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In the field of cardiovascular health, rosuvastatin, a potent statin, holds significance as it aids in lowering cholesterol levels and mitigating the risk of cardiovascular diseases. While generally well tolerated, it is not without side effects. Common adverse reactions exist, and rare severe events such as liver injury and myopathy can occur. This case report sheds light on a specific incident involving a 49-year-old male patient who presented with a range of distressing symptoms, including loose motion, fever accompanied by chills, vomiting, nausea, abdominal pain, and disrupted sleep. Following an extensive investigation encompassing the patient’s medical history and laboratory tests, a diagnosis of drug-induced acute hepatitis was established, with rosuvastatin identified as the causative agent. Consequently, the statin therapy was promptly discontinued, and the patient was provided with symptomatic treatment until the liver-related investigations returned to normal. This case report underscores the paramount importance of diligent monitoring and surveillance in identifying and managing potential adverse effects associated with statin therapy, thereby safeguarding patient well-being and ensuring their safety.