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302 results on '"SALERNO, Alfredo"'

2. Data from Targeting Human γδ T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer

Author

Dieli, Francesco, primary, Vermijlen, David, primary, Fulfaro, Fabio, primary, Caccamo, Nadia, primary, Meraviglia, Serena, primary, Cicero, Giuseppe, primary, Roberts, Andrew, primary, Buccheri, Simona, primary, D'Asaro, Matilde, primary, Gebbia, Nicola, primary, Salerno, Alfredo, primary, Eberl, Matthias, primary, and Hayday, Adrian C., primary

Published
2023
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3. Supplementary Figures 1-4, Tables 1-2 from Targeting Human γδ T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer

Author

Dieli, Francesco, primary, Vermijlen, David, primary, Fulfaro, Fabio, primary, Caccamo, Nadia, primary, Meraviglia, Serena, primary, Cicero, Giuseppe, primary, Roberts, Andrew, primary, Buccheri, Simona, primary, D'Asaro, Matilde, primary, Gebbia, Nicola, primary, Salerno, Alfredo, primary, Eberl, Matthias, primary, and Hayday, Adrian C., primary

Published
2023
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20. Selective depression of interferon-[gamma] and granulysin production with increase of proliferative response by V[gamma]9/V[delta]2 T cells in children with tuberculosis

Author

Dieli, Francesco, Sireci, Guido, Caccamo, Nadia, Sano, Caterina Di, Titone, Lucina, Romano, Amelia, Carlo, Paola Di, Barera, Annalisa, Accardo-Palumbo, Antonia, Krensky, Alan M., and Salerno, Alfredo

Subjects
T cells -- Physiological aspects, T cells -- Research, Immune system -- Physiological aspects, Immune system -- Research, Tuberculosis -- Care and treatment, Tuberculosis -- Research, Infection -- Physiological aspects, Infection -- Research, Health
Published
2002

21. Identification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A *0201 CD8+ T lymphocytes

Author

Caccamo, Nadia, Milano, Salvatore, Sano, Caterina Di, Cigna, Diego, Ivanyi, Juraj, Krensky, Alan M., Dieli, Francesco, and Salerno, Alfredo

Subjects
Mycobacterium tuberculosis -- Physiological aspects, Mycobacterium tuberculosis -- Genetic aspects, Bacteriology, Medical -- Reports, Bacteriology, Medical -- Research, Antigenic determinants -- Genetic aspects, Antigenic determinants -- Physiological aspects, Health
Published
2002

30. gammadelta T Cell Modulation in Anticancer Treatment

Author

CACCAMO, Nadia Rosalia, DIELI, Francesco, MERAVIGLIA, Serena, GUGGINO, Giuliana, SALERNO, Alfredo, Caccamo, N, Dieli, F, Meraviglia, S, Guggino, G, and Salerno, A.

Subjects
gamma delta T cells, immunotherapy, cancer
Abstract

The broad antimicrobial and antitumoral reactivity of Vgamma9Vdelta2 T cells, their ability to produce inflammatory cytokines involved in protective immunity against intracellular pathogens and tumors and their strong cytolytic and bactericidal activities suggest their direct involvement in immune control of cancers and infections. gammadelta T cells can be selectively activated by naturally occurring or synthetic phosphoantigens, and drugs that enhance their accumulation into stressed cells, offering new avenues for the development of gammadelta T cell-based immunotherapies. The recent development of small drugs selectively activating Vgamma9Vdelta2 T lymphocytes, which upregulate endogenous phosphoantigens, has enabled investigators to design experimental approaches of cancer immunotherapies; several ongoing phase I and II clinical trials are focused on the role of direct bioactivity of drugs and of adoptive cell therapies involving phosphoantigen-activated Vgamma9Vdelta2 T lymphocytes in humans. In this review, we focus on the recent advances of the activation/expansion of gammadelta T cells in vitro and in vivo that may represent a promising target for the design of novel and highly innovative immunotherapy in patients with different types of cancer.

Published
2010

34. New insight on immunological activation pathways of Langerhans cells, possible tolerogenic role

Author

LA MANNA, Marco Pio, BAZAN, Viviana, GERBINO, Aldo, SALERNO, Alfredo, Gerbino, A, Zummo, G, Crescimanno, G, La Manna, M, Bazan, V, and Salerno, A

Subjects
Langerhans cells, Role Tolerogenic
Abstract

Langerhans cells are the prototype of antigen presenting cell, their role is to work as sentinel in the epidermis. Like every APC Langerhans cells act as bridge between innate and acquired immunity recognizing antigens into the epidermis and bringing them to drying lymph node, their work is well described by the Langerhans cell paradigm. Recently many works designed a new and amazing role of Langerhans cells in fact they often showed tolerogenic capacity, while in many cases, they seems not necessary to promote activation of acquired immunity. Anyway Langerhans cells remaining an interesting target for new vaccine strategies because of their localization in the epidermis and the ability to capture antigens trough different recognition pathways. Also interesting is the possible use of langerhans cells for their tolerogenic capacity, in many experimental models these cells opportunely addressed with appropriated cytokines appears able to down-regulate immune system response in autoimmune pathology.

Published
2009

35. Aminobisphosphonates as new weapons for gammadelta T Cell-based immunotherapy of cancer

Author

CACCAMO, Nadia Rosalia, MERAVIGLIA, Serena, CICERO, Giuseppe, GULOTTA, Gaspare, MOSCHELLA, Francesco, CORDOVA, Adriana, GULOTTA, Eliana, SALERNO, Alfredo, DIELI, Francesco, CACCAMO, N, MERAVIGLIA, S, CICERO, G, GULOTTA, G, MOSCHELLA, F, CORDOVA, A, GULOTTA, E, SALERNO, A, and DIELI, F

Subjects
Adjuvants, Immunologic, Diphosphonates, Cell Line, Tumor, Neoplasms, T-Lymphocytes, Protein Prenylation, Animals, Humans, Receptors, Antigen, T-Cell, gamma-delta, Immunotherapy, Human gamma delta T cells, tumors, phosphoantigens, bisphosphonates, immunotherapy
Abstract

BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill most tumour cells because of recognition by T cell receptor and natural killer receptors. OBJECTIVE: We discuss the possibility that the intentional activation of gammadelta T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in cancer patients. METHODS: The antitumoral effects of gammadelta T cells both in vitro and in vivo have been demonstrated suggesting a new therapeutic approach for translation into the clinical setting. RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent a particularly interesting target for immunotherapeutic protocols based on N-aminobisphosphonate administration and several Phase I-II trials are ongoing investigating the activity of zoledronic acid plus IL-2 in solid tumours.

Published
2008

36. In Naive mice in vivo localization of WI specific CD8+CD28- induced cells

Author

MACALUSO, Pasquale, BUSCEMI, Maria, SPATOLA, Giovanni Francesco, UZZO, Maria Laura, LA MANNA, Marco Pio, SIRECI, Guido, SALERNO, Alfredo, GERBINO, Aldo, Macaluso,P, Buscemi,M, Spatola,GF, Uzzo,ML, La Manna,MP, Sireci,G, Salerno,A, and Gerbino,A

Subjects
CD8+CD28, Settore BIO/17 - Istologia, Settore MED/04 - Patologia Generale
Published
2008

37. Frequency, phenotype and function of Mycobacterium tuberculosis-specific CD8 T cells in patients with active tuberculosis and in individuals with latent infection

Author

CACCAMO, Nadia Rosalia, GUGGINO, Giuliana, MERAVIGLIA, Serena, GELSOMINO, Giuseppe, SALERNO, Alfredo, DIELI, Francesco, NOUTA, J, KLEIN, M, OTTENHOFF, THM, CACCAMO, N, GUGGINO, G, MERAVIGLIA, S, GELSOMINO, G, NOUTA, J, KLEIN, M, SALERNO, A, DIELI, F, and OTTENHOFF, THM

Subjects
Mycobacterium tuberculosis, CD8 T cells, phenotype
Published
2008

44. CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production

Author

CACCAMO, Nadia Rosalia, MERAVIGLIA, Serena, LA MENDOLA, Carmela, DIELI, Francesco, SALERNO, Alfredo, BATTISTINI, L, BONNEVILLE, M, POCCIA, F, FOURNIE', JJ, BORSELLINO, G, KROCZEK, RA, SCOTET, E, CACCAMO, N, BATTISTINI, L, BONNEVILLE, M, POCCIA, F, FOURNIE', JJ, MERAVIGLIA, S, BORSELLINO, G, KROCZEK, RA, LA MENDOLA, C, SCOTET, E, DIELI, F, and SALERNO, A

Subjects
Vgamma9Vdelta2 T lymphocytes, CXCR5, Help B cells
Abstract

Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.

Published
2006

47. Memory and effector CD8 T cell subset in human tuberculosis

Author

CACCAMO, Nadia Rosalia, MERAVIGLIA, Serena, GUGGINO, Giuliana, SCARPA, Francesco, LA MENDOLA, Carmela, BUCCHERI, Simona, DIELI, Francesco, SALERNO, Alfredo, D'ASARO M, CACCAMO N, MERAVIGLIA S, GUGGINO G, SCARPA F, LA MENDOLA C, BUCCHERI S, D'ASARO M, DIELI F, and SALERNO A

Published
2006

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