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1. FD MAC Protocol Design for Co-Existing WLANs in 5G Cellular Networks

Author: S. Diakite, F. M. Rizo, and S. Y. M. Bandiri
Subjects: Directional transmission, Inter-user interference, Medium Access Control (MAC), Three-node FD communication, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: Abstract In this paper, we design full-duplex (FD) medium access control (MAC) protocol for co-existing wireless local area networks (WLANs) in 5G cellular networks (WCFD-MAC). Our design considers some significant features of 5G networks, exceptionally, beamforming and FD capabilities at both, the base station and user equipment. FD communications may generate interferences, namely self-interference (SI) in bidirectional FD (BFD) and inter-user interferences in three-node FD (TNFD). Several efforts have been performed to mitigate the SI in BFD communications. However, the inter-user interferences in TNFD are still considered as a major drawback in FD networks. These interferences must be mitigated by an efficient MAC protocol design. WCFD-MAC protocol allows two neighboring users to simultaneously participate in TNFD communication without interfering with each other by using directional transmission and a three-node angle condition (TAC). Directional transmission combined with TAC increases system throughput. WCFD-MAC protocol allows a new half-duplex (HD) communication scheme referred to as three-node HD (TNHD). This scheme may occur when bidirectional FD (BFD) and TNFD communications cannot occur. TNHD scheme includes device-to-device (D2D) communication and allows energy efficiency, which is one of the keys requirements of 5G wireless networks. Simulations results show that WCFD-MAC protocol achieves higher throughput than existing works in the literature.
Published: 2021
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2. Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data

Author: Mohamed Maiga, Laurent Dembele, Perrine Courlet, Akash Khandelwal, Antoine Dara, Fanta Sogore, Ousmaila Diakité, Fatoumata O. Maiga, François Dao, Sekou Sissoko, Yacouba Barre, Siaka Goita, Mahamadou Diakite, Seidina A. S. Diakite, Abdoulaye A. Djimde, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, and Claudia Demarta-Gatsi
Subjects: Science
Abstract: Abstract The selection and combination of dose regimens for antimalarials involve complex considerations including pharmacokinetic and pharmacodynamic interactions. In this study, we use immediate ex vivo P. falciparum field isolates to evaluate the effect of cabamiquine and pyronaridine as standalone treatments and in combination therapy. We feed the data into a pharmacometrics model to generate an interaction map and simulate meaningful clinical dose ratios. We demonstrate that the pharmacometrics model of parasite growth and killing provides a detailed description of parasite kinetics against cabamiquine-susceptible and resistant parasites. Pyronaridine monotherapy provides suboptimal killing rates at doses as high as 720 mg. In contrast, the combination of a single dose of 330 mg cabamiquine and 360 mg pyronaridine provides over 90% parasite killing in most of the simulated patients. The described methodology that combines a rapid, 3R-compliant in vitro method and modelling to set meaningful doses for new antimalarials could contribute to clinical drug development.
Published: 2024
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3. Double Gastric and Duodenal Perforations at The Fousseyni Daou Hospital in Kayes in One Case

Author: G, Sogoba,, primary, S, Sangare,, additional, I, Traore, L., additional, S, Diakite, A., additional, M, Magassa,, additional, D, Katile,, additional, L, Goita,, additional, and M, Kouyate,, additional
Published: 2023
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4. Assessing health systems in Guinea for prevention and control of priority zoonotic diseases: A One Health approach

Author: Claire J. Standley, Ellen P. Carlin, Erin M. Sorrell, Alpha M. Barry, Ebi Bile, Aboubacar S. Diakite, Mamady S. Keita, Lamine Koivogui, Seny Mane, Lise D. Martel, and Rebecca Katz
Subjects: Medicine (General), R5-920
Abstract: To guide One Health capacity building efforts in the Republic of Guinea in the wake of the 2014–2016 Ebola virus disease (EVD) outbreak, we sought to identify and assess the existing systems and structures for zoonotic disease detection and control. We partnered with the government ministries responsible for human, animal, and environmental health to identify a list of zoonotic diseases – rabies, anthrax, brucellosis, viral hemorrhagic fevers, trypanosomiasis and highly pathogenic avian influenza – as the country's top priorities. We used each priority disease as a case study to identify existing processes for prevention, surveillance, diagnosis, laboratory confirmation, reporting and response across the three ministries. Results were used to produce disease-specific systems “maps” emphasizing linkages across the systems, as well as opportunities for improvement. We identified brucellosis as a particularly neglected condition. Past efforts to build avian influenza capabilities, which had degraded substantially in less than a decade, highlighted the challenge of sustainability. We observed a keen interest across sectors to reinvigorate national rabies control, and given the regional and global support for One Health approaches to rabies elimination, rabies could serve as an ideal disease to test incipient One Health coordination mechanisms and procedures. Overall, we identified five major categories of gaps and challenges: (1) Coordination; (2) Training; (3) Infrastructure; (4) Public Awareness; and (5) Research. We developed and prioritized recommendations to address the gaps, estimated the level of resource investment needed, and estimated a timeline for implementation. These prioritized recommendations can be used by the Government of Guinea to plan strategically for future One Health efforts, ideally under the auspices of the national One Health Platform. This work demonstrates an effective methodology for mapping systems and structures for zoonotic diseases, and the benefit of conducting a baseline review of systemic capabilities prior to embarking on capacity building efforts. Keywords: Guinea, One Health, Zoonotic disease, Health systems assessment, Capacity building
Published: 2019
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5. Volvulus of the Sigmoid Colon without Necrosis: Therapeutic Aspects in Hospital Fousseyni Daou Hospital in Kayes, Mali

Author: Lamine Issaga Traore, Sidy Sangare, Mamaye Kouyate, Gaoussou Sogoba, Drissa Katile, Adama S. Diakite, Lassana Goita, Sadio Dembele, Djibril Traore, and Drissa Traore
Subjects: General Engineering, Energy Engineering and Power Technology
Published: 2022
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6. Ulcero-necrotic Wound and Its Socio-economic Impact: A Retrospective Study from Kayes, Mali

Author: Lamine Issaga Traore, Sidy Sangare, Gaoussou Sogoba, Mamaye Kouyate, Abdoulaye Cisse, Bakary S. Keita, Lassina Goita, Adama S. Diakite, Mariam Sanogo, and Drissa Traore
Published: 2023
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7. How the origin of stars in the Galaxy impacts the composition of planetary building blocks

Author: N. Cabral, A. Guilbert-Lepoutre, B. Bitsch, N. Lagarde, and S. Diakite
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics - Earth and Planetary Astrophysics
Abstract: Context. Our Galaxy is composed of different stellar populations with varying chemical abundances, which are thought to imprint the composition of planet building blocks (PBBs). As such, the properties of stars should affect the properties of planets and small bodies formed in their systems. In this context, high-resolution spectroscopic surveys open a window into the chemical links between and their host stars. Aims. We aim to determine the PBB composition trends for various stellar populations across the Galaxy by comparing the two large spectroscopic surveys APOGEE and GALAH. We assess the reliability of the PBB composition as determined with these surveys with a propagation error study. Methods. Stellar spectroscopic abundances from the large surveys GALAH-DR3 and APOGEE-DR17 were used as input with a stoichiometric condensation model. We classified stars into different Galactic components and we quantified the PBB composition trends as a function of [Fe/H]. We also analysed the distribution composition patterns in the [α/Fe]–[Fe/H] diagram. Results. Our propagation error study suggests that the overall trends with [Fe/H] and [α/Fe] are robust, which is supported by the double study of both APOGEE and GALAH. We therefore confirm the existence of a bimodal PBB composition separating the thin disc stars from the thick disc stars. Furthermore, we confirm that the stoichiometric water PBB content is anti-correlated with [Fe/H]. Conclusions. Our results imply that metal-poor stars both in the thin and thick disks are suitable hosts for water-rich PBBs and for ice-rich small bodies. However, for metal-poor stars ([Fe/H]α-content dependence of the water mass fraction. Given the importance of the initial water abundance of the PBBs in recent planet formation simulations, we expect that the star origin influences the exoplanet population properties across the Galaxy.
Published: 2023
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8. Ex Vivo Plasmodium malariae Culture Method for Antimalarial Drugs Screen in the Field

Author: Abdoulaye Djimde, Seidina A. S. Diakite, Fanta Sogore, Ousmaila Diakite, Brice Campo, Laurent Dembele, Amadou Niangaly, Aboubecrin Sedhigh Haidara, Bintou Diarra, Amadou Daou, Yacouba Bare, Yaw Aniweh, Gordon A. Awandare, Fatoumata I Ballo, Cheick Papa Oumar Sangare, Nouhoum Diallo, and Mahamadou Diakite
Subjects: Quinine, biology, business.industry, Plasmodium malariae, biology.organism_classification, medicine.disease, Lumefantrine, Virology, chemistry.chemical_compound, Infectious Diseases, chemistry, Chloroquine, parasitic diseases, medicine, Artemether, Artemisinin, business, Malaria, Ex vivo, medicine.drug
Abstract: In vitro and ex vivo cultivation of Plasmodium (P) falciparum has facilitated active research into the malaria parasite toward the quest for basic knowledge and the discovery of effective drug treatments. Such a drug discovery program is currently difficult for P. malariae simply because of the absence of in vitro and ex vivo cultivation system for its asexual blood stages supporting antimalarial evaluation. Despite availability of artemisinin combination therapies effective on P. falciparum, P. malariae is being increasingly detected in malaria endemic countries. P. malariae is responsible for chronic infections and is associated with a high burden of anemia and morbidity. Here, we optimized and adapted ex vivo conditions under which P. malariae can be cultured and used for screening antimalarial drugs. Subsequently, this enabled us to test compounds such as artemether, chloroquine, lumefantrine, and quinine for ex vivo antimalarial activity against P. malariae.
Published: 2021
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9. Preventive and Curative treatment of malaria during pregnancy in Mali: Evaluation of the Healthcare Professionals based on the Malian National Malaria Control Program (NMCP) Guidelines

Author: Estelle N.H. Youl, Samou Sidibé, Modibo Sangare, Mahamadou Ballo, Fatoumata Daou, Karim Traore, Sekou Bah, Abdoulaye Guindo, Drissa Konaté, Mahamadou Diakite, and Seidina A. S. Diakite
Subjects: Pregnancy, medicine.medical_specialty, Health professionals, Curative treatment, business.industry, Family medicine, parasitic diseases, Medicine, Malaria control, business, medicine.disease, Malaria
Abstract: Malaria infections in pregnancy should be treated promptly with safe and efficacious antimalarial drugs to prevent harmful effects on the mother and fetus. To succeed, the Malian has developed NMCP guidelines for the management of malaria cases in pregnant women. The study aimed at the analysis of the prescription of antimalarial drugs based on the Mali's NMCP guidelines. We conducted a cross-sectional study during malaria transmission season from June to August 2020. The sampling concerned all prescriptions for pregnant women containing at least one antimalarial drug. The frequency of prescription of antimalarial drugs was 85%. 132 (74.16%) were preventive treatments and 46 (25.84%) curative treatments. 30 (90.91%) of pregnant women in the first trimester received one dose of Sulfadoxine-Pyrimethamine. 6 (12.5%) received three doses in the third trimester. Of the 46 antimalarial drugs prescribed for the treatment of uncomplicated malaria, 30 (65.22%) were Artemether-lumefantrine (tablet), 10 (21.74%) were Quinine (tablet). 29 (63.04%) were compliant with NMCP guidelines and 17 (36.96%) were not. The non-compliances concerned 3 prescriptions of Artemether-lumefantrine in the first trimester, 3 and 5 prescriptions of Quinine (tablet) in the second and third trimester respectively and at the end 2 and 4 non-compliances respectively for the prescription of injectable dosage forms of Quinine and Artesunate. This study showed a great noncompliance with the Mali's NMCP guidelines in the prescription of antimalarial in pregnant women. Chemoprophylaxis should be prohibited in the first trimester. Keywords: Curative and Preventive Treatment, Malaria in Pregnancy, Malaria Transmission, Mali
Published: 2021
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10. Diagnosis and Management of Pylorian Hypertrophy in Infants at Fousseyni Daou Hospital in Kayes, Mali

Author: Kouyate Mamaye, A S Diakite, S Sidibe S, A Doumbia, Coulibaly – O, Kane Moustapha, and M Haidara
Subjects: Immunology
Abstract: Summary: Hypertrophic pyloric stenosis is an obstruction of the lumen of the pylorus by muscular hypertrophy of the pyloric sphincter fg [1]. It is a rare disease in Africa: a recent publication in Tanzania reported 102 cases in 5 years [10]. Currently the diagnosis is based on abdominal ultrasound and the treatment is surgical. It affects 2 or 3 children out of 1000 and is more common in boys with a ratio of [4]. It occurs between 3 and 6 weeks of life and rarely after 12 weeks. Materials and methods: We conducted a retrospective study from January 2018 to December 2021 using patient records in the pediatric surgery department of the Fousseyni Daou hospital in Kayes. Results: During the study period we had performed 3260 consultations and we had performed 975 surgical interventions in patients hospitalized in the pediatric surgery department. 8 cases of hypertrophy of the pylorus were operated on, i.e. 0.82% of the operations, including 6 boys and 2 girls. The weight of the patients was between 2kg800 and 3kg500. The age of our patients varied between 05 days and 37 days of life 3 patients had been referred to us by the malnutrition unit of our pediatrics department. The hemoglobin level and the rhesus group had been carried out in all the patients and a moderate anemia had been detected in 3 patients. The ionogram had been performed in only 3 of the patients. Ultrasound confirmed the diagnosis of pyloric hypertrophy in all patients. A pyloromyotomy was performed in all patients with uncomplicated consequences. Conclusion: Pyloric hypertrophy is a rare pathology in our region (Kayes), the diagnosis is ultrasound and the treatment remains surgical.
Published: 2022
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11. Cross-Renal Ectopia about a Case

Author: S, Diakite, A., primary, S, Diallo, M., additional, D, Cisse,, additional, M, Toure, S., additional, A, Diawara,, additional, M, Magassa,, additional, G, Sogoba,, additional, S, Sangare,, additional, I, Traore, L., additional, I, Sissoko,, additional, D, Sangare,, additional, G, Berthe, H. J., additional, and L, Diakite, M., additional
Published: 2022
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12. Epidemiological, Clinical and Therapeutic Study of Urolithiasis at the Fousseyni Daou Hospital in Kayes, About 111 Cases

Author: S, Diakite, A., primary, A, Traore, C., additional, I, Traore, L., additional, S, Sangare,, additional, G, Sogoba,, additional, G, Berthe, H. J., additional, S, Dembele,, additional, L, Goita,, additional, M, Kouyate,, additional, I, Sissoko,, additional, D, Sangare, additional, S, Diallo, M., additional, M, Magassa,, additional, and L, Diakite, M., additional
Published: 2022
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13. Epidemio-Clinical Diagnostic and Therapeutic Aspects of Acute Intestinal Invagination in Infants and Children at Fousseyni Daou Hospital in Kayes (Mali)

Author: M, Kouyate,, primary, L, Traore, I., additional, S, Sangare,, additional, S, Diakite, A., additional, S, Toure,, additional, M, Magassa,, additional, B, Dicko,, additional, M, Kane,, additional, and M, Haidara,, additional
Published: 2022
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14. Gaia Early Data Release 3 The Gaia Catalogue of Nearby Stars

Author: Zoltan Balog, G. Tauran, Vincenzo Ripepi, Gerry Gilmore, M. Barros, Łukasz Wyrzykowski, Alberto Cellino, E. Poggio, P. Gavras, Simchon Faigler, Marc Audard, C. Nicolas, M. Vaillant, A. Mora, Paolo Tanga, Silvio Leccia, Despina Hatzidimitriou, A. Dapergolas, Eva Sciacca, Alberto Krone-Martins, N. Cheek, M. Hauser, Ulrike Heiter, S. Managau, L. Rohrbasser, Mathias Schultheis, E. Utrilla, Minia Manteiga, Marcella Marconi, Xavier Luri, F. De Angeli, Shay Zucker, Paolo Giacobbe, J. Juaristi Campillo, H. I. Siddiqui, J. Torra, F. X. Pineau, Roy Gomel, Thierry Morel, T. Cornez, Eric Gosset, Mario Gai, Jose M Hernandez, G. Giuffrida, A. de Torres, Laszlo Szabados, S. Ragaini, E. van Dillen, D. Semeux, Leanne P. Guy, R. Drimmel, L. M. Sarro, S. Voutsinas, Johannes Sahlmann, Damien Ségransan, S. Liao, Derek W. Morris, Jan Rybizki, André Moitinho, T. Roegiers, Bengt Edvardsson, Tristan Cantat-Gaudin, Martin Altmann, C. Turon, Laurent Chemin, K. Janßen, D. Garabato, Alejandra Recio-Blanco, Michał Pawlak, Lorenzo Rimoldini, Sergei A. Klioner, F. Torra, Carine Babusiaux, Alfred Castro-Ginard, G. Plum, Mariateresa Crosta, Iain A. Steele, A. Yoldas, Alex Lobel, J.-L. Bassilana, Harry Enke, Rosanna Sordo, Francesca Fragkoudi, F. De Luise, M. Bernet, Alessandro Sozzetti, M. Kontizas, Roberto Molinaro, C. Diener, S. Regibo, D. Barbato, T. Pauwels, R. E. de Souza, C. Fabricius, D. Souami, L. Martin Polo, M. Ramos-Lerate, Douglas J. Marshall, A. G. Butkevich, P. Madrero Pardo, P. Re Fiorentin, J. F. Le Campion, Jérôme Berthier, N. Tonello, Ummi Abbas, Y. Lebreton, M. Biermann, D. Munoz, N. Brouillet, David Teyssier, O. Vanel, P. A. Palicio, A. Jean-Antoine Piccolo, A. F. Lanza, Jesus Salgado, E. del Pozo, Antti Penttilä, R. Geyer, Ramachrisna Teixeira, L. Chaoul, Mike Smith, Rossella Cancelliere, J. M. Martín-Fleitas, D. Baines, M. Romero-Gómez, E. Anglada Varela, E. Livanou, X. Peñalosa Esteller, S. Diakite, Alberto Vecchiato, Thomas Wevers, Daniel Hestroffer, Sebastian L. Hidalgo, M. David, Angela Bragaglia, J. De Ridder, Mark Taylor, Roberto Morbidelli, A. Sagristà Sellés, Nigel Hambly, Arnaud Siebert, R. L. Smart, P. Burgess, Y. Le Fustec, Alessandro Bressan, H. Steidelmüller, Alberto Riva, H. E. Huckle, Morgan Fouesneau, N. Bauchet, P. Osborne, S. Marinoni, Krzysztof A. Rybicki, A. Masip, Laia Casamiquela, R. Messineo, A. Garofalo, Antonella Vallenari, R. Mor, Sahar Shahaf, P. de Laverny, G. Sadowski, Peter G. Jonker, A. Kochoska, F. Taris, A. F. Mulone, M. Ajaj, C. Ducourant, T. A. Lister, F. A. Jansen, Ruth Carballo, J. M. Carrasco, Tatiana Muraveva, W. van Reeven, P. Sartoretti, Jordi Portell, Andreas Korn, E. Salguero, Ana Ulla, P. Di Matteo, Coryn A. L. Bailer-Jones, J. Bakker, F. Riclet, G. Altavilla, Ulrich Bastian, P. Esquej, R. Buzzi, M. Segol, A. C. Lanzafame, L. Balaguer-Núñez, Beatrice Bucciarelli, C. Panem, E. Balbinot, T. Carlucci, Davide Massari, P. de Teodoro, Sébastien Lambert, M. I. Carnerero, Amina Helmi, F. Solitro, C. Robin, Carlos Dafonte, Tsevi Mazeh, A. Panahi, C. Fabre, Sergi Blanco-Cuaresma, Deborah Busonero, Maroussia Roelens, O. Marchal, Tomaz Zwitter, B. Holl, G. Holland, William Thuillot, Michael Davidson, E. Licata, Michele Bellazzini, Teresa Antoja, E. Szegedi-Elek, Francesca Figueras, Eric Slezak, Sergio Messina, N. Samaras, E. Poujoulet, Mark Cropper, A. Burlacu, R. Blomme, Elmé Breedt, Annie C. Robin, H. E. Delgado, Z. Kostrzewa-Rutkowska, Georges Kordopatis, Conny Aerts, L. Noval, Daniel Michalik, P. J. Richards, L. Karbevska, Grigori Fedorets, Maria Süveges, F. Crifo, J. Guiraud, D. Eappachen, K. Kruszyńska, Gisella Clementini, P. Yvard, Carme Jordi, L. Bramante, G. Busso, P. David, E. Fraile, Ugo Becciani, A. Lorca, Sanjeev Khanna, Alex Bombrun, Isabella Pagano, C. Dolding, A. M. Piersimoni, Paolo Montegriffo, A. Abreu Aramburu, Anthony G. A. Brown, Simon Hodgkin, Ennio Poretti, M. Fabrizio, I. Gonzalez-Santamaria, N. A. Walton, P. Panuzzo, Benoit Carry, Raphael Guerra, J. J. González-Vidal, T. Lebzelter, Nami Mowlavi, C. Barache, M. M. S. Marcos Santos, S. Cowell, Marco Castellani, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, N. Leclerc, S. Bartolomé, J. Álvarez Cid-Fuentes, F. van Leeuwen, S. Bouquillon, Uwe Lammers, D. W. Evans, L. Eyer, M. van Leeuwen, A. Guerrier, J. González-Núñez, H. E. P. Lindstrøm, Miguel García-Torres, Ilaria Musella, L. Palaversa, W. Roux, W. Löffler, J.-B. Delisle, Dimitri Pourbaix, Timo Prusti, J. Osinde, M. Riello, G. Orrù, C. Crowley, Alessandra Mastrobuono-Battisti, Hector Canovas, D. L. Harrison, Y. Lasne, E. F. del Peloso, Laurent Galluccio, N. Hładczuk, T. Boch, Martin A. Barstow, László Molnár, Aldo Dell'Oro, C. Pagani, Krzysztof Nienartowicz, Stefano Bertone, Patrick Charlot, Eduard Masana, Elisabetta Caffau, N. Robichon, Luciana Bianchi, Federica Spoto, Felix Franke, J. L. Halbwachs, R. Gutiérrez-Sánchez, L. Pulone, Yassine Damerdji, Frédéric Arenou, Richard I. Anderson, Elena Pancino, David Hobbs, P. Castro Sampol, Yves Fremat, Pierre Kervella, C. Zurbach, Sofia Randich, Robert G. Mann, J. C. Segovia, Diego Bossini, D. Katz, Nicholas Rowell, P. Ramos, E. Racero, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Enrique Solano, S. G. Baker, W. J. Cooper, F. Royer, S. Accart, George M. Seabroke, João Alves, Emese Plachy, Thomas Hilger, Pedro García-Lario, Gérard Jasniewicz, Kevin Benson, Christos Siopis, J. Souchay, Agnes Fienga, Giovanni Comoretto, F. Julbe, A. Hutton, Pierre Fernique, Céline Reylé, F. Pailler, Stefan Jordan, J. H. J. de Bruijne, C. A. Stephenson, E. Gerlach, Elisa Distefano, Karri Muinonen, Y. Viala, H. Zhao, L. Siltala, C. P. Murphy, Maria-Rosa L. Cioni, Andrea Chiavassa, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, Federico Marocco, Nicoletta Sanna, Alexey Mints, Juan Zorec, Ángel Gómez, I. Bellas-Velidis, M. G. Lattanzi, C. M. Raiteri, E. Brugaletta, Mikael Granvik, O. L. Creevey, Guy Rixon, Francois Mignard, P. M. Marrese, M. A. Álvarez, Caroline Soubiran, Rene Andrae, C. Ordénovic, A. Delgado, V. Sanchez Gimenez, J. Castañeda, D. Vicente, R. De March, A. Garcia-Gutierrez, M. Weiler, F. Thévenin, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Jon Marchant, Monica Rainer, Alessandro Spagna, Andrej Prsa, M. Sarasso, Nicolas Rambaux, Paul J. McMillan, Ludovic Delchambre, M. Garcia-Reinaldos, M. Haywood, C. Fouron, S. Girona, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Barcelona, Xunta de Galicia, Generalitat de Catalunya, INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Astronomische Rechen-Institut [Heidelberg] (ARI), Zentrum für Astronomie der Universität Heidelberg (ZAH), Universität Heidelberg [Heidelberg]-Universität Heidelberg [Heidelberg], Systèmes de Référence Temps Espace (SYRTE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Mésocentre de calcul (MESOCENTRE), Université de Franche-Comté (UFC), Centre de Données Astronomiques de Strasbourg, Partenaires INRAE, Géoazur (GEOAZUR 7329), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), THALES, Université de Namur [Namur] (UNamur), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] = Heidelberg University-Universität Heidelberg [Heidelberg] = Heidelberg University, Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), THALES [France], Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Cantabria, Gaia Collaboration, Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Astronomy, and ITA
Subjects: trigonometric parallaxes, Solar neighborhood, Stars: luminosity function, mass function, Astronomy, Astrophysics, 01 natural sciences, luminosity function, mass function [Stars], Astronomi, astrofysik och kosmologi, luminosity: mass function [Stars], Astronomy, Astrophysics and Cosmology, MAIN-SEQUENCE, Hertzsprung-Russell-diagram, 010303 astronomy & astrophysics, Stars:low-mass brown-dwarfs, wide binaries, Physics, education.field_of_study, north galactic pole, Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, BROWN DWARF, Astrophysics - Solar and Stellar Astrophysics, mass function, NORTH GALACTIC POLE, Physical Sciences, symbols, CIRCULAR-VELOCITY CURVE, Halo, astro-ph.SR, Hertzsprung–Russell diagram, stars: luminosity function, astro-ph.GA, Posterior probability, Population, main-sequence, Luminosity-Function, FOS: Physical sciences, Mass-Function, Astronomy & Astrophysics, Computer Science::Digital Libraries, Photometry (optics), DWARF LUMINOSITY-FUNCTION, dwarf luminosity-function, sky-survey, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, luminosity function [stars], low-mass [Stars], 0103 physical sciences, Stars: luminosity: mass function, Stars: low-mass, WHITE-DWARFS, education, Solar and Stellar Astrophysics (astro-ph.SR), brown dwarf, catalogs, astrometry, Hertzsprung-Russell and C-M diagrams, stars: low-mass, solar neighborhood, Astrophysics - Astrophysics of Galaxies, SKY-SURVEY, white-dwarfs, Science & Technology, 010308 nuclear & particles physics, Luminosity function, White dwarf, TRIGONOMETRIC PARALLAXES, Astronomy and Astrophysics, Low-mass, 115 Astronomy, Space science, WIDE BINARIES, Stars, Physics::History of Physics, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), solar-neighborhood, Catalogs, circular-velocity curve, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Aims. We produce a clean and well-characterised catalogue of objects within 100 pc of the Sun from the Gaia Early Data Release 3. We characterise the catalogue through comparisons to the full data release, external catalogues, and simulations. We carry out a first analysis of the science that is possible with this sample to demonstrate its potential and best practices for its use., Methods. Theselection of objects within 100 pc from the full catalogue used selected training sets, machine-learning procedures, astrometric quantities, and solution quality indicators to determine a probability that the astrometric solution is reliable. The training set construction exploited the astrometric data, quality flags, and external photometry. For all candidates we calculated distance posterior probability densities using Bayesian procedures and mock catalogues to define priors. Any object with reliable astrometry and a non-zero probability of being within 100 pc is included in the catalogue., Results. We have produced a catalogue of 331 312 objects that we estimate contains at least 92% of stars of stellar type M9 within 100 pc of the Sun. We estimate that 9% of the stars in this catalogue probably lie outside 100 pc, but when the distance probability function is used, a correct treatment of this contamination is possible. We produced luminosity functions with a high signal-to-noise ratio for the main-sequence stars, giants, and white dwarfs. We examined in detail the Hyades cluster, the white dwarf population, and wide-binary systems and produced candidate lists for all three samples. We detected local manifestations of several streams, superclusters, and halo objects, in which we identified 12 members of Gaia Enceladus. We present the first direct parallaxes of five objects in multiple systems within 10 pc of the Sun., Conclusions. We provide the community with a large, well-characterised catalogue of objects in the solar neighbourhood. This is a primary benchmark for measuring and understanding fundamental parameters and descriptive functions in astronomy.
Published: 2021
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15. Assessment of Three Campaigns to Support Women Victims of Obstetric and Non-Obstetric Fistula at the Fousseyni Daou Regional Hospital in Kayes

Author: S, Diakite A., primary, D, Cisse, additional, S, Diallo M., additional, S, Fofana A., additional, M, Magassa, additional, G, Sogoba, additional, S, Sangare, additional, I, Traore L., additional, I, Sissoko, additional, A, Diarra, additional, D, Sangare, additional, G, Berthe H. J., additional, and L, Diakite M., additional
Published: 2022
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16. Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali

Author: Karim Traore, Ibrahim Sanogo, Drissa Konaté, Seydou Doumbia, Mory Doumbouya, Mahamadou Diakite, Sekou Bah, Modibo Sangare, Bourama Keita, Souleymane Dama, Seidina A. S. Diakite, Merepen A. Guindo, and Djeneba Dabitao
Subjects: Adolescent, Endemic Diseases, Plasmodium falciparum, Drug Resistance, Amodiaquine, RM1-950, Lumefantrine, Mali, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, 0302 clinical medicine, Piperaquine, parasitic diseases, medicine, Humans, Original Research Article, Artemisinin, Malaria, Falciparum, Child, 030203 arthritis & rheumatology, Pharmacology, Quinine, biology, Traditional medicine, Mefloquine, business.industry, Infant, Chloroquine, medicine.disease, biology.organism_classification, Artemisinins, chemistry, Child, Preschool, Quinolines, Therapeutics. Pharmacology, business, Malaria, medicine.drug
Abstract: Background In 2006, the National Malaria Control Program in Mali recommended artemisinin-based combination therapy as the first-line treatment for uncomplicated malaria. Since the introduction of artemisinin-based combination therapy, few reports are available on the level of resistance of Plasmodium falciparum to the most common anti-malarial drugs in Mali. Methods From 2016 to 2017, we assessed the ex-vivo drug sensitivity of P. falciparum isolates in Kéniéroba, a village located in a rural area of southern Mali. We collected P. falciparum isolates from malaria-infected children living in Kéniéroba. The isolates were tested for ex-vivo sensitivity to commonly used anti-malarial drugs, namely chloroquine, quinine, amodiaquine, mefloquine, lumefantrine, dihydroartermisinin, and piperaquine. We used the 50% inhibitory concentration determination method, which is based on the incorporation of SYBR® Green into the parasite’s genetic material. Results Plasmodium falciparum isolates were found to have a reduced ex-vivo sensitivity to quinine (25.7%), chloroquine (12.2%), amodiaquine (2.7%), and mefloquine (1.3%). In contrast, the isolates were 100% sensitive to lumefantrine, dihydroartermisinin, and piperaquine. A statistically significant correlation was found between 50% inhibitory concentration values of quinine and amodiaquine (r = 0.80; p
Published: 2020

17. Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum

Author: Jens E.V. Petersen, Steven B. Haase, Joseph W. Saelens, Karim Traore, Drissa Konaté, Rick M. Fairhurst, Steve M. Taylor, Elizabeth Freedman, Natalie Vance, Robert C. Moseley, Seidina A. S. Diakite, and Mahamadou Diakite
Subjects: Male, Transcriptional Activation, Adolescent, Hemoglobin, Sickle, Plasmodium falciparum, malaria, Microbiology, Sickle Cell Trait, Transcriptome, Hemoglobins, Gene expression, parasitic diseases, medicine, Humans, transcriptional regulation, Malaria, Falciparum, Child, Molecular Biology, Gene, Genetics, Sickle cell trait, comparative studies, biology, Hemoglobin A, biology.organism_classification, medicine.disease, Phenotype, QR1-502, stress adaptation, Child, Preschool, Chaperone (protein), biology.protein, Female, Research Article, Genetic screen
Abstract: Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening falciparum malaria in African children. Despite this clear protection, the molecular mechanisms by which HbAS confers these protective phenotypes remain incompletely understood. As a forward genetic screen for aberrant parasite transcriptional responses associated with parasite neutralization in HbAS red blood cells (RBCs), we performed comparative transcriptomic analyses of Plasmodium falciparum in normal (HbAA) and HbAS erythrocytes during both in vitro cultivation of reference parasite strains and naturally occurring P. falciparum infections in Malian children with HbAA or HbAS. During in vitro cultivation, parasites matured normally in HbAS RBCs, and the temporal expression was largely unperturbed of the highly ordered transcriptional program that underlies the parasite’s maturation throughout the intraerythrocytic development cycle (IDC). However, differential expression analysis identified hundreds of transcripts aberrantly expressed in HbAS, largely occurring late in the IDC. Surprisingly, transcripts encoding members of the Maurer’s clefts were overexpressed in HbAS despite impaired parasite protein export in these RBCs, while parasites in HbAS RBCs underexpressed transcripts associated with the endoplasmic reticulum and those encoding serine repeat antigen proteases that promote parasite egress. Analyses of P. falciparum transcriptomes from 32 children with uncomplicated malaria identified stage-specific differential expression: among infections composed of ring-stage parasites, only cyclophilin 19B was underexpressed in children with HbAS, while trophozoite-stage infections identified a range of differentially expressed transcripts, including downregulation in HbAS of several transcripts associated with severe malaria in collateral studies. Collectively, our comparative transcriptomic screen in vitro and in vivo indicates that P. falciparum adapts to HbAS by altering its protein chaperone and folding machinery, oxidative stress response, and protein export machinery. Because HbAS consistently protects from severe P. falciparum, modulation of these responses may offer avenues by which to neutralize P. falciparum parasites. IMPORTANCE Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening malaria, yet the molecular mechanisms that underlie HbAS protection from severe malaria remain incompletely understood. Here, we used transcriptome sequencing (RNA-seq) to measure the impact of HbAS on the blood-stage transcriptome of Plasmodium falciparum in in vitro time series experiments and in vivo samples from natural infections. Our in vitro time series data reveal that, during its blood stage, P. falciparum’s gene expression in HbAS is impacted primarily through alterations in the abundance of gene products as opposed to variations in the timing of gene expression. Collectively, our in vitro and in vivo data indicate that P. falciparum adapts to HbAS by altering its protein chaperone and folding machinery, oxidative stress response, and protein export machinery. Due to the persistent association of HbAS and protection from severe disease, these processes that are modified in HbAS may offer strategies to neutralize P. falciparum.
Published: 2021
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18. Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program ofPlasmodium falciparum

Author: Jens E.V. Petersen, Steven B. Haase, Elizabeth Freedman, Steve M. Taylor, Robert C. Moseley, Karim Traore, Seidina A. S. Diakite, Joseph W. Saelens, Drissa Konaté, Mahamadou Diakite, Natalie Vance, and Rick M. Fairhurst
Subjects: Genetics, Sickle cell trait, biology, Plasmodium falciparum, medicine.disease, biology.organism_classification, Phenotype, Transcriptome, parasitic diseases, Gene expression, medicine, Gene, Malaria, Genetic screen
Abstract: Sickle-trait hemoglobin (HbAS) confers near-complete protection from severe, life-threatening falciparum malaria in African children. Despite this clear protection, the molecular mechanisms by which HbAS confers these protective phenotypes remain incompletely understood. As a forward genetic screen for aberrant parasite transcriptional responses associated with parasite neutralization in HbAS red blood cells (RBCs), we performed comparative transcriptomic analyses ofPlasmodium falciparumin normal (HbAA) and HbAS erythrocytes during bothin vitrocultivation of reference parasite strains and naturally-occurringP. falciparuminfections in Malian children with HbAA or HbAS. Duringin vitrocultivation, parasites matured normally in HbAS RBCs, and the temporal expression was largely unperturbed of the highly ordered transcriptional program that underlies the parasite’s maturation throughout the intraerythrocytic development cycle (IDC). However, differential expression analysis identified hundreds of transcripts aberrantly expressed in HbAS, largely occurring late in the IDC. Surprisingly, transcripts encoding members of the Maurer’s clefts were overexpressed in HbAS despite impaired parasite protein export in these RBCs, while parasites in HbAS RBCs underexpressed transcripts associated with the endoplasmic reticulum and those encoding serine repeat antigen proteases that promote parasite egress. Analyses ofP. falciparumtranscriptomes from 32 children with uncomplicated malaria identified stage-specific differential expression: among infections composed of ring-stage parasites, only cyclophilin 19B was underexpressed in children with HbAS, while trophozoite-stage infections identified a range of differentially-expressed transcripts, including downregulation in HbAS of several transcripts associated with severe malaria in collateral studies. Collectively, our comparative transcriptomic screenin vitroandin vivoindicates thatP. falciparumadapts to HbAS by altering its protein chaperone and folding machinery, oxidative stress response, and protein export machinery. Because HbAS consistently protects from severeP. falciparum, modulation of these responses may offer avenues by which to neutralizeP. falciparumparasites.ImportanceSickle-trait hemoglobin (HbAS) confers near-complete protection from severe, life-threatening malaria, yet the molecular mechanisms that underlie HbAS protection from severe malaria remain incompletely understood. Here, we use RNA-seq to measure the impact of HbAS on the blood stage transcriptome ofPlasmodium falciparuminin vitrotime series experiments andin vivosamples from natural infections. Our in vitrotime series data reveal that, during its blood stage,P. falciparum’sgene expression in HbAS is impacted primarily through alterations in the abundance of gene products as opposed to variations in the timing of gene expression. Collectively, ourin vitroandin vivodata indicate thatP. falciparumadapts to HbAS by altering its protein chaperone and folding machinery, oxidative stress response, and protein export machinery. Due to the persistent association of HbAS and protection from severe disease, these processes that are modified in HbAS may offer strategies to neutralizeP. falciparum.
Published: 2021
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19. A comprehensive analysis of drug resistance molecular markers and Plasmodium falciparum genetic diversity in two malaria endemic sites in Mali

Author: Fousseyni Doucoure, Gordon A. Awandare, Bourama Keita, Djeneba Dabitao, Mahamoudou B. Touré, Taane G. Clark, Mahamadou Diakite, Drissa Konaté, Ibrahim Sanogo, Seydou Doumbia, Susana Campino, Merepen A. Guindo, Nafomon Sogoba, Seidina A. S. Diakite, Antoine Dara, Mory Doumbouya, Modibo Sangare, Karim Traore, and Amadou Cisse
Subjects: lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030231 tropical medicine, Plasmodium falciparum, Drug Resistance, Drug resistance, Biology, Mali, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Antimalarials, 0302 clinical medicine, Chloroquine, Genotype, parasitic diseases, medicine, lcsh:RC109-216, 030304 developmental biology, Drug-resistance, Genetics, 0303 health sciences, Genetic diversity, Research, Haplotype, Genetic Variation, medicine.disease, biology.organism_classification, 3. Good health, Infectious Diseases, Parasitology, Molecular surveillance, Next-generation sequencing, Malaria, Biomarkers, medicine.drug
Abstract: Background Drug resistance is one of the greatest challenges of malaria control programme in Mali. Recent advances in next-generation sequencing (NGS) technologies provide new and effective ways of tracking drug-resistant malaria parasites in Africa. The diversity and the prevalence of Plasmodium falciparum drug-resistance molecular markers were assessed in Dangassa and Nioro-du-Sahel in Mali, two sites with distinct malaria transmission patterns. Dangassa has an intense seasonal malaria transmission, whereas Nioro-du-Sahel has an unstable and short seasonal malaria transmission. Methods Up to 270 dried blood spot samples (214 in Dangassa and 56 in Nioro-du-Sahel) were collected from P. falciparum positive patients in 2016. Samples were analysed on the Agena MassARRAY® iPLEX platform. Specific codons were targeted in Pfcrt, Pfmdr1, Pfdhfr, and Pfdhps, Pfarps10, Pfferredoxin, Pfexonuclease and Pfmdr2 genes. The Sanger’s 101-SNPs-barcode method was used to assess the genetic diversity of P. falciparum and to determine the parasite species. Results The Pfcrt_76T chloroquine-resistance genotype was found at a rate of 64.4% in Dangassa and 45.2% in Nioro-du-Sahel (p = 0.025). The Pfdhfr_51I-59R-108N pyrimethamine-resistance genotype was 14.1% and 19.6%, respectively in Dangassa and Nioro-du-Sahel. Mutations in the Pfdhps_S436-A437-K540-A581-613A sulfadoxine-resistance gene was significantly more prevalent in Dangassa as compared to Nioro-du-Sahel (p = 0.035). Up to 17.8% of the isolates from Dangassa vs 7% from Nioro-du-Sahel harboured at least two codon substitutions in this haplotype. The amodiaquine-resistance Pfmdr1_N86Y mutation was identified in only three samples (two in Dangassa and one in Nioro-du-Sahel). The lumefantrine-reduced susceptibility Pfmdr1_Y184F mutation was found in 39.9% and 48.2% of samples in Dangassa and Nioro-du-Sahel, respectively. One piperaquine-resistance Exo_E415G mutation was found in Dangassa, while no artemisinin resistance genetic-background were identified. A high P. falciparum diversity was observed, but no clear genetic aggregation was found at either study sites. Higher multiplicity of infection was observed in Dangassa with both COIL (p = 0.04) and Real McCOIL (p = 0.02) methods relative to Nioro-du-Sahel. Conclusions This study reveals high prevalence of chloroquine and pyrimethamine-resistance markers as well as high codon substitution rate in the sulfadoxine-resistance gene. High genetic diversity of P. falciparum was observed. These observations suggest that the use of artemisinins is relevant in both Dangassa and Nioro-du-Sahel.
Published: 2019
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20. Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C.

Author: Jeanette T Beaudry, Michael A Krause, Seidina A S Diakite, Michael P Fay, Gyan Joshi, Mahamadou Diakite, Nicholas J White, and Rick M Fairhurst
Subjects: Medicine, Science
Abstract: Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to microvascular endothelial cells (MVECs) and impairing their activation of MVECs to produce pathological responses. Therefore, we hypothesized that parasites causing malaria in HbAS or HbAC heterozygotes have overcome this protective mechanism by expressing PfEMP1 variants which mediate relatively strong binding to MVECs. To test this hypothesis, we performed 31 cytoadherence comparisons between parasites from HbAA and HbAS (or HbAC) Malian children with malaria. Ring-stage parasites from HbAA and HbAS (or HbAC) children were cultivated to trophozoites, purified, and then inoculated in parallel into the same wildtype uninfected RBCs. After one cycle of invasion and maturation to the trophozoite stage expressing PfEMP1, parasite strains were compared for binding to MVECs. In this assay, there were no significant differences in the binding of parasites from HbAS and HbAC children to MVECs compared to those from HbAA children (HbAS, fold-change = 1.46, 95% CI 0.97-2.19, p = 0.07; HbAC, fold-change = 1.19, 95% CI 0.77-1.84, p = 0.43). These data suggest that in-vitro reductions in cytoadherence by HbS and HbC may not be selecting for expression of high-avidity PfEMP1 variants in vivo. Future studies that identify PfEMP1 domains or amino-acid motifs which are selectively expressed in parasites from HbAS children may provide further insights into the mechanism of malaria protection by the sickle-cell trait.
Published: 2014
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21. A Pilot Study on Autism Spectrum Disorders in Mali: Parental Concerns About Child Developmental Milestones and Late Diagnostic Age

Author: Seidina A. S. Diakite, Mahamadou Diakite, Seydou Doumbia, Modibo Kouyate, D. Konaté, Kassoum Kayentao, Gordon A. Awandare, Mohamed S Haidara, Adama Karembe, Modibo Sangare, Hyung-Goo Kim, Amadou Toure, Oumar Sidibe, Fatoumata Doumbia, Housseini Dolo, Drissa Traore, Ya Diarra, and Bourama Keita
Subjects: Developmental Milestone, PARENTAL CONCERNS, medicine, Autism, medicine.disease, Psychology, Developmental psychology
Abstract: BackgroundIn Mali, the health facility-based prevalence of autism spectrum disorders (ASD) in Mali was 4.5% (105/2,343) and the age of first medical visit for autistic children was around 7 years old in 2018. Parental recognition of developmental abnormalities initiates the early autism detection and diagnosis. We aimed to assess the feasibility of a main study to associate parental concerns with early first medical visits and subsequent ASD diagnostic in Mali.MethodsWe conducted a pilot study from November 2017 to July 2019. We surveyed 57 parents of autistic children aged 3-14 years old.ResultsParents were concerned over verbal communication in 54.1% and reciprocal social interaction in 43.8%. Children with ASD had their first medical visit after 18 months old in 66.7%, ≥ two medical visits in 87.7%, and were identified after 36 months old in 76.8%.ConclusionParental concerns were not significantly associated with early first medical visit and ASD identification. This pilot study will help in the design of larger studies on the same topic in Mali.
Published: 2021
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22. Plasmodium malariae and Plasmodium falciparum comparative susceptibility to antimalarial drugs in Mali

Author: Mahamadou Diakite, Yaw Aniweh, Abdoulaye Djimde, Laurent Dembele, Aliou Traore, Cheick Papa Oumar Sangare, Gordon A. Awandare, Nouhoum Diallo, Brice Campo, Seidina A. S. Diakite, Fanta Sogore, and Aboubecrin Sedhigh Haidara
Subjects: 0301 basic medicine, Microbiology (medical), 030106 microbiology, 030231 tropical medicine, Plasmodium falciparum, Plasmodium malariae, Lumefantrine, Mali, Plasmodium, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, 0302 clinical medicine, Chloroquine, Piperaquine, parasitic diseases, medicine, Humans, Pharmacology (medical), Artemether, Prospective Studies, Malaria, Falciparum, Pharmacology, biology, business.industry, biology.organism_classification, medicine.disease, Virology, Artemisinins, Infectious Diseases, Cross-Sectional Studies, chemistry, business, Malaria, medicine.drug
Abstract: Objectives To evaluate Plasmodium malariae susceptibility to current and lead candidate antimalarial drugs. Methods We conducted cross-sectional screening and detection of all Plasmodium species malaria cases, which were nested within a longitudinal prospective study, and an ex vivo assessment of efficacy of a panel of antimalarials against P. malariae and Plasmodium falciparum, both PCR-confirmed mono-infections. Reference compounds tested included chloroquine, lumefantrine, artemether and piperaquine, while candidate antimalarials included the imidazolopiperazine GNF179, a close analogue of KAF156, and the Plasmodium phosphatidylinositol-4-OH kinase (PI4K)-specific inhibitor KDU691. Results We report a high frequency (3%–15%) of P. malariae infections with a significant reduction in ex vivo susceptibility to chloroquine, lumefantrine and artemether, which are the current frontline drugs against P. malariae infections. Unlike these compounds, potent inhibition of P. malariae and P. falciparum was observed with piperaquine exposure. Furthermore, we evaluated advanced lead antimalarial compounds. In this regard, we identified strong inhibition of P. malariae using GNF179, a close analogue of KAF156 imidazolopiperazines, which is a novel class of antimalarial drug currently in clinical Phase IIb testing. Finally, in addition to GNF179, we demonstrated that the Plasmodium PI4K-specific inhibitor KDU691 is highly inhibitory against P. malariae and P. falciparum. Conclusions Our data indicated that chloroquine, lumefantrine and artemether may not be suitable for the treatment of P. malariae infections and the potential of piperaquine, as well as new antimalarials imidazolopiperazines and PI4K-specific inhibitor, for P. malariae cure.
Published: 2021

23. The Galactic Anticentre

Author: Vincenzo Ripepi, A. de Torres, Annie C. Robin, Mariateresa Crosta, C. Diener, L. Noval, Daniel Michalik, P. J. Richards, L. Karbevska, K. Kruszyńska, E. Fraile, André Moitinho, Michał Pawlak, P. Panuzzo, M. Riello, Benoit Carry, A. Yoldas, Harry Enke, N. Tonello, P. Gavras, M. Vaillant, Rosanna Sordo, E. del Pozo, Lorenzo Rimoldini, M. Bernet, G. Orrù, W. van Reeven, J. M. Martín-Fleitas, S. Diakite, P. Burgess, P. Osborne, Derek W. Morris, M. I. Carnerero, Amina Helmi, Mike Smith, Iain A. Steele, Alessandro Sozzetti, M. Kontizas, A. Sagristà Sellés, Roberto Molinaro, B. Holl, D. Baines, D. Molina, J. Fernández-Hernández, S. Marinoni, Michele Bellazzini, Maria Süveges, Teresa Antoja, D. Barbato, Uwe Lammers, Isabella Pagano, Davide Massari, G. Plum, P. Ramos, G. Jevardat de Fombelle, M. Biermann, C. Crowley, Mathias Schultheis, D. W. Evans, P. A. Palicio, Paolo Montegriffo, Ramachrisna Teixeira, R. Blomme, Elmé Breedt, T. A. Lister, F. A. Jansen, Ruth Carballo, Marcella Marconi, A. Abreu Aramburu, J. M. Carrasco, F. Royer, S. Accart, A. Burlacu, S. Regibo, Andrej Prsa, M. Sarasso, Nicolas Rambaux, A. F. Mulone, Ana Ulla, Eric Gosset, Alessandra Mastrobuono-Battisti, George M. Seabroke, H. E. Delgado, Federico Marocco, C. Nicolas, T. Lebzelter, Nami Mowlavi, C. Barache, Nicoletta Sanna, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Silvio Leccia, A. Jean-Antoine Piccolo, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, F. Figueras, G. Busso, C. Fabre, P. Di Matteo, F. Riclet, F. Solitro, Eric Slezak, N. Samaras, João Alves, Emese Plachy, Timo Prusti, F. van Leeuwen, J. Osinde, O. Marchal, M. Ajaj, C. Ducourant, Tatiana Muraveva, Shay Zucker, H. Steidelmüller, Alberto Riva, D. Semeux, N. Cheek, Laurent Galluccio, Martin A. Barstow, Alex Bombrun, S. Liao, M. van Leeuwen, R. E. de Souza, P. de Laverny, T. Roegiers, Paul J. McMillan, G. Holland, Alexey Mints, G. Giuffrida, L. M. Sarro, Juan Zorec, G. Sadowski, P. Yvard, Carme Jordi, J. L. Halbwachs, Laurent Chemin, Ludovic Delchambre, M. Garcia-Reinaldos, Ugo Becciani, Diego Bossini, Ángel Gómez, Sergi Blanco-Cuaresma, Rossella Cancelliere, C. Fabricius, J. De Ridder, L. Eyer, L. Pulone, Simon Hodgkin, Ennio Poretti, F. De Angeli, M. Haywood, E. Anglada Varela, Antonella Vallenari, F. X. Pineau, D. Garabato, A. Guerrier, H. E. P. Lindstrøm, Thomas Hilger, I. Bellas-Velidis, Frédéric Arenou, Paolo Giacobbe, Ilaria Musella, Tristan Cantat-Gaudin, L. Palaversa, Pedro García-Lario, David Hobbs, C. Turon, E. Balbinot, P. de Teodoro, Sébastien Lambert, D. Katz, Angela Bragaglia, Anthony G. A. Brown, Paolo Tanga, P. Castro Sampol, J. C. Segovia, Alejandra Recio-Blanco, Yves Fremat, Jon Marchant, Jose M Hernandez, S. Ragaini, Sofia Randich, P. Re Fiorentin, J. F. Le Campion, Gisella Clementini, M. Segol, P. David, R. Drimmel, F. Crifo, J. Guiraud, M. David, R. L. Smart, M. Fabrizio, I. Gonzalez-Santamaria, D. Eappachen, M. G. Lattanzi, Miguel García-Torres, Andreas Korn, S. Voutsinas, László Molnár, Simchon Faigler, A. Mora, Nicholas Rowell, Antti Penttilä, R. Geyer, Sanjeev Khanna, Aldo Dell'Oro, H. E. Huckle, C. Dolding, N. Leclerc, Monica Rainer, R. Mor, J. Bakker, Maroussia Roelens, Douglas J. Marshall, A. G. Butkevich, Nigel Hambly, A. Masip, Laia Casamiquela, R. Messineo, Martin Altmann, A. M. Piersimoni, Alessandro Spagna, Gerry Gilmore, Stefano Bertone, Patrick Charlot, O. Vanel, Daniel Hestroffer, Marco Castellani, Sebastian L. Hidalgo, W. Roux, Łukasz Wyrzykowski, Krzysztof A. Rybicki, M. M. S. Marcos Santos, Raphael Guerra, Alberto Cellino, E. Poggio, Gérard Jasniewicz, J. J. González-Vidal, S. Cowell, Peter G. Jonker, C. M. Raiteri, S. Bartolomé, J. Álvarez Cid-Fuentes, Elisabetta Caffau, J. J. Aguado, N. R. Millar, Ulrike Heiter, Federica Spoto, Felix Franke, A. Baudesson-Stella, M. Barros, Tsevi Mazeh, A. Panahi, E. Brugaletta, R. Buzzi, Elena Pancino, G. Altavilla, E. Racero, Enrique Solano, Mikael Granvik, Minia Manteiga, C. Robin, Tomaz Zwitter, Deborah Busonero, Alberto Krone-Martins, Marc Audard, Kevin Benson, Christos Siopis, L. Balaguer-Núñez, C. A. L. Bailer-Jones, E. Poujoulet, O. L. Creevey, E. Szegedi-Elek, C. Fouron, Michael Davidson, E. Licata, Despina Hatzidimitriou, Mark Cropper, Z. Kostrzewa-Rutkowska, S. Managau, A. Dapergolas, Sergio Messina, Laszlo Szabados, H. I. Siddiqui, W. Löffler, Mario Gai, J.-B. Delisle, Leanne P. Guy, S. G. Baker, W. J. Cooper, Alfred Castro-Ginard, Conny Aerts, A. Lorca, Xavier Luri, Damien Ségransan, Grigori Fedorets, A. Garofalo, J. Juaristi Campillo, F. De Luise, F. Pailler, F. Taris, L. Bramante, Thierry Morel, T. Cornez, L. Martin Polo, M. Ramos-Lerate, Jordi Portell, E. Salguero, Sergei A. Klioner, K. Janßen, Ulrich Bastian, Stefan Jordan, P. Esquej, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Y. Lebreton, Carlos Dafonte, S. Girona, D. Munoz, Dimitri Pourbaix, William Thuillot, J. H. J. de Bruijne, N. Brouillet, L. Chaoul, F. Torra, Alex Lobel, J.-L. Bassilana, Francesca Fragkoudi, M. Romero-Gómez, C. A. Stephenson, T. Pauwels, Eva Sciacca, Alessandro Bressan, Morgan Fouesneau, E. Livanou, E. Gerlach, X. Peñalosa Esteller, Roberto Morbidelli, L. Rohrbasser, Johannes Sahlmann, Elisa Distefano, P. Sartoretti, Karri Muinonen, Zoltan Balog, Y. Viala, J. Torra, H. Zhao, L. Siltala, G. Tauran, D. Souami, P. Madrero Pardo, David Teyssier, Jesus Salgado, J. Souchay, C. P. Murphy, Maria-Rosa L. Cioni, N. A. Walton, S. Bouquillon, Andrea Chiavassa, Agnes Fienga, Giovanni Comoretto, F. Julbe, A. Hutton, Yassine Damerdji, Richard I. Anderson, Pierre Fernique, Céline Reylé, M. Hauser, E. Utrilla, Pierre Kervella, C. Zurbach, Robert G. Mann, Ummi Abbas, Hector Canovas, D. L. Harrison, Y. Lasne, Mark Taylor, Y. Le Fustec, E. F. del Peloso, N. Bauchet, E. van Dillen, Jan Rybizki, N. Hładczuk, T. Boch, J. González-Núñez, Carine Babusiaux, C. Pagani, Krzysztof Nienartowicz, Eduard Masana, G. Kordopatis, N. Robichon, Luciana Bianchi, R. Gutiérrez-Sánchez, Arnaud Siebert, A. Kochoska, T. Carlucci, Jérôme Berthier, J. Castañeda, D. Vicente, R. De March, A. Garcia-Gutierrez, M. Weiler, F. Thévenin, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Guy Rixon, Francois Mignard, P. M. Marrese, M. A. Álvarez, Caroline Soubiran, Rene Andrae, C. Ordénovic, A. Delgado, V. Sanchez Gimenez, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Barcelona, Xunta de Galicia, European Commission, Centros de Excelencia Severo Ochoa, BARCELONA SUPERCOMPUTING CENTER (BSC), SEV2015-0493, Krone Martins, A. [0000-0002-2308-6623], McMillan, P. [0000-0002-8861-2620], Carrasco Martínez, J. P. [0000-0002-3029-5853], Sozzetti, A. [0000-0002-7504-365X], Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MINECO/ICTI2013-2016/MDM-2014-0369, Centrode Excelencia Científica Instituto de Ciencias del Cosmos Universidad de Barcelona, MINECO/ICTI2013-2016/SEV2015-0493, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), National Natural Science Foundation of China (NSFC), Estonian Ministry of Education and Research, Centre National D'Etudes Spatiales (CNES), Agence Nationale de la Recherche (ANR), Centre National de la Recherche Scientifique (CNRS), European Commission (EC), European Research Council (ERC), Institut des Sciences de l'Univers (INSU), Institut National Polytechnique (INP), Institut National de Physique nucleaire et de Physique des Particules (IN2P3), Deutsches Zentrum für Luft- und Raumfahrt (DLR), Hungarian Academy of Sciences, Hungarian National Research, Development, and Innovation Office (NKFIH), Science Foundation Ireland (SFI), Israel Science Foundation (ISF), Agenzia Spaziale Italiana (ASI), Italian Istituto Nazionale di Astrofisica (INAF), Netherlands Organisation for Scientific Research (NWO), Polish National Science Centre, Ministry of Science and Higher Education (MNiSW), Fundacao para a Ciencia e a Tecnologia (FCT), Slovenian Research Agency, Agencia Estatal de Investigación (AEI), Generalitat de Catalunya, United Kingdom Science and Technology Facilities Council (STFC), United Kingdom Space Agency (UKSA), Gaia Collaboration, Universidad de Cantabria, Astronomy, Kapteyn Astronomical Institute, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), M2A 2021, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), and Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: trigonometric parallaxes, SOLAR NEIGHBORHOOD, Astronomy, SAGITTARIUS DWARF GALAXY, Astrophysics, 01 natural sciences, sagittarius dwarf galaxy, 010303 astronomy & astrophysics, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], solar neighborhood, Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, Gelexy: kinematics and dynamics, Kinematics and Dynamics, Open clusters and asssociations: individual: Berkeley 29, sky survey, Disk, Physical Sciences, kinematics and dynamics [Gelexy], old open clusters, MILKY-WAY, Astrophysics::Earth and Planetary Astrophysics, open clusters and associations: individual: Berkeley 29, Galaxy: kinematics and dynamics, disk [Galaxy], individual: Berkeley 29 [open clusters and associations], Astrometria, Berkeley 29, EXPLORING HALO SUBSTRUCTURE, LOCAL KINEMATICS, Milky Way, FOS: Physical sciences, Open Clusters and Associations, Individual, exploring halo substructure, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, Computer Science::Digital Libraries, stellar structure, Galaxy: disk, Open clusters and associations: individual: Saurer 1, Galactic halo, Halo, Settore FIS/05 - Astronomia e Astrofisica, individual: Berkeley 29 [Open clusters and asssociations], 0103 physical sciences, distances [stars], halo [Galaxy], Disc, Stars: distances, milky-way, Saurer 1, Astrophysics::Galaxy Astrophysics, canis-major, Science & Technology, 010308 nuclear & particles physics, TRIGONOMETRIC PARALLAXES, Galaxy: halo, stars: distances, open clusters and associations: individual: Saurer 1, Astrophysics - Astrophysics of Galaxies, Astronomy and Astrophysics, Galactic plane, kinematics and dynamics [Galaxy], 115 Astronomy, Space science, CANIS-MAJOR, Stars, Galaxy, Physics::History of Physics, Estels, individual: Saurer 1 [open clusters and associations], Distances, local kinematics, OLD OPEN CLUSTERS, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), SKY SURVEY, Open cluster, STELLAR STRUCTURE
Abstract: Aims. We aim to demonstrate the scientific potential of the Gaia Early Data Release 3 (EDR3) for the study of different aspects of the Milky Way structure and evolution and we provide, at the same time, a description of several practical aspects of the data and examples of their usage., Methods. We used astrometric positions, proper motions, parallaxes, and photometry from EDR3 to select different populations and components and to calculate the distances and velocities in the direction of the anticentre. In this direction, the Gaia astrometric data alone enable the calculation of the vertical and azimuthal velocities; also, the extinction is relatively low compared to other directions in the Galactic plane. We then explore the disturbances of the current disc, the spatial and kinematical distributions of early accreted versus in situ stars, the structures in the outer parts of the disc, and the orbits of open clusters Berkeley 29 and Saurer 1., Results. With the improved astrometry and photometry of EDR3, we find that: (i) the dynamics of the Galactic disc are very complex with oscillations in the median rotation and vertical velocities as a function of radius, vertical asymmetries, and new correlations, including a bimodality with disc stars with large angular momentum moving vertically upwards from below the plane, and disc stars with slightly lower angular momentum moving preferentially downwards; (ii) we resolve the kinematic substructure (diagonal ridges) in the outer parts of the disc for the first time; (iii) the red sequence that has been associated with the proto-Galactic disc that was present at the time of the merger with Gaia-Enceladus-Sausage is currently radially concentrated up to around 14 kpc, while the blue sequence that has been associated with debris of the satellite extends beyond that; (iv) there are density structures in the outer disc, both above and below the plane, most probably related to Monoceros, the Anticentre Stream, and TriAnd, for which the Gaia data allow an exhaustive selection of candidate member stars and dynamical study; and (v) the open clusters Berkeley 29 and Saurer 1, despite being located at large distances from the Galactic centre, are on nearly circular disc-like orbits., Conclusions. Even with our simple preliminary exploration of the Gaia EDR3, we demonstrate how, once again, these data from the European Space Agency are crucial for our understanding of the different pieces of our Galaxy and their connection to its global structure and history.
Published: 2021
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24. Gaia early data release 3: summary of the contents and survey properties (Corrigendum)

Author: Mathias Schultheis, Marcella Marconi, N. Robichon, Luciana Bianchi, F. Crifo, J. Guiraud, D. Eappachen, R. Gutiérrez-Sánchez, Sanjeev Khanna, A. M. Piersimoni, Raphael Guerra, J. J. González-Vidal, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, Tristan Cantat-Gaudin, Alejandra Recio-Blanco, Ummi Abbas, Francesca Figueras, R. Blomme, Elmé Breedt, G. Busso, A. Jean-Antoine Piccolo, Gerry Gilmore, A. Panahi, S. Messina, C. Babusiaux, Łukasz Wyrzykowski, Mark Taylor, Alex Bombrun, M. Barros, M. Riello, M. Ajaj, C. Ducourant, Tatiana Muraveva, Alberto Cellino, E. Poggio, Y. Le Fustec, C. P. Murphy, Maria-Rosa L. Cioni, Hector Canovas, D. L. Harrison, Y. Lasne, Elena Pancino, N. Bauchet, G. Orrù, Sergi Blanco-Cuaresma, Simon Hodgkin, Ennio Poretti, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, Andrea Chiavassa, E. Szegedi-Elek, A. G. A. Brown, Laszlo Szabados, A. Masip, Laia Casamiquela, R. Messineo, C. Crowley, Alessandra Mastrobuono-Battisti, E. Poujoulet, Zoltan Balog, L. Eyer, A. Guerrier, H. E. P. Lindstrøm, Ilaria Musella, Laurent Galluccio, Martin A. Barstow, Aldo Dell'Oro, Mark Cropper, Z. Kostrzewa-Rutkowska, Angela Bragaglia, Arnaud Siebert, Damien Ségransan, A. Kochoska, J. L. Halbwachs, E. F. del Peloso, N. Hładczuk, F. Pailler, Stefan Jordan, Stefano Bertone, L. Pulone, Frédéric Arenou, Patrick Charlot, David Hobbs, P. Castro Sampol, Yves Fremat, Sofia Randich, Marc Audard, Despina Hatzidimitriou, A. Dapergolas, L. Palaversa, W. van Reeven, M. Hauser, E. Utrilla, Georges Kordopatis, Sergei A. Klioner, Alex Lobel, J.-L. Bassilana, G. Tauran, T. Prusti, H. Steidelmüller, Alberto Riva, Diego Bossini, Maria Süveges, Isabella Pagano, J. H. J. de Bruijne, Elisabetta Caffau, Federica Spoto, Felix Franke, T. Boch, M. I. Carnerero, T. Carlucci, Grigori Fedorets, J. Castañeda, W. Löffler, Enrique Solano, Paolo Montegriffo, A. Abreu Aramburu, T. Lebzelter, Nami Mowlavi, C. Barache, C. A. Stephenson, A. Lorca, L. Bramante, Amina Helmi, J.-B. Delisle, B. Holl, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, F. van Leeuwen, C. Robin, D. Katz, E. Gerlach, Elisa Distefano, Michele Bellazzini, P. de Laverny, G. Sadowski, Tomaz Zwitter, A. Burlacu, Teresa Antoja, Rossella Cancelliere, F. Torra, C. Pagani, Annie C. Robin, Johannes Sahlmann, Karri Muinonen, Eva Sciacca, D. Vicente, Krzysztof Nienartowicz, A. F. Mulone, Shay Zucker, Nicholas Rowell, H. E. Delgado, Dimitri Pourbaix, G. Giuffrida, H. E. Huckle, Federico Marocco, L. Noval, Daniel Michalik, P. J. Richards, Y. Viala, E. van Dillen, L. Karbevska, H. Zhao, L. Siltala, Nicoletta Sanna, K. Kruszyńska, E. Fraile, R. De March, Y. Lebreton, C. M. Raiteri, D. W. Evans, Ana Ulla, Francesca Fragkoudi, Jan Rybizki, E. Brugaletta, L. Rohrbasser, Andreas Korn, S. G. Baker, A. Garcia-Gutierrez, L. M. Sarro, R. Buzzi, T. Pauwels, Jérôme Berthier, L. Chaoul, W. J. Cooper, Eduard Masana, M. van Leeuwen, D. Garabato, P. Panuzzo, Maroussia Roelens, Benoit Carry, Deborah Busonero, Michael Davidson, J. González-Núñez, Thomas Hilger, E. Licata, M. Weiler, Mikael Granvik, Alessandro Bressan, Morgan Fouesneau, Miguel García-Torres, W. Roux, Pedro García-Lario, Iain A. Steele, P. Ramos, Alessandro Sozzetti, Roberto Molinaro, O. L. Creevey, D. Barbato, Lorenzo Rimoldini, Uwe Lammers, Alexey Mints, P. Sartoretti, E. Livanou, D. Souami, P. Madrero Pardo, David Teyssier, M. Bernet, Yassine Damerdji, X. Peñalosa Esteller, C. Fabre, F. Thévenin, Gérard Jasniewicz, Roberto Morbidelli, Jesus Salgado, Juan Zorec, Ángel Gómez, Douglas J. Marshall, A. G. Butkevich, M. Biermann, E. Racero, J. Torra, R. Gomel, O. Vanel, Daniel Hestroffer, Sebastian L. Hidalgo, P. A. Palicio, F. De Angeli, Richard L. Smart, J. M. Martín-Fleitas, Derek W. Morris, F. Royer, S. Diakite, S. Accart, C. Dolding, P. Burgess, Richard I. Anderson, A. Garofalo, I. Bellas-Velidis, George M. Seabroke, P. Osborne, Claus Fabricius, Jon Marchant, Ramachrisna Teixeira, João Alves, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Paolo Giacobbe, Emese Plachy, M. Fabrizio, I. Gonzalez-Santamaria, F. Taris, Kevin Benson, Christos Siopis, M. M. S. Marcos Santos, S. Cowell, Jose M Hernandez, S. Ragaini, Jordi Portell, Linda K. Molnar, R. Drimmel, Pierre Kervella, C. Zurbach, S. Bartolomé, J. Álvarez Cid-Fuentes, E. Salguero, Ulrich Bastian, Robert G. Mann, Marco Castellani, J. Osinde, E. Balbinot, Caroline Soubiran, Rene Andrae, J. Souchay, M. G. Lattanzi, S. Voutsinas, Agnes Fienga, Giovanni Comoretto, P. Esquej, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Carlos Dafonte, Alfred Castro-Ginard, J. C. Segovia, Monica Rainer, F. Julbe, A. Hutton, Peter G. Jonker, William Thuillot, A. de Torres, F. De Luise, Pierre Fernique, Céline Reylé, M. Kontizas, G. Plum, Martin Altmann, L. Martin Polo, M. Ramos-Lerate, P. de Teodoro, Sébastien Lambert, G. Altavilla, André Moitinho, D. Munoz, N. Brouillet, Alessandro Spagna, C. Ordénovic, Gisella Clementini, C. Nicolas, Michał Pawlak, Silvio Leccia, A. Delgado, M. Romero-Gómez, N. Cheek, A. Yoldas, Harry Enke, Rosanna Sordo, V. Sanchez Gimenez, Mike Smith, P. David, D. Baines, Paolo Tanga, Guy Rixon, Alberto Krone-Martins, S. Managau, N. A. Walton, S. Bouquillon, C. Fouron, Francois Mignard, Xavier Luri, J. Juaristi Campillo, S. Girona, Thierry Morel, T. Cornez, P. M. Marrese, M. A. Álvarez, S. Liao, Andrej Prsa, M. Sarasso, Nicolas Rambaux, Paul J. McMillan, Ludovic Delchambre, M. Garcia-Reinaldos, M. Haywood, E. Anglada Varela, Antonella Vallenari, S. Regibo, R. E. de Souza, Sahar Shahaf, J. De Ridder, M. Segol, Simchon Faigler, A. Mora, Ulrike Heiter, Carla Cacciari, Minia Manteiga, H. I. Siddiqui, Mario Gai, Leanne P. Guy, N. Leclerc, T. A. Lister, F. A. Jansen, Ruth Carballo, J. M. Carrasco, Bengt Edvardsson, P. Di Matteo, K. Janßen, F. Riclet, F. Solitro, O. Marchal, G. Holland, F. X. Pineau, C. Turon, P. Re Fiorentin, Tsevi Mazeh, Mariateresa Crosta, C. Diener, J. F. Le Campion, Vincenzo Ripepi, M. David, R. Mor, N. Tonello, E. del Pozo, J. Bakker, Davide Massari, A. Sagristà Sellés, Marco Delbo, Eric Slezak, P. Gavras, N. Samaras, S. Marinoni, M. Vaillant, J. M. Petit, P. Yvard, Carme Jordi, Ugo Becciani, Antti Penttilä, R. Geyer, Nigel Hambly, Krzysztof A. Rybicki, L. Balaguer-Núñez, C. A. L. Bailer-Jones, Conny Aerts, Eric Gosset, D. Semeux, T. Roegiers, and Laurent Chemin
Subjects: Physics, Addenda, 010504 meteorology & atmospheric sciences, Errata, Parallaxes, Astronomy, Astronomy and Astrophysics, Astrophysics, Astrometry, Photometric, 01 natural sciences, Techniques, catalogs, astrometry, parallaxes, proper motions, techniques: photometric, errata, addenda, Settore FIS/05 - Astronomia e Astrofisica, Space and Planetary Science, 0103 physical sciences, Proper motions, Catalogs, 010303 astronomy & astrophysics, Data release, 0105 earth and related environmental sciences
Abstract: We present the early installment of the third Gaia data release, Gaia EDR3, consisting of astrometry and photometry for 1.8 billion sources brighter than magnitude 21, complemented with the list of radial velocities from Gaia DR2. Gaia EDR3 contains celestial positions and the apparent brightness in G for approximately 1.8 billion sources. For 1.5 billion of those sources, parallaxes, proper motions, and the (G_BP-G_RP) colour are also available. The passbands for G, G_BP, and G_RP are provided as part of the release. For ease of use, the 7 million radial velocities from Gaia DR2 are included in this release, after the removal of a small number of spurious values. New radial velocities will appear as part of Gaia DR3. Finally, Gaia EDR3 represents an updated materialisation of the celestial reference frame (CRF) in the optical, the Gaia-CRF3, which is based solely on extragalactic sources. The creation of the source list for Gaia EDR3 includes enhancements that make it more robust with respect to high proper motion stars, and the disturbing effects of spurious and partially resolved sources. The source list is largely the same as that for Gaia DR2, but it does feature new sources and there are some notable changes. The source list will not change for Gaia DR3. Gaia EDR3 represents a significant advance over Gaia DR2, with parallax precisions increased by 30 percent, proper motion precisions increased by a factor of 2, and the systematic errors in the astrometry suppressed by 30--40 percent for the parallaxes and by a factor ~2.5 for the proper motions. The photometry also features increased precision, but above all much better homogeneity across colour, magnitude, and celestial position. A single passband for G, G_BP, and G_RP is valid over the entire magnitude and colour range, with no systematics above the 1 percent level.
Published: 2021

25. Peripheral Arterial Disease of the Lower Limbs: Epidemiological and Ultrasound Profile of Patients with Stenosis at the Conakry University Hospital

Author: MD, Balde, primary, MB, Bah, additional, EY, Balde, additional, M, Beavogui, additional, A, Camara, additional, C, Tamko, additional, IS, Barry, additional, MA, Balde, additional, A, Kone, additional, IS, Sylla, additional, S, Diakite, additional, M, Diallo, additional, and M, Conde, additional
Published: 2021
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26. Gaia Early Data Release 3 -- Catalogue validation

Author: C. Fabricius, Antonella Vallenari, Sébastien Lambert, Alessia Garofalo, Annie C. Robin, D. Busonero, P. Ramos, Frédéric Arenou, Sanjeev Khanna, Xavier Luri, Tristan Cantat-Gaudin, Eduardo Balbinot, N. Robichon, T. Muraveva, Carine Babusiaux, M. Fabrizio, A. Masip, Amina Helmi, F. Figueras, E. Licata, Teresa Antoja, Angela Bragaglia, Carme Jordi, Pierre Kervella, J. M. Carrasco, Federica Spoto, A. Garcia-Gutierrez, M. Weiler, M. Romero-Gómez, S. Diakite, N. Bauchet, Stefano Rubele, C. Barache, P. M. Marrese, N. Leclerc, Céline Reylé, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Agenzia Spaziale Italiana, Istituto Nazionale di Astrofisica, Agence Nationale de la Recherche (France), Astronomy, Research unit Astroparticle Physics, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], Università di Bologna Dipartimento di Fisca e Astronomia, INAF - Osservatorio di Astrofisica e Scienza dello Spazio di Bologna, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University [Cambridge]-Smithsonian Institution, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Systèmes de Référence Temps Espace (SYRTE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and ITA
Subjects: FOS: Physical sciences, Astrophysics, 01 natural sciences, Two stages, Photometry (optics), External data, techniques: photometric, 0103 physical sciences, Statistical analysis, 010303 astronomy & astrophysics, Physics, 010308 nuclear & particles physics, photometric [Techniques], Astronomy, Astronomy and Astrophysics, Astrometry, Light curve, Astrophysics - Astrophysics of Galaxies, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), astrometry, Catalogs, Parallax, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Data release, catalogs
Abstract: [Context] The third Gaia data release is published in two stages. The early part, Gaia EDR3, gives very precise astrometric and photometric properties for nearly two billion sources together with seven million radial velocities from Gaia DR2. The full release, Gaia DR3, will add radial velocities, spectra, light curves, and astrophysical parameters for a large subset of the sources, as well as orbits for solar system objects. [Aims] Before the publication of the catalogue, many different data items have undergone dedicated validation processes. The goal of this paper is to describe the validation results in terms of completeness, accuracy, and precision for the Gaia EDR3 data and to provide recommendations for the use of the catalogue data. [Methods] The validation processes include a systematic analysis of the catalogue contents to detect anomalies, either individual errors or statistical properties, using statistical analysis and comparisons to the previous release as well as to external data and to models. [Results] Gaia EDR3 represents a major step forward, compared to Gaia DR2, in terms of precision, accuracy, and completeness for both astrometry and photometry. We provide recommendations for dealing with issues related to the parallax zero point, negative parallaxes, photometry for faint sources, and the quality indicators., Fabricius, C., et al., This work was supported by the Spanish Ministry of Science, Innovation and University (MICIU/FEDER, UE) through grants RTI2018-095076-B-C21, ESP2016-80079-C2-1-R, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia ‘María de Maeztu’) through grants MDM-2014-0369 and CEX2019-000918-M. T.M., D.B., A.G. and E.L. acknowledge financial support from the Agenzia Spaziale Italiana (ASI) provided through contracts 2014-025-R.0, 2014-025-R.1.2015 and 2018-24-HH.0 to the Italian Istituto Nazionale di Astrofisica. P.K. acknowledges support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 695099 (project CepBin), and the French Agence Nationale de la Recherche (ANR), under grant ANR-15-CE31-0012-01 (UnlockCepheids). This research has made an extensive use of Aladin and the SIMBAD, VizieR databases operated at the Centre de Données Astronomiques (Strasbourg) in France and of the software TOPCAT (Taylor 2005).
Published: 2020
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27. Spatio-Temporal Dynamic of Malaria Incidence: A Comparison of Two Ecological Zones in Mali

Author: François Freddy Ateba, Mady Cissoko, Mathias Dolo, Mahamoudou B. Touré, Sory Ibrahim Diawara, Lansana Sangaré, Mamadou D. Coulibaly, Sidibe M’Baye Thiam, Seidina A. S. Diakite, Manuel Febrero-Bande, Peter J. Winch, Aliou Sissako, Aissata Sacko, Drissa Konaté, Issaka Sagara, Seydou Doumbia, Ayouba Diarra, Nafomon Sogoba, Mahamadou Diakite, Sekou F. Traore, Donald J. Krogtad, Hannah C. Marker, Jeffrey G. Shaffer, Amagana Dolo, O. Koita, Jean Gaudart, Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización, Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biostatistique et technologies de l'information et de la communication (BioSTIC) - [Hôpital de la Timone - APHM] (BiosTIC ), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Universidade de Santiago de Compostela [Spain] (USC ), Tulane University School of Public Health and Tropical Medicine [New Orleans, LA, USA], Dupuis, Christine, Université des sciences, des techniques et des technologies de Bamako, and Université des sciences, des techniques et des technologies de Bamako (USTTB)
Subjects: Multivariate statistics, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], normalized difference vegetation index, lcsh:Medicine, Principal components analysis, Mali, lag, Environmental data, 0302 clinical medicine, Normalized difference vegetation index, 030212 general & internal medicine, Passive case detection, biology, Ecology, Incidence (epidemiology), Incidence, Temperature, Vegetation, 3. Good health, [SDV] Life Sciences [q-bio], Geography, Population Surveillance, plasmodium falciparum, 030231 tropical medicine, Plasmodium falciparum, malaria, Geo-epidemiology, Generalized additive models, Normalized Difference Vegetation Index, Article, generalized additive models, 03 medical and health sciences, principal components analysis, parasitic diseases, medicine, Humans, passive case detection, Generalized additive model, lcsh:R, Public Health, Environmental and Occupational Health, Humidity, 15. Life on land, biology.organism_classification, medicine.disease, geo-epidemiology, Lag, Malaria
Abstract: Malaria transmission largely depends on environmental, climatic, and hydrological conditions. In Mali, malaria epidemiological patterns are nested within three ecological zones. This study aimed at assessing the relationship between those conditions and the incidence of malaria in Dangassa and Koila, Mali. Malaria data was collected through passive case detection at community health facilities of each study site from June 2015 to January 2017. Climate and environmental data were obtained over the same time period from the Goddard Earth Sciences (Giovanni) platform and hydrological data from Mali hydraulic services. A generalized additive model was used to determine the lagged time between each principal component analysis derived component and the incidence of malaria cases, and also used to analyze the relationship between malaria and the lagged components in a multivariate approach. Malaria transmission patterns were bimodal at both sites, but peak and lull periods were longer lasting for Koila study site. Temperatures were associated with malaria incidence in both sites. In Dangassa, the wind speed (p = 0.005) and river heights (p = 0.010) contributed to increasing malaria incidence, in contrast to Koila, where it was humidity (p &lt, 0.001) and vegetation (p = 0.004). The relationships between environmental factors and malaria incidence differed between the two settings, implying different malaria dynamics and adjustments in the conception and plan of interventions.
Published: 2020
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28. Effect of routine seasonal malaria chemoprevention on malaria trends in children under 5 years in Dangassa, Mali

Author: Mahamadou Diakite, Sekou F. Traore, Karim Traore, Seydou Doumbia, Agnès Guindo, Drissa Konaté, Ayouba Diarra, Donald J. Krogtad, Sibe Thiam, Sory I. Diawara, Ibrahim Sissoko, Mahamoudou B. Touré, Bourama Keita, Nafomon Sogoba, Seidina A. S. Diakite, and Moussa Keita
Subjects: medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, Endemic Diseases, NMCP, lcsh:RC955-962, World Health Organization, Mali, Chemoprevention, lcsh:Infectious and parasitic diseases, Cohort Studies, Antimalarials, Risk Factors, Environmental health, parasitic diseases, Prevalence, Gametocyte, Humans, Medicine, lcsh:RC109-216, Children, SMC, business.industry, Proportional hazards model, Research, Incidence (epidemiology), Public health, Health Plan Implementation, Infant, medicine.disease, Malaria, Infectious Diseases, Child, Preschool, Community health, Tropical medicine, Regression Analysis, Malaria indicators, Parasitology, Seasons, business, Cohort study
Abstract: Background Seasonal malaria chemoprevention (SMC) is a new strategy to prevent malaria in children under 5 years old. It has been recommended by the World Health Organization since 2012 in malaria-endemic areas with seasonal transmission. This study aimed to assess the changes in malaria indicators through two consecutive years of SMC routine implementation in children under 5 years old in Dangassa, where malaria is endemic with a long and high transmission season. Methods From 2012 to 2016, a cohort study was conducted in Dangassa village. The study team based in the village followed all malaria clinical cases in children under 5 years old at the community health centre. During the study, SMC was routinely implemented in collaboration with the National Malaria Control Programme. The Cox regression model was used in order to compare malaria risk during the study. Results The Cox regression model showed a significant reduction in malaria clinical incidence, both in 2015 (HR = 0.27 (0.18–0.40), 95% CI) and in 2016 (HR = 0.23 (0.15–0.35), 95% CI) of SMC implementation compared to October 2013. Gametocyte and fever prevalence was lower between September and October during SMC implementation (2015 and 2016) compared to the same period before SMC implementation (2013–2014). A slight increase of malaria incidence was observed in December at the end of SMC implementation. Conclusion SMC has significantly reduced both malaria incidence and gametocyte prevalence and improved haemoglobin levels in children under 5 years old after 2 years of routine implementation.
Published: 2020
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29. Gaia Early Data Release 3: Acceleration of the solar system from Gaia astrometry

Author: Vincenzo Ripepi, P. Gavras, M. Vaillant, Mathias Schultheis, László Molnár, E. Poujoulet, Mark Cropper, C. Babusiaux, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, A. de Torres, Aldo Dell'Oro, J. Castañeda, Z. Kostrzewa-Rutkowska, A. Bombrun, André Moitinho, Marcella Marconi, Rossella Cancelliere, M. Hauser, M. Ajaj, C. M. Raiteri, L. Eyer, Michał Pawlak, H. I. Siddiqui, C. Ducourant, Tatiana Muraveva, Tsevi Mazeh, A. Panahi, Federico Marocco, Stefano Bertone, D. Vicente, Patrick Charlot, A. Guerrier, R. De March, Mario Gai, J. Souchay, H. E. P. Lindstrøm, Nicoletta Sanna, Agnes Fienga, Giovanni Comoretto, Jon Marchant, A. Lorca, E. Utrilla, A. Garcia-Gutierrez, Ilaria Musella, L. Balaguer-Núñez, Leanne P. Guy, N. Leclerc, E. Brugaletta, A. Yoldas, Harry Enke, Rosanna Sordo, Zoltan Balog, H. E. Huckle, L. Palaversa, Monica Rainer, T. A. Lister, F. A. Jansen, Ruth Carballo, Alessandro Spagna, J. M. Carrasco, Mikael Granvik, Derek W. Morris, F. Julbe, A. Hutton, J. Osinde, D. W. Evans, M. van Leeuwen, M. Weiler, F. Thévenin, F. Torra, Iain A. Steele, Lorenzo Rimoldini, Alessandro Sozzetti, Francesca Fragkoudi, K. Janßen, O. L. Creevey, J. González-Núñez, T. Pauwels, R. Buzzi, Miguel García-Torres, S. Liao, G. Tauran, Lennart Lindegren, C. Fouron, Pierre Fernique, Céline Reylé, P. Di Matteo, E. Szegedi-Elek, F. Pailler, Stefan Jordan, Roberto Molinaro, Elisabetta Caffau, Federica Spoto, Felix Franke, D. Barbato, Isabelle Lecoeur-Taïbi, Tristan Cantat-Gaudin, Alejandra Recio-Blanco, E. Livanou, W. Roux, X. Peñalosa Esteller, P. A. Palicio, J. H. J. de Bruijne, Sergi Blanco-Cuaresma, Deborah Busonero, F. Riclet, Conny Aerts, Georges Kordopatis, Guy Rixon, F. Solitro, Davide Massari, Mike Smith, D. Baines, Roberto Morbidelli, Gerry Gilmore, G. Plum, Alexey Mints, O. Marchal, Juan Zorec, Ángel Gómez, C. A. Stephenson, Michael Davidson, C. Fabricius, E. Licata, Sergio Messina, Laszlo Szabados, M. Biermann, A. Garofalo, G. Holland, F. De Angeli, Andreas Korn, E. Anglada Varela, Grigori Fedorets, S. Girona, E. Gerlach, Antonella Vallenari, M. Riello, Łukasz Wyrzykowski, Damien Ségransan, F. Taris, L. Bramante, Alberto Cellino, S. Regibo, Andrej Prsa, M. Sarasso, E. Poggio, W. Löffler, Paolo Giacobbe, Jordi Portell, Elisa Distefano, Eric Slezak, I. Bellas-Velidis, Nicolas Rambaux, E. Balbinot, J.-B. Delisle, Maroussia Roelens, E. Salguero, P. de Teodoro, E. van Dillen, Y. Lebreton, Francois Mignard, Sergei A. Klioner, Ulrich Bastian, N. Samaras, G. Orrù, R. E. de Souza, P. Esquej, Paul J. McMillan, A. C. Lanzafame, Sébastien Lambert, Beatrice Bucciarelli, Jose M Hernandez, M. Bernet, S. Ragaini, Gisella Clementini, A. F. Mulone, Ludovic Delchambre, C. Panem, Eric Gosset, P. David, M. Garcia-Reinaldos, Ana Ulla, F. Crifo, J. Guiraud, Mariateresa Crosta, L. Chaoul, C. Diener, Carlos Dafonte, Karri Muinonen, Alex Lobel, J.-L. Bassilana, Maria Süveges, Isabella Pagano, Dimitri Pourbaix, D. Eappachen, M. Haywood, R. Drimmel, Y. Viala, S. Voutsinas, D. Semeux, William Thuillot, N. A. Walton, Paolo Montegriffo, A. Abreu Aramburu, C. Fabre, H. Zhao, Alessandro Bressan, S. Bouquillon, Sanjeev Khanna, T. Lebzelter, N. Tonello, L. Siltala, M. G. Lattanzi, C. Crowley, P. Yvard, Carme Jordi, Elena Pancino, E. del Pozo, Jan Rybizki, Nami Mowlavi, C. Barache, Morgan Fouesneau, J. De Ridder, Ugo Becciani, Martin Altmann, F. van Leeuwen, P. M. Marrese, M. A. Álvarez, A. Jean-Antoine Piccolo, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, Caroline Soubiran, C. P. Murphy, A. M. Piersimoni, Alessandra Mastrobuono-Battisti, Peter G. Jonker, A. Sagristà Sellés, T. Roegiers, S. Marinoni, Johannes Sahlmann, Rene Andrae, P. Sartoretti, G. Altavilla, Raphael Guerra, F. X. Pineau, M. Segol, T. Prusti, J. J. González-Vidal, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, Andrea Chiavassa, Laurent Chemin, C. Turon, H. Steidelmüller, Douglas J. Marshall, A. G. Butkevich, Alberto Riva, P. de Laverny, Simchon Faigler, Laurent Galluccio, A. Mora, P. Re Fiorentin, C. Ordénovic, J. F. Le Campion, A. Delgado, V. Sanchez Gimenez, M. David, G. Sadowski, R. L. Smart, A. Masip, Laia Casamiquela, R. Messineo, R. Mor, J. Bakker, C. Dolding, J. M. Martín-Fleitas, S. Diakite, Coryn A. L. Bailer-Jones, D. Souami, P. Madrero Pardo, Martin A. Barstow, David Teyssier, Ummi Abbas, Jesus Salgado, Paolo Tanga, A. Burlacu, O. Vanel, Ulrike Heiter, Daniel Hestroffer, Sebastian L. Hidalgo, H. E. Delgado, Alberto Krone-Martins, C. Robin, Kevin Benson, Christos Siopis, S. Managau, P. Burgess, Tomaz Zwitter, M. M. S. Marcos Santos, S. Cowell, J. L. Halbwachs, Xavier Luri, Antti Penttilä, R. Geyer, Minia Manteiga, Yassine Damerdji, Nigel Hambly, S. Bartolomé, J. Álvarez Cid-Fuentes, P. Osborne, J. Juaristi Campillo, Mark Taylor, Richard I. Anderson, Y. Le Fustec, Thierry Morel, T. Cornez, Krzysztof A. Rybicki, L. Pulone, N. Bauchet, Pierre Kervella, C. Zurbach, Alfred Castro-Ginard, Frédéric Arenou, P. Ramos, Robert G. Mann, Annie C. Robin, J. C. Segovia, M. Barros, Hector Canovas, D. L. Harrison, Y. Lasne, L. Noval, David Hobbs, E. F. del Peloso, P. Castro Sampol, Yves Fremat, F. De Luise, Daniel Michalik, P. J. Richards, L. Karbevska, N. Hładczuk, K. Kruszyńska, T. Boch, Sofia Randich, A. G. A. Brown, C. Pagani, L. Martin Polo, M. Ramos-Lerate, Krzysztof Nienartowicz, Eduard Masana, E. Racero, E. Fraile, Marc Audard, N. Robichon, Luciana Bianchi, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Jérôme Berthier, Despina Hatzidimitriou, R. Gutiérrez-Sánchez, M. Fabrizio, I. Gonzalez-Santamaria, A. Dapergolas, P. Panuzzo, Benoit Carry, Francesca Figueras, R. Blomme, Elmé Breedt, D. Munoz, Diego Bossini, G. Busso, D. Katz, Simon Hodgkin, Ennio Poretti, N. Brouillet, Marco Castellani, Nicholas Rowell, Arnaud Siebert, M. Romero-Gómez, Shay Zucker, W. van Reeven, A. Kochoska, G. Giuffrida, Eva Sciacca, T. Carlucci, L. M. Sarro, M. I. Carnerero, Amina Helmi, D. Garabato, B. Holl, Michele Bellazzini, L. Rohrbasser, Teresa Antoja, J. Torra, Thomas Hilger, Pedro García-Lario, Gérard Jasniewicz, Enrique Solano, S. G. Baker, W. J. Cooper, F. Royer, S. Accart, George M. Seabroke, João Alves, Emese Plachy, C. Nicolas, Silvio Leccia, N. Cheek, Uwe Lammers, Ramachrisna Teixeira, Techniche Universtât Desden, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Lund Observatory, Lund University [Lund], Zentrum für astronomie, Universität Heidelberg [Heidelberg], Department of nuclear medicine, Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Merck Serono S.A [Geneva Research Center], Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] = Heidelberg University, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Gaia Collaboration, Unidad de Excelencia Científica María de Maeztu Instituto de Ciencias del Cosmos Universidad de Barcelona, MDM-2014-0369, Centro de Excelencia Científica Severo Ochoa, Instituto de Ciencias del Cosmos de la Universidad de Barcelona, SEV2015-0493, Deliste, J. B. [0000-0001-5844-9888], Sozzeti, A. [0000-0002-7504-365X], Forderung der wissenschaftlichen Forschung (FWF), Belgian federal Science Policy Office (BELSPO), Hertha Firnberg Programme, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (COFECUB), National Natural Science Foundation of China (NSFC), China Scholarship Council (CSC), European Commission (EC), European Research Council (ERC), Hungarian National Research, Development, and Innovation Office (NKFIH), Science Foundation Ireland (SFI), Israel Science Foundation (ISF), Agenzia Spaziale Italiana (ASI), Istituto Nazionale di Astrofisica (INAF), Netherlands Research School for Astronomy (NOVA), Fundacao para a Ciencia e a Tecnologia (FCT), Agencia Estatal de Investigación (AEI), European Space Agency (ESA), Centre National D'Etudes Spatiales (CNES), Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR), Narodowe Centrum Nauki (NCN), Slovenian Research Agency, Swedish National Space Agency (SNSA), United Kingdom Science and Technology Facilities Council (STFC), Universitat de Barcelona (UB), Generalitat de Catalunya, Xunta de Galicia, Universidad de Cantabria, ITA, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Astronomy, and Kapteyn Astronomical Institute
Subjects: Data Analysis, Solar System, Astronomy, kinematics and dynamics, virgo cluster, Astrophysics, 01 natural sciences, bar, Astronomi, astrofysik och kosmologi, large-magellanic-cloud, Methods, Astronomy, Astrophysics and Cosmology, 010303 astronomy & astrophysics, Physics, Astrophysics of Galaxies, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, VIRGO CLUSTER, Kinematics and Dynamics, Amplitude, kinematics, Physical Sciences, MILKY-WAY, astrometry, Galaxy: kinematics and dynamics, PROPER MOTION, Proper motion, perturbation, proper motions, reference systems, methods: data analysis, Astrophysics - Astrophysics of Galaxies, FOS: Physical sciences, Context (language use), proper motion, Astronomy & Astrophysics, MASS, Computer Science::Digital Libraries, Gravitational potential, Acceleration, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, data analysis [methods], Vector spherical harmonics, KINEMATICS, distance, milky-way, Science & Technology, PERTURBATION, 010308 nuclear & particles physics, Astronomy and Astrophysics, kinematics and dynamics [Galaxy], 115 Astronomy, Space science, Physics::History of Physics, BAR, Galaxy, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), DISTANCE, mass, LARGE-MAGELLANIC-CLOUD
Abstract: Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions., Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar systembarycentre with respect to the rest frame of the Universe. Apart from being an important scientific result by itself, the acceleration measured in this way is a good quality indicator of the Gaia astrometric solution., Methods. Theeffect of the acceleration was obtained as a part of the general expansion of the vector field of proper motions in vector spherical harmonics (VSH). Various versions of the VSH fit and various subsets of the sources were tried and compared to get the most consistent result and a realistic estimate of its uncertainty. Additional tests with the Gaia astrometric solution were used to get a better idea of the possible systematic errors in the estimate., Results. Our best estimate of the acceleration based on Gaia EDR3 is (2.32 +/- 0.16) x 10(-10) m s(-2) (or 7.33 +/- 0.51 km s(-1) Myr-1) towards alpha = 269.1 degrees +/- 5.4 degrees, delta = -31.6 degrees +/- 4.1 degrees, corresponding to a proper motion amplitude of 5.05 +/- 0.35 mu as yr(-1). This is in good agreement with the acceleration expected from current models of the Galactic gravitational potential. We expect that future Gaia data releases will provide estimates of the acceleration with uncertainties substantially below 0.1 mu as yr(-1).
Published: 2020
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30. Predictive factors of heart failure in hospitalized patients in the medico-surgical cardiology department of Donka national hospital

Author: A. Kone, N. Zoumanigui, A.K. Falana, M.C. Camara, E.Y. Balde, I.S. Barry, M.B. Bah, Z. Onivogui, S. Diakite, K.P. Zoumanigui, A. Bongono, M.S. Camara, M. Beavogui, M.D. Balde, and M. Conde
Subjects: Cardiology and Cardiovascular Medicine
Published: 2022
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31. Filariasis attenuates anemia and proinflammatory responses associated with clinical malaria: a matched prospective study in children and young adults.

Author: Housseini Dolo, Yaya I Coulibaly, Benoit Dembele, Siaka Konate, Siaka Y Coulibaly, Salif S Doumbia, Abdallah A Diallo, Lamine Soumaoro, Michel E Coulibaly, Seidina A S Diakite, Aldiouma Guindo, Michael P Fay, Simon Metenou, Thomas B Nutman, and Amy D Klion
Subjects: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract: Wuchereria bancrofti (Wb) and Mansonella perstans (Mp) are blood-borne filarial parasites that are endemic in many countries of Africa, including Mali. The geographic distribution of Wb and Mp overlaps considerably with that of malaria, and coinfection is common. Although chronic filarial infection has been shown to alter immune responses to malaria parasites, its effect on clinical and immunologic responses in acute malaria is unknown.To address this question, 31 filaria-positive (FIL+) and 31 filaria-negative (FIL-) children and young adults, matched for age, gender and hemoglobin type, were followed prospectively through a malaria transmission season. Filarial infection was defined by the presence of Wb or Mp microfilariae on calibrated thick smears performed between 10 pm and 2 am and/or by the presence of circulating filarial antigen in serum. Clinical malaria was defined as axillary temperature ≥37.5°C or another symptom or sign compatible with malaria infection plus the presence of asexual malaria parasites on a thick blood smear. Although the incidence of clinical malaria, time to first episode, clinical signs and symptoms, and malaria parasitemia were comparable between the two groups, geometric mean hemoglobin levels were significantly decreased in FIL- subjects at the height of the transmission season compared to FIL+ subjects (11.4 g/dL vs. 12.5 g/dL, p
Published: 2012
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32. α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes.

Author: Michael A Krause, Seidina A S Diakite, Tatiana M Lopera-Mesa, Chanaki Amaratunga, Takayuki Arie, Karim Traore, Saibou Doumbia, Drissa Konate, Jeffrey R Keefer, Mahamadou Diakite, and Rick M Fairhurst
Subjects: Medicine, Science
Abstract: α-Thalassemia results from decreased production of α-globin chains that make up part of hemoglobin tetramers (Hb; α(2)β(2)) and affects up to 50% of individuals in some regions of sub-Saharan Africa. Heterozygous (-α/αα) and homozygous (-α/-α) genotypes are associated with reduced risk of severe Plasmodium falciparum malaria, but the mechanism of this protection remains obscure. We hypothesized that α-thalassemia impairs the adherence of parasitized red blood cells (RBCs) to microvascular endothelial cells (MVECs) and monocytes--two interactions that are centrally involved in the pathogenesis of severe disease.We obtained P. falciparum isolates directly from Malian children with malaria and used them to infect αα/αα (normal), -α/αα and -α/-α RBCs. We also used laboratory-adapted P. falciparum clones to infect -/-α RBCs obtained from patients with HbH disease. Following a single cycle of parasite invasion and maturation to the trophozoite stage, we tested the ability of parasitized RBCs to bind MVECs and monocytes. Compared to parasitized αα/αα RBCs, we found that parasitized -α/αα, -α/-α and -/-α RBCs showed, respectively, 22%, 43% and 63% reductions in binding to MVECs and 13%, 33% and 63% reductions in binding to monocytes. α-Thalassemia was associated with abnormal display of P. falciparum erythrocyte membrane protein 1 (PfEMP1), the parasite's main cytoadherence ligand and virulence factor, on the surface of parasitized RBCs.Parasitized α-thalassemic RBCs show PfEMP1 display abnormalities that are reminiscent of those on the surface of parasitized sickle HbS and HbC RBCs. Our data suggest a model of malaria protection in which α-thalassemia ameliorates the pro-inflammatory effects of cytoadherence. Our findings also raise the possibility that other unstable hemoglobins such as HbE and unpaired α-globin chains (in the case of β-thalassemia) protect against life-threatening malaria by a similar mechanism.
Published: 2012
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33. Assessing health systems in Guinea for prevention and control of priority zoonotic diseases: A One Health approach

Author: Seny Mane, Claire J. Standley, Alpha M. Barry, Ellen P. Carlin, Rebecca Katz, Mamady S. Keita, Lise D. Martel, Lamine Koivogui, Ebi Bile, Erin M. Sorrell, and Aboubacar S. Diakite
Subjects: Resource (biology), 030231 tropical medicine, Capacity building, Disease, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, One Health, Baseline (configuration management), Environmental planning, Government, lcsh:R5-920, Zoonotic disease, Public Health, Environmental and Occupational Health, medicine.disease, Influenza A virus subtype H5N1, 3. Good health, Infectious Diseases, Health systems assessment, Rabies, Guinea, Business, lcsh:Medicine (General), Research Paper
Abstract: To guide One Health capacity building efforts in the Republic of Guinea in the wake of the 2014–2016 Ebola virus disease (EVD) outbreak, we sought to identify and assess the existing systems and structures for zoonotic disease detection and control. We partnered with the government ministries responsible for human, animal, and environmental health to identify a list of zoonotic diseases – rabies, anthrax, brucellosis, viral hemorrhagic fevers, trypanosomiasis and highly pathogenic avian influenza – as the country's top priorities. We used each priority disease as a case study to identify existing processes for prevention, surveillance, diagnosis, laboratory confirmation, reporting and response across the three ministries. Results were used to produce disease-specific systems “maps” emphasizing linkages across the systems, as well as opportunities for improvement. We identified brucellosis as a particularly neglected condition. Past efforts to build avian influenza capabilities, which had degraded substantially in less than a decade, highlighted the challenge of sustainability. We observed a keen interest across sectors to reinvigorate national rabies control, and given the regional and global support for One Health approaches to rabies elimination, rabies could serve as an ideal disease to test incipient One Health coordination mechanisms and procedures. Overall, we identified five major categories of gaps and challenges: (1) Coordination; (2) Training; (3) Infrastructure; (4) Public Awareness; and (5) Research. We developed and prioritized recommendations to address the gaps, estimated the level of resource investment needed, and estimated a timeline for implementation. These prioritized recommendations can be used by the Government of Guinea to plan strategically for future One Health efforts, ideally under the auspices of the national One Health Platform. This work demonstrates an effective methodology for mapping systems and structures for zoonotic diseases, and the benefit of conducting a baseline review of systemic capabilities prior to embarking on capacity building efforts. Keywords: Guinea, One Health, Zoonotic disease, Health systems assessment, Capacity building
Published: 2019

34. Validation of two parent-reported autism spectrum disorders screening tools M-CHAT-R and SCQ in Bamako, Mali

Author: Amadou Toure, Souleymane Coulibaly, K Traoré, Modibo Kouyate, Yaya Ibrahim Coulibaly, Hamza B. Toure, Housseini Dolo, Arouna Togora, Mahamadou Diakite, Modibo Sangare, Adama Karembe, Daniel H. Geschwind, C.O. Guinto, Seydou Doumbia, Seidina A. S. Diakite, and Gordon A. Awandare
Subjects: University of Sciences, AUC, CHU, DNS, ICD-10, International Statistical Classification of Diseases and Related Health Problems-10, Autism, AMALDEME, Malian association for mental deficiencies, M-CHAT-R, Modified checklist for autism in toddlers-Revised, Mali, Negative predictive value, CSCOM, lcsh:RC346-429, AUC, Area under the Curve, 0302 clinical medicine, Positive likelihood, Modified checklist for autism in toddlers-Revised, DNS, National direction of health, PPV, Positive predictive value, 030212 general & internal medicine, Modified checklist for autism in toddlers-Revised/Follow up, CSRef, Pediatric, DRS, Regional direction of health, screening and diagnosis, Malian association for mental deficiencies, Social communication, 4. Education, Autism spectrum disorders, DSM-V, Checklist, 3. Good health, Diagnostic and Statistical Manual of Mental Disorders, Detection, Mental Health, Neurology, Community health, Original Article, FAPH, Faculty of Pharmacy, USTTB, CSCOM, Community health centers, 4.2 Evaluation of markers and technologies, Clinical psychology, Positive predictive value, Area under the Curve, Regional direction of health, Intellectual and Developmental Disabilities (IDD), University hospital centers, Social communication questionnaire, CHU, University hospital centers, FMOS, Context (language use), PPV, Techniques and Technologies of Bamako, ASD, FAPH, National direction of health, NPV, 03 medical and health sciences, LR+, Positive likelihood, ICD-10, Clinical Research, medicine, NPV, Negative predictive value, LR+, Screening tool, District health centers, DSM-V, Diagnostic and Statistical Manual of Mental Disorders, LR-, Negative likelihood, LR, SCQ, Social communication questionnaire, USTTB, University of Sciences, Techniques and Technologies of Bamako, International Statistical Classification of Diseases and Related Health Problems-10, Faculty of Pharmacy, Negative likelihood, lcsh:Neurology. Diseases of the nervous system, National health, business.industry, Prevention, Social environment, M-CHAT-R, Community health centers, CSRef, District health centers, medicine.disease, AMALDEME, Faculty of medicine and odonto-stomatology, Brain Disorders, M-CHAT-R/F, ASD, Autism spectrum disorders, DRS, M-CHAT-R/F, Modified checklist for autism in toddlers-Revised/Follow up, business, SCQ, 030217 neurology & neurosurgery, FMOS, Faculty of medicine and odonto-stomatology
Abstract: Background: Early screening is crucial for early autism spectrum disorders (ASD) diagnosis and intervention. ASD screening tools have mostly been constructed based on the Western cultural context. We hypothesized that their use in Mali may require a prior validation. Objective: To validate the modified checklist for autism in toddlers-Revised (M-CHAT-R) and the social communication questionnaire (SCQ) in the Malian sociocultural context for ASD screening. Study design: We administered M-CHAT-R and SCQ in 947 toddlers aged 16–30 months old at the district and community health centers in Bamako and 120 patients (60 autistic and 60 age and sex matched controls) aged ≥4 years old at the psychiatry department in Bamako. Toddlers at moderate to high risk of ASD underwent M-CHAT-R/F and clinical evaluation by an ASD multidisciplinary team. M-CHAT-R and SCQ were evaluated for cultural appropriateness by Malian anthropologists. The sensitivity, specificity, PPV, NPV were determined for both M-CHAT-R and SCQ. Health professionals have been trained during ASD seminary on how to use M-CHAT-R and SCQ for ASD screening in Bamako. Results: We found for the M-CHAT-R a sensitivity of 50%, a specificity of 100%, a PPV of 100% and a NPV of 87%. The SCQ had a sensitivity of 71%, a specificity of 72%, a PPV of 73% and a NPV of 70%. We have found four out of 20 items on the M-CHAT-R that were culturally inappropriate in the Malian context. Discussion: M-CHAT-R and SCQ can be used for early autism screening in Mali. In the future, we plan to train a descent number of Malian physicians in chief and pediatricians at the district hospitals across the country to integrate the early ASD screening into the national health system. Conclusion: M-CHAT-R has a perfect specificity and SCQ a fair diagnostic accuracy for ASD in Mali. Keywords: M-CHAT-R, SCQ, NPV, PPV, Mali
Published: 2019

35. Hematological Indices in Malian Children Change Significantly During a Malaria Season and with Increasing Age: Implications for Malaria Epidemiological Studies

Author: Kazutoyo Miura, Jennifer M. Anderson, Ababacar Diouf, Mahamadou Diakite, Seidina A. S. Diakite, Abdoul S. Keita, Karim Traore, Saibou Doumbia, Drissa Konaté, Rick M. Fairhurst, Mory Doumbouya, and Carole A. Long
Subjects: Erythrocyte Indices, Male, Rural Population, 0301 basic medicine, medicine.medical_specialty, Anemia, 030231 tropical medicine, Physiology, Parasitemia, Hematocrit, Mali, Cohort Studies, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Virology, White blood cell, Epidemiology, Prevalence, medicine, Humans, Malaria, Falciparum, Child, medicine.diagnostic_test, business.industry, Age Factors, Articles, medicine.disease, Red blood cell, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Child, Preschool, Immunology, Female, Parasitology, Seasons, Hemoglobin, business, Malaria
Abstract: Standard hematological indices are commonly used in malaria epidemiological studies to measure anemia prevalence and calculate blood parasite densities. In Africa, few studies have investigated how these indices change during a malaria transmission season and with increasing age. To address these knowledge gaps, we collected blood from 169 healthy Malian children aged 3-12 years before (May 2010) and after (January 2011) a transmission season. Red blood cell (RBC) count, hemoglobin (Hb) level, hematocrit (Ht), white blood cell (WBC) count, and WBC subsets were measured in paired blood samples, and the data were stratified by month (May, January) and age group (3-5, 6-8, and 9-12 years). From May to January, RBC count (4.53-4.70 × 10(6)/μL; P < 0.0001), Hb level (11.5-11.9 g/dL; P < 0.0001), and Ht (37.1-39.2%; P < 0.0001) increased, and WBC count (6.46-5.96 × 10(3)/μL; P = 0.0006) decreased. From May to January, the prevalence of WBC subsets also changed: 35-43% neutrophils, 6.5-7.6% monocytes, and 53-45% lymphocytes (P < 0.001). These seasonal changes were not associated with the number of malaria episodes experienced in the interim or the presence of RBC polymorphisms. In May, Hb (11.2, 11.4, and 11.8 g/dL; P = 0.0013) and Ht (36.5%, 36.7%, and 38.1%; P = 0.0154) increased and WBC count (8.04, 6.43, and 5.76 × 10(3)/μL; P < 0.0001) decreased with age group; similar differences were observed in January. These data suggest that season- and age-based reference values for hematological indices are needed to better estimate anemia prevalence and parasite density in malaria epidemiological studies.
Published: 2016
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36. Gaia Data Release 2

Author: H. E. Huckle, F. Riclet, R. Buzzi, D. J. Marshall, Deborah Busonero, Michael Davidson, C Boeche, Sergio Messina, F. X. Pineau, G. Jasniewicz, L. Balaguer-Núñez, C. A. L. Bailer-Jones, L. Chaoul, J. L. Halbwachs, D. Teyssier, A. F. Lanza, Alberto Vecchiato, Shay Zucker, Francois Taris, Conny Aerts, L. Pulone, Mario Gai, L. M. Sarro, Frédéric Arenou, Á. L. Juhász, Alessandro Bressan, Joao Alves, Morgan Fouesneau, David Hobbs, Yves Fremat, L. Ruiz-Dern, A. Hutton, Sofia Randich, Gerry Gilmore, D. Garabato, Leanne P. Guy, J. González-Núñez, M. Weiler, H. Steidelmüller, D. de Martino, M. A. Álvarez, Vincenzo Ripepi, G. Gracia-Abril, Uwe Lammers, P. de Laverny, G. Sadowski, Nicolas Mary, Bengt Edvardsson, Laszlo Szabados, Łukasz Wyrzykowski, David Barrado, Alberto Cellino, Damien Ségransan, T Roegiers, Olivier Wertz, A. Recio-Blanco, Sergei A. Klioner, J. Durán, A. Panahi, A. Karampelas, Alex Lobel, J.-L. Bassilana, H. Voss, Sven Zschocke, A. Bombrun, F. De Angeli, Toni Santana-Ros, J. C. Segovia, D. Vicente, S. Blanco-Cuaresma, A. G. Butkevich, M. Riello, Amina Helmi, J. Bakker, J. Souchay, A. Kewley, R Alvarez, Daniel Hestroffer, Sergey E. Koposov, Tsevi Mazeh, Maria Süveges, F. F. Suess, P. Drazinos, B. Holl, H. Ziaeepour, T. Wevems, Eva Sciacca, P. Esquej, A. Gueguen, J. Heu, R. Geyer, J. Fernández-Hernández, E. Licata, Laurent Galluccio, J. Cuypers, Peter G. Jonker, Ummi Abbas, Elena Pancino, Jean Surdej, E. Anglada Varela, Michele Bellazzini, Teresa Antoja, Martin A. Barstow, László Molnár, Isabella Pagano, E. Solano, E. Brugaletta, P. Koubsky, Paolo Tanga, Alberto Krone-Martins, M. Clotet, Nigel Hambly, R. L. Smart, Paolo Giacobbe, Simchon Faigler, G. Giuffrida, Aldo Dell'Oro, Yveline Lebreton, Stefano Bertone, Mario G. Lattanzi, Paul S. Barklem, D. Tapiador, Patrick Charlot, A. H. Andrei, Luciano Nicastro, S. Managau, Lorenzo Rimoldini, Mario Di Martino, Paolo Montegriffo, A. Abreu Aramburu, O. Marchal, Marcella Marconi, K. Janßen, K. Findeisen, Xavier Luri, A. Berihuete, M. Schultheis, P. Di Matteo, R. Mor, C. Barata, A. Mora, W. van Reeven, Mikael Granvik, M. Barros, Carine Babusiaux, A. G. A. Brown, Mark Taylor, Y. Le Fustec, T. Lebzelter, Nami Mowlavi, O. L. Creevey, F. Barblan, Thierry Morel, Timo Prusti, A. Riva, S. Girona, S. Liao, Viktor Votruba, Frédéric Royer, Laurent Chemin, G. Altavilla, A. M. Piersimoni, Davide Massari, Marco Delbo, S. Diakite, V. Valette, N. Bach, H. Lenhardt, André Moitinho, Christophe Barache, S. Galleti, Michał Pawlak, A. Yoldas, Harry Enke, Rosanna Sordo, A. Jean-Antoine-Piccolo, Patrice David, Giacomo Cannizzaro, W. Löffler, J. Torra, Tristan Cantat-Gaudin, Marc Audard, D. Katz, Jose M Hernandez, Gijs Nelemans, S. Ragaini, P. Osborne, D. Terrett, A. J. Falcão, D. L. Harrison, G. Plum, R. G. Mann, Ulrike Heiter, Carla Cacciari, Gal Matijevic, J. M. Petit, A. Titarenko, Despina Hatzidimitriou, Juan Zorec, Angela Bragaglia, Nicholas Rowell, Annie C. Robin, Mario David, Tri L. Astraatmadja, Giovanni Comoretto, F. Julbe, Derek W. Morris, R. Drimmel, F. García-Sedano, A. Dapergolas, L. Noval, Mike Smith, Grigori Fedorets, H. Palacin, L. Bramante, D. Molina, Jesus Salgado, C. Dolding, M. Vaillant, Daniel Michalik, H. I. Siddiqui, Minia Manteiga, P. J. Richards, D. Barbato, A. Fonti, Raphael Guerra, J. J. González-Vidal, E. del Pozo, Mariateresa Crosta, M. Žerjal, F. Torra Clotet, C. Diener, M. Hauser, G. Walmsley, Sonia Nieto, I. Bellas-Velidis, T. Boch, Antonella Vallenari, M. Segol, S. Voutsinas, F. Leroux, A. F. Mulone, Pierre Fernique, Céline Reylé, P. Panuzzo, W. Hofmann, S. Bouquillon, F. Crifo, S. Cowell, Ana Ulla, Benoit Carry, C. Ordenovic, F. Pailler, E. Utrilla, Dimitri Pourbaix, A. Hypki, Stefan Jordan, T. Carlucci, Gráinne Costigan, Alfred Castro-Ginard, C. Fabre, C. Crowley, R. Borrachero, Sébastien Lambert, J. H. J. de Bruijne, D. W. Evans, C. Turon, T. Brüsemeister, F. De Luise, R. Haigron, Carme Jordi, G. Marschalkó, C. von Essen, C. Pagani, Katrien Kolenberg, M. van Leeuwen, N. R. Millar, Gisella Clementini, A. de Torres, Ugo Becciani, S. Marinoni, Geraldine Bourda, A. F. Silva, L. Eyer, Misha Haywood, C. Fabricius, Krzysztof Nienartowicz, Miguel García-Torres, S. Regibo, P. Gavras, Gábor Marton, Elisa Distefano, A. Guerrier, H. E. P. Lindstrøm, N. A. Walton, N. Brouillet, G. Eynard Bontemps, T. A. Lister, F. A. Jansen, Ruth Carballo, Steve Vogt, J. M. Carrasco, G. Mantelet, M. Romero-Gómez, Ramachrisna Teixeira, Kjell Eriksson, A. Kochoska, Johannes Sahlmann, Joakim Klar, R. Gutiérrez-Sánchez, Ilaria Musella, L. Palaversa, Karri Muinonen, J. M. Martín-Fleitas, T. Sagristà Sellés, Marco Castellani, Y. Viala, Laia Casamiquela, R. Messineo, Eduard Masana, R. de Souza, H. Stoev, L. Siltala, B. Frezouls, E. Szegedi-Elek, Tomaz Zwitter, G. Kordopatis, C. Ducourant, Tatiana Muraveva, P. Burgess, J. De Ridder, E. Salguero, A. Burlacu, I-C. Shih, U. Stampa, V. Icardi, Iain A. Steele, Alessandro Sozzetti, M. Kontizas, Roberto Molinaro, F. Solitro, H. E. Delgado, G. Holland, J.-B. Lavigne, Andreas Korn, M. Biermann, E. Fraile, M. Fabrizio, Francesca Figueras, R. Blomme, P. Teyssandier, Elisabetta Caffau, G. Busso, Maroussia Roelens, Maarten A. Breddels, Simon Hodgkin, Luciana Bianchi, Olivier Bienaymé, Silvio Leccia, C. Le Poncin-Lafitte, Morgan Fraser, M. Ramos-Lerate, M. Gomes, N. Cheek, J. Osinde, Jérôme Berthier, Kevin Benson, Christos Siopis, P. Balm, E. Gosset, Yassine Damerdji, Richard I. Anderson, C. Zurbach, Jonas Debosscher, G. Cocozza, William O'Mullane, Andrea Chiavassa, F.E. van Leeuwen, Diego Bossini, Federica Spoto, G. Jevardat de Fombelle, Nicoletta Sanna, J. Guiraud, G. Tauran, K. W. Smith, E. Poujoulet, Mark Cropper, Z. Kostrzewa-Rutkowska, F. Glass, J. Gerssen, Thomas Hilger, C.A. Stephenson, D. Ordóñez-Blanco, Andrej Prsa, M. Sarasso, E. Kontizas, Luciana Federici, Paul J. McMillan, Nicolas Rambaux, Ludovic Delchambre, M. Garcia-Reinaldos, T. Pauwels, M. Farràs Casas, S. Bartholomé Muñoz, E. Livanou, E. Van Hemelryck, Roberto Morbidelli, R. Kohley, A. Garofalo, Jovan Veljanoski, Jon Marchant, Jordi Portell, Ulrich Bastian, M. Lopez, Bernardino Arcay, H. Savietto, Alessandro Spagna, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Carlos Dafonte, Y. Lasne, P. Sartoretti, E. Racero, William Thuillot, A. Gavel, J. Castañeda, Gaetano Valentini, A. Rivard, E. Poggio, N. Garralda, R. De March, S. G. Baker, S. Accart, M. Altmann, F. Filippi, George M. Seabroke, F. Thévenin, A. van Elteren, Emese Plachy, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Guy Rixon, S Uzzi, M Vaschetto, Francois Mignard, E. Antiche, P. M. Marrese, N. Leclerc, Caroline Soubiran, Rene Andrae, A. Delgado, and Rossella Cancelliere
Subjects: Physics, 010504 meteorology & atmospheric sciences, Astronomy, Astronomy and Astrophysics, galaxies: dwarf, Astrophysics, Astrometry, globular clusters: general, 01 natural sciences, Settore FIS/05 - Astronomia e Astrofisica, Space and Planetary Science, 0103 physical sciences, Local Group, astrometry, High Energy Physics, Galaxy: kinematics and dynamics, astrometry, globular clusters: general, galaxies: dwarf, Local Group, errata, addenda, Galaxy: kinematics and dynamics, addenda, 010303 astronomy & astrophysics, Data release, Astrophysique, errata, 0105 earth and related environmental sciences
Abstract: 0, info:eu-repo/semantics/published
Published: 2020
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37. Gaia Data Release 1: catalogue validation

Author: G. Giuffrida, I.-C. Shih, Amina Helmi, Angela Bragaglia, André Moitinho, Nicholas A. Walton, C. Babusiaux, H. Ziaeepour, Alberto Krone-Martins, E. Antiche, Frédéric Arenou, Céline Reylé, F. Figueras, P. M. Marrese, N. Leclerc, Xavier Luri, Caroline Soubiran, Sergi Blanco-Cuaresma, L. Ruiz-Dern, J. Souchay, M. Barros, C. Fabricius, Carme Jordi, Elena Pancino, Antonella Vallenari, Annie C. Robin, Rosine Lallement, Sébastien Lambert, Maarten A. Breddels, S. Soria, M. Romero-Gómez, K. Findeisen, G. Costigan, R. Sordo, J. Heu, Laurent Galluccio, R. Mor, C. Turon, J. M. Carrasco, S. Diakite, Tristan Cantat-Gaudin, Laurent Eyer, C. Barache, P. Sartoretti, Jovan Veljanoski, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Ciènces del Cosmos (ICC), Universitat de Barcelona (UB), Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Systèmes de Référence Temps Espace (SYRTE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Universidade de Lisboa (ULISBOA), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Roma (OAR), M2A 2017, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astrofisico di Arcetri (OAA), INAF - Osservatorio Astronomico di Bologna (OABO), Université de Genève = University of Geneva (UNIGE), Universidade de Lisboa = University of Lisbon (ULISBOA), Universiteit Leiden, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), and Astronomy
Subjects: Cúmuls de galàxies, 010504 meteorology & atmospheric sciences, Astrometria, Computer science, FOS: Physical sciences, Paral·laxi, computer.software_genre, 01 natural sciences, astrometry, parallaxes, proper motions, methods: data analysis, surveys, catalogs, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics, proper motions, surveys, 0103 physical sciences, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Parallax, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Clusters of galaxies, Astronomy and Astrophysics, Astrometry, Galaxies, methods: data analysis, Astrophysics - Astrophysics of Galaxies, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Galàxies, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), parallaxes, astrometry, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Data mining, Astrophysics - Instrumentation and Methods for Astrophysics, Data release, computer, catalogs
Abstract: Before the publication of the Gaia Catalogue, the contents of the first data release have undergone multiple dedicated validation tests. These tests aim at analysing in-depth the Catalogue content to detect anomalies, individual problems in specific objects or in overall statistical properties, either to filter them before the public release, or to describe the different caveats of the release for an optimal exploitation of the data. Dedicated methods using either Gaia internal data, external catalogues or models have been developed for the validation processes. They are testing normal stars as well as various populations like open or globular clusters, double stars, variable stars, quasars. Properties of coverage, accuracy and precision of the data are provided by the numerous tests presented here and jointly analysed to assess the data release content. This independent validation confirms the quality of the published data, Gaia DR1 being the most precise all-sky astrometric and photometric catalogue to-date. However, several limitations in terms of completeness, astrometric and photometric quality are identified and described. Figures describing the relevant properties of the release are shown and the testing activities carried out validating the user interfaces are also described. A particular emphasis is made on the statistical use of the data in scientific exploitation., Comment: 34 pages, 52 figures, 3 tables. Submitted to A&A on Oct. 14 as part of the Gaia DR1 special issue, accepted with minor revisions on Dec. 19
Published: 2017
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38. Fréquence du déficit en glucose-6-phosphate déshydrogénase (A-376/202) dans trois groupes ethniques vivant en zone d’endémie palustre au Mali

Author: Charles Arama, M. Traoré, Mahamadou Diakite, Amadou Tapily, Modibo Daou, Aldiouma Guindo, B. Maiga, B. Sangaré, Seidina A. S. Diakite, Amagana Dolo, and Ogobara K. Doumbo
Subjects: Blood smear, parasitic diseases, Ethnic group, medicine, Physiology, Restriction fragment length polymorphism, Biology, medicine.disease, Malaria, Pathology and Forensic Medicine, Glucose-6-phosphate dehydrogenase deficiency
Abstract: Erythrocyte G6PD deficiency is the most common worldwide enzymopathy. The aim of this study was to determine erythrocyte G6PD deficiency in 3 ethnic groups of Mali and to investigate whether erythrocyte G6PD deficiency was associated to the observed protection against malaria seen in Fulani ethnic group. The study was conducted in two different areas of Mali: in the Sahel region of Mopti where Fulani and Dogon live as sympatric ethnic groups and in the Sudanese savannah area where lives mostly the Malinke ethnic group. The study was conducted in 2007 in Koro and in 2008 in Naguilabougou. It included a total 90 Dogon, 42 Fulani and 80 Malinke ethnic groups. Malaria was diagnosed using microscopic examination after Giemsa-staining of thick and thin blood smear. G6PD deficiency (A-(376/202)) samples were identified using RFLP (Restriction Fragment Length Polymorphism) assay and analysis of PCR-amplified DNA amplicon. G6PD deficiency (A-(376/202)) rate was 11.1%, 2.4%, and 13.3% in Dogon, Fulani, and Malinke ethnic group respectively. Heterozygous state for G6PD (A-(376/202)) was found in 7.8% in Dogon; 2.4% in Fulani and 9.3% in Malinke ethnic groups while hemizygous state was found at the frequency of 2.2% in Dogon and 4% in Malinke. No homozygous state was found in our study population.We conclude that G6PD deficiency is not differing significantly between the three ethnic groups, Fulani, Dogon and Malinke.
Published: 2014
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39. Autism seminary for public engagement: evaluation of knowledge and attitudes of traditional medical practitioners in Mali

Author: Mahamadou Diakite, Gordon A. Awandare, Seydou Doumbia, Arouna Togora, Modibo Sangare, Housseini Dolo, Modibo Kouyate, Bakary Dembele, Amadou Toure, Seidina A. S. Diakite, and Souleymane Coulibaly
Subjects: Recall, 030503 health policy & services, Applied Mathematics, Mindset, Mental illness, medicine.disease, behavioral disciplines and activities, Child development, Social relation, 3. Good health, 03 medical and health sciences, Nonverbal communication, 0302 clinical medicine, mental disorders, medicine, Autism, 030212 general & internal medicine, Public engagement, 0305 other medical science, Psychology, Clinical psychology
Abstract: Background: Autism spectrum disorders (ASD) are stigmatizing in Africa and traditional medical practitioners occupy the first line of diagnosis and treatment due to the cultural perception of ASD, and the scarcity of conventional health services in Mali. We aimed to assess the knowledge, attitudes, and practices (KAP) concerning autism among traditional medical practitioners in Bamako, Mali. Methods: We conducted a 6-week cross-sectional survey following a 1-day autism awareness seminary on September 9th, 2017 in Bamako. A questionnaire was designed to assess the KAP regarding autism. To assess their practices, parents of autistic children were asked about their experiences with traditional medical practitioners. Results: Of the 37 study participants 67.60% were males and 56.8% had not heard about autism before the seminary. After the seminary, 73% claimed to understand the diagnosis criteria of autism, but only 16.2% could recall symptoms from all the three domains (reciprocal social interaction, verbal and nonverbal communication, and stereotyped behaviors/restricted interests) of a child development impaired by autism. Of traditional medical practitioners, 73% believed autism was caused by devils, God’s will, bad luck and divine punishment of maternal misbehavior; 65% were used to treating mental illness, and 78.4% felt traditional healing was the only treatment option in autism. Negative attitudes towards autistic children were present in 18.9%, suggesting a very strong cultural mindset on autism. Conclusion: Knowledge on autism was poor among traditional medical practitioners. A culturally tailored autism public engagement strategy is necessary to positively change the mindset of Malian traditional medical practitioners.
Published: 2019
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40. Plasmodium falciparum Clearance Rates in Response to Artesunate in Malian Children With Malaria: Effect of Acquired Immunity

Author: Seidina A. S. Diakite, Mory Doumbouya, Michael P. Fay, Saibou Doumbia, Tatiana M. Lopera-Mesa, Serena Chiang, Karim Traore, Daouda Ndiaye, Drissa Konaté, Abdoul S. Keita, Mahamadou Diakite, Kasia Stepniewska, Rick M. Fairhurst, Juliana M. Sá, Carole A. Long, Jennifer M. Anderson, and Amir E. Zeituni
Subjects: Male, Erythrocytes, Adolescent, medicine.medical_treatment, Plasmodium falciparum, antimalarial immunity, malaria, Antibodies, Protozoan, Artesunate, Dihydroartemisinin, Parasitemia, Adaptive Immunity, Biology, Mali, Parasite load, Parasite Load, Cohort Studies, Antimalarials, Major Articles and Brief Reports, chemistry.chemical_compound, parasitic diseases, medicine, Humans, Immunology and Allergy, Parasites, Artemether, Malaria, Falciparum, Artemisinin, Child, parasite clearance, Amodiaquine, Infant, biology.organism_classification, medicine.disease, Virology, Artemisinins, Infectious Diseases, artemisinin, chemistry, Child, Preschool, Immunoglobulin G, Immunology, Female, Malaria, medicine.drug
Abstract: Artemisinins rapidly kill all asexual blood stages of Plasmodium falciparum [1], including young ring forms before they sequester in the microvessels of vital organs, and are thus more effective than quinolines in reducing malaria morbidity and mortality [2, 3]. For this reason, artemisinin-based combination therapies (ACTs) are first-line treatments for P. falciparum malaria worldwide [4]. ACTs are the use of artemisinin or one of its derivatives—artesunate, artemether, dihydroartemisinin (DHA)—in combination with a partner drug. DHA, the active metabolite of all artemisinins, has a short half-life (approximately 1–3 hours) in plasma; therefore, partner drugs with longer half-lives (ie, approximately 7–21 days) are needed to eliminate residual parasites [5, 6]. Parasite resistance to nearly every commonly used partner drug is entrenched or emerging in western Cambodia [7]. Reports of artemisinin resistance in western Cambodia [8, 9] and western Thailand [10]—where antimalarial-resistant parasites have previously emerged and spread to Africa [11–13]—are thus extremely worrisome. This phenotype manifests as a slow parasite clearance rate in response to an artemisinin taken orally to treat uncomplicated malaria [14]. Unlike quinoline resistance, artemisinin resistance does not associate with known molecular markers of drug resistance or reduced parasite drug susceptibility in vitro [8, 9, 15]. Slow parasite clearance may be partly defined as a parasite-heritable trait [9, 10, 16] and was recently associated with a major region of the parasite genome [17]. Microsatellite-defined parasite genetics, however, has not been able to account for all the variation in parasite clearance rates in Cambodia and Thailand [9, 10, 16]. Few studies have explored how host factors, such as naturally acquired immunity and red blood cell (RBC) polymorphisms, influence parasite clearance rates in response to artemisinins. A retrospective analysis of 18 699 patients with P. falciparum malaria treated with artemisinins found that parasite clearance was slowest in low-transmission settings and relatively fast in high-transmission settings, suggesting that acquired immunity accelerates parasite clearance [18]. A recent prospective study suggested that hemoglobin (Hb) E is associated with slow parasite clearance rate in Pursat, western Cambodia [9], but the effect of acquired immunity on this parameter is not well defined. This is because, in southeast Asia, age is an inadequate surrogate of immunity to malaria and no in vitro correlate of parasite-clearing immunity has been identified. Few parasite clearance rates have been reported from Africa [19], where ACTs were recently introduced and artemisinin monotherapies have been used for 15 years in some areas [20]. The proposed mechanism of action of artemisinins involves endoperoxide-derived, free radicals that alkylate and oxidize the proteins and lipids of intraerythrocytic parasites [21]. Artemisinin-treated parasites undergo pyknosis rapidly in vivo and are cleared from the bloodstream by “pitting” in the spleen, which returns previously infected, intact RBCs back into circulation (Figure (Figure11A) [22–25]. Although largely determined by the rates of pyknosis and pitting, the parasite clearance rate is nonetheless a complex phenotype produced by a combination of parasite and host factors. Parasite expression of cytoadherence ligands, for example, can determine when late ring-stage parasites sequester in microvessels and disappear from peripheral blood (Figure (Figure11C) [26]. If parasites sequester en masse [26] while parasite clearance is being monitored, parasite densities may decrease markedly by an artemisinin-independent mechanism. Host antibody responses that prevent sequestration and opsonize parasitized RBCs may also accelerate parasite clearance (Figure (Figure11B). Figure 1. Clearance of ring-stage Plasmodium falciparum parasites from peripheral blood during a parasite clearance rate study. Dihydroartemisinin, the active metabolite of all artemisinins, causes ring-stage parasites to undergo pyknosis (A). These circulating ... To obtain baseline surveillance data for the emergence or spread of artemisinin resistance in Africa and to investigate the role of acquired immunity in parasite clearance, we measured parasite clearance rates in response to artesunate in a high transmission area of Mali, where ACTs were introduced only 2 years previously and where children rapidly acquire antimalarial immunity with age.
Published: 2013
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41. A novel cytofluorometric assay for the detection and quantification of glucose-6-phosphate dehydrogenase deficiency

Author: Rick M. Fairhurst, Shivang S. Shah, Seidina A. S. Diakite, Thomas E. Wellems, Mahamadou Diakite, Karim Traore, Dominic P. Kwiatkowski, and Kirk A. Rockett
Subjects: Hemolytic anemia, 0303 health sciences, Multidisciplinary, medicine.diagnostic_test, 030231 tropical medicine, Heterozygote advantage, Dehydrogenase, Jaundice, Biology, medicine.disease, Bioinformatics, Article, Methemoglobin, 3. Good health, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, Immunology, parasitic diseases, medicine, Allelic heterogeneity, medicine.symptom, 030304 developmental biology, Glucose-6-phosphate dehydrogenase deficiency
Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymopathy that affects hundreds of millions of people worldwide, conferring increased risk of neonatal jaundice and oxidant-induced hemolytic anemia. Screening and diagnosis of G6PD deficiency is currently performed using genetic or biochemical assays, the former being cost ineffective in populations with significant allelic heterogeneity, and the latter being limited in ability to detect female heterozygotes. Cytochemical assays can obviate these shortcomings, but at the expense of added technical complexity and labor. We describe here a simple, novel cytofluorometric method that extends the classic methemoglobin reduction test, assessing G6PD deficiency at the level of an individual erythrocyte. In preliminary testing in Malian children, there was strong concordance between our method and established genetic and biochemical techniques. The assay is robust and economical, and could serve as a screening method as well as a research tool, especially for high-throughput applications such as flow cytometry.
Published: 2016
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42. Evaluation du programme de nutrition communautaire dans cinq CSCOM au Mali

Author: Hamadoun Sangho, Y Dagnoko, M Mint Tayeb, M Guindo Traoré, RB Samaké Ba, H. Dembélé Keita, SS Sangho, Kassoum Koné, A. Sidibé Keita, M. Traoré, and Seidina A. S. Diakite
Subjects: Gerontology, Malnutrition, Community health center, business.industry, Environmental health, Community health, medicine, Mosquito net, medicine.disease, business
Abstract: Introduction : notre étude avait pourobjectifde mesurer le niveau de réalisation des activités du programme de nutrition communautaire (PNC) dans les régions de Koulikoro, Ségou et dans le district de Bamako au Mali. Méthodologie : L'évaluation était ex-post. Elle a été réalisée à travers une étude transversale ets'est déroulée en janvier 2009 dans les 5 CSCOM du programme (Monimpébougou, Faraba, Sébénikoro, NiamakoroI et II). Les entretiens à l'aide d'un questionnaireont été réalisés auprès de 225 femmes enceintes et 225 mères d'enfants de moins de 5 ans. La saisie et l'analyse des données ont été faites avecle logiciel Epi 6. Nous avons fait une analyse uni variée des variables.. Résultats : L'évaluation a montré que le programme a formé 166 relais communautaires au dépistage de la malnutrition aiguë, 15 agents de santé à la prise en charge de la malnutrition aiguë ; a doté tous les relais en vélo, tous les CSCom en kit de démonstration nutritionnelle et en motos; toutes les Associations de Santé Communautaire ont reçu un moulin dans le but de soutenir les activités de nutrition. Parmi les femmes enceintes enquêtées, 80,9% dormaient sous une moustiquaire imprégnée ; 64,9% ont pris du Fer Acide Folique (FAF) ; 59,1% ont pris de la SulfadoxinePyriméthamine. Parmi les mères d'enfants de moins de 5 ans enquêtées, 86% ont affirmé que l'enfant a pris de la vitamine A; 73,8% ont pris du FAF après l'accouchement et 71,6% des enfants ont été exclusivement allaités au sein jusqu'à 6 mois. Conclusion : Le PNC a amélioré lesindicateurs des centres. Son accompagnement par la communauté sera un atout pour la pérennité.
Published: 2011
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43. Prevalence of maternal and placental malaria and of neonatal low birth weight in a semi-urban area of Bamako (Mali)

Author: Sory Ibrahim Diawara, Drissa Konaté, Mahamadou Diakite, Karim Traore, Anatole Tounkara, Seydou Doumbia, Mory Doumbia, Saibou Doumbia, Aminata Famanta, Seidina A. S. Diakite, Abdoul S. Keita, Sekou F. Traore, and Daouda Thiéro
Subjects: Adult, Pediatrics, medicine.medical_specialty, Placenta Diseases, Adolescent, Cross-sectional study, Birth weight, Population, Context (language use), Mali, Congenital malaria, Pregnancy, parasitic diseases, Prevalence, medicine, Humans, Child, education, education.field_of_study, business.industry, Infant, Newborn, Urban Health, Public Health, Environmental and Occupational Health, Infant, Low Birth Weight, Middle Aged, medicine.disease, Malaria, Low birth weight, Cross-Sectional Studies, Pregnancy Complications, Parasitic, Female, medicine.symptom, business
Abstract: In 2006, the Malian government established a program for free insecticide-treated net (ITNs) distribution during antenatal care visit (ANC) and intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) for pregnant women. In March to November of 2009, we conducted a cross-sectional study in peri-urban areas of Bamako, Mali to determine the malaria prevalence among pregnant women and their newborn children in the context of this policy. We included 379 pregnant women aged 15 to 45 years. At delivery, malaria was diagnosed using peripheral thick smears in mothers and newborns, as well as umbilical cord blood and placental blood. The prevalence of Plasmodium falciparum malaria was 2.4, 1.6 and 0.5% respectively in mother, placenta and cord samples; we observed a low birth weight rate of 12.1%. Approximately 77% of our parturient were housewives. The illiteracy rate among this group was 72.3%. Of the 379 women, 73% had at least three prenatal visits, 83% had received at least one free ITNs and 72% had received IPTp-SP during antenatal visit. Among them, 81% claimed to have complied with IPTp-SP. No congenital malaria was found. The prevalence of malaria in both mother and newborn has show a significant decrease in Bamako, compared with previous studies before the implementation of IPTp-SP policy in Mali. A high rate of coverage and use of IPTp-SP and ITNs correlate with lower malaria prevalence in pregnant women.
Published: 2011
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44. Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method

Author: Camille Roussel, Seidina A. S. Diakite, Pascal Amireault, Papa Alioune Ndour, Julien Duez, John P. Holleran, Vicky M. Avery, Pierre Buffet, C. Pionneau, Mickael Dussiot, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), HRA Pharma Laboratoires Paris, Bill and Melinda Gates Foundation [OPP1043892], Laboratory of excellence GR-Ex, Paris, France, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Erythrocyte Indices, Plasmodium, Blood transfusion, Erythrocytes, medicine.medical_treatment, Clinical Biochemistry, Blood preservation, Drug Evaluation, Preclinical, Erythrocytes, Abnormal, Spleen, Biology, Parasitemia, Microsphere, law.invention, Antimalarials, law, Biomimetics, Erythrocyte Deformability, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Erythrocyte deformability, Humans, Blood Transfusion, Deformability, Filtration, Transfusion, Biochemistry (medical), hemic and immune systems, Hematology, Equipment Design, Erythrocyte Aging, Microspheres, 3. Good health, Malaria, Erythrocyte, medicine.anatomical_structure, Blood Preservation, Blood circulation, Immunology, Applications, circulatory and respiratory physiology, Clearance
Abstract: International audience; During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.
Published: 2015
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45. Prévalence et éléments pronostiques de la dissection aortique en phase aigue et dans notre contexte

Author: Ibrahim Sangaré, N Sidibé, I. B. Diall, HO Bâ, S Coulibaly, K. M. Sanogo, S Diakite, I Minta, and Ba Diallo
Subjects: Constant factor, Aortic dissection, medicine.medical_specialty, business.industry, General surgery, Medicine, Retrospective cohort study, Disease, University hospital, business, medicine.disease, Oral contraception
Abstract: Les auteurs rapportent les résultats d'une étude rétrospective portant sur 6 cas de dissection aortique hospitalisés en phase aigue entre Février 2008 et Juillet 2010 dans le service de cardiologie du Centre Hospitalier Universitaire du Point G à Bamako au Mali. L'objectif était à partir de cette série de dégager la prévalence et les éléments pronostiques de la maladie en phase aigue. L'échographie transthoracique et la tomodensitométrie thoracique ont permis de faire le diagnostic de la maladie. L'Hypertension artérielle (HTA) était le facteur étiologique constant dans la série. Le tabac et la contraception orale étaient en plus retrouvés respectivement chez 3 et 1 patients. Chez tous les patients le traitement restera médical faute de plateau technique pour la chirurgie. L'évolution a été favorable dans seulement 2 cas, les 4 autres décéderont dans un tableau de rupture.
Published: 2011
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46. Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C

Author: Michael P. Fay, Nicholas J. White, Gyan Joshi, Seidina A. S. Diakite, Michael Krause, Mahamadou Diakite, Jeanette T. Beaudry, and Rick M. Fairhurst
Subjects: Epidemiology, Hemoglobin, Sickle, lcsh:Medicine, Mali, Pediatrics, Pathogenesis, Animal Cells, Red Blood Cells, Medicine and Health Sciences, Malaria, Falciparum, lcsh:Science, Child, Protozoans, Multidisciplinary, Hemoglobin C, Malarial Parasites, Hemoglobin A, Hematology, Phenotype, Infectious Diseases, Child, Preschool, Alpha-Thalassemia, Biological Assay, Cellular Types, Genetic Dominance, Research Article, Adolescent, Plasmodium falciparum, Biology, Infectious Disease Epidemiology, Autosomal Recessive Diseases, Immunity, parasitic diseases, medicine, Cell Adhesion, Genetics, Parasitic Diseases, Animals, Humans, Parasites, Pediatric Hematology, Sickle Cell Disease, Blood Cells, Protozoan Infections, Population Biology, lcsh:R, Organisms, Endothelial Cells, Infant, Biology and Life Sciences, Heterozygote advantage, Cell Biology, medicine.disease, biology.organism_classification, Tropical Diseases, Parasitic Protozoans, Malaria, Hemoglobinopathies, Immunology, Microvessels, lcsh:Q, Hemoglobin, Ex vivo
Abstract: Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to microvascular endothelial cells (MVECs) and impairing their activation of MVECs to produce pathological responses. Therefore, we hypothesized that parasites causing malaria in HbAS or HbAC heterozygotes have overcome this protective mechanism by expressing PfEMP1 variants which mediate relatively strong binding to MVECs. To test this hypothesis, we performed 31 cytoadherence comparisons between parasites from HbAA and HbAS (or HbAC) Malian children with malaria. Ring-stage parasites from HbAA and HbAS (or HbAC) children were cultivated to trophozoites, purified, and then inoculated in parallel into the same wildtype uninfected RBCs. After one cycle of invasion and maturation to the trophozoite stage expressing PfEMP1, parasite strains were compared for binding to MVECs. In this assay, there were no significant differences in the binding of parasites from HbAS and HbAC children to MVECs compared to those from HbAA children (HbAS, fold-change = 1.46, 95% CI 0.97-2.19, p = 0.07; HbAC, fold-change = 1.19, 95% CI 0.77-1.84, p = 0.43). These data suggest that in-vitro reductions in cytoadherence by HbS and HbC may not be selecting for expression of high-avidity PfEMP1 variants in vivo. Future studies that identify PfEMP1 domains or amino-acid motifs which are selectively expressed in parasites from HbAS children may provide further insights into the mechanism of malaria protection by the sickle-cell trait.
Published: 2014

47. Abdominal Surgical Complications Of Intestinal Parasites: A Review Of 13 Cases From Conakry Ignace D

Author: A Keita, A Toure, S Diakite, FB Toure, D Nabe, and LT Soumaoro
Subjects: medicine.medical_specialty, business.industry, Medicine, business, Surgery
Published: 2013
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48. Profil clinico-bactériologique de l’infection urinaire dans un service de réanimation pédiatrique

Author: D.D. Batouche, S. Diakite, A. Negadi, Kheir Eddine Kerboua, Z. Mentouri, and L. Sadaoui
Subjects: 03 medical and health sciences, 0302 clinical medicine, Nephrology, 030225 pediatrics
Abstract: Introduction L’infection urinaire (IU), relativement frequente chez l’enfant, presente une symptomatologie d’autant plus atypique quand l’enfant est plus jeune et hospitalise en milieu de reanimation. L’objectif principal etait d’etudier le profil bacterio-clinique de l’infection urinaire dans le service de reanimation pediatrique du CHU d’Oran. Patients et methodes L’etude prospective de fevrier 2014–avril 2014 prend en compte les patients hospitalises en reanimation, sondes a l’admission au niveau du service de la reanimation pediatrique. La positivite d’un ECBU a ete basee sur les criteres de Kaas qui exigent la presence de leucocytes avec un nombre superieur ou egal a 10 elements/mL et une bacteriurie superieure a 10 germes/mL avec la presence d’une seule espece bacterienne. Criteres d’exclusion : les patients deja sondes avant l’admission. Resultats Quatre-vingt-douze admissions pour detresses vitales variees, la frequence de l’infection urinaire nosocomiale etait estimee a 6,52 % avec une nette predominance feminine. L’âge moyen des enfants etait de 46,54 mois avec des extremes (2 jours et 11 ans). La clinique etait tres polymorphe en rapport avec le tableau clinique a l’admission, la fievre etait presente chez 77 % des patients. Seize pourcent des patients etaient ventiles. A l’examen cytobacteriologiques, les germes rencontres par ordre decroissant etaient : le candida sp, le streptococcus sp, et Acinetobacter baumanni. Apres traitement, l’evolution a court terme etait favorable ou une recidive a ete notee dans un cas. Tous les patients avaient une fonction renale normale. Discussion La fievre chez l’enfant admis n’est pas specifique a l’infection urinaire, car il s’agit de patient, intube, ventile, porteur de plusieurs catheters, et polymedicamenteux. Le candida sp est de loin le germe le plus frequent dans notre etude, suivent ensuite le streptococcus sp, le streptococcus et l’acinetobacter baumanni. Dans la majorite des etudes, l’E. Coli domine le profil bacteriologique de l’IU aussi bien chez l’enfant que chez l’adulte, avec des pourcentages allant de 33 a 87 % selon les etudes [1] . Conclusion Notre etude a permis d’approcher de facon globale cette pathologie qui touche essentiellement les nourrissons et les jeunes enfants chez qui le diagnostic reste difficile vue la non-specificite des signes cliniques.
Published: 2016
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49. Plasma Uric Acid Levels Correlate with Inflammation and Disease Severity in Malian Children with Plasmodium falciparum Malaria

Author: Neida K. Mita-Mendoza, Alan T. Remaley, Mory Doumbouya, Michael P. Fay, Karim Traore, Tatiana M. Lopera-Mesa, Ana Rodriguez, Saibou Doumbia, Seidina A. S. Diakite, Drissa Konaté, Diana L. van de Hoef, Carole A. Long, Rick M. Fairhurst, Jennifer M. Anderson, Mahamadou Diakite, and Wenjuan Gu
Subjects: Adolescent, Epidemiology, lcsh:Medicine, Inflammation, Pathogenesis, Mali, Microbiology, Severity of Illness Index, Infectious Disease Epidemiology, Proinflammatory cytokine, chemistry.chemical_compound, Blood plasma, medicine, Parasitic Diseases, Humans, Malaria, Falciparum, lcsh:Science, Xanthine oxidase, Child, Biology, Creatinine, Multidisciplinary, biology, Population Biology, lcsh:R, Child Health, Plasmodium falciparum, Vectors and Hosts, biology.organism_classification, Malaria, Uric Acid, Host-Pathogen Interaction, Plasmodium Falciparum, Infectious Diseases, chemistry, Cerebral Malaria, Child, Preschool, Immunology, Uric acid, Medicine, Cytokines, lcsh:Q, Public Health, medicine.symptom, Inflammation Mediators, Research Article
Abstract: Background Plasmodium falciparum elicits host inflammatory responses that cause the symptoms and severe manifestations of malaria. One proposed mechanism involves formation of immunostimulatory uric acid (UA) precipitates, which are released from sequestered schizonts into microvessels. Another involves hypoxanthine and xanthine, which accumulate in parasitized red blood cells (RBCs) and may be converted by plasma xanthine oxidase to UA at schizont rupture. These two forms of ‘parasite-derived’ UA stimulate immune cells to produce inflammatory cytokines in vitro. Methods and Findings We measured plasma levels of soluble UA and inflammatory cytokines and chemokines (IL-6, IL-10, sTNFRII, MCP-1, IL-8, TNFα, IP-10, IFNγ, GM-CSF, IL-1β) in 470 Malian children presenting with uncomplicated malaria (UM), non-cerebral severe malaria (NCSM) or cerebral malaria (CM). UA levels were elevated in children with NCSM (median 5.74 mg/dl, 1.21-fold increase, 95% CI 1.09–1.35, n = 23, p = 0.0007) and CM (median 5.69 mg/dl, 1.19-fold increase, 95% CI 0.97–1.41, n = 9, p = 0.0890) compared to those with UM (median 4.60 mg/dl, n = 438). In children with UM, parasite density and plasma creatinine levels correlated with UA levels. These UA levels correlated with the levels of seven cytokines [IL-6 (r = 0.259, p
Published: 2012

50. [Causes, signs and outcome of 30 patients with pulmonary embolus]

Author: Ib, Diall, S, Coulibaly, I, Minta, Ho, Ba, M, Diakite, N, Sidibe, I, Sangare, S, Diakite, K, Sanogo, and Ba, Diallo
Subjects: Adult, Aged, 80 and over, Male, Middle Aged, Mali, Fibrin Fibrinogen Degradation Products, Electrocardiography, Echocardiography, Humans, Female, Prospective Studies, Pulmonary Embolism, Aged, Retrospective Studies
Abstract: Authors studied 30 cases of pulmonary emboli in BAMAKO in the departments of Cardiology at Point G hospital. The purpose of this work was to determine the pulmonary emboli's frequency, their signs and symptoms and to observe their outcome. Was eligible to study every patient hospitalised for pulmonary emboli confirmed by clinical signs and D- dimere test, with ECG and echocardiogram in most cases. The pulmonary emboli' frequency was 1,7%, with an average age of 51 years ± 16,9. Among causes the most frequent were hypertension (50%), phlebitis (40%), chronic cor pulmonale (30%), and heart failure (40%). Signs were respiratory distress (80%), haemoptysis (43%), syncope (20%), and circulatory collapse (15%). ECG show mostly right ventricular hypertrophy (93,3%) and x ray sometimes a characteristic aspect. Cardiac echography show essentially ventricular and auricular dilatation with a thrombus in 6,7% of the cases. The treatment was by heparin, AVK and analgesic. Mortality in study was 11, 3 %. So pulmonary embolus is always at high risk and sometimes it's diagnostic is difficult.
Published: 2012

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