-Liszewska, Marzenna Tarnowska-Matusiak, Robert Mróz, Piotr Napora, Wojciech Naumnik, Artur Niemiec, Władysław Pierzchała, Grzegorz Przybylski, Katarzyna Styka, Danuta Wrońska, Branislava Milenkovic, Dobrivoje Novkovic, Matijaz Flezar, Niksa Segota, Snezana Ulcar Kostic, Albert Klobucar, Leif Bjermer, Dan Curiac, Christer Janson, Pekka Koskinen, Bo Lundback, Åke Olsson, Shih-Lung Cheng, Ming-Lin Ho, Jeng-Yuan Hsu, Wu-Huei Hsu, Ping-Hung Kuo, Chin-Chou Wang, Yu-Feng Wei, Kuang-Yao Yang, Watchara Boonsawat, Somchai Chantarothorn, Warangkana Keeratichananont, Kittipong Maneechotesuwan, Kanok Pipatvech, Piamlarp Sangsayunh, Sibel Arinc, Sermin Borekci, Arzu Kaner Erturk, Filiz Kosar, Hakan Gunen, Ismail Hanta, Pinar Akin Kabalak, Tunc Alp Demir, Sibel Nayci, Serir Aktogu Ozkan, Abdullah Sayiner, Esra Uzaslan, Viktor Blazhko, Volodymyr Gavrysyuk, Olena Golub, Liudmyla Iashyna, Tetiana Ilashchuk, Volodymyr Koshlia, Olena Krakhmalova, Vitali Kryvenko, Lesia Kuryk, Olena Levchenko, Yuriy Mostovoy, Mykola Ostrovskyy, Tetyana Pertseva, Olena Piura, Nadiya Rudnytska, Ganna Stupnytska, Nataliia Velychko, Oleh Yakovenko, Lilia Rodriguez Ables, Roger Abrahams, Bassil Aish, Jose Alvarez, Fernando Arencibia, Chander Arora, Samir Arora, Francis Averill, Kwabena Ayesu, Stephen Basheda, Steven Bauer, Jose Bautista, Matthew Beacom, Richard Beasley, Hernando Bernal, Subodh Bhuchar, J'Cinda Bitters, John Burk, Elizabeth Burkett, James Cain, Robert Call, Christopher Chappel, Bartolome Celli, Tom Christensen, Jeremy Cole, Jerome Daniel, Nguyen Dang, Enrique Davis, Samuel Deleon, Robert DeLuca, Ernesto Diaz, Anthony DiMarco, Calvin Dixon, Ankur Doshi, Hugh Durrence, Alain Eid, John Elsen, Herbon Fleming, May Flores, Charles Fogarty, Scott Franczek, Stephen Fritz, Gregory Funk, Stuart Garay, Bernard Garcia, Luis Ramos Gonez, Gregory Gottschlich, Joseph Graif, Carl Griffin, Yamirka Duardo Guerra, David Headley, Mitzie Hewitt, Susan Hole, Robert Holladay, Ira Horowitz, Yu-Luen Hsu, Jonathan Ilowite, Stephen Jones, Ravindra Kashyap, Edward Kerwin, Ahtaram Khan, Nicole Kimzey, James Krainson, Flory Kreutter, Kannappan Krishnaswamy, Shahrukh Kureishy, Albert Lai, Alex Lechin, Daria Lee, Marcus Lee, Williams Leeds, Joseph Lillo, Edward Lisberg, Lawrence Madoff, Narendra Maheskwari, Mujibur Majumder, Sashi Makam, Douglas Mapel, Matthew Mardiney, Jennifer Martin, David Maybee, Isaac Melamed, Elvin Mendez, Stuart Millstone, Joseph Montes, Lee Morrow, Frank Murphy, Dany Obeid, France Occy, Godson Oguchi, Juan Ortiz, Francisco Padron, Ward Paine, James Pearle, Enrique Pelayo, Vandely Perez, David Pham, Carlos Piniella, Kevin Pritchett, Padmashri Rastogi, Stephen Ryan, Syed Rehman, Jackson Rhudy, Eustace Riley, James Riser, Clifford Risk, Emory Robinette, Christopher Roney, Gary Ruoff, David Russian, Mercedes Samson, Jay Sandberg, Jose Santiago, William Sargeant, Alan Schecter, Frank Sciurba, Jeffrey Scott, Ilia Segal, Sudhir Sehgal, Frederic Seifer, Sudhir Sekhsaria, Richard Sellman, Paul Shapero, Jeffrey Shea, Lawrence Sher, John Sibille, Jawed Siddiqui, William Sims, Toniya Singh, Deren Sinkowitz, Denise Smyth, Daniel Soteres, Daniel Sousa, Ralph Steele, Thomas Stern, Jose Suarez, Sever Surdulescu, Ricardo Tan, Tonny Tanus, Raymond Tidman, Aurelio Torres-Consuegra, Barry Troyan, John Updegrove, Sanjay Vadgama, Armando Pineda-Velez, Eduardo Viera, Andrew Wachtel, Ralph Wade, Jimin Wang, Dave Webster, Paul Weinberg, Terry Wells, Jeffrey White, Bram Wieskopf, Hugh Windom, Patrick Wright, David Wyatt, Bassam Yousef, Zahid Zafar, Chau Ngo, Huong Le, Lan Nguyen, Thanh Nguyen, Nhung Nguyen
Subjects: Male, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Anti-asthmatic Agent, law.invention, Pulmonary Disease, Chronic Obstructive, Leukocyte Count, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, Monoclonal, Receptors, Medicine, Anti-Asthmatic Agents, 030212 general & internal medicine, Humanized, COPD Exacerbations, benralizumab, clinical trials, COPD, Subcutaneous, General Medicine, Middle Aged, anti–IL-5Rα, Benralizumab, Pulmonary Disease, Chronic Obstructive/drug therapy, [SDV] Life Sciences [q-bio], Female, Antibodies, Monoclonal, Humanized/administration & dosage, Chronic Obstructive, Benralizumab COPD exacerbations, Injections, Subcutaneous, Socio-culturale, Aged, Antibodies, Monoclonal, Humanized, Double-Blind Method, Eosinophils, Humans, Patient Acuity, Receptors, Interleukin-5, Antibodies, chronic obstructive pulmonary disease, Injections, Pulmonary Disease, 03 medical and health sciences, Phase III, Anti-Asthmatic Agents/administration & dosage, In patient, business.industry, Eosinophils/metabolism, medicine.disease, Clinical trial, Receptors, Interleukin-5/antagonists & inhibitors, chemistry, Multicenter study, randomized controlled trial, Immunology, Interleukin-5, business
Abstract: BACKGROUND: The efficacy and safety of benralizumab, an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody, for the prevention of exacerbations in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) are not known.METHODS: In the GALATHEA and TERRANOVA trials, we enrolled patients with COPD (at a ratio of approximately 2:1 on the basis of eosinophil count [≥220 per cubic millimeter vs. RESULTS: In GALATHEA, the estimates of the annualized exacerbation rate were 1.19 per year (95% confidence interval [CI], 1.04 to 1.36) in the 30-mg benralizumab group, 1.03 per year (95% CI, 0.90 to 1.19) in the 100-mg benralizumab group, and 1.24 per year (95% CI, 1.08 to 1.42) in the placebo group; the rate ratio as compared with placebo was 0.96 for 30 mg of benralizumab (P = 0.65) and 0.83 for 100 mg of benralizumab (P = 0.05). In TERRANOVA, the estimates of the annualized exacerbation rate for 10 mg, 30 mg, and 100 mg of benralizumab and for placebo were 0.99 per year (95% CI, 0.87 to 1.13), 1.21 per year (95% CI, 1.08 to 1.37), 1.09 per year (95% CI, 0.96 to 1.23), and 1.17 per year (95% CI, 1.04 to 1.32), respectively; the corresponding rate ratios were 0.85 (P = 0.06), 1.04 (P = 0.66), and 0.93 (P = 0.40). At 56 weeks, none of the annualized COPD exacerbation rate ratios for any dose of benralizumab as compared with placebo reached significance in either trial. Types and frequencies of adverse events were similar with benralizumab and placebo.CONCLUSIONS: Add-on benralizumab was not associated with a lower annualized rate of COPD exacerbations than placebo among patients with moderate to very severe COPD, a history of frequent moderate or severe exacerbations, and blood eosinophil counts of 220 per cubic millimeter or greater (Funded by AstraZeneca [GALATHEA and TERRANOVA] and Kyowa Hakko Kirin [GALATHEA]; GALATHEA and TERRANOVA ClinicalTrials.gov numbers, NCT02138916 and NCT02155660.).
Published: 2019

18. Clinical Characteristics and Risk of Exacerbations Associated With Different Diagnostic Criteria of Asthma-COPD Overlap

Author: Soler-Cataluña JJ, Novella L, Soler C, Nieto ML, Esteban V, Sánchez-Toril F, and Miravitlles M
Subjects: Exacerbations, COPD, Asthma-COPD overlap, Asthma, respiratory tract diseases
Abstract: Introduction: There is currently no universally accepted definition of asthma-COPD overlap (ACO). Objective: To compare the prevalence of ACO in patients with asthma or COPD, and to assess their clinical characteristics and the capacity of the different definitions to predict the risk of exacerbation. Method: Prospective observational study with a 12-month follow-up in an asthma cohort and a COPD cohort. Four diagnostic criteria were compared: A) the Spanish 2012 consensus; B) the 2016 international consensus; C) the 2017 consensus between the Spanish COPD guidelines (GesEPOC) and GEMA asthma guidelines; and D) the single criterion of >= 300 eosinophils/mu L, proposed by GOLD 2019. The risk of exacerbations was evaluated in each group. Results: A total of 345 patients were included, 233 (67.5%) with COPD and 112 (32.5%) with asthma, aged 63 +/- 14 years, 70.4% men. Fifteen (4.3%) patients met the criteria for ACO according to the criteria described under A above; 30 (8.7%) with the criteria of B; 118 (34.2%) with the criteria of C; and 97 (28.1%), with the D criterion. The ACO-COPD subtype were older, had worse lung function, and an increased risk of exacerbation compared with the ACO-asthma group. Of all the definitions evaluated, those which distinguished a higher risk of exacerbations were the GesEPOC-GEMA consensus and the GOLD proposal. Conclusions: The prevalence of ACO varies enormously depending on the diagnostic criteria used. The ACO population is heterogeneous, and the ACO-COPD subtype is very different from the ACO-asthma subtype. The definitions that include eosinophilia identify ACO patients with a greater risk of exacerbation. (C) 2020 Published by Elsevier Espana, S.L.U. on behalf of SEPAR.
Published: 2020

19. Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

Author: L. Fernandez Pellon, E. Macias Fernandez, Manuel J Rial, E. Morchon Miguel, V. Vilella Tomás, P. Marin Martinez, V. De Luque Piñana, V. García Paz, M. Morales Villarejo, J. Ruiz Hornillos, J. Herrero Jarque, J. Florido Lopez, J. Beitia Mazuecos, M. Rojas Vilchez, J. Medina Gallardo, J. Valldeperas Combas, A. Pallarés Sanmartín, I. García Núñez, J. Castro Landin, R. Diaz Campos, G. Gala Ortiz, M. Mena Rodriguez, O. Villarreal Balza De Vallejo, Vicente Plaza, E. Pinto Nogues, A. Suárez Rodríguez, P. Sánchez López, S. Díaz Angulo, F. Sola Martinez, M. Moscardó Orenes, M. Alvariño Martin, R. Tejedor Romera, J. Orta Cuevas, Z. Vasquez Gambasica, B. García Figueroa, A. Letran Camacho, M. Modesto Alapont, M. Cervera Del Pino, P. Benito Martinez, S. Varela Losada, F. Carballada Gonzalez, Irina Bobolea, M. Díaz Palacios, Y. Anta Mejias, D. González De Olano, J. Martos Velasco, P. Prieto Montaño, A. Sanchez Alonso, M. Martínez Ceres, J. Donado Uña, Ò. Sotorra Elias, B. Alcázar Navarrete, A. Arnedillo Muñoz, J. Alcazar Ramirez, J. Jiménez López, M. Alvarez Puebla, M. Antón Girones, J. Compaired Villa, P. Mata Calderon, M. Escribano Rodriguez, C. Morales García, I. Molero Sancho, M. De Las Marinas Alvarez, T. Bazus Gonzalez, M. Soria Esojo, A. Vega Castro, A. Moreno Fernandez, G. Jorro Martínez, E. Ortega Sáenz De Tejada, A. Regueiro Moreira, M. Garcimartin Galicia, A. Alonso Gomez, R. Rodriguez Martinez, J. Liñana Santafé, I. Ansotegui Zubeldia, R. Lama Martinez, A. Saura Vinuesa, N. Segura Arazuri, M. Torrecillas Toro, M. Climent Gregori, M. Herrerias Peña, T. Peña Miguel, C. Vila Albelda, C. Diaz Donado, M. Hernandez, A. Losada Peña, M. Gandolfo Cano, J. Montoro Lacomba, J. Quiralte Enriquez, R. Rodríguez Pacheco, M. Arroyo Cozar, P. Rubinstein Aguñin, M. Blanco Aparicio, F. Alvarez Gutierrez, C. Merinas Lopez, R. Mayorgas Costoya, M. Franco Campos, J. Garcia De Pedro, V. Moreno Garcia, J. De Frutos Arribas, J. Alvarez Fernandez, A. Robles Iniesta, M. Do Muíño Joga, A. Bueso Fernandez, P. Serrano Dominguez, M. Jimenez Lara, P. Losada Llorente, C. Colás Sanz, I. Raducan, B. Requejo Mañana, M. Mota Godoy, M. Martos Calahorro, F. Ortiz Portal, J. Zapata Yébenes, F. Nicolau Pastrie, C. Rabade Castedo, M. Salvador Segarra, F. Callejas González, M. Chacon Patiño, G. González Álvarez, J. Olaguibel Rivera, P. Gonzalez Delgado, B. Orosa Bertol, E. De Santiago Delgado, J. Cumplido Bonny, R. Nuñez Orjales, Antonio Fernandez-Sanchez, B. Añíbarro Bausela, D. Ferrer Pargada, S. Niño Bernal, A. Cobas Paz, B. Huertas Barbudo, J. Ciruelos Ayuso, M. Lara Jiménez, D. Gutierrez Fernandez, G. Castaño De Las Pozas, Y. García Villamuza, F. Sánchez-Toril López, E. Naval Sendra, C. Andreu Balaguer, M. Rico Diaz, L. Navarro Seisdedos, D. El-Qutob López, J. Ruiz Cubillan, Miguel Ibáñez Rodríguez, L. Fontan Garcia-Boente, M. Rivera Ortun, A. Padilla Galo, M. Muñoz Pamplona, I. Perez Sampedro, F. Garcia Gonzalez, E. Gómez Nieves, S. Aparicio Español, Astrid Crespo, A. Lloris Bayo, R. Lleonart Bellfill, E. Burches Baixauli, R. Andujar Espinosa, I. Picans, F. Linde De Luna, A. Tabar Purroy, L. Valverde Vazquez, R. Blanco Gonzalez, M. Ballester Canelles, P. Barranco Sanz, F. Ruano Perez, A. Romero Ortiz, S. Jimenez Timon, G. De Luiz Martínez, C. Baeza Martinez, G. Bernaola Hortigüela, J. Chamorro Mohedad, M. Garcés Sotillos, R. Moreno Borque, M. Moro, I. Ali García, S. Lizarza Mendizabal, J. Almagro Lopez, C. Perez Carral, J. Cegoñino De Sus, M. Reche Frutos, R. González Perez, M. Domínguez Fuentes, L. Cassini Gomez De Cadiz, A. Feliu Vila, M. Dordal Culla, M. Corbacho Abelaira, Y. Puente Crespo, D. Romero Ribate, J. Rozadilla Sacanell, J. Lopez Caballero, A. Velez Ruiz De Lobera, A. Montoro De Francisco, M. Ramirez Prieto, N. Marina Malanda, J. Juanola Pla, M. Millan Gonzalez, N. Subira Farre, P. Cordero Rodriguez, F. Gonzalez Barcala, S. Herrera Lara, M. Peña Arellano, J. Igea Aznar, R. Alvarez Sintes, E. Martinez Moragon, J. Greses Giner, M. Martínez Riaza, G. Mediero Carrasco, P. Catalán Serra, M. Rodriguez Hernandez, S. Porcel Carreño, Joaquín Sastre, A. Ruiz San Francisco, R. Bernabeu Mora, M. Alwakil Olbah, H. Izaguirre Flores, J. Subiza Garrido-Lestache, B. Labeguerie Arenaza, B. Presedo Garazo, S. Cimbollek, A. Fuster Gomila, G. Minguez Martin, M. Martín Pérez, S. Garrido Fernández, F. Iglesias Rio, A. Veres Racamonde, B. Rodriguez Jimenez, F. Muñoz Bellido, A. Moral De Gregorio, A. López Viña, J. Marin Torrado, I. Flores Martín, M. Avilés Inglés, A. Lahuerta Castro, and P. Galindo Bonilla
Subjects: Adult, Male, Spirometry, medicine.medical_specialty, Vital capacity, Anxiety, Hospital Anxiety and Depression Scale, Severity of Illness Index, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Forced Expiratory Volume, Internal medicine, Health care, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, Depression (differential diagnoses), Asthma, medicine.diagnostic_test, Depression, business.industry, Middle Aged, medicine.disease, respiratory tract diseases, 030228 respiratory system, Female, medicine.symptom, business
Abstract: Background It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control. Objective To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision. Methods We enrolled 3182 patients with moderate to severe asthma. All were evaluated with spirometry, the Asthma Control Test, and the Hospital Anxiety and Depression Scale at baseline and at 6 months. Treatments were decided by specialists according to published guidelines. Results At baseline, 24.2% and 12% of the patients were diagnosed with anxiety and depression, respectively, according to the Hospital Anxiety and Depression Scale. After 6 months, anxiety and depression improved, affecting 15.3% and 8.1% of patients, respectively (P Conclusion Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters.
Published: 2018

20. Effectiveness and pharmacoeconomic analysis of the treatment of severe asthma with omalizumab in clinical practice

Author: Martínez-Moragón, Eva, Climent, María, Chiner, Eusebi, Fernández-Aracil, Cleofé, Sánchez-Toril, Fernando, and Lluch-Tortajada, Inmaculada
Subjects: Quality of life, Calidad de vida, Cost-benefit analysis, Costes en salud, Omalizumab, Análisis coste-beneficio, Health care costs, Asthma, Asma
Abstract: Objective To assess socio-sanitary expenditure after the addition of omalizumab to standard treatment in the control of severe asthma and to analyse its effectiveness under standard clinical practice. Method Observational retrospective multicentre study conducted in 12 pneumology services in the Valencian Community, Spain. Data from 186 patients were analysed. Results of the year before and after the addition of omalizumab were compared. Effectiveness was calculated based on a 3- point increase in the Asthma Control Test and a reduction in the number of annual exacerbations. Utility was calculated by the number of quality adjusted life years. The economic assessment included both direct and indirect costs and results were expressed in terms of incremental cost-effectiveness and incremental cost-utility ratio. Results Significant improvements were found in lung function, asthma control, quality of life, and quality adjusted life years between the year before and after the introduction of omalizumab. Taking into account direct and indirect costs, the incremental cost-effectiveness for each avoided exacerbation was € 1,789.28 (95% CI: € 1,019.13-3,038.12) and € 4,569.38 (95% CI: 3,442.86-6,075.05) per 3-point increase in the Asthma Control Test score. The incremental cost-utility ratio per quality adjusted life years gained was € 50,239.98 (95% CI: 37,209.88-68,923.84). Conclusions The addition of omalizumab to the treatment regime of patients with severe asthma is effective under standard clinical practice, decreases direct and indirect costs, and provides significant improvements in the health status of patients. Resumen Objetivo Evaluar el gasto sociosanitario tras la incorporación de omalizumab al tratamiento estándar en el control del asma grave, así como analizar su efectividad, en condiciones de práctica clínica. Método Estudio observacional, retrospectivo y multicéntrico realizado en 12 servicios de neumología de la Comunidad Valenciana. Se analizaron datos de 186 pacientes. Se compararon resultados del año previo y los cinco años posteriores a la incorporación de omalizumab. La efectividad se calculó a partir del incremento de tres puntos en el Asthma Control Test y la reducción del número de exacerbaciones anuales. La utilidad se calculó mediante el número de años de vida ajustados por calidad. En la evaluación económica se incluyeron costes directos e indirectos. Los resultados se expresaron en términos de relación coste-efectividad incremental y relación coste-utilidad incremental. Resultados Se detectaron mejoras significativas en la función pulmonar, el control del asma, la calidad de vida y el número de años de vida ajustados por calidad, entre el año anterior y el posterior al inicio de omalizumab. Teniendo en cuenta los costes directos e indirectos, la relación coste-efectividad incremental por exacerbación evitada fue de 1.789,28 € (intervalo de confianza 95%: 1.019,13-3.038,12) y de 4.569,38 € (intervalo de confianza 95%: 3.442,86-6.075,05) por incremento de tres puntos en el Asthma Control Test. La relación coste-utilidad incremental por número de años de vida ajustados por calidad ganada fue de 50.239,98 € (intervalo de confianza 95%: 37.209,88-68.923,84). Conclusiones La introducción de omalizumab en el tratamiento del asma grave es efectiva en condiciones de práctica clínica. Disminuye los costes directos e indirectos y proporciona mejoras significativas en el estado de salud de los pacientes.
Published: 2019

21. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author: William W Busse, Eugene R Bleecker, J Mark FitzGerald, Gary T Ferguson, Peter Barker, Stephanie Sproule, Richard F Olsson, Ubaldo J Martin, Mitchell Goldman, Anahí Yañez, Marcelo Fernández, Alberto Tolcachier, Juan Belloni, Jorge Taborda, Maria De Salvo, Jorge Maspero, Carlos Victorio, Miguel Chirino Navarta, Monica Grilli, Pablo Rodríguez, María Otaola, Víctor Cambursano, Patricia Malamud, Ana Stok, German Arce, Osiris Roza, Fernando Scherbovsky, Pedro Elias, Maria Salazan Saez, Matthew Peters, Martin Phillips, John Upham, Peter Gibson, Francis Thien, Jo Douglass, Paul Thomas, Philip Bardin, Dimitar Sajkov, Mark Hew, David Langton, Andreia Pez, Carlos Fritscher, Jorge Hetzel, Waldo Mattos, Rafael Stelmach, Martti Antila, Ana Luisa Fernandes, Hristo Metev, Yavor Ivanov, Aneliya Bogdanova, Ana Dancheva Markova, Marinka Peneva, Rumyana Veselinova, Tatyana Petkova, Vanushka Petrova, Elena Shopova, Yuliya Ivanova, Rumyana Yotsova, Ginka Kirkova, Galina Petrova, Svetoslav Dachev, Kostadinka Sotirova, Mariyana Stoyanova, Oleg Yakov, Vanya Ilieva-Fartunova, Catherine Lemiere, Michel Laviolette, William Yang, Bonavuth Pek, William Patrick Killorn, Claude Poirier, Guy Chouinard, Lyle Melenka, Richard Leigh, Parameswaran Nair, Delbert Dorscheid, James Martin, Juana Pavie, Andres Rosenblut, Claudia Cartagena, Carlos Quilodran, Silvia Muñoz, Ivana Malkusova, Josef Veverka, Stanislav Holub, Jaroslav Mares, Radovan Kozel, Daniela Kopecka, Vladimir Zindr, Pavel Cerva, Pascal Chanez, Arnaud Bourdin, Gilles Devouassoux, Camille Taille, Frédéric De Blay, Francois Goupil, Christophe Leroyer, Delphine Gourcerol, Toufik Didi, Alain Didier, Gilles Garcia, Philippe Bonniaud, Riazate Rossanaly Vasram, Marek Lommatzsch, Ulf Harnest, Anneliese Linnhoff, Claus Keller, Gerhard Hoheisel, Karin Förster, Thomas Schultz, Isabelle Schenkenberger, Joachim Kirschner, Tibor Schmoller, Stefan Zielen, Marc Kornmann, Ekkehard Beck, Lutz Volgmann, Rolf Dichmann, Axel Overlack, Jörg Winkler, Petra Mikloweit, Sabine Ballenberger, Mathias Rolke, Stephanie Korn, Helmut Pabel, Martin Hoffmann, Jan Feimer, Klaus Rabe, Regina Deckelmann, Tobias Welte, Hiroyuki Ohbayashi, Soichiro Hozawa, Terufumi Shimoda, Makoto Yoshida, Toshikazu Nagakura, Tadashi Kamei, Yasuyuki Sano, Shinichiro Kagami, Hisaho Takahashi, Michiko Haida, Goro Kimura, Hiroyuki Nakamura, Yasuo To, Masaharu Shinkai, Tadasuke Shimokawaji, Makoto Kudo, Noriharu Shijyubo, Takao Tochigi, Motokazu Kato, Akihiko Tanaka, Yasuhiro Gon, Norihisa Sasaki, Tetsuro Ohdaira, Chiharu Omori, Toshiki Takahashi, Satomi Takeuchi, Kiyotaka Nakajima, Hironi Makita, Masahiro Kaneko, Kenjiro Furuta, Masami Taniguchi, Yoshito Inobe, Hiroshi Miki, Yoichi Nakamura, Naoki Miyazawa, Shuichi Yano, Masayuki Iijima, Tsuyoshi Yamato, Javier Diaz, Alberto Matsuno, Efrain Felix, Alfredo Guerreros, Alejandro Daly, Fernando Rodriguez Chariarse, Danilo Salazar, Socorro Castro, William Chavez, Rolando Estrella, Teresita Aquino, Tito Atienza, Ronnie Samoro, Marie Grace Dawn Isidro, Piotr Kuna, Adam Antczak, Michał Bednarek, Danuta Mądra-Rogacka, Teresa Hofman, Marek Jutel, Ewa Pisarczyk-Bogacka, Agata Kot, Robert Mróz, Małgorzata Czupryńska-Borkowska, Małgorzata Żurowska-Gębala, Andrzej Dyczek, Grażyna Jasieniak-Pinis, Piotr Wojnowski, Ewa Trębas-Pietraś, Małgorzata Dobryniewska, Marcin Stobiecki, Marzenna Tarnowska-Matusiak, Alina Magner, Andrzej Kolczyński, Tomasz Kachel, Zbigniew Bartuzi, Bernadetta Majorek-Olechowska, Paweł Śliwiński, Violetta Balicka, Elżbieta Hajoł, Jacek Stachera, Marta Rachel, Marek Michnar, Jarosław Tałałaj, Ewa Springer, Piotr Napora, Tomasz Grzelewski, Renata Bijata-Bronisz, Anna Świderska, Grzegorz Mincewicz, Zbigniew Sankowski, Tomasz Fijołek, Artur Kwaśniewski, Joanna Jerzyńska, Jerzy Cygler, Ryszard Olesiejuk, Iwona Von Steiner, Wojciech Machowiak, Krzysztof Filipek, Piotr Piskorz, Ewa Uhryn, Marita Nittner-Marszalska, Elżbieta Rybicka-Liszewska, Anna Bodzenta-Łukaszyk, Marta Chełmińska, Izabella Krupa-Borek, Wojciech Skucha, Anna Płoszczuk, Traian Mihaescu, Ioan Dorin Petrui, Angelica Savu, Ghiulten Apti, Claudia Toma, Ana Trailescu, Sergei Sokurenko, Vasiliy Trofimov, Igor Leshchenko, Natalia Shaporova, Inna Ilyashevich, Irina Stitsenko, Alexander Vizel, Yulia Ilkovich, Dmitrii Tikhanov, Svetlana Goncharova, Andrey Ezhov, Galina Ignatova, Nadezhda Izmozherova, Nadezhda Berdnikova, Ludmila Goryachkina, Veronika Popova, Laura Bolieva, Andrey Rebrov, Vladimir Nosov, Olga Magnitskaya, Sergey Nedogoda, Vladimir Abrosimov, Artem Molotkov, Galina Reshedko, Mikhail Smirnov, Marina Osipenko, Elena Pavlysh, Svetlana Myasoedova, Liudmila Lenskaya, Valery Chistyakov, Elena Vishneva, Liliya Uon, Anna Zateyschikova, Svetlana Laleko, Tatiana Pak, Axel Bruning, Visvakuren Naidoo, Jeevren Reddy, Richard Van Zyl Smit, Hae-Sim Park, Young Joo Cho, Sang-Heon Cho, Sang Haak Lee, Byung Jae Lee, Ju Sang Kim, You Sook Cho, Choon-Sik Park, Mi-Kyeong Kim, Young-Il Koh, Joo-Hee Kim, Sook Young Lee, Sang Pyo Lee, Jung Won Park, Kwang Ha Yoo, Hyoungkyu Yoon, Jaechun Lee, Gyu-Young Hur, Soo Keol Lee, HeeKyoo Kim, David Ramos Barbón, Elena Laffond Yges, Eva Martínez Moragón, Miguel Arias Guillen, Alberto Saura Vinuesa, Fernando Sánchez-Toril López, José Luis Velasco Garrido, Borja García-Cosio Piqueras, Luis Pérez de Llano, Antonio Luis Valero Santiago, Myriam Calle Rubio, Leif Bjermer, Bo Lundbäck, Bilun Gemicioglu, Sevim Bavbek, Dane Ediger, Munevver Erdinc, Ismail Hanta, Sibel Nayci, Sibel Arinc, Liudmyla Iashyna, Yuriy Mostovoy, Mykola Ostrovskyy, Lesia Kuryk, Ivan Lemko, Tetyana Ospanova, Liubov Moskalenko, Oleksii Korzh, Viktor Blazhko, Olena Krakhmalova, Liliia Romaniuk, Yevgeniya Dytyatkovs'ka, Oleh Yakovenko, Volodymyr Gavrysyuk, Hassan Burhan, Dinesh Saralaya, Stephen Scott, Alyn Morice, Ewart Jackson-Voyzey, Thida Win, Shuab Nasser, Richard Harrison, Rekha Chaudhuri, Monica Nordstrom, Pradip De, Matthew Masoli, Adel Mansur, Anthony Gunstone, Robert Niven, Timothy Harrison, Suresh Babu, Subodh Bhuchar, Shahrukh Kureishy, John Zwetchkenbaum, Lawrence Kaplan, Eugene Bleecker, Santiago Reyes, Faisal Fakih, Marvin Heuer, Ryan Klein, Michael Marcus, Iftikhar Hussain, Tonny Tanus, Hengameh Raissy, Sady Alpizar, Hector Rodriguez, Gerald Gleich, Tracy Bridges, Joe Pouzar, Gary Steven, Jonathan Matz, Shana Krstevska, Dama Ziworitin, Adolfo Kaplan, James Sublett, James DeAngelo, Amy Darter, John Agaiby, John Hagan, Enrique Davis, Dareen Siri, Charlene Mcevoy, Chrisette Dharma, Najmuddin Karimjee, Steven Kelsen, Manuel Frade, Amy Silverthorn, Joel Kline, Francis Averill, Jose Ruiz, Emory Robinette, Zeeshan Shaikh, Carlos Aguilar, William Nish, German Alvarez, Younus Ismail, Purvi Parikh, Mila Leong, Dennis Murphy, Francisco Garcia, Alan Goldsobel, Antonio Blanco, Edward Campbell, Guido Perez, Geoffrey Chupp, Toby Bates, Vandely Perez, Sally Wenzel, Kartik Shenoy, Rohit Katial, David Bernstein, Neil Parikh, William Sims, Gary Ferguson, David Pham, Anu George, Richard Beasley, Gilberto Perez, Robert Garver, Miriam Garcia-Portela, Stephen Wong, Weily Soong, Richard Guillot, Golda Hudes, Ahmed Arif, Josefa Binker, Manuel Villareal, Ulrike Ziegner, Joseph Ojile, Sanjeev Goswami, Carlos Piniella, Ilia Segal, Heidi Zafra, Mitchell Lee, Martha Tarpay, John Panuto, Rajan Merchant, Peter Springsteen, Timothy Scialla, Paul Shapero, Karen Allen, Mark Moss, Humberto Cruz, Jeffrey Rumbyrt, Amy Boyd, Robert Nathan, Jonathan Bernstein, Joshua Jacobs, Elliot Ginchansky, Janice Johnston, Barbara Baxter, Thomas Johnson II, Stephen Apaliski, Clinton Corder, David Fuentes, Joseph Diaz, Chau Ngo, Lan Le, Department of Medicine, University of Wisconsin-Madison-School of Medicine and Public Health, Fundación Cidea Allergy and Respiratory Research Unit, University of Oxford [Oxford], University of Newcastle, Newcastle, NSW Australia., Defence Science and Technology Laboratory (Dstl), Ministry of Defence (UK) (MOD), Organização Multinacional de Formação, Agence Universitaire de la Francophonie (AUF), University of Calgary, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), laboratoire du sommeil, CHU Grenoble, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Strasbourg, Centre Hospitalier du Mans, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Service de pneumologie, Centre hospitalier de la région d'Annecy, Cytokines, chimiokines et immunopathologie, Université Paris-Sud - Paris 11 (UP11)-IFR13-Institut National de la Santé et de la Recherche Médicale (INSERM), J.W. Goethe Universität, Institut für Geowissenschaften, Altenhöferallee 1, D-60438 Frankfurt am Main, Germany, Department of Pulmonary Medicine, Leiden University Medical Center (LUMC), Hannover Medical School [Hannover] (MHH), Japan Energy Corporation, Medical University of Łódź (MUL), Wroclaw Medical University, Saint-Petersburg State University, Physical Department, Petrodvoretz, 194508 St.-Petersburg, Russia, Physical Department (PD), St Petersburg State University (SPbU)-St Petersburg State University (SPbU), Ankara University, Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Department of Earth Sciences, University of Cambridge, University of Cambridge [UK] (CAM), Center for Genomics and Personalized Medicine, Wake Forest University, Mayo Clinic [Rochester], Department of Wildlife Management, Pir Mehr Ali Shah Arid Agriculture University, Lab Biotecnol Bacteriana, Inst Ciencia & Tecnol Alimentos & Nutr ICTAN, Universidade da Coruña, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Centre recherche en CardioVasculaire et Nutrition (C2VN), Université de Brest (UBO), University of Oxford, University of Newcastle [Callaghan, Australia] (UoN), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Universiteit Leiden-Universiteit Leiden, Wrocław Medical University, Department of Earth Sciences [University of Cambridge], and Pir Mehr Ali Shah Arid Agriculture University = PMAS-Arid Agriculture University Rawalpindi (AAUR)
Subjects: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, [SDV]Life Sciences [q-bio], Antibodies, Monoclonal, Humanized, Placebo, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Time, law.invention, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Clinical endpoint, Humans, Medicine, Anti-Asthmatic Agents, 030212 general & internal medicine, Child, Adverse effect, ComputingMilieux_MISCELLANEOUS, Aged, Asthma, business.industry, Middle Aged, medicine.disease, Benralizumab, 3. Good health, Clinical trial, Treatment Outcome, 030228 respiratory system, Tolerability, chemistry, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract: Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody that has been shown to safely reduce exacerbations and improve lung function for patients with asthma. We assessed the long-term safety and efficacy of benralizumab for patients with severe, uncontrolled eosinophilic asthma.We conducted a randomised, double-blind, parallel-group, phase 3 extension study at 447 sites in 24 countries. Eligible patients had to have completed the SIROCCO or CALIMA trials and remained on subcutaneous benralizumab 30 mg every 4 weeks (Q4W) or every 8 weeks (Q8W). Patients who had received placebo in those trials were re-randomised in a 1:1 ratio, using an interactive web-based system, to benralizumab 30 mg either Q4W or Q8W (first three doses 4 weeks apart). Treatment lasted for 56 weeks for adult patients (age ≥18 years) and 108 weeks for adolescent patients (age 12-17 years). The primary endpoint was the safety and tolerability of the two dosing regimens of benralizumab up to 68 weeks for adult patients (including the follow-up visit post-treatment) and up to 56 weeks for adolescent patients. This endpoint was assessed in the full analysis set, which included all patients from the SIROCCO and CALIMA predecessor studies who received at least one dose of study treatment in BORA and did not continue into another trial. This study is registered with ClinicalTrials.gov (NCT02258542).Between Nov 19, 2014, and July 6, 2016, we enrolled 1926 patients, of whom 633 had received benralizumab Q4W and 639 had received benralizumab Q8W in SIROCCO or CALIMA. The remaining 654 patients had received placebo in those trials and were randomly re-assigned in this trial to receive benralizumab Q4W (n=320) or Q8W (n=334). 1576 patients, including 783 who received benralizumab Q4W (265 newly assigned) and 793 who received benralizumab Q8W (281 newly assigned), were included in the full analysis set. The most common adverse events in all groups were viral upper respiratory tract infection (14-16%) and worsening asthma (7-10%). The most common serious adverse events were worsening asthma (3-4%), pneumonia (1% to 1%), and pneumonia caused by bacterial infection (0-1%). The percentages of patients who had any on-treatment adverse event, any serious adverse event, or any adverse event leading to treatment discontinuation during BORA were similar between patients originally assigned benralizumab and those originally assigned placebo and between benralizumab treatment regimens. The percentage of patients who had any adverse event was similar between SIROCCO or CALIMA (71-75%; benralizumab group only) and BORA (65-71%), as was the percentage of patients who had an adverse event that led to treatment discontinuation (2% in SIROCCO and CALIMA vs 2-3% in BORA).The 2 years of safety results validate that observations observed in the first year of benralizumab continued through a second year of treatment. No new consequences of long-term eosinophil depletion occurred, and the incidence of other adverse events, including opportunistic infections, were similar during the second year.AstraZeneca and Kyowa Hakko Kirin.
Published: 2019

22. Effectiveness and pharmacoeconomic analysis of the treatment of severe asthma with omalizumab in clinical practice

Author: Martínez-Moragón E, Climent M, Chiner E, Fernández-Aracil C, Sánchez-Toril F, and Lluch-Tortajada I
Subjects: Quality of life, Cost-benefit analysis, macromolecular substances, Omalizumab, Health care costs, Asthma
Abstract: Objective: To assess socio-sanitary expenditure after the addition of omalizumab to standard treatment in the control of severe asthma and to analyse its effectiveness under standard clinical practice. Method: Observational retrospective multicentre study conducted in 12 pneumology services in the Valencian Community, Spain. Data from 186 patients were analysed. Results of the year before and after the addition of omalizumab were compared. Effectiveness was calculated based on a 3 point increase in the Asthma Control Test and a reduction in the number of annual exacerbations. Utility was calculated by the number of quality adjusted life years. The economic assessment included both direct and indirect costs and results were expressed in terms of incremental cost effectiveness and incremental cost utility ratio. Results: Significant improvements were found in lung function, asthma control, quality of life, and quality adjusted life years between the year before and after the introduction of omalizumab. Taking into account direct and indirect costs, the incremental cost effectiveness for each avoided exacerbation was (sic) 1,789.28 (95% CI: (sic) 1,019.13-3,038.12) and (sic) 4,569.38 (95% CI: 3,442.86-6,075.05) per 3-point increase in the Asthma Control Test score. The incremental cost-utility ratio per quality adjusted life years gained was (sic) 50,239.98 (95% CI: 37,209.88-68,923.84). Conclusions: The addition of omalizumab to the treatment regime of patients with severe asthma is effective under standard clinical practice, decreases direct and indirect costs, and provides significant improvements in the health status of patients.
Published: 2019

23. Demographic Study of Tobacco Addiction in Health District 5, Valencia, Spain

Author: Peris Cardells, R., Rico Salvador, I., Herrera de Pablo, P., Pérez Jiménez, A., Sánchez-Tóril López, F., and Pérez Fernández, J.A.
Published: 2004
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24. Estudio demográfico del tabaquismo en el Área de Salud 5 de Valencia

Author: Peris Cardells, R., Rico Salvador, I., Herrera de Pablo, P., Pérez Jiménez, A., Sánchez-Tóril López, F., and Pérez Fernández, J.A.
Published: 2004
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25. Airway Responsiveness to Inhaled Acetaldehyde in Subjects with Allergic Rhinitis: Relationship to Methacholine Responsiveness

Author: Prieto, L., Sánchez-Toril, F., Gutiérrez, V., and Marín, M. J.
Published: 2002
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26. Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation

Author: PRIETO, L., SÁNCHEZ-TORIL, F., BROTONS, B., SORIANO, S., CASAÑ, R., and BELENGUER, J. L.
Published: 2000

27. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author: Busse, William W, primary, Bleecker, Eugene R, additional, FitzGerald, J Mark, additional, Ferguson, Gary T, additional, Barker, Peter, additional, Sproule, Stephanie, additional, Olsson, Richard F, additional, Martin, Ubaldo J, additional, Goldman, Mitchell, additional, Yañez, Anahí, additional, Fernández, Marcelo, additional, Tolcachier, Alberto, additional, Belloni, Juan, additional, Taborda, Jorge, additional, De Salvo, Maria, additional, Maspero, Jorge, additional, Victorio, Carlos, additional, Navarta, Miguel Chirino, additional, Grilli, Monica, additional, Rodríguez, Pablo, additional, Otaola, María, additional, Cambursano, Víctor, additional, Malamud, Patricia, additional, Stok, Ana, additional, Arce, German, additional, Roza, Osiris, additional, Scherbovsky, Fernando, additional, Elias, Pedro, additional, Saez, Maria Salazan, additional, Peters, Matthew, additional, Phillips, Martin, additional, Upham, John, additional, Gibson, Peter, additional, Thien, Francis, additional, Douglass, Jo, additional, Thomas, Paul, additional, Bardin, Philip, additional, Sajkov, Dimitar, additional, Hew, Mark, additional, Langton, David, additional, Pez, Andreia, additional, Fritscher, Carlos, additional, Hetzel, Jorge, additional, Mattos, Waldo, additional, Stelmach, Rafael, additional, Antila, Martti, additional, Fernandes, Ana Luisa, additional, Metev, Hristo, additional, Ivanov, Yavor, additional, Bogdanova, Aneliya, additional, Markova, Ana Dancheva, additional, Peneva, Marinka, additional, Veselinova, Rumyana, additional, Petkova, Tatyana, additional, Petrova, Vanushka, additional, Shopova, Elena, additional, Ivanova, Yuliya, additional, Yotsova, Rumyana, additional, Kirkova, Ginka, additional, Petrova, Galina, additional, Dachev, Svetoslav, additional, Sotirova, Kostadinka, additional, Stoyanova, Mariyana, additional, Yakov, Oleg, additional, Ilieva-Fartunova, Vanya, additional, Lemiere, Catherine, additional, Laviolette, Michel, additional, Yang, William, additional, Pek, Bonavuth, additional, Killorn, William Patrick, additional, Poirier, Claude, additional, Chouinard, Guy, additional, Melenka, Lyle, additional, Leigh, Richard, additional, Nair, Parameswaran, additional, Dorscheid, Delbert, additional, Martin, James, additional, Pavie, Juana, additional, Rosenblut, Andres, additional, Cartagena, Claudia, additional, Quilodran, Carlos, additional, Muñoz, Silvia, additional, Malkusova, Ivana, additional, Veverka, Josef, additional, Holub, Stanislav, additional, Mares, Jaroslav, additional, Kozel, Radovan, additional, Kopecka, Daniela, additional, Zindr, Vladimir, additional, Cerva, Pavel, additional, Chanez, Pascal, additional, Bourdin, Arnaud, additional, Devouassoux, Gilles, additional, Taille, Camille, additional, De Blay, Frédéric, additional, Goupil, Francois, additional, Leroyer, Christophe, additional, Gourcerol, Delphine, additional, Didi, Toufik, additional, Didier, Alain, additional, Garcia, Gilles, additional, Bonniaud, Philippe, additional, Vasram, Riazate Rossanaly, additional, Lommatzsch, Marek, additional, Harnest, Ulf, additional, Linnhoff, Anneliese, additional, Keller, Claus, additional, Hoheisel, Gerhard, additional, Förster, Karin, additional, Schultz, Thomas, additional, Schenkenberger, Isabelle, additional, Kirschner, Joachim, additional, Schmoller, Tibor, additional, Zielen, Stefan, additional, Kornmann, Marc, additional, Beck, Ekkehard, additional, Volgmann, Lutz, additional, Dichmann, Rolf, additional, Overlack, Axel, additional, Winkler, Jörg, additional, Mikloweit, Petra, additional, Ballenberger, Sabine, additional, Rolke, Mathias, additional, Korn, Stephanie, additional, Pabel, Helmut, additional, Hoffmann, Martin, additional, Feimer, Jan, additional, Rabe, Klaus, additional, Deckelmann, Regina, additional, Welte, Tobias, additional, Ohbayashi, Hiroyuki, additional, Hozawa, Soichiro, additional, Shimoda, Terufumi, additional, Yoshida, Makoto, additional, Nagakura, Toshikazu, additional, Kamei, Tadashi, additional, Sano, Yasuyuki, additional, Kagami, Shinichiro, additional, Takahashi, Hisaho, additional, Haida, Michiko, additional, Kimura, Goro, additional, Nakamura, Hiroyuki, additional, To, Yasuo, additional, Shinkai, Masaharu, additional, Shimokawaji, Tadasuke, additional, Kudo, Makoto, additional, Shijyubo, Noriharu, additional, Tochigi, Takao, additional, Kato, Motokazu, additional, Tanaka, Akihiko, additional, Gon, Yasuhiro, additional, Sasaki, Norihisa, additional, Ohdaira, Tetsuro, additional, Omori, Chiharu, additional, Takahashi, Toshiki, additional, Takeuchi, Satomi, additional, Nakajima, Kiyotaka, additional, Makita, Hironi, additional, Kaneko, Masahiro, additional, Furuta, Kenjiro, additional, Taniguchi, Masami, additional, Inobe, Yoshito, additional, Miki, Hiroshi, additional, Nakamura, Yoichi, additional, Miyazawa, Naoki, additional, Yano, Shuichi, additional, Iijima, Masayuki, additional, Yamato, Tsuyoshi, additional, Diaz, Javier, additional, Matsuno, Alberto, additional, Felix, Efrain, additional, Guerreros, Alfredo, additional, Daly, Alejandro, additional, Rodriguez Chariarse, Fernando, additional, Salazar, Danilo, additional, Castro, Socorro, additional, Chavez, William, additional, Estrella, Rolando, additional, Aquino, Teresita, additional, Atienza, Tito, additional, Samoro, Ronnie, additional, Isidro, Marie Grace Dawn, additional, Kuna, Piotr, additional, Antczak, Adam, additional, Bednarek, Michał, additional, Mądra-Rogacka, Danuta, additional, Hofman, Teresa, additional, Jutel, Marek, additional, Pisarczyk-Bogacka, Ewa, additional, Kot, Agata, additional, Mróz, Robert, additional, Czupryńska-Borkowska, Małgorzata, additional, Żurowska-Gębala, Małgorzata, additional, Dyczek, Andrzej, additional, Jasieniak-Pinis, Grażyna, additional, Wojnowski, Piotr, additional, Trębas-Pietraś, Ewa, additional, Dobryniewska, Małgorzata, additional, Stobiecki, Marcin, additional, Tarnowska-Matusiak, Marzenna, additional, Magner, Alina, additional, Kolczyński, Andrzej, additional, Kachel, Tomasz, additional, Bartuzi, Zbigniew, additional, Majorek-Olechowska, Bernadetta, additional, Śliwiński, Paweł, additional, Balicka, Violetta, additional, Hajoł, Elżbieta, additional, Stachera, Jacek, additional, Rachel, Marta, additional, Michnar, Marek, additional, Tałałaj, Jarosław, additional, Springer, Ewa, additional, Napora, Piotr, additional, Grzelewski, Tomasz, additional, Bijata-Bronisz, Renata, additional, Świderska, Anna, additional, Mincewicz, Grzegorz, additional, Sankowski, Zbigniew, additional, Fijołek, Tomasz, additional, Kwaśniewski, Artur, additional, Jerzyńska, Joanna, additional, Cygler, Jerzy, additional, Olesiejuk, Ryszard, additional, Von Steiner, Iwona, additional, Machowiak, Wojciech, additional, Filipek, Krzysztof, additional, Piskorz, Piotr, additional, Uhryn, Ewa, additional, Nittner-Marszalska, Marita, additional, Rybicka-Liszewska, Elżbieta, additional, Bodzenta-Łukaszyk, Anna, additional, Chełmińska, Marta, additional, Krupa-Borek, Izabella, additional, Skucha, Wojciech, additional, Płoszczuk, Anna, additional, Mihaescu, Traian, additional, Petrui, Ioan Dorin, additional, Savu, Angelica, additional, Apti, Ghiulten, additional, Toma, Claudia, additional, Trailescu, Ana, additional, Sokurenko, Sergei, additional, Trofimov, Vasiliy, additional, Leshchenko, Igor, additional, Shaporova, Natalia, additional, Ilyashevich, Inna, additional, Stitsenko, Irina, additional, Vizel, Alexander, additional, Ilkovich, Yulia, additional, Tikhanov, Dmitrii, additional, Goncharova, Svetlana, additional, Ezhov, Andrey, additional, Ignatova, Galina, additional, Izmozherova, Nadezhda, additional, Berdnikova, Nadezhda, additional, Goryachkina, Ludmila, additional, Popova, Veronika, additional, Bolieva, Laura, additional, Rebrov, Andrey, additional, Nosov, Vladimir, additional, Magnitskaya, Olga, additional, Nedogoda, Sergey, additional, Abrosimov, Vladimir, additional, Molotkov, Artem, additional, Reshedko, Galina, additional, Smirnov, Mikhail, additional, Osipenko, Marina, additional, Pavlysh, Elena, additional, Myasoedova, Svetlana, additional, Lenskaya, Liudmila, additional, Chistyakov, Valery, additional, Vishneva, Elena, additional, Uon, Liliya, additional, Zateyschikova, Anna, additional, Laleko, Svetlana, additional, Pak, Tatiana, additional, Bruning, Axel, additional, Naidoo, Visvakuren, additional, Reddy, Jeevren, additional, Van Zyl Smit, Richard, additional, Park, Hae-Sim, additional, Cho, Young Joo, additional, Cho, Sang-Heon, additional, Lee, Sang Haak, additional, Lee, Byung Jae, additional, Kim, Ju Sang, additional, Cho, You Sook, additional, Park, Choon-Sik, additional, Kim, Mi-Kyeong, additional, Koh, Young-Il, additional, Kim, Joo-Hee, additional, Lee, Sook Young, additional, Lee, Sang Pyo, additional, Park, Jung Won, additional, Yoo, Kwang Ha, additional, Yoon, Hyoungkyu, additional, Lee, Jaechun, additional, Hur, Gyu-Young, additional, Lee, Soo Keol, additional, Kim, HeeKyoo, additional, Ramos Barbón, David, additional, Laffond Yges, Elena, additional, Martínez Moragón, Eva, additional, Arias Guillen, Miguel, additional, Saura Vinuesa, Alberto, additional, Sánchez-Toril López, Fernando, additional, Velasco Garrido, José Luis, additional, García-Cosio Piqueras, Borja, additional, Pérez de Llano, Luis, additional, Valero Santiago, Antonio Luis, additional, Rubio, Myriam Calle, additional, Bjermer, Leif, additional, Lundbäck, Bo, additional, Gemicioglu, Bilun, additional, Bavbek, Sevim, additional, Ediger, Dane, additional, Erdinc, Munevver, additional, Hanta, Ismail, additional, Nayci, Sibel, additional, Arinc, Sibel, additional, Iashyna, Liudmyla, additional, Mostovoy, Yuriy, additional, Ostrovskyy, Mykola, additional, Kuryk, Lesia, additional, Lemko, Ivan, additional, Ospanova, Tetyana, additional, Moskalenko, Liubov, additional, Korzh, Oleksii, additional, Blazhko, Viktor, additional, Krakhmalova, Olena, additional, Romaniuk, Liliia, additional, Dytyatkovs'ka, Yevgeniya, additional, Yakovenko, Oleh, additional, Gavrysyuk, Volodymyr, additional, Burhan, Hassan, additional, Saralaya, Dinesh, additional, Scott, Stephen, additional, Morice, Alyn, additional, Jackson-Voyzey, Ewart, additional, Win, Thida, additional, Nasser, Shuab, additional, Harrison, Richard, additional, Chaudhuri, Rekha, additional, Nordstrom, Monica, additional, De, Pradip, additional, Masoli, Matthew, additional, Mansur, Adel, additional, Gunstone, Anthony, additional, Niven, Robert, additional, Harrison, Timothy, additional, Babu, Suresh, additional, Bhuchar, Subodh, additional, Kureishy, Shahrukh, additional, Zwetchkenbaum, John, additional, Kaplan, Lawrence, additional, Bleecker, Eugene, additional, Reyes, Santiago, additional, Fakih, Faisal, additional, Heuer, Marvin, additional, Klein, Ryan, additional, Marcus, Michael, additional, Hussain, Iftikhar, additional, Tanus, Tonny, additional, Raissy, Hengameh, additional, Alpizar, Sady, additional, Rodriguez, Hector, additional, Gleich, Gerald, additional, Bridges, Tracy, additional, Pouzar, Joe, additional, Steven, Gary, additional, Matz, Jonathan, additional, Krstevska, Shana, additional, Ziworitin, Dama, additional, Kaplan, Adolfo, additional, Sublett, James, additional, DeAngelo, James, additional, Darter, Amy, additional, Agaiby, John, additional, Hagan, John, additional, Davis, Enrique, additional, Siri, Dareen, additional, Mcevoy, Charlene, additional, Dharma, Chrisette, additional, Karimjee, Najmuddin, additional, Kelsen, Steven, additional, Frade, Manuel, additional, Silverthorn, Amy, additional, Kline, Joel, additional, Averill, Francis, additional, Ruiz, Jose, additional, Robinette, Emory, additional, Shaikh, Zeeshan, additional, Aguilar, Carlos, additional, Nish, William, additional, Alvarez, German, additional, Ismail, Younus, additional, Parikh, Purvi, additional, Leong, Mila, additional, Murphy, Dennis, additional, Garcia, Francisco, additional, Goldsobel, Alan, additional, Blanco, Antonio, additional, Campbell, Edward, additional, Perez, Guido, additional, Chupp, Geoffrey, additional, Bates, Toby, additional, Perez, Vandely, additional, Wenzel, Sally, additional, Shenoy, Kartik, additional, Katial, Rohit, additional, Bernstein, David, additional, Parikh, Neil, additional, Sims, William, additional, Ferguson, Gary, additional, Pham, David, additional, George, Anu, additional, Beasley, Richard, additional, Perez, Gilberto, additional, Garver, Robert, additional, Garcia-Portela, Miriam, additional, Wong, Stephen, additional, Soong, Weily, additional, Guillot, Richard, additional, Hudes, Golda, additional, Arif, Ahmed, additional, Binker, Josefa, additional, Villareal, Manuel, additional, Ziegner, Ulrike, additional, Ojile, Joseph, additional, Goswami, Sanjeev, additional, Piniella, Carlos, additional, Segal, Ilia, additional, Zafra, Heidi, additional, Lee, Mitchell, additional, Tarpay, Martha, additional, Panuto, John, additional, Merchant, Rajan, additional, Springsteen, Peter, additional, Scialla, Timothy, additional, Shapero, Paul, additional, Allen, Karen, additional, Moss, Mark, additional, Cruz, Humberto, additional, Rumbyrt, Jeffrey, additional, Boyd, Amy, additional, Nathan, Robert, additional, Bernstein, Jonathan, additional, Jacobs, Joshua, additional, Ginchansky, Elliot, additional, Johnston, Janice, additional, Baxter, Barbara, additional, Johnson II, Thomas, additional, Apaliski, Stephen, additional, Corder, Clinton, additional, Fuentes, David, additional, Diaz, Joseph, additional, Ngo, Chau, additional, and Le, Lan, additional
Published: 2019
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28. El papel de la neumología ante la Estrategia de cronicidad del Sistema Nacional de Salud

Author: M. Carmen Aguar Benito, Juan José Soler-Cataluña, and Fernando Sánchez Toril
Subjects: Pulmonary and Respiratory Medicine, business.industry, Medicine, business, Humanities
Abstract: Resumen La mayor expectativa de vida y el progresivo envejecimiento de nuestra poblacion estan produciendo un cambio en el patron epidemiologico asistencial, con una disminucion de las enfermedades agudas y un pronunciado aumento de las cronicas. Este importante cambio conlleva notables consecuencias sociales, sanitarias y economicas, lo que plantea la necesidad de una reordenacion en la forma de atender a nuestros pacientes. En este contexto, la Estrategia para el abordaje de la cronicidad del Sistema Nacional de Salud propone un cambio de enfoque sustancial para pasar de una medicina de rescate tradicional a una medicina centrada en el paciente y su entorno, una medicina planificada, proactiva, participativa y multidisciplinar. Algunas de las enfermedades cronicas mas prevalentes son de origen respiratorio. En la EPOC, esta aproximacion integral ha demostrado reducir las exacerbaciones, mejorar la calidad de vida e incluso disminuir el coste. Sin embargo, la heterogeneidad de las intervenciones dificulta las conclusiones definitivas. Algo parecido sucede en asma y en otras enfermedades respiratorias. La neumologia puede y debe participar de los nuevos paradigmas de la cronicidad, aportando conocimiento, experiencia, innovacion, investigacion y valor anadido.
Published: 2015

29. The Role of Pulmonology in the National Health System Chronicity Strategy

Author: Juan José Soler-Cataluña, M. Carmen Aguar Benito, and Fernando Sánchez Toril
Subjects: medicine.medical_specialty, National Health Programs, Population, World Health Organization, Pulmonary Disease, Chronic Obstructive, Quality of life (healthcare), Patient Education as Topic, Cost Savings, Multidisciplinary approach, Internal medicine, Health care, Epidemiology, Pulmonary Medicine, Humans, Medicine, Intensive care medicine, education, Pulmonologists, Patient Care Team, education.field_of_study, Delivery of Health Care, Integrated, business.industry, Disease Management, Professional-Patient Relations, General Medicine, Models, Theoretical, Respiration Disorders, Asthma, Pulmonology, Spain, Chronic Disease, Quality of Life, Physical therapy, Life expectancy, Interdisciplinary Communication, business
Abstract: Longer life expectancy and the progressive aging of the population are changing the epidemiological pattern of healthcare, with a reduction in the incidence of acute diseases and a marked increase in chronic diseases. This change brings important social, healthcare and economic consequences that call for a reorganization of patient care. In this respect, the Spanish National Health System has developed a Chronicity strategy that proposes a substantial change in focus from traditional rescue medicine to patient- and environment-centered care, with a planned, proactive, participative and multidisciplinary approach. Some of the more common chronic diseases are respiratory. In COPD, this integrated approach has been effective in reducing exacerbations, improving quality of life, and even reducing costs. However, the wide variety of management strategies, not only in COPD but also in asthma and other respiratory diseases, makes it difficult to draw definitive conclusions. Pulmonologists can and must participate in the new chronicity models and contribute their knowledge, experience, innovation, research, and special expertise to the development of these new paradigms.
Published: 2015

30. Ciberseguridad e IoT

Author: Sánchez Toril, Eduardo, Orejón Lozano, Selva María, Sánchez Toril, Eduardo, and Orejón Lozano, Selva María
Abstract: Los ponentes nos hablan de la CiberSeguridad y la consecuente necesidad de mejorar la protección y el cuidado de las marcas tanto personales como corporativas en Internet, así como del Internet de las cosas.
Published: 2018

31. Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

Author: Sastre, Joaquín, primary, Crespo, Astrid, additional, Fernandez-Sanchez, Antonio, additional, Rial, Manuel, additional, Plaza, Vicente, additional, González, F. Callejas, additional, López, J. Jiménez, additional, Riaza, M. Martínez, additional, Orenes, M. Moscardó, additional, Montaño, P. Prieto, additional, Toro, M. Torrecillas, additional, Balaguer, C. Andreu, additional, Girones, M. Antón, additional, Martinez, C. Baeza, additional, Martín, I. Flores, additional, Delgado, P. Gonzalez, additional, Calahorro, M. Martos, additional, Carrasco, G. Mediero, additional, Pacheco, R. Rodríguez, additional, Tomás, V. Vilella, additional, Godoy, M. Mota, additional, Yébenes, J. Zapata, additional, Balza De Vallejo, O. Villarreal, additional, Fernandez, J. Alvarez, additional, Gonzalez, T. Bazus, additional, De Las Pozas, G. Castaño, additional, Donado, C. Diaz, additional, Angulo, S. Díaz, additional, Ortiz, G. Gala, additional, Mañana, B. Requejo, additional, Gonzalez, R. Blanco, additional, Nieves, E. Gómez, additional, Torrado, J. Marin, additional, Culla, M. Dordal, additional, Pla, J. Juanola, additional, Bellfill, R. Lleonart, additional, Velasco, J. Martos, additional, Nogues, E. Pinto, additional, Ortun, M. Rivera, additional, Aguñin, P. Rubinstein, additional, Farre, N. Subira, additional, Combas, J. Valldeperas, additional, Zubeldia, I. Ansotegui, additional, Hortigüela, G. Bernaola, additional, Ayuso, J. Ciruelos, additional, Álvarez, G. González, additional, Peña, M. Herrerias, additional, Castro, A. Lahuerta, additional, Llorente, P. Losada, additional, Martinez, P. Marin, additional, Malanda, N. Marina, additional, Gonzalez, F. Garcia, additional, Miguel, T. Peña, additional, Hernandez, M., additional, Timon, S. Jimenez, additional, Carreño, S. Porcel, additional, Olbah, M. Alwakil, additional, Muñoz, A. Arnedillo, additional, Mohedad, J. Chamorro, additional, Fernandez, D. Gutierrez, additional, Camacho, A. Letran, additional, Lopez, C. Merinas, additional, Gonzalez, M. Millan, additional, Bernal, S. Niño, additional, Pellon, L. Fernandez, additional, Miguel, E. Morchon, additional, Portal, F. Ortiz, additional, Rodríguez, A. Suárez, additional, Alapont, M. Modesto, additional, Raducan, I., additional, Segarra, M. Salvador, additional, Bonilla, P. Galindo, additional, Calderon, P. Mata, additional, Rodriguez, M. Mena, additional, Martinez, R. Lama, additional, Pérez, M. Martín, additional, Villarejo, M. Morales, additional, Aparicio, M. Blanco, additional, Muíño Joga, M. Do, additional, Garcia-Boente, L. Fontan, additional, Paz, V. García, additional, Barcala, F. Gonzalez, additional, Orjales, R. Nuñez, additional, Castedo, C. Rabade, additional, Diaz, M. Rico, additional, Fernandez, A. Moreno, additional, Español, S. Aparicio, additional, San Francisco, A. Ruiz, additional, Navarrete, B. Alcázar, additional, Gomez De Cadiz, L. Cassini, additional, Rodriguez, M. Escribano, additional, Lopez, J. Florido, additional, Jiménez, M. Lara, additional, Caballero, J. Lopez, additional, Ceres, M. Martínez, additional, Costoya, R. Mayorgas, additional, García, C. Morales, additional, Vilchez, M. Rojas, additional, Ortiz, A. Romero, additional, Mazuecos, J. Beitia, additional, Castro, A. Vega, additional, Arenaza, B. Labeguerie, additional, Mendizabal, S. Lizarza, additional, Sampedro, I. Perez, additional, Vazquez, L. Valverde, additional, De Sus, J. Cegoñino, additional, Villa, J. Compaired, additional, Pargada, D. Ferrer, additional, Jarque, J. Herrero, additional, Patiño, M. Chacon, additional, Gomila, A. Fuster, additional, Pastrie, F. Nicolau, additional, Lopez, J. Almagro, additional, Martinez, P. Benito, additional, Ruiz De Lobera, A. Velez, additional, Gonzalez, F. Carballada, additional, Carral, C. Perez, additional, Racamonde, A. Veres, additional, Del Pino, M. Cervera, additional, Sacanell, J. Rozadilla, additional, García, I. Ali, additional, Mejias, Y. Anta, additional, Bausela, B. Añíbarro, additional, Cozar, M. Arroyo, additional, Sanz, P. Barranco, additional, Bobolea, I., additional, Fernandez, A. Bueso, additional, De Santiago Delgado, E., additional, Campos, R. Diaz, additional, Uña, J. Donado, additional, Vila, A. Feliu, additional, Cano, M. Gandolfo, additional, De Pedro, J. Garcia, additional, Galicia, M. Garcimartin, additional, De Olano, D. González, additional, Barbudo, B. Huertas, additional, Viña, A. López, additional, Peña, A. Losada, additional, Martin, G. Minguez, additional, De Francisco, A. Montoro, additional, Borque, R. Moreno, additional, Moro, M., additional, Prieto, M. Ramirez, additional, Frutos, M. Reche, additional, Jimenez, B. Rodriguez, additional, Rodríguez, M., additional, Ribate, D. Romero, additional, Perez, F. Ruano, additional, Hornillos, J. Ruiz, additional, López, P. Sánchez, additional, Martinez, F. Sola, additional, Garrido-Lestache, J. Subiza, additional, Gambasica, Z. Vasquez, additional, Albelda, C. Vila, additional, Ramirez, J. Alcazar, additional, De Luiz Martínez, G., additional, Núñez, I. García, additional, De Luna, F. Linde, additional, Sáenz De Tejada, E. Ortega, additional, Galo, A. Padilla, additional, Martinez, R. Rodriguez, additional, Esojo, M. Soria, additional, Espinosa, R. Andujar, additional, Inglés, M. Avilés, additional, Mora, R. Bernabeu, additional, Campos, M. Franco, additional, Arellano, M. Peña, additional, Puebla, M. Alvarez, additional, Figueroa, B. García, additional, Fernández, S. Garrido, additional, Rivera, J. Olaguibel, additional, Purroy, A. Tabar, additional, Garazo, B. Presedo, additional, Losada, S. Varela, additional, Villamuza, Y. García, additional, Bonny, J. Cumplido, additional, Sintes, R. Alvarez, additional, Landin, J. Castro, additional, Paz, A. Cobas, additional, Abelaira, M. Corbacho, additional, Rio, F. Iglesias, additional, Sanmartín, A. Pallarés, additional, Picans, I., additional, Moreira, A. Regueiro, additional, Romera, R. Tejedor, additional, Aznar, J. Igea, additional, Bellido, F. Muñoz, additional, Hernandez, M. Rodriguez, additional, Perez, R. González, additional, Flores, H. Izaguirre, additional, Gutierrez, F. Alvarez, additional, Cimbollek, S., additional, De Luque Piñana, V., additional, Gallardo, J. Medina, additional, Garcia, V. Moreno, additional, Cuevas, J. Orta, additional, Crespo, Y. Puente, additional, Enriquez, J. Quiralte, additional, Dominguez, P. Serrano, additional, Elias, Ò. Sotorra, additional, Pamplona, M. Muñoz, additional, Lara, M. Jimenez, additional, De Gregorio, A. Moral, additional, Martin, M. Alvariño, additional, Canelles, M. Ballester, additional, Baixauli, E. Burches, additional, Serra, P. Catalán, additional, Gregori, M. Climent, additional, Rodriguez, P. Cordero, additional, De Las Marinas Alvarez, M., additional, Palacios, M. Díaz, additional, El-Qutob López, D., additional, Giner, J. Greses, additional, Lara, S. Herrera, additional, Martínez, G. Jorro, additional, Santafé, J. Liñana, additional, Bayo, A. Lloris, additional, Moragon, E. Martinez, additional, Sancho, I. Molero, additional, Lacomba, J. Montoro, additional, Sendra, E. Naval, additional, Seisdedos, L. Navarro, additional, Bertol, B. Orosa, additional, Iniesta, A. Robles, additional, Cubillan, J. Ruiz, additional, Sánchez-Toril López, F., additional, Vinuesa, A. Saura, additional, Gomez, A. Alonso, additional, De Frutos Arribas, J., additional, Fernandez, E. Macias, additional, Alonso, A. Sanchez, additional, Sanz, C. Colás, additional, Fuentes, M. Domínguez, additional, Sotillos, M. Garcés, additional, and Arazuri, N. Segura, additional
Published: 2018
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32. Diseño e implementación de un procedimiento para la reducción de proyecciones de soldadura por resistencia, en la planta de carrocerías 'Body III' en Ford España

Author: Sánchez-Toril Mora, Jorge
Subjects: Soldadura por resistencia, TECNOLOGIA ELECTRONICA, Máster Universitario en Ingeniería Industrial-Màster Universitari en Enginyeria Industrial, Proyecciones de soldadura, Bosch6000, Calidad
Abstract: [ES] Realización de programa de recogida y análisis de datos de proyecciones funcional para toda la planta Body III y mejora de la calidad en puntos de soldadura por resistencia en la estación 6Y.El presente proyecto se inicia con el sistema de adquisición de datos proveniente de las máquinas de soldadura (Bosch6000). Posteriormente se deberá desarrollar un sistema de análisis de dichos datos que permita concluir con varios informes automatizados. Finalmente deberá programarse la máquina de soldadura, cambiando los parámetros de soldado para evitar proyecciones (errores en los puntos de soldadura).
Published: 2016

33. The role of pulmonology in the National Health System Chronicity Strategy

Author: Soler-Cataluña JJ, Sánchez Toril F, and Aguar Benito MC
Subjects: Asma, Asthma, Atención integral, Case-management program, Chronic disease, Chronic obstructive pulmonary disease, Cronicidad, Disease-management program, Enfermedad pulmonar obstructiva crónica, Gestión de casos, Gestión de enfermedad, Integrated care program
Abstract: Longer life expectancy and the progressive aging of the population is changing the epidemiological pattern of healthcare, with a reduction in the incidence of acute diseases and a marked increase in chronic diseases. This change brings important social, healthcare and economic consequences that call for a reorganization of patient care. In this respect, the Spanish National Health System has developed a Chronicity strategy that proposes a substantial change in focus from traditional rescue medicine to patient- and environment-centered care, with a planned, proactive, participative and multidisciplinary approach. Some of the more common chronic diseases are respiratory. In COPD, this integrated approach has been effective in reducing exacerbations, improving quality of life, and even reducing costs. However, the wide variety of management strategies, not only in COPD but also in asthma and other respiratory diseases, makes it difficult to draw definitive conclusions. Pulmonologists can and must participate in the new chronicity models and contribute their knowledge, experience, innovation, research, and special expertise to the development of these new paradigms.
Published: 2015

34. Efectividad y análisis farmacoeconómico del tratamiento del asma grave con omalizumab en la práctica clínica.

Author: Martínez-Moragón, Eva, Climent, María, Chiner, Eusebi, Fernández-Aracil, Cleofé, Sánchez-Toril, Fernando, and Lluch-Tortajada, Inmaculada
Published: 2019
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35. Diseño e implementación de un procedimiento para la reducción de proyecciones de soldadura por resistencia, en la planta de carrocerías 'Body III' en Ford España

Author: Martínez De Juan, José Luís, Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials, Sánchez-Toril Mora, Jorge, Martínez De Juan, José Luís, Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials, and Sánchez-Toril Mora, Jorge
Abstract: [ES] Realización de programa de recogida y análisis de datos de proyecciones funcional para toda la planta Body III y mejora de la calidad en puntos de soldadura por resistencia en la estación 6Y.El presente proyecto se inicia con el sistema de adquisición de datos proveniente de las máquinas de soldadura (Bosch6000). Posteriormente se deberá desarrollar un sistema de análisis de dichos datos que permita concluir con varios informes automatizados. Finalmente deberá programarse la máquina de soldadura, cambiando los parámetros de soldado para evitar proyecciones (errores en los puntos de soldadura).
Published: 2016

36. Estructura motorizada para soporte de paneles solares, con seguimiento solar y medida de temperatura

Author: Sánchez-Toril Mora, Jorge
Subjects: TECNOLOGIA ELECTRONICA, Grado en Ingeniería Mecánica-Grau en Enginyeria Mecànica
Abstract: [ES] La motivación que ha llevado a realizar este proyecto es el diseño de un seguidor solar para Valencia con la instalación de módulos solares fotovoltaicos y la producción eficiente de energía eléctrica. Esto lleva implícito la mejora del rendimiento respecto a un sistema fijo convencional. Para el diseño del seguidor solar tendremos en cuenta: • Los conocimientos sobre el comportamiento del sol, para poder optimizar y aprovechar de manera eficiente la radiación recibida. • La robustez del seguidor para prevenir fallos y averías que perjudiquen a la producción ya que la se encuentra expuesto a las inclemencias del tiempo que pueden deteriorar las características de los materiales. • El diseño del producto para conseguir un buen precio en relación a su potencia y así competir con los sistemas fijos.
Published: 2014

37. Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation

Author: F. Sánchez-Toril, Prieto L, Casañ R, S. Soriano, J.L. Belenguer, and B. Brotons
Subjects: medicine.medical_specialty, Evening, Immunology, Provocation test, chemistry.chemical_compound, immune system diseases, Internal medicine, medicine, Immunology and Allergy, Asthma, Morning, Bronchus, business.industry, Respiratory disease, Acetaldehyde, respiratory system, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, chemistry, Anesthesia, Cardiology, Methacholine, business, circulatory and respiratory physiology, medicine.drug
Abstract: Background Although airway hyperresponsiveness to inhaled acetaldehyde has been documented in Japanese patients with asthma, the response to this bronchoconstrictor agent has never been studied in Caucasians. Objectives The objectives of the study were to determine differences in airway responsiveness to acetaldehyde between asthmatic and healthy subjects, and to examine the relationship between acetaldehyde responsiveness and the variability of peak expiratory flow (PEF). Methods The response to methacholine and acetaldehyde challenges was measured in 81 non-smoking adults (61 asthmatics and 20 normal controls). Subjects recorded PEF morning and evening for 14 days. The response to both bronchoconstrictor agents was measured by the PC20 (provocative concentration required to produce a 20% fall in FEV1). PEF variation was expressed as amplitude percentage mean, and as low percentage best (lowest PEF expressed as a percentage of the best PEF recorded). Results The two types of challenge yielded a similarly high level of sensitivity (100% for methacholine and 92% for acetaldehyde) and specificity (90 and 100%, respectively) to distinguish between asthma and controls. Asthmatic subjects were on average 265-fold less sensitive to acetaldehyde than to methacholine. PC20 acetaldehyde correlated weakly but significantly with both indices of PEF variation (amplitude percentage mean: ρ = − 0.36, P = 0.004; low percentage best: ρ = 0.42, P = 0.001). Conclusions These results indicate that airway hyperresponsiveness to acetaldehyde is a sensitive and specific indicator for separating asthmatic and normal subjects. Airway responsiveness to methacholine or acetaldehyde and PEF variation are not reflecting the same pathophysiological process in the airways.
Published: 2000

38. Prevalencia de la enfermedad pulmonar obstructiva crónica y del asma. Estudio transversal

Author: S. Soriano, J.L. Belenguer, J.A. Pérez, B. Brotons, J. Hernández, and F. Sánchez-Toril
Subjects: Pulmonary and Respiratory Medicine, business.industry, Medicine, business, Humanities
Abstract: Se estudian 467 sujetos comprendidos entre los 35 y 65 anos de edad, extraidos de una muestra seleccionada aleatoriamente de la poblacion del Area Sanitaria 5 de la Comunidad Valenciana. A traves de un cuestionario y de una espirografia se obtienen tasas para sintomas respiratorios, tabaquismo, antecedentes pulmonares, profesionales y funcion pulmonar. Se observa una prevalencia para el asma del 2,78% (IC: 2,76-2,79), para la bronquitis cronica del 4,0% (IC del 2,375,77) y para la limitacion al flujo aereo del 6,4% (IC: 4,5-8,3). El habito tabaquico estaba presente en el 33,2%. Se detecta una relacion significativa entre el grado de intensidad de los sintomas y funcion pulmonar. No hay diferencias entre fumadores y no fumadores con respecto al FEV1, % y la relacion entre exposicion laboral y espirografia solo se observa para el FEV1/FVC %.
Published: 1994

39. Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation

Author: L, Prieto, F, Sánchez-Toril, B, Brotons, S, Soriano, R, Casañ, and J L, Belenguer
Subjects: Adult, Male, Airway Resistance, Peak Expiratory Flow Rate, Acetaldehyde, Asthma, Bronchial Provocation Tests, Bronchoconstrictor Agents, Forced Expiratory Volume, Humans, Female, Single-Blind Method, Bronchial Hyperreactivity, Methacholine Chloride
Abstract: Although airway hyperresponsiveness to inhaled acetaldehyde has been documented in Japanese patients with asthma, the response to this bronchoconstrictor agent has never been studied in Caucasians.The objectives of the study were to determine differences in airway responsiveness to acetaldehyde between asthmatic and healthy subjects, and to examine the relationship between acetaldehyde responsiveness and the variability of peak expiratory flow (PEF).The response to methacholine and acetaldehyde challenges was measured in 81 non-smoking adults (61 asthmatics and 20 normal controls). Subjects recorded PEF morning and evening for 14 days. The response to both bronchoconstrictor agents was measured by the PC20 (provocative concentration required to produce a 20% fall in FEV1). PEF variation was expressed as amplitude percentage mean, and as low percentage best (lowest PEF expressed as a percentage of the best PEF recorded).The two types of challenge yielded a similarly high level of sensitivity (100% for methacholine and 92% for acetaldehyde) and specificity (90 and 100%, respectively) to distinguish between asthma and controls. Asthmatic subjects were on average 265-fold less sensitive to acetaldehyde than to methacholine. PC20 acetaldehyde correlated weakly but significantly with both indices of PEF variation (amplitude percentage mean: rho = - 0.36, P = 0. 004; low percentage best: rho = 0.42, P = 0.001).These results indicate that airway hyperresponsiveness to acetaldehyde is a sensitive and specific indicator for separating asthmatic and normal subjects. Airway responsiveness to methacholine or acetaldehyde and PEF variation are not reflecting the same pathophysiological process in the airways.
Published: 1999

40. [The prevalence of chronic obstructive pulmonary disease and asthma. A cross-sectional study]

Author: B, Brotons, J A, Pérez, F, Sánchez-Toril, S, Soriano, J, Hernández, and J L, Belenguer
Subjects: Adult, Male, Analysis of Variance, Middle Aged, Asthma, Respiratory Function Tests, Random Allocation, Age Distribution, Cross-Sectional Studies, Spain, Odds Ratio, Prevalence, Humans, Female, Lung Diseases, Obstructive, Sex Distribution
Abstract: Four hundred sixty-seven patients between 35 and 65 years of age were studied, all taken from a random sample of the population of Health Area 5 of the Valencian Community. Figures for respiratory symptoms, smoking, previous lung disease, professional activity and lung function were obtained through questionnaires and spirometry. The prevalence of asthma found was 2.78% (C.I. 2.76-2.79); chronic bronchitis was 4.07% (C.I. 2.37-5.77) and airflow limitation was 6.4% (C.I. 4.5-8.3). Smokers represented 33.2% of the sample. A significant association was found between the level of intensity of symptoms and lung function. There were no differences between smokers and non smokers with respect to FEV1%. An association between workplace exposure and spirometry was found only for FEV1/FVC%.
Published: 1994

41. [Pneumatocele as a form of presentation of Pneumocystis carinii pneumonia]

Author: F, Sánchez-Toril, A, Robles, M, López, J, Berbegal, F, Pasquau, and F, del Campo
Subjects: Adult, Lung Diseases, Male, Radiography, Cysts, Pneumonia, Pneumocystis, Blotting, Western, HIV Seropositivity, Trimethoprim, Sulfamethoxazole Drug Combination, Humans, Enzyme-Linked Immunosorbent Assay
Abstract: Pulmonary infection by Pneumocystis carinii in patients with acquired immunodeficiency syndrome (AIDS) can result in different radiological patterns with an ever expanding spectrum. A 40-year-old male, infected with the human immunodeficiency virus (HIV), presented with toxic symptoms and multiple pulmonary cystic lesions in the context of a Pneumocystis carinii pneumonia. The rarity of this radiological presentation is discussed and literature is reviewed. In addition, the possible pathogenetic mechanisms are discussed, and emphasis is made on the need for higher suspicion index in similar presentations in patients at risk of HIV infection.
Published: 1991

42. Differences in airway responsiveness to acetaldehyde and methacholine in asthma and chronic bronchitis

Author: Sánchez-Toril, F., primary, Prieto, L., additional, Peris, R, additional, Pérez, J.A, additional, Millan, M, additional, and Marín, J, additional
Published: 2000
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43. Prevalencia de la enfermedad pulmonar obstructiva crónica y del asma. Estudio transversal

Author: Brotons, B., primary, Pérez, J.A., additional, Sánchez-Toril, F., additional, Soriano, S., additional, Hernández, J., additional, and Belenguer, J.L., additional
Published: 1994
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44. Absceso mediastínico anterior secundario a rotura esofágica espontánea: descripción de un caso

Author: Sánchez-Toril López, F., primary, Palop Medina, J., additional, Camacho Lozano, J., additional, Piquer Villa, A., additional, Castro Navalón, J., additional, and Delgado Gomis, F., additional
Published: 1992
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45. [Woman of fertile age with pleural effusion and an interstitial lung pattern]

Author: N, Gómez-León, R, Alvarez-Sala, C, Melero, A, Molina, F, Sánchez-Toril, and R, Daimiel
Subjects: Adult, Pleural Effusion, Radiography, Lung Neoplasms, Lymphangioma, Humans, Female

46. Asma y analgésicos

Author: Prieto, L., primary, Sánchez-Toril, F., additional, Morales, M.C., additional, Palop, J., additional, and Castro, J., additional
Published: 1985
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47. Efecto broncodilatador de los antiinflamatorios no esteroideos en el asma. Comunicacion de un caso

Author: Sanchez-Toril, F., Prieto, L., Palop, J., Juyol, M., Paricio, A., and Castro, J.
Published: 1985
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48. Primary Sjögren Syndrome and Pleural Effusion

Author: Alvarez-Sala, R., Sanchez-Toril, F., Garcia-Martinez, J., Zaera, A., and Masa, J.F.
Published: 1989
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49. The Importance of Small Airway Dysfunction in Asthma: The GEMA-FORUM III Task Force.

Author: Plaza V, Trigueros JA, Cisneros C, Domínguez-Ortega J, Cimbollek S, Fernández S, Hernández J, López JD, Ojanguren I, Padilla A, Pallarés A, Sánchez-Toril FJ, Torrego A, Urrutia I, and Quirce S
Subjects: Humans, Respiratory System, Spirometry, Asthma
Published: 2021
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50. [The prevalence of chronic obstructive pulmonary disease and asthma. A cross-sectional study].

Author: Brotons B, Pérez JA, Sánchez-Toril F, Soriano S, Hernández J, and Belenguer JL
Subjects: Adult, Age Distribution, Analysis of Variance, Asthma physiopathology, Cross-Sectional Studies, Female, Humans, Lung Diseases, Obstructive physiopathology, Male, Middle Aged, Odds Ratio, Prevalence, Random Allocation, Respiratory Function Tests statistics & numerical data, Sex Distribution, Spain epidemiology, Asthma epidemiology, Lung Diseases, Obstructive epidemiology
Abstract: Four hundred sixty-seven patients between 35 and 65 years of age were studied, all taken from a random sample of the population of Health Area 5 of the Valencian Community. Figures for respiratory symptoms, smoking, previous lung disease, professional activity and lung function were obtained through questionnaires and spirometry. The prevalence of asthma found was 2.78% (C.I. 2.76-2.79); chronic bronchitis was 4.07% (C.I. 2.37-5.77) and airflow limitation was 6.4% (C.I. 4.5-8.3). Smokers represented 33.2% of the sample. A significant association was found between the level of intensity of symptoms and lung function. There were no differences between smokers and non smokers with respect to FEV1%. An association between workplace exposure and spirometry was found only for FEV1/FVC%.
Published: 1994
Full Text: View/download PDF

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