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Nowadays breast cancer in rheumatoid arthritis patients is the most controversial one. Rheumatoid arthritis is an inflammatory autoimmune disorder. RA may induce the order disease like cancer especially breast cancer in most women. Breast cancer starts when the breast cell begins to grow out of control. Inflammatory, anticancer drugs may show severe side effects. To overcome these herbal plants are used to make drastic changes in medical treatments. The main objective of this paper is assessment of Anti-inflammatory, anti-arthritic, anti-microbial and anti-cancer activity against the Michigan cancer foundation (MCF-7) human breast cancer cell line using the extracts Andrographis echioides. Anti-inflammatory and anti-arthritic activity show maximum inhibition of albumin denaturation, anti-proteinase, hypo-tonicity induced hemolysis, anti-lipoxygenase activity with standard drugs such as aspirin, diclofenac sodium and indomethacin at the concentration of 100µg/ml under in vitro condition. Thus the potential inhibition of protein (egg albumin) denaturation (85.80%) and for the human red blood cell (HRBC) membrane stabilization model 85.50% was observed at the concentration of 100µg/ml. The antioxidant and cytotoxicity activity of Andrographis echioides showed better inhibition in a dose-dependent manner against MCF-7 human breast cancer cell lines. The antimicrobial activity of Andrographis echioides showed maximum inhibition of E.coli (11mm), Enterococcus aerogenes and Staphylococcus aureus (10mm), and Candida albicans (11mm) at 100µg/ml concentration. The innovation of the present study revealed that the stem of Andrographis echioides have potential source for natural anti-arthritis, cytotoxicity, anti-microbial, antioxidant activity, anti-inflammatory and anticancer activities.

Introduction:The most fatal of all gynecological cancers is ovarian cancer. Of all gynecological cancers, it has the greatest fatality-to-case ratio. It is the 4th most prevalent cancer among women. The lifetime risk of being diagnosed with ovarian carcinoma is 1% to 1.5 %, with a nearly 0.5% chance of dying from it. Suboptimal primary cytoreductive surgery has great prognostic significance. The reason was because of inappropriate preoperative evaluation, which decides the kind of surgery being performed and the surgeons expertise of the surgeon in performing staging laparotomy if indicated. Hence, a gynecologist must be able to differentiate benign from the malignant ovarian mass. Several studies have revealed that the diagnosis of ovarian mass by investigations like Ultrasonogram, Doppler, MRI, CT has been proved to be uncertain despite the need for expertise. The goal of this study was to assess the ability of the Risk of Malignancy Index Scoring System (RMI- 4) in differentiating benign from malignant ovarian masses and to compare the scoring patterns to histopathological findings. Objectives: To validate the efficiency of the Risk of Malignancy Index(RMI-4) in discriminating benign and malignant ovarian tumors.To correlate the calculated value of the Risk of Malignancy Index(RMI-4) to the histopathological report.To evaluate the performance of individual parameters and the Risk of Malignancy Index(RMI-4) in differentiating benign and malignant ovarian tumors. Materials and methods: A prospective observational study in one year from date of approval from institutional ethical committee i. e from 2019 to 2021on women attending Gynecology outpatient and inpatient department diagnosed with an ovarian mass at Government Maternity Hospital, Tirupati. Results : 50 women with ovarian mass were selected for the study. Patients with endometriosis, fibroid uterus, Pelvic inflammatory disease, menstruation, pregnancy, ectopic pregnancy, and other non-gynecological conditions like peritonitis, diverticulitis, inflammatory bowel disease, tuberculosis, liver disease, recent surgery, are excluded. General and gynecological examinations were done for all cases. Ultrasound pelvis was done for all the patients and the presence of bilateral ovarian mass, multiloculated tumor, presence of solid areas, ascites, and extra ovarian metastasis was noted. An ultrasound score (U) of 1 was given if none or one of the features are found, and a score of 4 was given if two or more of these features were noted. Size of the tumor measured. A score of 1 was given for a tumor less than 7 cm and a score of 2 for a tumor size more than or equal to 7 cm size. Postmenopausal status was defined as more than one year of amenorrhea or age older than 50 years for women who had undergone hysterectomy they were scored as M=4. All other patients who did not meet these criteria were defined in a premenopausal status which scored M=1. The Risk of Malignancy Index (RMI-4) was calculated by using the formula: RMI-4 = U x M x S x CA 125. Laparotomy was done for all cases and the specimen was sent for histopathological examination which is the gold standard.90% of the tumors were benign and 10% were malignant.Prediction of malignancy by CA 125, ultrasound, and RMI-4 was analyzed.The optimal cut-off value of RMI-4 was 450 with a sensitivity of 95.56%, specificity of 100%, PPV of 100%, and NPV of 71.43%.Though the Specificity and PPV of CA125 were high, Sensitivity was less (86.67%).This study showed that RMI-4 had better performance than CA 125, USG score, and menopausal score in predicting malignancy. Conclusion:RMI-4 is a multimodal approach that is simple and easily applicable in the preoperative evaluation of a patient with an ovarian mass.Risk of Malignancy Index -4 (RMI-4) is a reliable method in discriminating benign and malignant ovarian mass preoperatively.Risk of Malignancy Index -4 (RMI-4) is a better scoring index in differentiating benign and malignant ovarian mass when compared to individual tests of ultrasonogram or CA125 level.The optimal cut-off point of Risk of Malignancy Index -4 (RMI-4) at which benign and malignant tumors can be discriminated was 450 in the present study.RMI-4 is the most useful scoring system in the proper selection of patient.Since the specificity of Risk of Malignancy Index -4 (RMI-4) was high, there is a potential role for this index in the selection of cases for conservative management or minimally invasive surgery in case of benign ovarian masses.

In addition to environmental degradation and financial issues due to their high cost, the use of synthetic pesticides, particularly insecticides, has led to ecological issues such pest tolerance to chemicals, a return of pests, and harm to human and animal health. Natural goods are a safer and more environmentally friendly option that has minimal or no mammalian toxicity. Wide-ranging testing is being done on numerous plant items for their potential as repellents. Plant products have insecticidal properties because they include secondary metabolites. Given its potential for commercial use, the plant merits further examination. Given their effectiveness against them and ease of biodegradability, several botanicals are increasingly emerging as a feasible component in parasite management techniques. In the current investigation, the plant Lantana camara’s larvicidal activity has been selected and investigated and given its potential for commercial use, the plant merits further examination.

Optimization of process parameters is a critical requirement in food processing and food product industries for the development of highly acceptable product. Quantification of mass transfer kinetics under different processing conditions is essential step for optimizing the osmotic dehydration process. A Box-Behnken Design (BBD), adopted from response surface methodology (RSM) approach was used for evaluating and quantifying the moisture loss and solids gain kinetics of aonla segments in salt solution during the osmotic dehydration process. The independent variables were fixed at three levels (salt concentration- 2, 4, 6%; process temperature - 45, 50, 55 OC and process time - 60, 120, 180 minutes). The process responses were water loss percentage (WL%) and solids gain percentage (SG%). Validation experiments were conducted at optimum conditions to verify predictions and adequacy of the models. The optimum conditions predicted were 5.02% salt concentration, 54.8 OC temperature and 60.64 minutes process time to attain a desired effect of maximum water loss (6.42%) and minimum solid gain (1.09%) in osmotic dehydration of aonla in salt medium.

This study characterized the acute toxicity of Monocrotophos on histological alterations in the different organs like gills, Hepatopancreas and ovary of Anomuran Crab, Emerita asiatica. Though Emerita asiatica is not a commercially viable crab, but it plays a vital role in the coastal environment to maintain a stable marine ecosystem. Several steps and precautions measures should be taken to consume these members of the marine food chain to have aunwavering ecosystem and also to protect this species from extinction. Thus, it can be concluded that the use of Monocrotophos which has been legally banned in India is justified. It has been proved by several workers and has been conformed in present investigation that use of this organophosphate causes serious damage to the vital organ of sand crabs gill, hepatopancreas and ovary. The utilization of Monocrotophos should be minimized in the agricultural field area near to the coastal ecosystem.

Acute toxicity of Chlorpyrifos on histological alterations in the different organs like gills, hepatopancreas and ovary of anomuran crab, Emerita asiatica was studied. Though Emerita asiatica is not a commercially viable crab, but it plays a vital role in the environment to maintain a stable marine ecosystem. Several steps and precautions measures should be taken to conserve these members of the marine food chain to have a stable ecosystem and also to protect this species from extinction. Thus, it can be concluded that the use of Chlorpyrifos which has been legally banned in India is justified. It has been proved by several workers and has been conformed in present investigation that use of this Chlorpyrifos causes serious damage to the vital organ of sand crabs gill, hepatopancreas and ovary. The application of Chlorpyrifos could be reduced in the agricultural field to nearby coastal regions.

The focus of this study is on time series inferential statistical projection and analysis for long-term multi-trending trajectory forecast modelling. Inferential statistics was used for projection and analysis of long-term multi-trending trajectory forecasting. The proposed model is trained, tested and validated on three different types of stocks viz. NVIDIA, UNG and IBM taken from the NASDAQ stock market index. In Phase I, the long-term deterministic multi-trending model is assessed and fitted. Model skewed residual series is assessed using the goodness of fit in Phase II. The future stock close prices and long-term multi-trending trajectory paths are simulated and analyzed in Phase III. Finally, in Phase IV, epsilon-skew-normal results and normal distribution assumptions are compared. The experimental result shows that an uptrend trajectory of historical close price simulates an uptrend trajectory in the forecasted close price, a downtrend trajectory of historical close price simulates a downtrend trajectory in the forecasted close price, a sideways or mixed trend trajectory of historical close price simulates a sideways or mixed trend trajectory in the forecasted close price.

Browning is a major quality deterioration process affecting both visual colour and nutritional value of guava leather. The aim of the study was to determine the role of different sugars viz., sucrose, fructose, glucose and sorbitol in non-enzymatic browning and antioxidant activity of guava fruit leather. The total free amino acids, ascorbic acid and antioxidant activities were at significantly lower levels in glucose and fructose treated guava leather, while the sorbitol added samples had all of above parameters at the highest level; while a reverse trend was observed in browning index and non-enzymatic browning. Among the browning intermediate products, Hydroxymethylfurfural was present at higher concentration (12.80-32.32 ng/g) than furfural (0.29-0.95 ng/g) in guava leather samples. Among the treatments, hydroxymethylfurfural was found lowest in sorbitol (12.8 ng/g) and highest in fructose (32.3 ng/g). In brief, this paper describes a novel effort in bringing the in-vitro studies related to sugars and total free amino acids, influencing the biochemical and nutritional attributes which are responsible for browning in guava fruit leather.

Pomegranate is an important table and processed fruit owing to its nutritional quality. Extending the fruit life of the plant is very much limited owing to its metabolic activities viz., respiration, transpiration and microbial infection. An experiment was conducted to investigate the effect of different packaging materials on physico-chemical properties of pomegranate fruits during storage. Fruits were harvested with stalk and washed with sodium hypochlorite, air dried and graded. Fruits were stored under modified atmospheric packaging conditions using different packaging materials viz., polyethylene bag, polypropylene bag, Xtend® bag and silver nano bag Hima Fresh®. Fruits without package served as controls. Fruits were stored at low temperature 7±2 °C and 90±5 % RH. MAP treated fruits had higher quality parameters across all packaging treatments. PLW and respiration rate increased while, moisture content, colour, texture and acidity decreased with prolonged storage, but the rate of decrease was highest in unpacked fruits. MAP maintained the quality of pomegranate fruits upto 100 days compared to unpackaged fruits (40 days). Shelf life of stored fruit at ambient condition was 4 to 5 days. Fruit decay was 12 % in polyethylene whereas it was 6 % in Xtend® bag at the end of 100 day of storage.

The objective of the study is to look at the activation of stem cell-related markers in lung adenocarcinoma. Utilizing an unsupervised machine learning approach centered on the mRNA expression of pluripotent stem cells as well as its subsequent developed progeny, the mRNA stemness index of further around 500 LUAD patients from The Cancer Genome Atlas dataset was generated. In LUADs, mRNAsi had first been investigated using differential variations, survivability analyses, medical phases, and sexuality. A computational approach is used for identifying cell clusters utilizing fuzzy clustering. There at transcriptional as well as protein stages, the interactions between the genetic markers were investigated. The functionality and processes of the important genes were annotated using expression values. The degree of gene expression related to the clinical symptoms and the likelihood of surviving have also been confirmed. In cancer patients, the mRNAsi genes were highly elevated. In particular, the mRNAsi score rises with advanced trials and varies markedly by sexuality. Within several years, reduced mRNAsi categories will have superior overall survivability in large LUADs. Individuals with chronic LUAD had greater mRNAsi and had reduced average survivability. The important genes and the distinguished categories have been chosen based on their mRNAsi connections. Some of the major genes related to cell proliferating Gene Ontology concepts were found enriched out from the cell cycle Kyoto Encyclopedia of Genes and Genomes (KEGG) process. Specific genes were found to be linked to CSC features. Their activation grew in lockstep with the progression of LUAD’s pathology, so these markers appeared amplified in pan-cancers. These important markers were discovered to have substantial connections as a group, suggesting that they could be exploited as drug applications in the therapy of LUAD by suppressing stemness traits.

This study was explored to find out the relationship between social intelligence and teaching competency of high school teachers in Coimbatore district. A sample of 200 Secondary school teachers from various schools in Coimbatore district was selected through convenient sampling technique. A self-made tool prepared by the investigator was used to collect the data. Data was analyzed by using t-test. Results found that there is no significant difference between male and female high school teachers in their social intelligence, teaching competency. Finding also showed that there is no significant difference between male and female high school teachers in their social intelligence and teaching competency.

Internet of Things (IoT) role is inevitable in today’s scenario. The secure communication between IoT devices is given much importance. This study proposes a group key management approach with dual encryption scheme (AES and RSA) to ensure secure group communication. The doctors and devices /patients are the members (components) of the communication network and the data is exchanged between the devices and authenticated doctors. The group key along with the Identity key is utilized here to establish secure group communication between the members. The group key management ensures security, thereby avoiding the hacking of data. The group key is considered to be valid in group communication for a maximum time period (72 hrs).The proposed group communication model is implemented for Internet of Medical Things (IoMT) environment using dual encryption scheme. The process of group communication between the IoMT members is simulated and visualized by using NS3 software. The data for communication is evaluated by the performance metrics, viz. packet delivery ratio, throughput and delay. The proposed dual encryption scheme is shown to be highly secure and effective in this IoMT environment. &nbsp

In today's technologically driven world, social media has become an increasingly important part of our daily lives. It lets people interact with one another over the internet, which makes communication much easier. All of these advantages, however, appear to be too good to be true. However, all of these features and services come at the cost of our privacy. They monitor our daily activities on these platforms in order to provide targeted advertising and generate revenue. To overcome this problem, we suggest utilizing blockchain technology to build a completely decentralized social media platform in which no single organization or individual owns the data. This helps to assuage our privacy concerns.