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Introduction: With advancing health care sciences, the prevalence of Accidental Exposure to Patient's Blood (AEBP) amongst Health Care Personnel (HCP) is bound to increase. The only means of preventing such accidental exposure is safe working practices. It is the responsibility of the teachers to inculcate these practices amongst their students. Aim: To evaluate the knowledge, practice and attitude regarding Post Exposure Prophylaxis (PEP) and Hepatitis-B Virus (HBV) immunization amongst faculty and undergraduate students and to assess the frequency of these occupational exposure with the objective of inculcating safe working practices in the teaching curriculum. Materials and Methods: The present study is a descriptive analytical cross-sectional study done from May 2012 to August 2012 in a newly established ESIC dental college at Rohini, Delhi. A 36-item survey questionnaire was distributed to 50 faculty and 115 dental undergraduate students. The survey included questions on demographic details of the respondents, the prevalence of AEBP, the knowledge regarding PEP and HBV immunization and the status of the respondents. The data was analysed using SPSS 12.0 software using various statistical tests such as frequency analysis, Chi-square test and others. Results: The mean age of the study group was 23.3±6.3 years. The prevalence of such accidental exposure was high being 49.7% in our study group. More than half of these respondents did not report the injury. The knowledge regarding the transmissibility of blood borne pathogens and the post exposure prophylaxis was suboptimal amongst the students and even teachers. Almost 20% of the study group was not immunized for HBV. Conclusion: Managing AEBP in HCP is a challenging issue. They are highly prevalent, largely underreported and poorly managed because of the unawareness regarding the hospital's protocols for reporting and PEP as is seen in the present study. Besides the administrative measures, orientation and reinforcement training of all the staff including faculty is desirable to maintain high level of knowledge and effectively handle such occupational exposure. [ABSTRACT FROM AUTHOR]