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The superadiabatic dynamical density functional theory (superadiabatic-DDFT) is a promising new method for the study of colloidal systems out-of-equilibrium. Within this approach, the viscous forces arising from interparticle interactions are accounted for in a natural way by explicitly treating the dynamics of the two-body correlations. For bulk systems subject to spatially homogeneous shear, we use the superadiabatic-DDFT framework to calculate the steady-state pair distribution function and the corresponding viscosity for low values of the shear-rate. We then consider a variant of the central approximation underlying this superadiabatic theory and obtain an inhomogeneous generalization of a rheological bulk theory due to Russel and Gast. This paper thus establishes for the first time a connection between DDFT approaches, formulated to treat inhomogeneous systems, and existing work addressing nonequilibrium microstructure and rheology in bulk colloidal suspensions. [ABSTRACT FROM AUTHOR]

Layered franckeite is a natural superlattice composed of two alternating layers of different compositions, SnS 2 - and PbS-like. This creates incommensurability between the two species along the planes of the layers, resulting in spontaneous symmetry-break periodic ripples in the a-axis orientation. Nevertheless, natural franckeite heterostructure has shown potential for optoelectronic applications mostly because it is a semiconductor with 0.7 eV bandgap, air-stable, and can be easily exfoliated down to ultrathin thicknesses. Here, we demonstrate that few-layer franckeite shows a highly anisotropic nonlinear optical response due to its lattice structure, which allows for the identification of the ripple axis. Moreover, we find that the highly anisotropic third-harmonic emission strongly varies with material thickness. These features are further corroborated by a theoretical nonlinear susceptibility model and the nonlinear transfer matrix method. Overall, our findings help to understand this material and propose a characterization method that could be used in other layered materials and heterostructures to assign their characteristic axes. [ABSTRACT FROM AUTHOR]

Electrospinning is a cost-effective but very intricate method of producing polymeric nanofibers at room temperature. Unfortunately however, it is extremely difficult to predict the diameter or other properties of the fibers produced via electrospinning a prior. In this paper, we present a new approach to simulate fiber formation during electrospinning. Our work builds on the mathematical framework that was originally developed by Reneker and Yarin in 2000. Our approach incorporates the 3D electrostatic field that surrounds the fiber in a Lagrangian discrete particle tracking algorithm that tracks the trajectory of the fiber in air and predicts its deposition velocity and diameter. We investigate the effects of electrostatic field spatial variation on fiber electrospinning and compare our results with those obtained using a constant electrostatic field, the traditional approach, and with experiments (conducted using polyurethane). We considered three different electrospinning configurations of single-needle-plate-collector, single-needle-drum-collector, and two-needles-drum-collector to investigate how different electrostatic fields impact fiber formation. The computational model developed in this work helps to advance the current state of the art in modeling the electrospinning process. [ABSTRACT FROM AUTHOR]

We have developed and implemented an implicit electrolyte model in the Vienna Ab initio Simulation Package (VASP) that includes nonlinear dielectric and ionic responses as well as a nonlocal definition of the cavities defining the spatial regions where these responses can occur. The implementation into the existing VASPsol code is numerically efficient and exhibits robust convergence, requiring computational effort only slightly higher than the original linear polarizable continuum model. The nonlinear + nonlocal model is able to reproduce the characteristic "double hump" shape observed experimentally for the differential capacitance of an electrified metal interface while preventing "leakage" of the electrolyte into regions of space too small to contain a single water molecule or solvated ion. The model also gives a reasonable prediction of molecular solvation free energies as well as the self-ionization free energy of water and the absolute electron chemical potential of the standard hydrogen electrode. All of this, combined with the additional ability to run constant potential density functional theory calculations, should enable the routine computation of activation barriers for electrocatalytic processes. [ABSTRACT FROM AUTHOR]

It has been assumed that the negative divergence of all stress tensors in common use yields the same force. This work finds that this is untrue, and, in fact, can vary wildly. We demonstrate this for the hydrogen atom, the one-particle isotropic harmonic oscillator, and a particle in an infinite spherical well where the exact density, pair-density, and the first order reduced density matrix are known for ground and excited states without any approximation. The Ehrenfest stress-tensor is introduced as any stress-tensor whose negative divergence will yield the corresponding Ehrenfest force for the same system when the exact wave-function is utilized. Stress-tensors within the literature are examined to show those that are Ehrenfest stress-tensors. Those that differ are demonstrated by how they differ within an exact formulation. The proof that the negative divergence of an Ehrenfest stress-tensor yields the Ehrenfest force is summarized. [ABSTRACT FROM AUTHOR]

Pointed magnetic elements are introduced as an improvement upon rectangular strips currently employed in composite element magnetic barcodes. The coercivity of these elements, as measured using the magneto-optic Kerr effect, is found to strictly adhere to a single power law relationship with the element width, where the power law exponent is dependent on the length of the pointed region and takes values between − 0.98 and − 0.91. The steeper gradients here, along with the absence of the crossover region seen in rectangular devices, present these structures as a strict improvement in terms of potential device applications. These improvements are found to be present for all structures where the pointed region is as long as, or longer than, the magnetic element is wide. The remanent magnetization configuration, imaged using photo-emission microscopy with contrast from x-ray magnetic circular dichroism (XMCD-PEEM), is compared to the results of micromagnetic simulations. It is found to cant inward in the pointed section of the strip, aligning with the edges of the point, pinning the magnetization and giving a consistent magnetization reversal behavior for all element widths investigated. [ABSTRACT FROM AUTHOR]

The fracture response of geologic materials is of interest for applications, including geothermal energy harnessing and containment of underground explosions. To better understand the explosively induced fracture response of geomaterials, polymethyl methacrylate (PMMA) was used as a transparent rock surrogate to allow imaging of internal shock propagation and fracture growth processes. Experiments were conducted using high-speed shadowgraphy and photon Doppler velocimetry (PDV), which were compared to numerical simulations. Experiments measured fractures produced in 304.8 mm × 304.8 mm × 304.8 mm PMMA cubes with two simultaneously initiated detonators. The cubes were subjected to varying amounts and directions of externally applied uniaxial stresses, including no stress, 2 MPa stress, and 20 MPa stress. The fracture radius as a function of time was extracted from the high-speed videos. Post-test images of the PMMA cubes aided in the determination of three-dimensional effects not directly imaged by the cameras. The surface velocity history and the shock response captured in PDV and the high-speed videos were compared to the simulated explosive-induced shock response. The simulation results indicate that the shock drives the fracture for the first 20 μ s corresponding to a fracture radius of approximately 15 mm in the experiments. The gas-driven fracture extent was estimated analytically using an equilibrium stress distribution calculated after the shock wave propagation through the sample. Reduction in the gas pressure due to the leakage of the explosive products through the crack as a function of time was accounted for. The estimated fracture lengths were in agreement with the experimentally observed fracture lengths. [ABSTRACT FROM AUTHOR]

The IR spectra of CDF3 in the solid Ar and N2 matrices were measured and analyzed in the region of the Fermi polyads 2ν4/ν1/2ν2/ν4 + ν5, complicated by a close Fermi resonance ν4/ν3 + ν6. The symmetry lifting effect, observed in the N2 matrix, was found helpful for an accurate assignment of the individual components. The anharmonic calculation of the potential energy surface and the dipole moment function was performed on the MP2/aug-cc-pVTZ level. The unperturbed values of vibrational eigenstates were determined in the region of ν1 (CD stretching vibration) in both matrices. The experimental findings and theoretical analysis are in good agreement. [ABSTRACT FROM AUTHOR]

In the healthcare domain, the essential task is to understand and classify diseases affecting the vocal folds (VFs). The accurate identification of VF disease is the key issue in this domain. Integrating VF segmentation and disease classification into a single system is challenging but important for precise diagnostics. Our study addresses this challenge by combining VF illness categorization and VF segmentation into a single integrated system. We utilized two effective ensemble machine learning methods: ensemble EfficientNetV2L-LGBM and ensemble UNet-BiGRU. We utilized the EfficientNetV2L-LGBM model for classification, achieving a training accuracy of 98.88%, validation accuracy of 97.73%, and test accuracy of 97.88%. These exceptional outcomes highlight the system's ability to classify different VF illnesses precisely. In addition, we utilized the UNet-BiGRU model for segmentation, which attained a training accuracy of 92.55%, a validation accuracy of 89.87%, and a significant test accuracy of 91.47%. In the segmentation task, we examined some methods to improve our ability to divide data into segments, resulting in a testing accuracy score of 91.99% and an Intersection over Union (IOU) of 87.46%. These measures demonstrate skill of the model in accurately defining and separating VF. Our system's classification and segmentation results confirm its capacity to effectively identify and segment VF disorders, representing a significant advancement in enhancing diagnostic accuracy and healthcare in this specialized field. This study emphasizes the potential of machine learning to transform the medical field's capacity to categorize VF and segment VF, providing clinicians with a vital instrument to mitigate the profound impact of the condition. Implementing this innovative approach is expected to enhance medical procedures and provide a sense of optimism to those globally affected by VF disease. [ABSTRACT FROM AUTHOR]

Superadiabatic dynamical density functional theory (superadiabatic-DDFT), a first-principles approach based on inhomogeneous two-body correlation functions, is employed to investigate the response of interacting Brownian particles to time-dependent external driving. Predictions for the superadiabatic dynamics of the one-body density are made directly from the underlying interparticle interactions without the need for either adjustable fit parameters or simulation input. The external potentials we investigate have been chosen to probe distinct aspects of structural relaxation in dense, strongly interacting liquid states. Nonequilibrium density profiles predicted by the superadiabatic theory are compared with those obtained from both adiabatic DDFT and event-driven Brownian dynamics simulation. Our findings show that superadiabatic-DDFT accurately predicts the time-evolution of the one-body density. [ABSTRACT FROM AUTHOR]

We present magnetic characterization, charge resistivity, and optical photoluminescence measurements on amorphous yttrium iron oxide thin films (a -Y–Fe–O), with supporting comparisons to amorphous germanium (a -Ge) films. We measured magnetic properties with both SQUID magnetometry and polarized neutron reflectometry. These results not only confirm that a -Y–Fe–O is a disordered magnetic material with strong predominantly antiferromagnetic exchange interactions and a high degree of frustration, but also that it is best understood electrically as a disordered semiconductor. As with amorphous germanium, a -Y–Fe–O obeys expectations for variable-range hopping through localized electron states over a wide range of temperature. We also clarify the consequences of charge transport through such a semiconducting medium for non-local voltage measurements intended to probe spin transport in nominally insulating magnetic materials. We further compare non-local resistance measurements made with "quasi-dc" automated current reversal to ac measurements made with a lock-in amplifier. These show that the "quasi-dc" measurement has an effective ac current excitation with frequency up to approximately 22 Hz, and that this effective ac excitation can cause artifacts in these measurements including incorrect sign of the non-local resistance. This comprehensive investigation of non-local resistance measurements in a -Y–Fe–O shows no evidence of spin transport on micrometer length scales, which is contrary to our original work, and in line with more recent investigations by other groups. [ABSTRACT FROM AUTHOR]

Background: Obsessive-compulsive disorder (OCD) is a highly prevalent neuropsychiatric disorder. Recently, there has been a growing interest in investigating the association between pro-inflammatory cytokines and the pathogenesis of OCD. However, studies targeting interleukin-1β (IL-1β) and interleukin-6 (IL-6) in OCD are limited. Therefore, the present study aimed to explore the potential role of pro-inflammatory cytokines IL-1β and IL-6 in the pathophysiology and development of OCD. Methods: This study recruited 58 OCD patients and 30 age-sex-matched healthy controls (HCs). A qualified psychiatrist diagnosed OCD patients and assessed HCs based on the Diagnostic and Statistical Manual for Mental Health Disorders, 5th edition (DSM-5) criteria. We measured the severity of OCD using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Serum IL-1β and IL-6 levels were measured using ELISA kits following the appropriate methods. Results: The results showed that serum IL-1β levels were significantly elevated in OCD patients compared to HCs (23.68±1.65 pg/ml vs. 15.75±1.02 pg/ml; p = 0.002). Similarly, OCD patients exhibited significantly higher serum IL-6 levels than HCs (44.97±0.73 pg/ml vs. 37.04±0.35 pg/ml; p<0.001). We observed both cytokines were positively correlated with the Y-BOCS scores in OCD patients (IL-1β: r = 0.380, p = 0.015; IL-6: r = 0.324, p = 0.026) which indicates their role in disease pathophysiology. Conclusion: These results suggest that serum IL-1β and IL-6 levels may be associated with the pathophysiology of OCD. Also, these cytokines levels in blood samples can serve as early risk assessment tools for the development of OCD. We recommend further studies in a large and homogeneous population to support these findings. [ABSTRACT FROM AUTHOR]

Background: Generalized anxiety disorder (GAD) is a devastating mental health condition characterized by constant, uncontrolled worrying. Recent hypotheses indicate that pro-inflammatory cytokines and chemokines are potential contributors to the pathogenesis of GAD. Here, we aimed to assess the role of interleukin-2 (IL-2) and interleukin-10 (IL-10) in the pathophysiology and development of GAD. Methods: This study recruited 50 GAD patients diagnosed according to the DSM-5 criteria and 38 age-sex-matched healthy controls (HCs). A qualified psychiatrist evaluated all study subjects. The socio-demographic and clinical characteristics of the study population were determined using pre-structured questionnaires or interviews, and cytokine serum levels were estimated using commercially available ELISA kits. Results: We observed reduced serum IL-10 levels in GAD patients compared to HCs (33.69 ± 1.37 pg/ml vs. 44.12 ± 3.16 pg/ml). Also, we observed a significant negative correlation between altered IL-10 levels and GAD-7 scores (r=-0.315, p = 0.039). Moreover, IL-10 serum measurement exhibited good predictive value in receiver operating characteristics (ROC) analysis with an area under the curve (AUC) value of 0.793 (p < 0.001) with 80.65% sensitivity and 62.79% specificity at a cutoff value of 33.93 pg/ml. Conversely, we noticed elevated serum IL-2 levels in GAD patients than in HCs (14.81 ± 2.88 pg/ml vs. 8.08 ± 1.1 pg/ml); however, it failed to maintain any significant association with GAD-7 scores, implying that IL-2 might not be involved in GAD pathogenesis. The lower AUC value (0.640; p > 0.05) exhibited by IL-2 serum measurement in ROC analysis further supported that IL-2 might not be associated with GAD. Conclusion: This study provides new insights into the complex interplay between anti-inflammatory cytokines and GAD pathogenesis. Based on the present findings, we can assume that IL-10 but not IL-2 may be associated with the pathophysiology and development of GAD. However, further research with a larger population size and longitudinal design is required to confirm the potential diagnostic efficacy of IL-10. [ABSTRACT FROM AUTHOR]

Background: Major depressive disorder (MDD) is a common and debilitating mental illness characterized by persistent feelings of sadness, hopelessness, and a lack of interest in daily activities. The objective of this study was to investigate whether levels of macrophage inflammatory protein-1β (MIP-1β) and macrophage chemoattractant protein-2 (MCP-2) in the blood were associated with the pathophysiology and development of MDD compared to healthy controls (HCs). Methods: This case-control study was conducted involving 50 MDD patients and 38 HCs. We performed a comprehensive assessment to match age, sex, BMI, and socio-demographic profile between the groups. The study excluded participants with chronic infection, inflammatory diseases, coexisting psychiatric disorder, history of liver and kidney diseases, and individuals who are under antipsychotic medications. A professional psychiatrist diagnosed MDD patients and evaluated HCs based on the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) criteria. The severity of depression was assessed using the Hamilton Depression (Ham-D) rating scale. Commercially available enzyme-linked immunosorbent assay (ELISA) kits were used to quantify the serum MIP-1β and MCP-2 levels. Results: The results indicated elevated serum MIP-1β levels (207.73±24.24 pg/ml) in MDD patients compared to HCs (58.77±9.14 pg/ml). This difference in concentration is positively correlated with severity of disease symptoms (r = 0.451; p<0.001). Similarly, the levels of MCP-2 were found to be elevated in patients compared to controls (143.61±19.92 vs. 56.84±4.02 pg/ml; p = 0.003), with a positive correlation with the Ham-D scores (r = 0.373; p = 0.004). Conclusion: According to this study, elevated levels of MIP-1β and MCP-2 may be associated with the pathophysiology and development of MDD. These increased serum MIP-1β and MCP-2 levels could be used as risk assessment tools for MDD. The present findings urge further research and the development of therapeutic and diagnostic approaches for depression. [ABSTRACT FROM AUTHOR]

The role of macrophages in regulating the tumor microenvironment has spurned the exponential generation of nanoparticle targeting technologies. With the large amount of literature and the speed at which it is generated it is difficult to remain current with the most up-to-date literature. In this study we performed a topic modeling analysis of 854 abstracts of peer-reviewed literature for the most common usages of nanoparticle targeting of tumor associated macrophages (TAMs) in solid tumors. The data spans 20 years of literature, providing a broad perspective of the nanoparticle strategies. Our topic model found 6 distinct topics: Immune and TAMs, Nanoparticles, Imaging, Gene Delivery and Exosomes, Vaccines, and Multi-modal Therapies. We also found distinct nanoparticle usage, tumor types, and therapeutic trends across these topics. Moreover, we established that the topic model could be used to assign new papers into the existing topics, thereby creating a Living Review. This type of "birds-eye-view" analysis provides a useful assessment tool for exploring new and emerging themes within a large field. [ABSTRACT FROM AUTHOR]

Asymmetric deformation density analysis is applied on bilayer graphene flakes as molecular capacitors to identify the extent of asymmetric distribution of electrons and holes when exposed to bias voltage. Three triangular, orthorhombic, and hexagonal symmetries for graphene flakes are considered in two sizes and electric field potential is applied along the vector perpendicular to graphene flakes' plane to simulate 1–4 V as the bias voltage applied to molecular‐scale capacitors The number of electrons responsible for asymmetric distribution of electrons and holes, and occupied to virtual transfer are calculated, and electric field deformation density analysis is also performed that shows distributions of electrons and holes are quite asymmetric for the orthorhombic symmetry, while for the other symmetries, they are almost image of each other. It was found that isosurfaces of deformation density distribution possess a multilayer structure and accretion and depletion of electrons can be taken place between flakes or outside the parallel flakes, and it is shown that bias voltage is able to significantly remove symmetry of electrons and holes distribution. Inspection of molecular orbitals showed that electric field could change the energetic order of molecular orbitals, so that occupancy inversion is occurred for the orthorhombic systems that is responsible for their extraordinary properties. [ABSTRACT FROM AUTHOR]

Owing to their excellent properties, duplex stainless steels (DSSs) may be selected for the H2S environment. Operational limits are not defined and depend on fabrication processes. In this work, the susceptibilities of two DSSs 2205 to sulfide stress corrosion (SSC) in saline solutions with three pH levels were investigated. The difference between materials is the fabrication route: hot rolled (HR) tubes and powder metallurgy with compacting and sintering final operations by hot isostatic pressing (PM‐HIP). The susceptibility parameters were evaluated by slow strain rate tensile tests (SSRT). Both materials suffered embrittlement in solutions with pH 3.5 and 4.5, but the susceptibility was slightly better in the HR. In the solution with pH 5.5, the HR fractured with ductile behavior, while the PM‐HIP was brittle. The better resistance of HR to SSC can be explained by microstructural features, such as the lower grain size and austenite island interspace. [ABSTRACT FROM AUTHOR]

Sexual dimorphisms are generated by divergent processes, such as natural or sexual selection and niche convergence. Males and females of the lesser guitarfish, Zapteryx brevirostris, present morphological differences in their discs, and the relationships with the species biology and ecology were unrecognized. Analysing the morphometry of 201 specimens and the influence of bottom features on the frequencies of 188 specimens among life stages and sexes, we found strong evidence that gonadal maturation leads to dimorphisms on discs, validating a concavity on male pectoral fins as a secondary sexual dimorphism and rejecting the hypothesis that such dimorphisms were related to ecological pressures. The principal component analysis (PCA) and permutational MANOVA (PERMANOVA) analyses revealed that males and females shared similar body aspects until they reached maturity, mainly due to lower variations in WD, WR, LD, DPRO, and LSC at younger life stages. The relationships of these variables with LT corroborate the former results, showing a changing point around LT > 30 cm where females started to attain larger measurements than males. Moreover, we revealed ontogenetic shifts, with adults from both sexes exploring different habitats than juveniles and subadults. Differences in frequencies of each life stage were best explained by organic matter (OM) with the adults exploring bottom habitats of higher concentrations of OM than juveniles and subadults, strengthening the assumption that body differences between sexes are not related to ecological pressures. These results bring not only new insights about the possible advantages that those morphometric differences provide to males while mating but also information about the abiotic influences on species distribution, which, along with knowledge of local oceanographic dynamics and benthic community patterns, would inform actions for species conservation. [ABSTRACT FROM AUTHOR]

Ground magnetic field variations have been used to investigate ionospheric dynamics for more than a century. They are usually explained in terms of an electric circuit in the ionosphere driven by an electric field, but this is insufficient to explain how magnetic field disturbances are dynamically established. Here we explain and simulate how the ionosphere dynamically responds to magnetospheric forcing and how it leads to magnetic field deformation via Faraday's law. Our approach underscores the causal relationships, treating the magnetic field and velocity as primary variables (the B, v paradigm), whereas the electric field and current are derived, in contrast to the E, j paradigm commonly used in ionospheric physics. The simulation approach presented here could be used as an alternative to existing circuit‐based numerical models of magnetosphere‐ionosphere coupling. Plain Language Summary: Ground magnetic field variations have been used to investigate ionospheric dynamics for more than a century. They are usually explained in terms of an electric circuit in the ionosphere driven by an electric field; similar to how we would explain the magnetic field of a current‐carrying wire. However, this approach oversimplifies the complex reality in space plasmas. Here, the relationship between currents and magnetic fields is reversed: currents should be understood as a consequence of the magnetic field, and not the other way around. In this paper we explain and simulate how the ionosphere dynamically responds to forcing from above, and how it leads to magnetic field deformation that corresponds to an electrical current. Key Points: We present a model and simulation of how the magnetic field in the ionosphere dynamically changes in response to external forcingOur model emphasizes the causal relationships, treating B and v as primary instead of E and j, as is commonly done in ionospheric physicsSimulation results highlighting the self‐consistent ionospheric response in the B, v paradigm are presented [ABSTRACT FROM AUTHOR]

Non-additive measures are important for many applications. In this paper we propose an extension of the non-additive measure using the concept of Kerridge inaccuracy and cumulative Tsallis entropy. Several properties including non-linear transformation, bounds and characterizations are obtained using this measure. We also study different properties of the quantile version of the proposed measure. Finally, we numerically illustrate the usefulness of the measure and its quantile form using kernel density estimators. [ABSTRACT FROM AUTHOR]

A review of the author's data, partly still unpublished, on studying of liquid tellurium and cesium is given. No definite proofs indicating phase transitions in these liquids were found. New developments in studying the liquid–liquid phase transition are briefly described. [ABSTRACT FROM AUTHOR]

AbstractPurposeMaterials and methodsResultsConclusions\nImplications for rehabilitationTailored self-management support is recommended as first-line treatment for neck and low back pain, for which mHealth applications could be promising. However, there is limited knowledge about factors influencing the engagement with such apps. The aim of this study was to assess barriers and facilitators for engaging with a self-management mHealth app among adults suffering from neck and/or low back pain.We carried out a qualitative descriptive study among adults with neck and/or low back pain. The artificial intelligence-based selfBACK app supports tailored self-management of neck and low back pain and was used for 6 weeks. After these 6 weeks, participants were interviewed by phone.Thirty-two adults (17 males) with neck and/or low back pain participated (mean age = 54.9 (SD = 15.8)). Our results show that the mode of delivery and the novelty of the selfBACK app were perceived most often as a barrier to use the app. The action plans of the app and health-related factors were perceived most often as facilitating factors.This study provides insight into possible strategies to improve an mHealth service. Furthermore, it shows that adults with neck and/or low back pain are willing and ready to receive blended treatment.Adults with neck and/or low back pain are willing to receive blended care (combination of face-to-face contact with healthcare professional and use of eHealth service)When implementing eHealth services in rehabilitation treatment of adults with neck and/or low back pain, rehabilitation professionals need to choose an eHealth service which includes individual action plans, evidence-based content with health benefits, goal setting and rewards and incentives.When implementing eHealth services in rehabilitation treatment of adults with neck and/or low back pain, rehabilitation professionals need to choose an eHealth service which can be used on someone’s own smartphone.When implementing eHealth services in rehabilitation treatment of adults with neck and/or low back pain, rehabilitation professionals need to educate their patients about the importance and possible long-term benefits of self-managing their pain.Adults with neck and/or low back pain are willing to receive blended care (combination of face-to-face contact with healthcare professional and use of eHealth service)When implementing eHealth services in rehabilitation treatment of adults with neck and/or low back pain, rehabilitation professionals need to choose an eHealth service which includes individual action plans, evidence-based content with health benefits, goal setting and rewards and incentives.When implementing eHealth services in rehabilitation treatment of adults with neck and/or low back pain, rehabilitation professionals need to choose an eHealth service which can be used on someone’s own smartphone.When implementing eHealth services in rehabilitation treatment of adults with neck and/or low back pain, rehabilitation professionals need to educate their patients about the importance and possible long-term benefits of self-managing their pain. [ABSTRACT FROM AUTHOR]

Highlights This paper presents an experimental examination of the compression demeanor of lightweight corrugated core composite (CCC) sandwich panel and corrugated core smart composites (CCSC) sandwich panels subjected to quasi‐static edgewise compression loading. The existence of shape memory alloy (SMA) wires and pre‐strain percentages of SMA are the indicators studied in this article. The fabrication procedure presented and the appraisement of the mechanical properties of the CCC and CCSC sandwich panels are expressed. The core geometry of samples is trapezoid corrugated made of aluminum. The facesheets are four layers of woven glass fiber/ epoxy laminated composite. For evaluation of the efficacy of the presence of SMA wires on mechanical specifications of sandwich panels, three SMA wires with various pre‐strain percentages (0%, 3%, and 6%) are embedded in each composite facesheet. Mechanical properties of all types of CCC and CCSC sandwich panels such as maximum force, critical damage force, specific strength, absorb energy, specific toughness, Young's modulus, and specific stiffness were evaluated. Results showed that the CCC sandwich panel has higher mechanical specifications than the CCSC sandwich panels with 0% and 3% pre‐strain. Also, increasing pre‐strained SMA wires improves all mechanical parameters of CCSC sandwich panels. CCSC sandwich panel with 6% pre‐strain has the highest compression properties than other sandwich panels. Maximum Force, Critical Damage Force, Specific Strength, Absorbed Energy, Specific Toughness, Young's Modulus, and Specific Stiffness of CCSC sandwich panel with 6% pre‐strain are 14.73 kN, 13.6 kN, 9.55 MPa/g, 26.61 kJ, 0.346 MJ/m3g, 4395 MPa and 0.61 kN/mm g, respectively. Lightweight CCC sandwich panel and CCSC sandwich panel manufactured. Compression behavior of CCC sandwich panel and CCSC sandwich panel evaluated. Pre‐strained SMA wires improves energy absorption of CCSC sandwich panels. Higher specific toughness was obtained with 6% pre‐strain SMA. Presence of SMA wires with no pre‐strain cannot improve the specific strength. [ABSTRACT FROM AUTHOR]

Data indicating the important role of microorganisms in the formation of nodular monazite (NM) (kularite) of the Kular Range, Republic of Sakha (Yakutia), are presented. The NM contains microorganisms (cyanobacteria) replaced by REE-bearing phosphate (monazite) in the form of stromatolitic microedifices, as well as framboidal Fe sulfides in monazite. The Corg isotopic composition of kularite corresponds to biogenic carbon: the δ13С values vary from –22.2 to –22.3‰. [ABSTRACT FROM AUTHOR]

Copper levels in biological fluids are associated with Wilson's, Alzheimer's, Menke's, and Parkinson's diseases, making them good biochemical markers for these diseases. This study introduces a miniaturized screen-printed electrode (SPE) for the potentiometric determination of copper(II) in some biological fluids. Manganese(III) oxide nanoparticles (Mn2O3-NPs), dispersed in Nafion, are drop-casted onto a graphite/PET substrate, serving as the ion-to-electron transducer material. The solid-contact material is then covered by a selective polyvinyl chloride (PVC) membrane incorporated with 18-crown-6 as a neutral ion carrier for the selective determination of copper(II) ions. The proposed electrode exhibits a Nernstian response with a slope of 30.2 ± 0.3 mV/decade (R2 = 0.999) over the linear concentration range 5.2 × 10–9 – 6.2 × 10–3 mol/l and a detection limit of 1.1 × 10–9 mol/l (69.9 ng/l). Short-term potential stability is evaluated using constant current chronopotentiometry (CP) and electrochemical impedance spectroscopy (EIS). A significant improvement in the electrode capacitance (91.5 μF) is displayed due to the use of Mn2O3-NPs as a solid contact. The presence of Nafion, with its high hydrophobicity properties, eliminates the formation of the thin water layer, facilitating the ion-to-electron transduction between the sensing membrane and the conducting substrate. Additionally, it enhances the adhesion of the polymeric sensing membrane to the solid-contact material, preventing membrane delamination and increasing the electrode's lifespan. The high selectivity, sensitivity, and potential stability of the proposed miniaturized electrode suggests its use for the determination of copper(II) ions in human blood serum and milk samples. The results obtained agree fairly well with data obtained by flameless atomic absorption spectrometry. [ABSTRACT FROM AUTHOR]

Botrytis cinerea is a severe threat in agriculture, as it can infect over 200 different crop species with gray mold affecting food yields and quality. The conventional treatment using fungicides lead to emerging resistance over the past decades. Here, we introduce Photodynamic Inactivation (PDI) as a strategy to combat B. cinerea infections, independent of fungicide resistance. PDI uses photoactive compounds, which upon illumination create reactive oxygen species toxic for killing target organisms. This study focuses on different formulations of sodium–magnesium–chlorophyllin (Chl, food additive E140) as photoactive compound in combination with EDTA disodium salt dihydrate (Na2EDTA) as cell-wall permeabilizer and a surfactant. In an in vitro experiment, three different photosensitizers (PS) with varying Chl and Na2EDTA concentrations were tested against five B. cinerea strains with different resistance mechanisms. We showed that all B. cinerea mycelial spheres of all tested strains were eradicated with concentrations as low as 224 µM Chl and 3.076 mM Na2EDTA (LED illumination with main wavelength of 395 nm, radiant exposure 106 J cm−2). To further test PDI as a Botrytis treatment strategy in agriculture a greenhouse trial was performed on B. cinerea infected bell pepper plants (Capsicum annum L). Two different rates (560 or 1120 g Ha−1) of PS formulation (0.204 M Chl and 1.279 M Na2EDTA) and a combination of PS formulation with 0.05% of the surfactant BRIJ L4 (560 g Ha−1) were applied weekly for 4 weeks by spray application. Foliar lesions, percentage of leaves affected, percentage of leaf area diseased and AUDPC were significantly reduced, while percentage of marketable plants were increased by all treatments compared to a water treated control, however, did not statistically differ from each other. No phytotoxicity was observed in any treatment. These results add to the proposition of employing PDI with the naturally sourced PS Chl in agricultural settings aimed at controlling B. cinerea disease. This approach seems to be effective regardless of the evolving resistance mechanisms observed in response to conventional antifungal treatments. [ABSTRACT FROM AUTHOR]

Animal space use and spatial overlap can have important consequences for population‐level processes such as social interactions and pathogen transmission. Identifying how environmental variability and inter‐individual variation affect spatial patterns and in turn influence interactions in animal populations is a priority for the study of animal behaviour and disease ecology. Environmental food availability and macroparasite infection are common drivers of variation, but there are few experimental studies investigating how they affect spatial patterns of wildlife.Bank voles (Clethrionomys glareolus) are a tractable study system to investigate spatial patterns of wildlife and are amenable to experimental manipulations. We conducted a replicated, factorial field experiment in which we provided supplementary food and removed helminths in vole populations in natural forest habitat and monitored vole space use and spatial overlap using capture–mark–recapture methods.Using network analysis, we quantified vole space use and spatial overlap. We compared the effects of food supplementation and helminth removal and investigated the impacts of season, sex and reproductive status on space use and spatial overlap.We found that food supplementation decreased vole space use while helminth removal increased space use. Space use also varied by sex, reproductive status and season. Spatial overlap was similar between treatments despite up to threefold differences in population size.By quantifying the spatial effects of food availability and macroparasite infection on wildlife populations, we demonstrate the potential for space use and population density to trade‐off and maintain consistent spatial overlap in wildlife populations. This has important implications for spatial processes in wildlife including pathogen transmission. [ABSTRACT FROM AUTHOR]

The development and creation of a new generation vaccines based on recombinant proteins that assemble into virus-like particles (VLPs), as well as recombinant proteins in the form of nanoparticles, are promising directions in modern biotechnology. Due to their large size (20–200 nm) and multiplicity of viral antigenic determinants on the surface, VLPs can stimulate strong humoral and cellular immune responses. The main types of VLPs, as well as the features and disadvantages of the main expression systems used for their biosynthesis, are considered in this review. The main focus was on plant expression systems that ensure the biosynthesis of a target recombinant protein from a DNA matrix integrated into the nuclear or chloroplast genomes of a plant (stable expression) or from a matrix for temporary production of the target product (transient expression). Various approaches for increasing the yield of VLP-forming recombinant proteins, including fusion with a transit peptide that directed the protein into the chloroplast, were discussed. The possibility of accumulation of recombinant proteins expressed in plants and intended for creation of VLP-vaccines in another type of nanoparticle, protein bodies, using specific signal sequences was also considered. [ABSTRACT FROM AUTHOR]

Recent multi-point measurements, in particular from the Magnetospheric Multiscale (MMS) spacecraft, have advanced the understanding of micro-scale aspects of magnetic reconnection. In addition, the MMS mission, as part of the Heliospheric System Observatory, combined with recent advances in global magnetospheric modeling, have furthered the understanding of meso- and global-scale structure and consequences of reconnection. Magnetic reconnection at the dayside magnetopause and in the magnetotail are the drivers of the global Dungey cycle, a classical picture of global magnetospheric circulation. Some recent advances in the global structure and consequences of reconnection that are addressed here include a detailed understanding of the location and steadiness of reconnection at the dayside magnetopause, the importance of multiple plasma sources in the global circulation, and reconnection consequences in the magnetotail. These advances notwithstanding, there are important questions about global reconnection that remain. These questions focus on how multiple reconnection and reconnection variability fit into and complicate the Dungey Cycle picture of global magnetospheric circulation. [ABSTRACT FROM AUTHOR]

Reconfigurable robots are deployed for applications demanding area coverage, such as cleaning and inspections. Reconfiguration per context, considering beyond a small set of predefined shapes, is crucial for area coverage performance. However, the existing area coverage methods of reconfigurable robots are not always effective and require improvements for ascertaining the intended goal. Therefore, this article proposes a novel coverage strategy based on internal rehearsals to improve the area coverage performance of a reconfigurable robot. In this regard, a reconfigurable robot is embodied with the cognitive ability to predict the outcomes of its actions before executing them. A genetic algorithm uses the results of the internal rehearsals to determine a set of the robot's coverage parameters, including positioning, heading, and reconfiguration, to maximize coverage in an obstacle cluster encountered by the robot. The experimental results confirm that the proposed method can significantly improve the area coverage performance of a reconfigurable robot. [ABSTRACT FROM AUTHOR]

In bacteria, F-type ATPase (F-ATPase) plays a key role in bioenergetics and couples ATP synthesis/hydrolysis with the transport of ions (H+ or Na+) across the membrane. The ion specificity of the enzyme is determined by the amino acid sequence of subunits c and a. Here, we introduced several mutations (7 in subunit c and 6 in subunit a) into F-ATPase of thermophilic bacterium Bacillus sp. PS3 in order to change the ion specificity of the enzyme from proton to sodium. The mutations did not affect the ATPase activity of the enzyme, but led to loss of proton conductivity and impaired the binding of subunit a to the c-subunit oligomer, rather than changed the ion specificity. [ABSTRACT FROM AUTHOR]

The sources of thermophilic bacteria revealed in cold Lake Baikal sediments are considered. Comparative analysis of the taxonomic position of thermophilic microorganisms from four terrestrial hot springs at Lake Baikal coast and from the bottom sediments associated with hydrocarbon discharge was carried out. The sequences of thermophilic microorganisms with the same taxonomic position were revealed both in the hot springs and bottom sediments. Some microbial species occurred only in the hydrotherm samples or only in those from the sediments. Gas-saturated fluids from the hydrocarbon generation zone at the depth of 4‒6 km are the most probable source of thermophilic microorganisms in the bottom sediments. [ABSTRACT FROM AUTHOR]

Treatment with erythropoietin (EPO) can correct anaemia in chronic kidney disease (CKD) patients; however, up to 10% exhibit resistance or hyporesponsiveness to EPO. Non‐alcoholic fatty liver disease (NAFLD), prevalent liver disease in CKD patients, may limit EPO response because of thrombopoietin deficiency, iron homeostasis disorder and inflammation. Therefore, we hypothesized NAFLD is a risk factor for EPO responsiveness. To test our hypothesis, we evaluated the effect of EPO in healthy rats and rats with NAFLD induced by a high‐fat, high‐carbohydrate (HFHC) diet. After 12 weeks on the HFHC diet, NAFLD rats showed lower erythroid response to EPO treatment than healthy rats. We, then, determined that the primary cause of EPO hyporesponsiveness could be iron deficiency associated with inflammation, which reduces erythroid cell production. Specifically, the concentrations of hepcidin, ferritin, transferrin and white blood cells in NAFLD rats were 12.8‐, 16.4‐, 2.51‐ and 1.40‐fold higher than those in healthy rats, respectively. However, erythroid cell types in the bone marrow of NAFLD rats were significantly reduced. In conclusion, our data suggest that NAFLD could be a risk factor for EPO responsiveness, which is attributed to functional iron deficiency associated with inflammation. [ABSTRACT FROM AUTHOR]

Bootstrap is a widely applicable computational statistical method. The focus of this paper lies in developing a bootstrap method for linear mixed models under homoscedasticity violation (heteroscedasticity) in variance of errors. We assume that the form of heteroscedasticity is unknown. To generate bootstrap response data as close as possible to the actual response data, we transform the marginal residuals to ensure that the variance of the modified marginal residuals in bootstrap samples is an unbiased estimator for the variance of the response variable in the linear mixed models. The consistency is proved, implying that the parameter estimators by the proposed method are asymptotically unbiased. The simulations are conducted with varying error terms and sample sizes to show improvement of the proposed method in parameter estimation. The simulation results are compared to demonstrate that the proposed method outperforms the other considered approaches including the wild method in the heteroscedastic linear mixed models under small samples and performs competitively with the parametric method and both methods outperform the other considered methods in homoscedastic linear mixed models. The proposed bootstrap method is applied to squid data for illustration of its effectiveness. [ABSTRACT FROM AUTHOR]

The mathematical formulations for transverse compression of a thin elastic disc are considered, including various boundary conditions along the faces of the disc. The mixed boundary conditions corresponding to the loading by normal stresses in absence of sliding are studied in detail. These conditions support an explicit solution in a Fourier series for the boundary layers localised near the edge of the disc and also do not assume making use of the Saint-Venant principle underlying the traditional asymptotic theory for thin elastic structures. As an example, an axisymmetric problem is studied. Along with the leading order solution for a plane boundary layer, a two-term outer expansion is derived. The latter is expressed through the derivatives of the prescribed stresses. Generalisations of the developed approach are addressed. [ABSTRACT FROM AUTHOR]

The reactivity of 22 unsaturated molecules undergoing attack by a methyl radical (⋅CH3) have been elucidated using the condensed radical general‐purpose reactivity indicator (condensed radical GPRI) appropriate for relatively nucleophilic or electrophilic molecules. Using the appropriate radical GPRI equation for electrophilic attack or nucleophilic radical attack, seven different population schemes were used to assign the most reactive atoms in each of the 22 molecules. The results show that the condensed radical GPRI is sensitive to the population scheme chosen, but less sensitive than the radical Fukui function. Therefore, the reliability of these methods depends on the population scheme. Our investigation indicates that the condensed radical GPRI is most accurate in predicting the dominant products of the methyl radical addition reactions on a variety of unsaturated molecules when the Hirshfeld, Merz–Singh–Kollman, or Voronoi deformation density population schemes are used. Furthermore, for all populations schemes in the majority of instances where the radical Fukui function failed the radical GPRI was able to identify the most reactive atom under certain reactivity conditions. [ABSTRACT FROM AUTHOR]

Quantum dot-based epitaxially regrown photonic crystal surface emitting lasers are demonstrated at room temperature. The GaAs-based devices, which are monolithically integrated on the same wafer, exhibit ground state lasing at ∼1230 nm and excited state lasing at ∼1140 nm with threshold current densities of 0.69 and 1.05 kA/cm2, respectively. [ABSTRACT FROM AUTHOR]

The doubly dispersive (DD) equation finds extensive utility across scientific and engineering domains. It stands as a significant nonlinear physical model elucidating nonlinear wave propagation within the elastic inhomogeneous Murnaghan's rod (EIMR). With this in mind, we have focused on the integration of the DD model and the modified Khater (MK) method. Through the wave transformation, this model is effectively converted into an ordinary differential equation. In this paper, the goal of our work is to explore new wave solutions to the DD model by using the MK scheme. These solutions provide extremely helpful insights into the operation of the system. The three-dimensional (3D) plot and two-dimensional (2D) combined plot via the impacts of the parameters are provided for various parameters in this manuscript. We also discussed the dynamical properties of the model, which are accomplished through the bifurcation analysis, and also found the Hamiltonian function. This research makes a substantial contribution to the area by increasing our understanding of wave solutions in the DD, introducing novel investigation tools, and carrying out an in-depth investigation of the bifurcation and stability aspects of the system. As a direct result of this research, novel openings have been uncovered for further investigation and application in the various disciplines of science and engineering. [ABSTRACT FROM AUTHOR]

Context: Extracellular vesicles (EVs) derived from the oviductal fluid (oEVs) play a critical role in various reproductive processes, including sperm capacitation, fertilisation, and early embryo development. Aims: To characterise porcine oEVs (poEVs) from different stages of the estrous cycle (late follicular, LF; early luteal, EL; mid luteal, ML; late luteal, LL) and investigate their impact on sperm functionality. Methods: poEVs were isolated, characterised, and labelled to assess their binding to boar spermatozoa. The effects of poEVs on sperm motility, viability, acrosomal status, protein kinase A phosphorylation (pPKAs), tyrosine phosphorylation (Tyr-P), and in in vitro fertility were analysed. Key results: poEVs were observed as round or cup-shaped membrane-surrounded vesicles. Statistical analysis showed that poEVs did not significantly differ in size, quantity, or protein concentration among phases of the estrous cycle. However, LF poEVs demonstrated a higher affinity for binding to sperm. Treatment with EL, ML, and LL poEVs resulted in a decrease in sperm progressive motility and total motility. Moreover, pPKA levels were reduced in presence of LF, EL, and ML poEVs, while Tyr-P levels did not differ between groups. LF poEVs also reduced sperm penetration rate and the number of spermatozoa per penetrated oocyte (P < 0.05). Conclusions: poEVs from different stages of the estrous cycle play a modulatory role in sperm functionality by interacting with spermatozoa, affecting motility and capacitation, and participating in sperm–oocyte interaction. Implications: The differential effects of LF and LL poEVs suggest the potential use of poEVs as additives in IVF systems to regulate sperm–oocyte interaction. We examined the tiny structures called extracellular vesicles that come from the fluid in pig uterus in order to understand how these vesicles change during the reproductive cycle of female pigs. Those from the late stages of the cycle seemed to have a strong connection with sperm and a possible key role in fertility. These vesicles regulate sperm function and interaction with oocytes, and they could potentially be used in fertility treatments to improve the chances of successful fertilisation. Photograph by SM Toledo-Guardiola. This article belongs to the Collection Dedication to Jim Cummins. [ABSTRACT FROM AUTHOR]

AbstractPurposeMaterials and methodsResultsConclusions\nIMPLICATIONS FOR REHABILITATIONTo examine whether the Upper Extremity Functional Index (UEFI) score independently contributes to the Stroke Impact Scale (SIS) score and quantified its relative contribution to SIS scores in chronic stroke survivors.A cross-sectional study in a university-based rehabilitation centre with people with chronic stroke (N = 95) aged ≥ 50 years. The outcome measures included paretic hand grip strength, Fugl–Meyer Upper Extremity Assessment (FMA-UE), Wolf Motor Function Test (WMFT), UEFI, and SIS.Correlation analysis revealed that paretic hand grip strength, FMA-UE, UEFI, and WMFT scores exhibited a significant moderate positive correlation with SIS scores (r = 0.544–0.687, p < 0.001). The results of a regression model indicated that after adjustment for demographic factors and stroke-related impairments, the UEFI scores remained independently associated with SIS scores, accounting for 18.8% of the variance. The entire model explained 60.3% of the variance in SIS scores.Self-perceived UE motor function is a crucial component to be included in rehabilitation programmes aimed at enhancing quality of life and participation among chronic stroke survivors.Observation-based outcome measures, e.g., Fugl–Meyer Assessment for Upper Extremity (FMA-UE), Wolf Motor Function Test (WMFT) could not predict the health-related quality of life (Stroke Impact scale (SIS)) in chronic stroke survivors in our study, which was contradictory with current studies.A self-perceived outcome measure to evaluate upper extremity function (Upper Extremity Functional Index (UEFI)) could independently predict the health-related quality of life (SIS), accounting for 18.8% of the variance.Our study demonstrated that self-perceived UE motor function would be an important component to optimize the rehabilitation programmes aimed at enhancing quality of life and social participation among chronic stroke survivors.Observation-based outcome measures, e.g., Fugl–Meyer Assessment for Upper Extremity (FMA-UE), Wolf Motor Function Test (WMFT) could not predict the health-related quality of life (Stroke Impact scale (SIS)) in chronic stroke survivors in our study, which was contradictory with current studies.A self-perceived outcome measure to evaluate upper extremity function (Upper Extremity Functional Index (UEFI)) could independently predict the health-related quality of life (SIS), accounting for 18.8% of the variance.Our study demonstrated that self-perceived UE motor function would be an important component to optimize the rehabilitation programmes aimed at enhancing quality of life and social participation among chronic stroke survivors. [ABSTRACT FROM AUTHOR]

The article presents an analysis of the muscle synergies involved in making ball throws in different directions and from different starting positions. The study involved 6 highly qualified athletes engaged in rhythmic gymnastics. Electromyograms of the superficial muscles of the upper extremities and trunk were recorded synchronously during the movements, as well as video capture of the movements of body segments. Synergy parameters were extracted from the recorded signals using factor analysis using the principal component method. It has been established that individuals who have mastered a complex motor skill can demonstrate similar motor control strategies. This is manifested in the structuring of intermuscular interaction in the form of two general modules, the degree of involvement of muscles in which is highly similar in the implementation of different motor tasks. The first muscle module implements active movement of the upper limb by jointly activating the muscles of the forearm, shoulder and upper shoulder girdle, and also provides stabilization of the position of the trunk by synchronizing the activity of the muscles of the back and abdomen. The second muscle module is specific and is mainly associated with high involvement in the synergy of the muscles of the upper shoulder girdle and forearm for the implementation of exercises performed without visual control, or from starting positions that limit the mobility of certain parts of the body. Thus, the solution to the problem of coordination of many elements of the motor system may consist not only in reducing the number of executive organs—muscles involved in control, but also in organizing control variables in the form of modules at the kinematic level and their stabilization through muscle synergies. [ABSTRACT FROM AUTHOR]

Negative cumulative effects of lanthanides on the human body are well known; they are mainly related to the toxic effects of rare earth metals (REE) on muscle tissue. However, the effects of low concentrations of these metals on muscle are much less well studied. In our work, we identified an unusual stimulatory effect of low concentrations of europium (Eu3+) on spontaneous contractions of frog cardiac muscle atrial preparations. The aim of the present study was to investigate the stimulatory effect of europium (Eu3+) on the contraction of heart muscle atrial preparations, both normally and in the presence of the mitochondrial respiration inhibitor sodium azide (NaN3). The study was carried out using two experimental models: muscle preparations obtained from isolated atria of the frog Rana ridibunda heart and mitochondria isolated from the heart of male Wistar rats. As a result of these studies, it was found that Eu3+ at a concentration of 0.2 mM, at a temperature of 20°C, potentiated frog atrial contractions in situ, with an increase in both the amplitude and the maximum rate of increase in the strength of single spontaneous contractions. Spontaneous atrial contractions became more resistant to the effects of 1 mM NaN3. At the same time, Eu3+ did not affect the respiration of energized mitochondria, (activated by ADP (state 3) or 2,4-dinitrophenol (state 3UDNP)). The intensity of this respiration decreased under conditions of calcium loading of mitochondria regardless of the presence of Eu3+ in the medium. Thus, on the basis of these studies, it was concluded that Eu3+ ions at low concentration (0.2 mM) stimulate atrial contraction and have a positive inotropic effect. The stimulating effect of low concentration of Eu3+ on the heart can be explained by synergism in the action of Ca2+ and Eu3+ on calcium channels, stimulation of Ca2+-dependent processes in cardiomyocytes and absence of negative effect on mitochondrial respiration. [ABSTRACT FROM AUTHOR]

The main challenge facing agricultural crop production in the current global climate change scenario is sustainability. Drought, as a yield‐limiting factor, has become a major threat to international food security. Tolerance to drought is a complex trait and its response is carried out by various genes, transcription factors, microRNAs, hormones, proteins, cofactors, ions and metabolites. The complexity of the trait has limited the development of drought‐tolerant sweet potato cultivars by traditional breeding. Advances in sweet potato breeding to exploit the full potential of the crop to contribute to improved and higher performing sweet potato cultivars, adapted to increasingly risky rainfed conditions, mainly drought, are key to making food production systems more efficient and more tolerant to pressure from drought and other stressors. Genetic gain for yield potential in sweet potato has improved mostly in African countries, mainly as a result of an accelerated breeding scheme. The focus on maximising the utilisation of molecular tools for sweet potato improvement and yield has been recently explored in breeding programmes in sub‐Saharan Africa (SSA). This article provides an update on the trends and gaps in sweet potato breeding in SSA, reviewing the relevant strategies used to improve sweet potato in the region. Finally, the perspectives of using new advanced tools including genetic engineering and genome editing, and the challenges associated with climate change for further improvement of the crop are highlighted. Collaborative efforts in African countries are driving advances in breeding methods through the incorporation of molecular tools to develop drought‐tolerant sweet potato varieties that are important to global food security despite challenges posed by the drastic change in climate. [ABSTRACT FROM AUTHOR]

We present a comprehensive study of the nonproportionality of NaI(Tl) scintillation detectors within the context of dark matter search experiments. Our investigation, which integrates COSINE-100 data with supplementary γ spectroscopy, measures light yields across diverse energy levels from full-energy γ peaks produced by the decays of various isotopes. These γ peaks of interest were produced by decays supported by both long and short-lived isotopes. Analyzing peaks from decays supported only by short-lived isotopes presented a unique challenge due to their limited statistics and overlapping energies, which was overcome by long-term data collection and a time-dependent analysis. A key achievement is the direct measurement of the 0.87 keV light yield, resulting from the cascade following electron capture decay of 22 Na from internal contamination. This measurement, previously accessible only indirectly, deepens our understanding of NaI(Tl) scintillator behavior in the region of interest for dark matter searches. This study holds substantial implications for background modeling and the interpretation of dark matter signals in NaI(Tl) experiments. [ABSTRACT FROM AUTHOR]