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The benefits of information and communication technology have many positive impacts. However, if we are not aware of and comply with the regulations in using all the facilities and the ease of accesing the information itself, I t often causes various thing that can be detrimental. As for utilization of information technology and social media communication as a means of digital marketing for SMEs in Pagelaran Village, Ciomas District, Bogor Regency. The marketing of the product itself is still by direct marketing of offers between friends, from person to person, so that it has an impact on monotonous sales and not too many people or the surrounding community know about it. Word of mouth media makes these SMEs not yet developed. With the use of social media as a means of digital marketing, it is expected to increase sales and competitiveness in the wider market. The solution offered is to create social media, provide understanding, then proceed to mentoring, namely counseling and training on the use of social media which includes ad design and uploading advertising content on social media.

A chatbot is a computer program based on AI (Artificial Intelligence), namely virtual robots that simulate conversations like humans. Customer service (CS) is one of the many parts of a company that will directly contact customers. Therefore CS is expected to be able to provide fast and appropriate responses to customer complaints and needs. Using AI technology, Chatbot can help or replace customer service duties because it can provide information and help customers' constraints precisely and quickly. A chatbot is currently widely used by middle and upper companies. H3I is a kind of Chatbot that serving all loyal customers and can be implemented in various messenger platforms such as WhatsApp, Line, and others. For gathering the information, the authors use interview, observation, literature study. Moreover, the Prototype model is used for the development of Chatbot. The result was made a Chatbot for WhatsApp that can be used for customer service.

Background: Thalassemia and hemoglobinopathies have significant complications on the children's health. Also, they have a higher cost for treatment. The prevalence of these diseases differs from one area to another in Saudi Arabia. Aims: To detect the different hemoglobin abnormality and their frequency in the premarital population in Makkah city. Methods: A cross-sectional study was conducted, which included 473 subjects who attended the premarital screening tests at the maternity and children Hospital laboratory and Heraa hospital. We were collected the data of the complete blood count, hemoglobin electrophoresis, and iron profile from the participants. The statistical analysis was performed by SPSS program version 20. Results: 74.8% of the participants were normal, 9.3% had iron deficiency anemia (IDA), 6.3% were suspected to be alpha thalassemia trait, 3.4% had sickle cell trait, 3% were polycythemia, 1.5% had hereditary persistence fetal hemoglobin (HPFH), 1.1% were IDA with thalassemia trait, 0.4% were beta thalassemia trait, 0.2% had hemoglobin E trait. Conclusion: thalassemia trait and hemoglobinopathies are present in the premarital population in Makkah city at a low prevalence. The highest frequency was for the alpha thalassemia trait, then sickle cell trait, then HPFH, then beta-thalassemia trait, and lastly, hemoglobin E trait. IDA is present at a high frequency. Education to the population is essential to decrease the prevalence of these disorders.

Background Calamus rotang L. (CR) is an Indian shrub. The leaves and other organs of the plant are traditionally used in India for treatment of various diseases. The in vitro antioxidant property of the leaves extract was previously established. Thus, the current study aimed to evaluate the antioxidant and hepatoprotective effects of CR ethyl acetate extract at a dose of 350 mg/kg on CCl4 induced hepatotoxic rats through different mechanisms. Methods Histopathological examination of the treated rats’ group in comparison with positive and negative controls were performed. Quantitative measuring of the proinflammatory cytokines (TNF α), inflammatory regulators (Arginase, PPAR α) and the antiapoptotic protein Bcl-2 in comparison with positive and negative control groups was achieved using immunohistochemical examination. HPLC profiling of the polyphenol contents and molecular docking of the identified compounds against BH3 proapoptotic protein were correspondingly studied to evaluate the potential antiapoptotic property. Results The CR extract greatly protects the liver tissue through the suppression of TNF α, arginase and PPAR α induced by CCl4 as well as its enhancement of the antiapoptotic Bcl-2 protein. Fourteen polyphenols of different classes were identified in CR extract and tested via molecular docking for their potential antiapoptotic activities against BH3 protein. Naringin, rutin, 7-hydroxy flavone, and ellagic acid compounds exhibit the highest affinity and potential inhibition of pro-apoptotic protein BH3 via molecular docking study. Conclusions The ethyl acetate fraction of the leaves of C. rotang is rich in polyphenols that exhibited potent hepatoprotective effect on CCl4 induced hepatotoxic rats through its antioxidant, anti-inflammatory, anti-steatosis and antiapoptotic properties.

Heat stress has become more common in recent years, limiting wheat production in Huang-Huai-Hai plain in China. To identify the effect of long-term heat stress on wheat production, two heat-resistant (JM44, JM23) and two heat-sensitive (XM26, GC8901) wheat varieties were sown in heat tents and normal conditions, and heat stress (9 to 12℃ higher than control) was imposed for seven days at post-anthesis. All varieties under heat stress exhibited early senescence and reduced grain-filling rate, while the grain-filling period of heat-tolerant varieties was longer than that of the heat-sensitive. Furthermore, long-term heat stress significantly reduced kernel mass, grain number, harvest index, chlorophyll content, maximum quantum yield of PSⅡ photochemistry, effective quantum yield of PSⅡ photochemistry, photosynthetic rate, and transpiration efficiency. In addition, the distribution of dry matter to vegetative organs, catalase activity, and malondialdehyde content increased. These results indicated that the lesser yield reduction of heat-resistant varieties (11-26%) than that of heat-sensitive (16-37%) is due to relatively higher antioxidative and photosynthetic performance and higher assimilation in the grain from vegetative organs.

In this study, a mathematical model is formulated to examine the blood flow through a cylindrical stenosed blood vessel. The stenosis disease is caused because of the abnormal narrowing of flow in the body. This narrowing causes serious health issues like heart attack and may decrease blood flow in the blood vessel. Mathematical modeling helps us analyze such issues. A mathematical model is considered in this study to explore the blood flow in a stenosis artery and is solved numerically with the finite difference method. The artery is an elastic cylindrical tube containing blood defined as a viscoelastic fluid. A complete parametric analysis has been done for the flow velocity to clarify the applicability of the defined problem. Moreover, the flow characteristics such as the impedance, the wall shear stress in the stenotic region, the shear stresses in the throat of the stenosis and at the critical stenosis height are discussed. The obtained results show that the intensity of the stenosis occurs mostly at the highest narrowing areas compared with all other areas of the vessel, which has a direct impact on the wall shear stress. It is also observed that the resistive impedance and wall shear pressure get the maximum values at the critical height of the stenosis.

In recent years, a novel technique for producing robust cementitious materials, called nanocomposites, has emerged. These materials are comprised of clay minerals and polymers. As a result, a vertical flat plate has been used to evaluate a clay-based cementitious nanofluid in this research. The impacts of first-order chemical reactions, heat generation/heat absorption, and the Jeffrey fluid model are taken into account for the study of flow. Newtonian heating and the conditions for slippage velocity have also been considered. The mathematical problem for the flow analysis has been established in relations of partially coupled partial differential equations and the model has been generalized using constant proportional Caputo (CPC) fractional derivative. The problem is solved using the Laplace transform technique to provide precise analytical solutions. On the concentration, temperature, and velocity fields, the physics of a number of crucial flow parameters have been examined graphically. The acquired results have been condensed to a very well-known published work to verify the validity of the current work. It is important to note here that the rate of heat transfer in the fluid decreases by 10.17% by adding clay nanoparticles, while the rate of mass transfer decrease by 1.31% when the value of [Formula: see text] reaches 0.04.

The current study intends to find out the efficacy of Orlistat in the management of hyperlipidemia, Systolic Blood Pressure (SBP) and Body Mass Index (BMI).This retrospective study has evaluated the lipid profiles of the patients, who have been using metformin therapy for Type 2 diabetes. The study has obtained data regarding the parameters like triglyceride, Total cholesterol (TC), LDL cholesterol, HDL cholesterol and LDL/HDL ratio, systolic blood pressure and Body Mass Index (BMI). Random distribution of patients was done into placebo and Orlistat groups. The placebo group received only metformin, and patients in the Orlistat group received Orlistat along with metformin. After 24 weeks, the follow-up study was done, and statistical analysis was conducted.The study found that the Orlistat group has significant improvement (p0.05) more improvement in LDL cholesterol, HDL cholesterol, Total cholesterol, LDL/HDL Ratio and Triglycerides, while BMI and systolic blood pressure did not show a significant difference between placebo and Orlistat group.This study has concluded that Orlistat can be used for significant improvement in lipid profile. The study also found that Orlistat may not have a significant effect on reducing BMI and blood pressure without adequate lifestyle modification.

Background The management of patients presenting with an out of hospital cardiac arrest (OHCA) is resource intensive, and mortality remains very high. Several scoring systems have been developed to predict mortality and adverse neurological outcomes, and thus aid decision making for patients arriving to heart attack centres. Two of the most commonly used scoring systems are NULL-PLEASE (1) and MIRACLE2 (2). Purpose The MIRCALE2 score predicts poor neurological outcome at 6 months, as measured by Cerebral Performance Category (CPC). The NULL-PLEASE score predicts in-hospital morality. We aimed to compare both scores in predicting their primary end-points in a large tertiary centre in the UK. Method and results This was a retrospective analysis of 435 patient who were admitted with OHCA via the primary PCI pathway to a large tertiary cardiac centre between January 2016 and September 2020. Only comatosed OHCA survivors requiring pre-hospital ventilatory support were included. 319 patients were eligible 238 patients had complete set of data and were included in the final analysis. The association of the primary outcome was examined using logistic regression analysis. The predictive ability of the scores for the primary endpoint was tested using AUC analysis. In-hospital mortality was 45% (108 patients), with 53% having good neurological outcome at 6 months (CPC 3 had 74% sensitivity to predict in hospital mortality. Conclusion To our knowledge, this is the first study to compare the MIRCLE2 and NULL-PLEASE scoring systems. Both scores did not perform as expected in our large retrospective analysis. The NULL-PLEASE was more sensitive in predicting in-hospital mortality, although MIRACLE 2 score was easier to use as it had less variables to collect. Funding Acknowledgement Type of funding sources: None.

Background Consanguinity is prevalent in Egypt (35%) resulting in a high incidence of homozygosity. The influence of homozygosity on the genetics of Hypertrophic Cardiomyopathy (HCM) has not been adequately studied. Purpose The purpose of this study is to define the genetic architecture of HCM in Egypt using ethnically-matched case and control cohorts. Methods Prospective Egyptian patients (n=514) and controls (n=400) were recruited to Aswan Heart Centre for clinical phenotyping and genetic testing for 174 genes implicated in inherited cardiac conditions (Illumina). Rare variation (gnomAD filtering allele frequency ≤4x10–5) in 13 validated HCM genes were classified according to the American College of Medical Genetics (ACMG) guidelines and compared with a prospective HCM cohort of predominantly European ancestry (n=684). Results Significantly fewer rare variants detected in Egyptian patients could be classified as (likely) pathogenic compared to Europeans (40.8% vs. 61.6%, p-value=1.6x10–5). Incorporating analysis from these Egyptian case-control cohorts into the ACMG guidelines increased this yield to 53.8%. Homozygous variants were more frequently observed in Egyptian patients (4.1% vs 0.1%, p-value=2x10–7), with variants in the minor HCM genes MYL2, MYL3 and CSRP3 more likely to present in homozygosity than the major genes (MYH7, MYBPC3 and troponins), suggesting such variants are less penetrant in the heterozygous state. Conclusions The integration of Egyptian-specific genetic and phenotypic data significantly improves variant interpretation in HCM and consequently the precision of genetic testing. The observed prevalence of homozygosity and rare variation in minor HCM genes in Egyptian patients provides important insights into its disease-mechanisms and genetics. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Science and Technology Development FundAl Alfi Foundation

The growth hormone receptor (GHR) gene is member of the class I cytokine receptor family that important in growth regulation including in cattle. This study aimed to analyze the association between GHR|AluI gene with body weight, parameters in Grati-PO cattle population. A total of 304 blood samples were collected from the experimental station at the Beef Cattle Research Station, which were also equipped with 304 phenotypic data. DNA was extracted using a zymo extraction kit. Detection of of the polymorphism of GHR gene using PCR-RFLP method with AluI restriction enzymes. polymorphism indicators include genotype frequency, allele frequency, Hardy-Weinberg Equilibrium, observed heterozygosity (Ho), expected heterozygosity (He), polymorphism information content (PIC) and number of effective alleles (Ne). Association analysis was carried out using a linear mixed model. The performance of birth weight, weaning weight, yearling weight and 18 months weight were 25.4 + 0.2 kg; 113.8 + 2.3 kg; 159.9 + 2.7 kg and 213.7 + 3.6 kg, respectively. The result of association analysis was significant (P

Sumba Ongole (SO) cattle are Ongole cattle from India which were imported to Indonesia during the Dutch colonial era and were well adapted on Sumba Island, East Nusa Tenggara, Indonesia. Sumba Ongole (SO) cattle are known for high meat production. This research was conducted to identify one point mutation of g.415C/A (F94L marker) in the myostatin (MSTN) gene (exon 1) using PCR-RFLP method with TaqI restriction enzyme (T*CGA). DNA samples of SO bulls and cows (Total 153) from Sumba Island were used in this study. Results revealed that all samples in this study had CC genotype with C allele as the common allele. The mutation point of g.415C/A was not found in this study. However, one mutation point of g.400G/A was detected in this study without amino acid changes (synonymous). It was concluded that MSTN/TaqI gene in the present study is monomorphic and cannot be used as the genetic marker for productive traits of SO cattle.

Aim: To compare, through cone-beam computed tomography (CBCT), the root resorption and treatment efficiency of two different mini-implant-assisted modalities in intruding the maxillary incisors. Subjects and Methods: The present study composed of 26 patients (males, females) aged between 12-18 years who had deep bite and elongated maxillary incisors. They were randomly selected and divided into two group: anterior mini-implant group (AMG) and posterior mini-implant group (PMG). In the AMG, approximately 40 g of force was applied per side with elastic chains and in the PMG, with beta-titanium wires. This study was conducted on CBCT scans taken before intrusion and after 18 weeks of intrusion. Result: The incisors showed a significant reduction in length and volume, this amount was greater in AMG than PMG. Significant changes in labial inclination of all incisors, which were greater in PMG than AMG. Conclusion: Posterior mini-implants assisted maxillary incisors intrusion is preferred than anterior mini-implant assisted maxillary incisor intrusion in case of upright position, as the use of such mechanics directs them to less root resorption and more labial tipping.

Aim: Aims and objectives of the study were to measure shear bond strength of rebonded orthodontic brackets after using different enamel reconditioning techniques including (Diamond bur, Air abrasion with Aluminum Oxide particles, Ultra Sonic scaler, CO2 laser ).Subjects and methods : This in vitro study consists of five groups with ten samples in each group. Each sample was bonded with a metal bracket. After debonding, reconditioning of the tooth surface was performed by the finishing Diamond bur, Air abrasion, Ultra Sonic Scaler and Fractional CO2 Laser . Rebonding of the reconditioned teeth was again performed. Universal testing machine was used to evaluate the shear bond strength of the orthodontic brackets. Enamel surface topography was evaluated using scanning electron microscope. Results: The maximum average score of shear bond strength was in the LASER Group (16.4 Mega Pascal ) (MPa) followed by Ultra Sonic Scaler (16.2MPa), The Control Group (14.9MPa), Sand blasting Group (14.6MPa), at last the Diamond Burs group (11.3MPa) . There was a relationship between surface roughness and the bond strength achieved. The method which created a smoother uniform surface achieved the higher shear bond strength. Conclusions: Fractional CO2 Laser, Ultra Sonic scaler and Air abrasion can be used as preferred method of reconditioning the tooth surface after bond failure instead of diamond burs to achieve optimal bond strength of rebonded brackets.

Apart from Muntok White Pepper, until now there has been no geographical indication of being registered in the Bangka Belitung Islands. In fact, the potential for geographical indications in this area is very high. Several parties have tried to register potential geographic indications, but have not shown significant progress. This study aims to examine the problems in efforts to protect geographical indications in the Bangka Belitung Islands, to further seek ideal legal formulations so that these efforts can be resolved. Based on the analysis, this type of research is qualitative research. The data sources used in this study are primary data sources as well as secondary data sources. Data collection was carried out by conducting interviews and focus group discussions. Qualitative data analysis techniques. From the research conducted, it was concluded that the problems faced in efforts to register potential geographic indications include the factors of public knowledge that are not very familiar with the concept of geographical indications, relatively high costs, and minimal local government support.

Background: Injury to the facial region may lead to lifethreatening situations, it is difficult to physically examine thepatient with facial trauma. The growing frequency and mag-nitude of road traffic accidents, as well as the increase inepisodes of urban violence, have made these traumas a formof social disease. Multidetector Computed Tomography (MD-CT) is the imaging modality of choice and is one of the mostimportant imaging tools in evaluation of patients with sportrelated maxillofacial trauma. It helps in detecting the exactsite, number and extent of fractures, displacement of fragmentsand soft tissue injuries.Aim of Study: The aim of this study is to detect sportrelated different facial fractures by using conventional radi-ography and Multi Detector Computed Tomography (MDCT).Patients and Methods: Twenty eight patients were referredto Department of Radiodiagnosis, Zagazig University Hospitalsfor this prospective cross-sectional study.In this study, 28 patients with 60 facial fractures wereexamined by multidetctor CT from the most common fracturewas orbital fracture seen in 14 cases (50%).Our study included 28 patients who sustained sport traumato the facial skeleton with age range from 17-51 years old.Conventional plain radiography and MDCT were performedto all patients.Results: In this study, males were constitute most of thepatients with number of 22 patients which represents (78.6%) of the total while number of female patients was 6 which represents (21.4%) of the total.Conclusion: Facial injuries are commonly encounteredemergencies which needs early diagnosis and management.Road traffic accidents and social violence are the commonreasons which have led to increase in the frequency ofmaxillofacial injuries. However sport related facial injuriesis still a common cause, the complex anatomies of the facialbones require multiplanar imaging techniques for a detailedevaluation.

The objective of the study was to determine the optimal density of fingerlings of the Nile tilapia (Oreochromis niloticus) culture in floating cages with respect to growth performance and to know the effect of temperature on growth during the winter period. Tilapia fingerlings (mean weight 8.5 ± 0.36 g) were stocked at densities of 120, 180 and 360 fish/m3 for 10 weeks. During culture, fish were fed a diet contains 35% protein made of peanut seed, cottonseed, wheat bran, and Sorghum. The results showed that the increase in fish density reduced the final weight of the fish. The percentage of the fish weight increased and reached 111% ± 1.45% in the lowest fish density (120 fish/m3), 79% ± 1.87% in the medium density (240 fish/m3), and 63% ± 2.03% of high fish density (360 fish/m3), therefore the daily growth rate was better in the lowest density. The rate of food conversion ratio was also better in the lowest density with 2.17 ± 0.33, followed by the medium density with 2.79 ± 0.28 and then the highest density with 3.09 ± 0.21. However, the total production in the cage increased with increasing fish density, and the return to the cost of food was better with higher fish density. According to various performance evaluation criteria, it can be concluded that the medium density 240 fish/m3 is the best for growing Nile tilapia fingerlings in floating cages. It was observed that the growth rates of the three treatments were low due to the decrease in water temperature in most of the study period, which may indicate the useless of culture in cages in the winter season.