1. Maximizing success in single-session EUS-directed transgastric ERCP: a retrospective cohort study to identify predictive factors of stent migration
- Author
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Brianna Shinn, Maan El Halabi, Austin L. Chiang, Avik Sarkar, Thomas M. Runge, Cyrus R. Piraka, Jose Nieto, Mena Bakhit, Tina Boortalary, Vivek Kumbhari, Isaac Raijman, Ryan Law, Michel Kahaleh, David L. Diehl, Haroon Shahid, Harshit S. Khara, S Vikas Kumar, Monica Gaidhane, Mouen A. Khashab, Alexander Schlachterman, Arjun R. Sondhi, Justin S. Robbins, David E. Loren, Bradley Confer, Romy Bareket, Cristina Calogero, Yervant Ichkhanian, Thomas E. Kowalski, Tobias Zuchelli, Prashant Kedia, and Amy Tyberg
- Subjects
Cholangiopancreatography, Endoscopic Retrograde ,Univariate analysis ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Stomach ,Perforation (oil well) ,Gastric Bypass ,Gastroenterology ,Stent ,Retrospective cohort study ,Odds ratio ,Confidence interval ,Surgery ,medicine ,Humans ,Stents ,Radiology, Nuclear Medicine and imaging ,Adverse effect ,business ,Single session ,Retrospective Studies - Abstract
Background and Aims EUS-directed transgastric ERCP (the EDGE procedure) is a simplified method of performing ERCP in Roux-en-Y gastric bypass patients. The EDGE procedure involves placement of a lumen-apposing metal stent (LAMS) into the excluded stomach to serve as a conduit for passage of the duodenoscope for pancreatobiliary intervention. Originally a multistep process, urgent indications for ERCP have led to the development of single-session EDGE (SS-EDGE) with LAMS placement and ERCP performed in the same session. The goal of this study was to identify predictive factors of intraprocedural LAMS migration in SS-EDGE. Methods We conducted a multicenter retrospective review that included 9 tertiary medical centers across the United States. Data were collected and analyzed from 128 SS-EDGE procedures. The primary outcome was intraprocedural LAMS migration. Secondary outcomes were other procedural adverse events such as bleeding and perforation. Results Eleven LAMS migrations were observed in 128 procedures (8.6%). Univariate analysis of clinically relevant variables was performed, as was a binary logistic regression analysis of stent diameter and stent dilation. This revealed that use of a smaller (15 mm) diameter LAMS was an independent predictor of intraprocedural stent migration (odds ratio, 5.36; 95% confidence interval, 1.29-22.24; P = .021). Adverse events included 3 patients who required surgery and 2 who experienced intraprocedural bleeding. Conclusions Use of a larger-diameter LAMS is a predictive factor for a nonmigrated stent and improved procedural success in SS-EDGE. Although larger patient cohorts are needed to adequately assess these findings, performance of LAMS dilation and fixation may also decrease risk of intraprocedural LAMS migration and improve procedural success.
- Published
- 2021