Search

The present study was undertaken to investigate and validate the traditional claims ofClerodendrum paniculatum Linnfor its anti-anxiety activity.C. paniculatum linnbelongs to Verbenacae family. Ethnomedical importance of various species ofClerodendrumgenus has been reported in various indigenous systems of medicines and folk medicines. It is used as a medicine for the treatment of sore eyes, gonorrhoea, urinary tract infection and kidney problems. Till date there are no reports available regarding its pharmacological properties of hence, it is therefore worthwhile to study the unrevealed properties of this plant. The shade dried aerial parts of plant were extracted by extracted using ethyl acetate, petroleum ether and aqueous as a solvent. Obtained extracts were subjected for phytochemical screening and antianxiety activity was studied using elevated plus maze and light and dark models. Results of the phytochemical screening revealed the presence of flavonoids, tannins, glycosides, saponins, and terpenoid like compounds. In addition, among the extracts studied for anti-anxiety activity of ethyl acetate extract shown significant activity comparable with standard drug, diazepam. Petroleum ether and aqueous extracts shown least anti-anxiety activity in comparison with the standard.

The present study was undertaken for investigating and validating the traditional claims of Clerodendrum paniculatum Linn for its anti-convulsant activity. Clerodendrum paniculatumlinn belongs to verbenacae family. Ethno medical importance of various species of Clerodendrum genus has been reported in various indigenous systems of medicines and folk medicines. It is used as a medicine for the treatment of sore eyes, urinary tract, gonorrhoea and kidney problems. However pharmacological properties of plants have not yet been extensively studied, it is therefore thought worthwhile to study about the unrevealed properties of this plant. The aerial parts of plant are used for preparing extraction using ethyl acetate, petroleum ether and aqueous as a solvent. Shade dried, powdered (40 mesh size) leaves of Clerodendrum paniculatum Linn were extracted with ethyl acetate, petroleum ether and macerated with distilled water. On using solvent extraction phytochemical screening was analyzed, it reveals the presence of flavanoids, tannins, glycosides, saponins, and terpenoids like compounds. Anti-convulsant activity of ethyl acetate extract shows significant activity comparable with standard drug, Phyntoin. Petroleum ether and aqueous extracts shows little anti-convulsant activity.