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This article offers a transnational perspective on Canada's legislative response to globally expanded national security intelligence activities in the War on Terror since 2001. I situate Canada's new legislation against the backdrop of US and Japanese legislative responses and analyze the transition, including Bill C-13 (2014), Bill C-44 (2015), Bill C-51 (2015), and Bill C-59 (2019). I argue that the thrust of this legislative trend has been the active legalization of previously illegal surveillance activities by security intelligence agencies, rather than passive ineffectiveness in restricting state mass surveillance enabled by information and communication technologies. The transition is in synch with a global legislative trend that lowers the legal standards of privacy and personal data protection and weakens checks and balances in democratic governance. As a result, mass surveillance has increasingly undermined and regulated the rule of law, not vice versa. [ABSTRACT FROM AUTHOR]

This study aimed to examine whether attachment orientations (anxiety and avoidance) were associated with perceived stress through self-critical rumination (a specific type of rumination focused on the content of self-critical thoughts). It also aimed to examine the factor structure of the Portuguese version of the Self-Critical Rumination Scale (SCRS) and to present additional evidence on its construct validity and reliability. A sample of 317 Portuguese women from the general community was recruited online. Participants completed the SCRS and measures of self-compassion, perceived stress, difficulties in emotion regulation, and adult attachment. The results of the mediation analyses showed that self-critical rumination mediated the association between attachment anxiety and perceived stress but not the association between attachment avoidance and perceived stress. In addition, the SCRS showed good psychometric properties. Specifically, the scale showed adequate reliability (Cronbach's alpha was.933 and composite reliability was.932) and construct validity. Significant correlations were found between the SCRS and measures assessing constructs expected to be associated with self-critical rumination (self-compassion, perceived stress, difficulties in emotion regulation, and attachment anxiety and avoidance). Confirmatory factor analyses confirmed the one-factor structure of the Portuguese SCRS. This study identifies a new mechanism underlying the association between adult attachment and perceived stress. In addition, the results of the present study provide further evidence of the internal consistency and construct validity of the SCRS and indicate that the Portuguese version is a psychometrically robust and adequate measure of self-critical rumination. [ABSTRACT FROM AUTHOR]

Previous studies have shown that people would like to sacrifice benefits to themselves in order to avoid inequitable outcomes, not only when they receive less than others (disadvantageous inequity aversion) but also when they receive more (advantageous inequity aversion). This feature is captured by the theory of inequity aversion. The present study was inspired by what appears to be asymmetry in the research paradigm toward advantageous inequity aversion. Specifically, studies that supported the existence of advantageous inequity aversion always relied on the paradigm in which participants can determine allocations. Thus, it is interesting to know what would occur if participants could not determine allocations or simply passed judgment on predetermined allocations. To address this, a behavioral experiment (N = 118) and a skin conductance response (SCR) experiment (N = 29) were adopted to compare participants' preferences for advantageous inequity directly when allocations were determined and when allocations were predetermined in an allocating task. In the determined condition, participants could divide by themselves a sum of money between themselves and a matched person, whereas in the predetermined condition, they could simply indicate their satisfaction with an equivalent program-generated allocation. It was found that, compared with those in the determined condition, participants in the predetermined condition behaved as if they liked the advantageous inequity and equity to the same degree (Experiment One) and that the SCRs elicited by advantageous inequity had no differences from those elicited by equity, suggesting that participants did not feel negatively toward advantageous inequity in this situation (Experiment Two). The present study provided mutual corroboration (behavioral and electrophysiological data) to document that advantageous inequity aversion may differ as a function of the individual's role in determining allocations, and it would disappear if individual cannot determine allocations.

In 1951, the Canadian government created Privy Council Order 3486 (pc 3486) in order to engage in a covert phone-tapping program against individuals, organizations, and foreign governments (embassies) on Canadian soil. The program was codenamed ‘‘PICNIC’’ and was run by the Royal Canadian Mounted Police (RCMP), Canada’s then security service, specifically out of the Special Branch. In consultation with the RCMP, the government decided to continue the phone tapping indefinitely, with the RCMP writing warrants instead of a judge. After 1953 covert wiretapping continued through Section 11 of Canada’s Official Secrets Act. I argue that security can be understood and interpreted as an ideological construct. What did security mean in this period to the government and its intelligence services? Security was knowledge, in terms of safeguarding and hiding it and secretly collecting it. The article reveals the construction of state apparatus separated from the country’s legislative branch and changes our understanding of surveillance in the Cold War. In terms of wiretapping, the RCMP was not ‘‘going rogue’’ in its targeting of individuals in the Cold War, they were following orders. [ABSTRACT FROM AUTHOR]

Complement control protein modules (CCPs) occur in numerous functionally diverse extracellular proteins. Also known as short consensus repeats (SCRs) or sushi domains each CCP contains approximately 60 amino acid residues, including four consensus cysteines participating in two disulfide bonds. Varying in length and sequence, CCPs adopt a β-sandwich type fold and have an overall prolate spheroidal shape with N- and C-termini lying close to opposite poles of the long axis. CCP-containing proteins are important as cytokine receptors and in neurotransmission, cell adhesion, blood clotting, extracellular matrix formation, haemoglobin metabolism and development, but CCPs are particularly well represented in the vertebrate complement system. For example, factor H (FH), a key soluble regulator of the alternative pathway of complement activation, is made up entirely from a chain of 20 CCPs joined by short linkers. Collectively, therefore, the 20 CCPs of FH must mediate all its functional capabilities. This is achieved via collaboration and division of labour among these modules. Structural studies have illuminated the dynamic architectures that allow FH and other CCP-rich proteins to perform their biological functions. These are largely the products of a highly varied set of intramolecular interactions between CCPs. The CCP can act as building block, spacer, highly versatile recognition site or dimerization mediator. Tandem CCPs may form composite binding sites or contribute to flexible, rigid or conformationally 'switchable' segments of the parent proteins. [ABSTRACT FROM AUTHOR]

Abstract: Novel chimeric proteins made of a globin domain fused with a “cofactor free” monooxygenase domain have been identified within the Streptomyces avermitilis and Frankia sp. genomes by means of bioinformatics methods. Structure based sequence alignments show that the globin domains of both proteins can be unambiguously assigned to the truncated hemoglobin family, in view of the striking similarity to the truncated hemoglobins from Mycobacterium tuberculosis, Thermobifida fusca and Bacillus subtilis. In turn, the non-heme domains belong to a family of small (about 100 aminoacids) homodimeric proteins annotated as antibiotic biosynthesis monooxygenases, despite the lack of a cofactor (e.g., a metal, a flavin or a heme) necessary for oxygen activation. The chimeric protein from S. avermitilis has been cloned, expressed and characterized. The protein is a stable dimer in solution based on analytical ultracentrifugation experiments. The heme ligand binding properties with oxygen and carbonmonoxide resemble those of other Group II truncated hemoglobins. In addition, an oxygen dependent redox activity has been demonstrated towards easily oxidizable substrates such as menadiol and p-aminophenol. These findings suggest novel functional roles of truncated hemoglobins, which might represent a vast class of multipurpose oxygen activating/scavenging proteins whose catalytic action is mediated by the interaction with cofactor free monooxygenases. [Copyright &y& Elsevier]

Abstract: A new switch called a resonant-tunneling-semiconductor-controlled rectifier (RT-SCR) has been proposed. A two-transistor model is used for the device. One of the transistors in the two-transistor model is assumed to be a resonant tunneling transistor (RTT), while the other transistor is taken to be a bipolar transistor. The current–voltage relationships of the device have been numerically obtained and compared with the traditional thyristor characteristics. The new device requires smaller turn-on gate voltage than a comparable traditional device for the same gate current. This indicates that in comparison with the traditional thyristor, a smaller control current may be used to turn on the device at a particular voltage. [Copyright &y& Elsevier]

In the present study, spider-phobic children (N = 22) were exposed to subliminal presentations of spiders, snakes, and mushrooms, while skin conductance responses (SCRs) were measured. In addition, pre- and post-treatment symptom severity data were obtained. As a group, spider-phobic children did not react with differential SCRs to masked phobic pictures. In addition, no convincing evidence was found to suggest that individual variation in differential SCRs to phobic stimuli is linked to pre-treatment symptom severity or therapy outcome. These findings cast doubts on the idea that phobics' phenomenal experience of their fear as irrational and uncontrollable is a result of pre-attentive physiological fear activation. [ABSTRACT FROM AUTHOR]

Shiga toxin 2 (Stx2) is believed to be a major virulence factor of enterohemorrhagic Escherichia coli (EHEC) contributing to hemolytic uremic syndrome (HUS). The complement system has recently been found to be involved in the pathogenesis of EHEC-associated HUS. Stx2 was shown to activate complement via the alternative pathway, to bind factor H (FH) at short consensus repeats (SCRs) 6-8 and 18-20 and to delay and reduce FH cofactor activity on the cell surface. We now show that complement factor H-related protein 1 (FHR-1) and factor H-like protein 1 (FHL-1), proteins of the FH protein family that show amino acid sequence and regulatory function similarities with FH, also bind to Stx2. The FHR-1 binding site for Stx2 was located at SCRs 3-5 and the binding capacity of FHR-1*A allotype was higher than that of FHR-1*B. FHR-1 and FHL-1 competed with FH for Stx2 binding, and in the case of FHR-1 this competition resulted in a reduction of FH cofactor activity. FHL-1 retained its cofactor activity in the fluid phase when bound to Stx2. In conclusion, multiple interactions of key complement inhibitors FH, FHR-1 and FHL-1 with Stx2 corroborate our hypothesis of a direct role of complement in EHEC-associated HUS., (Copyright © 2013 Elsevier Ltd. All rights reserved.)