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2. Prevalence of atopic disorders in rheumatic diseases

Author

Karatay, Saliha, Yildirim, Kadir, Ugur, Mahir, Senel, Kazim, Erdal, Akin, Durmus, Bekir, Baysal, Ozlem, Altay, Zuhal, Sarac, Aysegul Jale, Gur, Ali, Ardicoglu, Ozge, Kamanli, Ayhan, Cevik, Remzi, Kaya, Arzu, Ersoy, Yuksel, Nas, Kemal, and Ozgocmen, Salih

Published
2013
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7. Awareness of osteoporotic patients

Author

Kutsal, Yesim Gokce, Atalay, Ayce, Arslan, Sule, Basaran, Aynur, Canturk, Ferhan, Cindas, Abdullah, Eryavuz, Merih, Irdesel, Jale, Karadavut, Kiymet-Ikbal, Kirazli, Yesim, Sindel, Dilsad, Senel, Kazim, Guler-Uysal, Fusun, and Yildirim, Kadir

Subjects
Health education -- Demographic aspects, Osteoporosis -- Educational aspects, Health
Published
2005

15. Relationship between some acute phase reactants and the Bath Ankylosing Spondylitis Disease Activity Index in patients with Ankylosing Spondylitis

Author

Yildirim, Kadir, Erdal, Akin, Karatay, Saliha, Melikoglu, Meltem Alkan, Ugur, Mahir, and Senel, Kazim

Subjects
Ankylosing spondylitis -- Research, Health, Research
Abstract

Objectives: The aims of this study were to investigate a possible relationship between the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and some acute phase reactant (APR) levels in patients [...]

Published
2004

23. A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study

Author

Kutsal, Yesim Gokce, primary, Eskiyurt, Nurten, additional, Irdesel, Jale, additional, Sepici, Vesile, additional, Ugurlu, Hatice, additional, Kirazli, Yesim, additional, Ardic, Fusun, additional, Korsic, Mirko, additional, Vlak, Tonko, additional, Grlickov, Mane, additional, Temelkova, Snezana Markovic, additional, Lazarov, Miroslav, additional, Pilipovic, Nada, additional, Popovic, Vera, additional, Dimic, Aleksandar, additional, Kovacev, Branka, additional, Ruci, Dorina, additional, Tafaj, Argjend, additional, Kucukalic-Selimovic, Elma, additional, Avdic, Dijana, additional, Seleskovic, Hajrija, additional, Pejicic, Snjezana, additional, Butun, Bulent, additional, Akyuz, Gulseren, additional, Cerrahoglu, Lale, additional, Sendur, Omer Faruk, additional, Yalcin, Peyman, additional, Oncel, Sema, additional, Saridogan, Merih, additional, Sarpel, Tunay, additional, Tosun, Mehmet, additional, Senel, Kazim, additional, Gursoy, Savas, additional, Canturk, Ferhan, additional, Demir, Huseyin, additional, Miskic, Blazenka, additional, Krpan, Dalibor, additional, Skreb, Franjo, additional, Grazio, Simeon, additional, Crncevic-Orlic, Zeljka, additional, Ozdener, Fatih, additional, and Oncel, Hakan, additional

Published
2013
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25. Prevalence of atopic disorders in rheumatic diseases

Author

Karatay, Saliha, primary, Yildirim, Kadir, additional, Ugur, Mahir, additional, Senel, Kazim, additional, Erdal, Akin, additional, Durmus, Bekir, additional, Baysal, Ozlem, additional, Altay, Zuhal, additional, Sarac, Aysegul Jale, additional, Gur, Ali, additional, Ardicoglu, Ozge, additional, Kamanli, Ayhan, additional, Cevik, Remzi, additional, Kaya, Arzu, additional, Ersoy, Yuksel, additional, Nas, Kemal, additional, and Ozgocmen, Salih, additional

Published
2012
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27. Expert opinion and key recommendations for the physical therapy and rehabilitation of patients with ankylosing spondylitis

Author

OZGOCMEN, Salih, primary, AKGUL, Ozgur, additional, ALTAY, Zuhal, additional, ALTINDAG, Ozlem, additional, BAYSAL, Ozlem, additional, CALIS, Mustafa, additional, CAPKIN, Erhan, additional, CEVIK, Remzi, additional, DURMUS, Bekir, additional, GUR, Ali, additional, KAMANLI, Ayhan, additional, KARKUCAK, Murat, additional, MADENCI, Ercan, additional, MELIKOGLU, Meltem A., additional, NAS, Kemal, additional, SENEL, Kazim, additional, and UGUR, Mahir, additional

Published
2011
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28. Psychological status is associated with health related quality of life in patients with rheumatoid arthritis

Author

Nas, Kemal, primary, Sarac, Aysegul Jale, additional, Gur, Ali, additional, Cevik, Remzi, additional, Altay, Zuhal, additional, Erdal, Akin, additional, Ersoy, Yuksel, additional, Kaya, Arzu, additional, Tekeoglu, Ibrahim, additional, Ugur, Mahir, additional, Durmus, Bekir, additional, Ardicoglu, Ozge, additional, Senel, Kazim, additional, Baysal, Ozlem, additional, Kamanli, Ayhan, additional, Karatay, Saliha, additional, Yildirim, Kadir, additional, and Ozgocmen, Salih, additional

Published
2011
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29. Pattern of Disease Onset, Diagnostic Delay, and Clinical Features in Juvenile Onset and Adult Onset Ankylosing Spondylitis

Author

OZGOCMEN, SALIH, primary, ARDICOGLU, OZGE, additional, KAMANLI, AYHAN, additional, KAYA, ARZU, additional, DURMUS, BEKIR, additional, YILDIRIM, KADIR, additional, BAYSAL, OZLEM, additional, GUR, ALI, additional, KARATAY, SALIHA, additional, ALTAY, ZUHAL, additional, CEVIK, REMZI, additional, ERDAL, AKIN, additional, ERSOY, YUKSEL, additional, SARAC, AYSEGUL J., additional, TEKEOGLU, IBRAHIM, additional, UGUR, MAHIR, additional, NAS, KEMAL, additional, SENEL, KAZIM, additional, and ULUSOY, HASAN, additional

Published
2009
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37. The relationship between functional disability and depression in patients with rheumatoid arthritis and ankylosing spondylitis.

Author

Karatay, Saliha, Melikoglu, Meltem alkan, and Senel, Kazim

Subjects
MENTAL depression, RHEUMATOID arthritis, ANKYLOSING spondylitis, DISABILITIES, PATIENTS
Abstract

This study was performed to investigate the relationship between functional disability and depression in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Twenty-three patients with RA, twenty-seven patients with AS and thirty-five healthy individuals were included. Morning stiffness duration, patient's pain evaluation, Stanford health assessment questionnaire (HAQ), Beck depression inventory (BDI), serum C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated in the RA group. Also, morning stiffness duration, pain levels, Bath ankylosing spondylitis functional index (BASFI), BDI, CRP and ESR levels were measured in the AS group. Significant positive correlations between BDI scores and age, disease duration, pain and HAQ scores were found in the RA group (p < 0.01, p < 0.05, p < 0.05, p < 0.001, respectively). Also, there were similar correlations between BDI scores and disease duration, pain and BASFI scores in the AS group (p < 0.05, p < 0.05, p < 0.001, respectively). In conclusion, depression is associated with chronic inflammatory disorders such as RA and AS. In addition, the degree of functional disability may play an important role on depression of these patients. [ABSTRACT FROM AUTHOR]

Published
2004
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38. Spastic paraparesis and sensorineural hearing loss in a patient with neurobrucellosis.

Author

Baykal, Tuba, Baygutalp, Fatih, Senel, Kazim, Levent, Akin, Erdal, Akin, Ugur, Mahir, and Ozgocmen, Salih

Subjects
DIAGNOSIS of brucellosis, CEREBROSPINAL fluid examination, METHYLPREDNISOLONE, ANTIBIOTICS, CYTOLOGICAL techniques, SENSORINEURAL hearing loss, ENZYME-linked immunosorbent assay, MAGNETIC resonance imaging, PERIPHERAL neuropathy, NEUROPHYSIOLOGY, REHABILITATION, LUMBAR puncture, SPLEEN diseases, STAINS & staining (Microscopy), NEUROMUSCULAR system, CONTRAST media, HEPATOMEGALY, THERAPEUTICS
Abstract

Objective: Brucellosis is a zoonotic disease and still a major public health problem in many geographic areas including Mediterranean basin and Middle East. Brucellosis causes multisystemic involvement and although rare central nervous system involvement causes serious manifestations. Neurobrucellosis occurs less than 5% of patients and presents with meningitis, encephalitis, myelitis, myelopathy, stroke, paraplegia, radiculoneuritis, intracerebral abscess, epidural abscess, demyelination and cranial nerve involvement or any combination of these manifestations. Spastic paraparesis and the sensorineural involvement are rarely reported in the literature. Methods: Herein we present a 28 years-old man with spastic paraparesis and sensorineural hearing loss due to neurobrucellosis. Results: The patient was treated with antibiotics combination for 6 months and underwent rehabilitation program. Conclusions: Neurobrucellosis should be ruled out in patients with unexplained neurological symptoms and/or sensorineural hearing loss particularly in those living in endemic areas. [ABSTRACT FROM AUTHOR]

Published
2012

39. A CANDIDATE INDENTIFICATION QUESTIONNAIRE FOR PATIENTS WITH POSTMENOPAUSAL OSTEOPOROSIS SWITCHED FROM TREATMENT WITH A DIALY OR WEEKLY BISHPOSPHONATE TO ONCE-MONTHLY IBANDRONATE-BONCURE: RESULTS OF TURKISH SUB-STUDY

Author

Eskiyurt, Nurten, Sendur, Omer Faruk, Yalcin, Peyman, Oncel, Sema, Saridogan, Merih, Sarpel, Tunay, Tosun, Mehmet, Kutsal, Yesim Gokce, Senel, Kazim, Gursoy, Savas, Canturk, Ferhan, Irdesel, Jale, Demir, Huseyin, Ozdener, Fatih, Oncel, Hakan, Serpici, Vesile, Ugurlu, Hatice, Kirazli, Yesim, Fusun ARDIC, Butun, Bulent, Akyuz, Gulseren, and Cerrahoglu, Lale

42. Prevalence of Rheumatoid Arthritis and Spondyloarthritis in Turkey: A Nationwide Study

Author

Tuncer, Tiraje, Uğurlu, Hatice, Kaçar, Cahit, Kurtaiş, Yeşim, Kutlay, Şehim, Bütün, Bülent, Yalçın, Peyman, Akarırmak, Ülkü, Altan, Lale, Ardıç, Füsun, Ardıçoğlu, Özge, Altay, Zuhal, Cantürk, Ferhan, Cerrahoğlu, Lale, Çevik, Remzi, Demir, Hüseyin, Durmaz, Berrin, Dursun, Nigar, Duruöz, Tuncay, Erdoğan, Canan, Evcik, Deniz, Gürsoy, Savaş, Hizmetli, Sami, Kaptanoğlu, Ece, Kayhan, Önder, Kırnap, Mehmet, Kokino, Siranuş, Kozanoğlu, Erkan, Kuran, Banu, Nas, Kemal, Öncel, Sema, Sindel, Dilşad, Orkun, Sevim, Sarpel, Tunay, Savaş, Serpil, Şendur, Ömer Faruk, Şenel, Kazım, Uzunca, Kaan, Tekeoğlu, İbrahim, Guillemin, Francis, Gilgil, Erdal, [Tuncer, Tiraje -- Kacar, Cahit -- Butun, Bulent] Akdeniz Univ, Sch Med, Div Rheumatol, Dept Phys Med & Rehabil, Antalya, Turkey -- [Kurtais, Yesim -- Kutlay, Sehim -- Yalcin, Peyman] Ankara Univ, Sch Med, Dept Phys Med & Rehabil, Ankara, Turkey -- [Akarirmak, Ulku] Istanbul Univ, Sch Cerrahpasa Med, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Altan, Lale] Uludag Univ, Sch Med, Dept Phys Med & Rehabil, Bursa, Turkey -- [Ardic, Fusun] Pamukkale Univ, Sch Med, Dept Phys Med & Rehabil, Denizli, Turkey -- [Ardicoglu, Ozge] Yildirim Beyazit Univ, Sch Med, Div Rheumatol, Dept Phys Med & Rehabil, Ankara, Turkey -- [Altay, Zuhal] Inonu Univ, Sch Med, Dept Phys Med & Rehabil, Malatya, Turkey -- [Canturk, Ferhan] Medilife Hlth Grp, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Cerrahoglu, Lale] Celal Bayar Univ, Sch Med, Dept Phys Med & Rehabil, Manisa, Turkey -- [Cevik, Remzi] Dicle Univ, Sch Med, Dept Phys Med & Rehabil, Diyarbakir, Turkey -- [Demir, Huseyin -- Kirnap, Mehmet] Erciyes Univ, Sch Med, Dept Phys Med & Rehabil, Kayseri, Turkey -- [Durmaz, Berrin] Ege Univ, Sch Med, Dept Phys Med & Rehabil, Izmir, Turkey -- [Dursun, Nigar] Kocaeli Univ, Sch Med, Dept Phys Med & Rehabil, Kocaeli, Turkey -- [Duruoz, Tuncay -- Kayhan, Onder] Marmara Univ, Sch Med, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Erdogan, Canan] Mersin Univ, Sch Med, Dept Phys Med & Rehabil, Mersin, Turkey -- [Evcik, Deniz] Ufuk Univ, Sch Med, Dept Phys Med & Rehabil, Ankara, Turkey -- [Gursoy, Savas] Gaziantep Univ, Sch Med, Dept Phys Med & Rehabil, Gaziantep, Turkey -- [Hizmetli, Sami -- Kaptanoglu, Ece] Cumhuriyet Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Sivas, Turkey -- [Kokino, Siranus] Trakya Univ, Sch Med, Dept Phys Med & Rehabil, Edirne, Turkey -- [Kozanoglu, Erkan -- Sarpel, Tunay] Cukurova Univ, Sch Med, Dept Phys Med & Rehabil, Adana, Turkey -- [Kuran, Banu] Sisli Etfal Hamidiye Educ & Res Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Nas, Kemal -- Tekeoglu, Ibrahim] Sakarya Univ, Sch Med, Div Rheumatol, Dept Phys Med & Rehabil, Sakarya, Turkey -- [Oncel, Sema] Dokuz Eylul Univ, Sch Med, Dept Phys Med & Rehabil, Izmir, Turkey -- [Sindel, Dilsad] Istanbul Univ, Sch Med, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Orkun, Sevim] Beyazpinar Phys Therapy & Rehabil Ctr, Dept Phys Med & Rehabil, Ankara, Turkey -- [Savas, Serpil] Suleyman Demirel Univ, Sch Med, Dept Phys Med & Rehabil, Isparta, Turkey -- [Sendur, Omer Faruk] Adnan Menderes Univ, Sch Med, Dept Phys Med & Rehabil, Aydin, Turkey -- [Senel, Kazim] Ataturk Univ, Sch Med, Dept Phys Med & Rehabil, Erzurum, Turkey -- [Ugurlu, Hatice] Necmettin Erbakan Univ, Sch Med, Dept Phys Med & Rehabil, Konya, Turkey -- [Uzunca, Kaan] Medikent Hosp, Dept Phys Med & Rehabil, Kirklareli, Turkey -- [Guillemin, Francis] Univ Lorraine, Fac Med, APEMAC, Directeur EA 4360, Nancy, France, Sarpel, Tunay -- 0000-0001-6517-5969, Akdeniz University, Chercheur indépendant, Ankara University, Istanbul University, Uludağ Üniversitesi = Uludag University, Pamukkale University, Ankara Yıldırım Beyazıt University (AYBU), Inönü University, Medilife Health Group, Istanbul, Celal Bayar University School of Medicine, Dicle University, Erciyes University (Erciyes University), Erciyes University, Ege University - EGE (Izmir, Turkey), Kocaeli University [Turkey], Marmara University [Kadıköy - İstanbul], Mersin University, Ufuk University, Gaziantep University, Cumhuriyet University [Sivas, Turkey], Trakya University, Cukurova University, Şişli Etfal Hamidiye Education and Research Hospital, University of Sakarya, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Suleyman Demirel University, Adnan Menderes Üniversitesi, Ataturk University, Necmettin Erbakan University, Meram Medical Faculty, Kirklareli University, Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Şehim Kutlay: 0000-0002-6869-6070, Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Dahili Tıp Bilimleri, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Çukurova Üniversitesi, Sivas Cumhuriyet Üniversitesi, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University, School of Medicine, Antalya, Turkey, Private Rheumatologist, Antalya, Turkey, Department of Physical Medicine and Rehabilitation, Ankara University, School of Medicine, Ankara, Turkey, Department of Physical Medicine and Rehabilitation, Istanbul University, School of Cerrahpaşa Medicine, Istanbul, Turkey, Department of Physical Medicine and Rehabilitation, Uludağ University, School of Medicine, Bursa, Turkey, Department of Physical Medicine and Rehabilitation, Pamukkale University, School of Medicine, Denizli, Turkey, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Yıldırım Beyazıt University, School of Medicine, Ankara, Turkey, Department of Physical Medicine and Rehabilitation, İnönü University, School of Medicine, Malatya, Turkey, Department of Physical Medicine and Rehabilitation, Medilife Health Group, Istanbul, Turkey, Department of Physical Medicine and Rehabilitation, Celal Bayar University, School of Medicine, Manisa, Turkey, Department of Physical Medicine and Rehabilitation, Dicle University, School of Medicine, Diyarbakır, Turkey, Department of Physical Medicine and Rehabilitation, Erciyes University, School of Medicine, Kayseri, Turkey, Department of Physical Medicine and Rehabilitation, Ege University, School of Medicine, Izmir, Turkey, Department of Physical Medicine and Rehabilitation, Kocaeli University, School of Medicine, Kocaeli, Turkey, Department of Physical Medicine and Rehabilitation, Marmara University, School of Medicine, Istanbul, Turkey, Department of Physical Medicine and Rehabilitation, Mersin University, School of Medicine, Mersin, Turkey, Department of Physical Medicine and Rehabilitation, Ufuk University, School of Medicine, Ankara, Turkey, Department of Physical Medicine and Rehabilitation, Gaziantep University, School of Medicine, Gaziantep, Turkey, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Cumhuriyet University, School of Medicine, Sivas, Turkey, Department of Physical Medicine and Rehabilitation, Trakya University, School of Medicine (Deceased), Edirne, Turkey, Department of Physical Medicine and Rehabilitation, Çukurova University, School of Medicine, Adana, Turkey, Department of Physical Medicine and Rehabilitation, Şişli Etfal Hamidiye Education and Research Hospital, Istanbul, Turkey, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Sakarya University, School of Medicine, Sakarya, Turkey, Department of Physical Medicine and Rehabilitation, Dokuz Eylül University, School of Medicine, İzmir, Turkey, Department of Physical Medicine and Rehabilitation, Istanbul University, School of Medicine, Istanbul, Turkey, Department of Physical Medicine and Rehabilitation, Beyazpınar Physical Therapy and Rehabilitation Center, Ankara, Turkey, Department of Physical Medicine and Rehabilitation, Süleyman Demirel University, School of Medicine, Isparta, Turkey, Department of Physical Medicine and Rehabilitation, Adnan Menderes University, School of Medicine, Aydın, Turkey, Department of Physical Medicine and Rehabilitation, Atatürk University, School of Medicine (Deceased), Erzurum, Turkey, Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University, School of Medicine, Konya, Turkey, Department of Physical Medicine and Rehabilitation, Medikent Hospital, Kırklareli, Turkey, University of Lorraine, Faculté de Médecine, EA 4360 APEMAC, Nancy, France, and Ege Üniversitesi

Subjects
musculoskeletal diseases, rheumatoid arthritis, medicine.medical_specialty, Epidemiology, Population, prevalence, Central region, Article, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, male, Internal medicine, Spondyloarthritis, medicine, controlled study, 030212 general & internal medicine, human, education, spondyloarthropathy, low back pain, 030203 arthritis & rheumatology, education.field_of_study, Case detection, business.industry, adult, questionnaire, Mean age, intervertebral disk hernia, spondyloarthritis, medicine.disease, University hospital, major clinical study, osteoporosis, Confidence interval, 3. Good health, stomatognathic diseases, aged, osteoarthritis, spondylosis, female, spondylarthritis, Rheumatoid arthritis, adolescent, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, fibromyalgia, Romatoloji, business
Abstract

WOS: 000435672000003, PubMed ID: 30207568, Objectives: This study aims to estimate the prevalence of rheumatoid arthritis (RA) and spondyloarthritis (SpA) in Turkey using the same telephone questionnaire developed for screening RA and SpA in France and used in Serbia and Lithuania. Material and methods: The study was performed in two steps. In step I, the French questionnaire was translated into Turkish and validated through a group of 200 patients (80 males, 120 females; mean age 44.0 +/- 13.1 years; range, 19 to 75 years) followed up at the rheumatology departments of University Hospitals in Antalya and Ankara. In step II, the validated Turkish questionnaire was administered face-to-face to randomly selected 4,012 subjects (1,670 males, 2,342 females; mean age 41.5 +/- 16.8 years; range, 16 to 97 years) by trained general practitioners across the country, in 25 provinces for case detection. The subjects who were suspected of having RA or SpA in accordance with the questionnaire were invited to the nearest university hospital for rheumatologic examination in order to confirm the diagnosis. Results: In step II, a total of 25 subjects (2 males, 23 females) were diagnosed as RA. The standardized RA prevalence for the general population of Turkey was calculated as 0.56% (95% confidence interval [CI]; 0.33-0.79), 0.10% (95% CI; -0.05-0.25) for males and 0.89% (95% CI; 0.51-1.27) for females. A total of 18 subjects (3 males, 15 females) were diagnosed as SpA. The standardized SpA prevalence for the general population of Turkey was 0.46% (95% CI; 0.25-0.67), 0.17% (95% CI; -0.03-0.37) for males and 0.65% (95% CI; 0.32-0.98) for females. The prevalence of RA was highest in the Northern region (2.00%) and the prevalence of SpA was highest in the Central region (1.49%). Conclusion: The prevalences of RA and SpA in Turkey are close to each other and there are significant inter-regional variations in prevalences of both RA and SpA., Sanofi Health Products Company, Turkey, This survey was supported with an unconditional Grant to Turkish League Against Rheumatism from Sanofi Health Products Company (former Aventis), Turkey. The secretary expenses was covered by EULAR Standing Committee on Epidemiology and Health Services Research.

Published
2018

43. Characteristics of Patients With Rheumatoid Arthritis in Turkey: Results From the Turkish League Against Rheumatism Rheumatoid Arthritis Registry

Author

Bal, Ajda, Ataman, Şebnem, Bodur, Hatice, Rezvani, Aylin, Paker, Nurdan, Taştekin, Nurettin, Göksel, Altınay Karatepe, Borman, Pınar, Yener, Mahmut, Nas, Kemal, Sezgin, Melek, Yazgan, Pelin, Tekeoğlu, İbrahim, Doğu, Beril, Altay, Zuhal, Kırnap, Mehmet, Gürgan, Alev, Gür, Ali, Hizmetli, Sami, Günendi, Zafer, Erdem, Rana, Uğurlu, Hatice, İnal, Elem, Ölmez, Neşe, Kozanoğlu, Erkan, Öken, Öznur, Özel, Sumru, Dündar, Ümit, Akıncı, Ayşen, Öztürk, Cihat, Çapacı, Kazım, Sivrioğlu, Konçuy, Altan, Lale, Duruöz, Mehmet Tuncay, Yağcı, İlker, Aydoğ, Ece, Çapkın, Erhan, Evcik, Deniz, Durmuş, Oğuz, Şendur, Ömer Faruk, Sertpoyraz, Filiz Meryem, Özgül, Ahmet, Şenal, Kazım, Bal, A, Ataman, S, Bodur, H, Rezvani, A, Paker, N, Tastekin, N, Karatepe, AG, Borman, P, Yener, M, Nas, K, Sezgin, M, Yazgan, P, Tekeoglu, I, Dogu, B, Altay, Z, Kirnap, M, Gurgan, A, Gur, A, Hizmetli, S, Gunendi, Z, Erdem, R, Ugurlu, H, Inal, E, Olmez, N, Kozanoglu, E, Oken, O, Ozel, S, Dundar, U, Akinci, A, Ozturk, C, Sivrioglu, K, Duruoz, MT, Aydog, E, Capkin, E, Altan, L, Evcik, D, Durmus, O, Yagci, I, Sendur, OF, Sertpoyraz, FM, Ozgul, A, Senel, K, Capaci, K, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Nas, Kemal, Tekeoğlu, İbrahim, Kırşehir Ahi Evran Üniversitesi, Bal, Ajda, Ataman, Şebnem, Bodur, Hatice, Rezvani, Aylin, Paker, Nurdan, Taştekin, Nurettin, Şenal, Kazım, Yeditepe Üniversitesi, Çukurova Üniversitesi, Ege Üniversitesi, İç Hastalıkları, Kırşehir Ahi Evran Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri, Fiziksel Tıp ve Rehabilitasyon ABD, [Bal, Ajda] Diskapi Traning & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey -- [Ataman, Sebnem] Ankara Univ, Fac Med, Dept Phys Med & Rehabil, TR-06100 Ankara, Turkey -- [Bodur, Hatice] Ankara Numune Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey -- [Rezvani, Aylin] Bezm Alem Valide Sultan Vakif Gureba Training & R, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Paker, Nurdan] Istanbul Phys Med & Rehabil Training & Res Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Tastekin, Nurettin] Trakya Univ, Fac Med, Dept Phys Med & Rehabil, Edirne, Turkey -- [Karatepe, Altinay Goksel] Izmir Bozyaka Training & Res Hosp, Dept Phys Med & Rehabil, Izmir, Turkey -- [Borman, Pinar -- Akinci, Aysen] Hacettepe Univ, Fac Med, Dept Phys Med & Rehabil, TR-06100 Ankara, Turkey -- [Yener, Mahmut] Sleyman Demirel Univ, Fac Med, Dept Phys Med & Rehabil, Isparta, Turkey -- [Nas, Kemal -- Tekeoglu, Ibrahim] Sakarya Univ, Fac Med, Dept Phys Med & Rehabil, Sakarya, Turkey -- [Sezgin, Melek] Mersin Univ, Fac Med, Dept Phys Med & Rehabil, Mersin, Turkey -- [Yazgan, Pelin] Istanbul Bilim Univ, Fac Med, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Dogu, Beril] Sisli Etfal Training & Res Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Altay, Zuhal] Inonu Univ, Fac Med, Dept Phys Med & Rehabil, Malatya, Turkey -- [Kirnap, Mehmet] Erciyes Univ, Fac Med, Dept Phys Med & Rehabil, Kayseri, Turkey -- [Gurgan, Alev -- Olmez, Nese] Ataturk Training & Res Hosp, Dept Phys Med & Rehabil, Izmir, Turkey -- [Gur, Ali] Gaziantep Univ, Fac Med, Dept Phys Med & Rehabil, Gaziantep, Turkey -- [Hizmetli, Sami] Cumhuriyet Univ, Fac Med, Dept Phys Med & Rehabil, Sivas, Turkey -- [Gunendi, Zafer] Gazi Univ, Fac Med, Dept Phys Med & Rehabil, Ankara, Turkey -- [Erdem, Rana] Ahi Evran Univ, Fac Med, Dept Phys Med & Rehabil, Kirsehir, Turkey -- [Ugurlu, Hatice] Necmettin Erbakan Univ, Meram Med Fac, Dept Phys Med & Rehabil, Konya, Turkey -- [Inal, Elem] Istanbul Haydarpasa Numune Training & Res Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Kozanoglu, Erkan] Cukurova Univ, Fac Med, Dept Phys Med & Rehabil, Adana, Turkey -- [Oken, Oznur -- Ozel, Sumru] Ankara Phys Med & Rehabil Training & Res Hosp, Ankara, Turkey -- [Dundar, Umit] Afyon Kocatepe Univ, Fac Med, Dept Phys Med & Rehabil, Afyon, Turkey -- [Ozturk, Cihat -- Capaci, Kazim] Ege Univ, Fac Med, Dept Phys Med & Rehabil, Izmir, Turkey -- [Sivrioglu, Koncuy -- Altan, Lale] Uludag Univ, Fac Med, Dept Phys Med & Rehabil, Bursa, Turkey -- [Duruoz, Mehmet Tuncay -- Yagci, Ilker] Marmara Univ, Fac Med, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Aydog, Ece] Yeditepe Univ, Fac Med, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Capkin, Erhan] Karadeniz Tech Univ, Fac Med, Dept Phys Med & Rehabil, Trabzon, Turkey -- [Evcik, Deniz] Ankara Univ, Vocat Sch Haymana, Dept Phys Med & Rehabil, TR-06100 Ankara, Turkey -- [Durmus, Oguz] GATA Haydarpasa Training Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey -- [Sendur, Omer Faruk] Adnan Menderes Univ, Fac Med, Dept Phys Med & Rehabil, Aydin, Turkey -- [Sertpoyraz, Filiz Meryem] Izmir Tepec Training & Res Hosp, Dept Phys Med & Rehabil, Izmir, Turkey -- [Ozgul, Ahmet] Akay Hosp, Dept Phys Med & Rehabil, Ankara, Turkey -- [Senel, Kazim] Ataturk Univ, Fac Med, Dept Phys Med & Rehabil, Erzurum, Turkey, Duruoz, Mehmet Tuncay -- 0000-0003-3584-2788, Ozgul, Ahmet -- 0000-0001-7901-6504, and Sivas Cumhuriyet Üniversitesi

Subjects
High rate, Academic education, rheumatoid arthritis, medicine.medical_specialty, Patient characteristics, Turkish, business.industry, Mean age, registry, medicine.disease, language.human_language, Disease activity, Rheumatology, Internal medicine, Rheumatoid arthritis, medicine, Physical therapy, language, Functional status, business, Romatoloji, Rheumatism
Abstract

WOS: 000352060500003, Objectives: This study investigates the demographic and clinical characteristics of patients with rheumatoid arthritis (RA) in Turkey, and attempts to identify strategies for the prevention, treatment, and support of RA. Patients and methods: A total of 2,359 patients (1,966 females, 393 males; mean age 51.6 +/- 12.5 years; range 18 to 75 years) with RA from 36 centers across Turkey, who were recorded in the Turkish League Against Rheumatism (TLAR) RA Registry between September 2007 and March 2011, were evaluated. Patients' demographic and clinical data were recorded. Disease activity, functional status, and radiographic damage were measured using the Disease Activity Score 28, the Health Assessment Questionnaire, and van der Heijde modified Sharp scoring method. Results: The mean duration of academic education received was 5.2 +/- 3.8 years, and 74.6% of the patients were homemakers. Non-biological disease-modifying anti-rheumatic drugs were used by 91.0% of the patients, while 10.2% used biological disease-modifying anti-rheumatic drugs. The mean Disease Activity Score 28, Health Assessment Questionnaire, and Sharp scores were 4.0 +/- 1.4, 0.38 +/- 0.37, and 31.2 +/- 57.1, respectively. Of the patients, 17.8% were in remission and 14.1% had low disease activity rates, while 42.7% and 25.5% had moderate and high disease activity rates. Conclusion: The majority of patients with RA in Turkey are middle-aged homemakers. Despite the high rates of disease-modifying anti-rheumatic drugs use, the majority of patients had moderate and high disease activity. These findings indicate that treatment needs of RA patients are not met sufficiently., Wyeth/Pfizer Company, The authors express their gratitude to all members of TLAR RA Study Group for their cooperation and to Wyeth/Pfizer Company for the sponsorship.

Published
2015

44. Musculoskeletal Pain in Elderly Patients with Osteoporosis: A Multicenter Study

Author

YAĞCI, İLKER, Gokce Kutsal, Yesim, Ozdemir, Oya, Karahan, Sevilay, Akyol, Yesim, Borman, Pinar, Dogan, Asuman, Eyigor, Sibel, Guzel, Rengin, Ortancil, Ozgur, Savas, Serpil, Senel, Kazim, Turhanoglu, Ayse Dicle, and Yagci, Ilker

Subjects
musculoskeletal diseases, DISORDERS, Osteoporosis, EPIDEMIOLOGY, pain, BURDEN, elderly, FRACTURE, PREVALENCE
Abstract

Objective: The aim of this study was to identify the ones with osteoporosis (OP) in elderly patients presenting with musculoskeletal complaints and to evaluate the distribution of region of pain and the medications used for the musculoskeletal disease(s) in these patients. Materials and Methods: 1141 elderly patients who were consecutively admitted to the outpatient clinics in nine different provinces were screened for the diagnosis of OR Age, gender, complaints, diagnosis and current medications related to musculoskeletal system disorder(s) were recorded. Results: 382 elderly (341 female, 41 male) with a mean age of 71.9 +/- 5.3 years had the diagnosis of OR Low (54.5%) and upper back (39.6%) pain were the most common complaints in both sexes. These were followed by knee, hip, cervical and shoulder pain, respectively. Osteoarthritis (36%), lumbar (21%) and cervical spondylosis/stenosis (10%) were the most common musculoskeletal diseases accompanying OR The mean number of drugs used was 3.0 +/- 1.2. The most commonly prescribed anti-osteoporotic agents were bisphosphonates (59%). For the musculoskeletal pain, non-steroidal anti-inflammatory drugs (systemic and/or topical) were used in 46.6% and paracetamol in 24.6% of patients. Conclusion: It is crucial to perform a thorough physical examination to reveal the underlying cause of back pain in elderly osteoporotic patients. Besides, in order to minimize polypharmacy, it should be kept in mind that non-pharmacological approaches can be used for the management of musculoskeletal diseases. Turk J Phys Med Rehab 2012;58:263-6.

Published
2012

46. Determination of spondylolisthesis in low back pain by clinical evaluation.

Author

Kalpakcioglu B, Altinbilek T, and Senel K

Subjects
Adult, Aged, Case-Control Studies, Female, Humans, Lordosis diagnostic imaging, Lordosis physiopathology, Lumbar Vertebrae diagnostic imaging, Lumbar Vertebrae physiopathology, Magnetic Resonance Imaging, Male, Middle Aged, Palpation, Reproducibility of Results, Severity of Illness Index, Tomography, X-Ray Computed, Low Back Pain etiology, Spondylolisthesis complications, Spondylolisthesis diagnosis
Abstract

Aim: Current guides recommend to evaluate the patients with low back pain complaints with initial clinical assessment and history, and to utilize radiological or other imaging technics, in case of possible diagnosis. The aim of this study was to compare the findings of radiological and clinical assessment, and validate the reliability of spondylolisthesis diagnosed with clinical assessment. This study is conducted on 100 patients with, and 30 patients without (control group) radiological diagnosis of spondylolisthesis, who had applied to Department of Physical Therapy and Rehabilitation, Haydarpasa Numune Hospital with low back pain complaints in one and a half year. Clinic assessment was consisted of 20 parameters including examinations of motor system such as, sign of slipping observed on palpation and inspection, extension of trunk and increase in lumbar lordosis. Antero-posterior, lateral, oblique and lateral flexion/extension radiographies were used for radiological assessment. Slipping degree and lumbar lordosis angle were measured., Results: Women/men patients ratio was 91/9 in spondylolisthesis group and 22/8 in control group. Age of 69% of patients were 50 and over. In both groups, sciatalgia was observed in more than half of the patients, and no significant difference was detected in localization (p > 0.05). In clinical assessment, weak and drooping abdominal wall, paravertebral muscle hypertrophy, increase in lumbar lordosis, sign of slipping observed on palpation and inspection, hamstring muscle spasm, pain during lateral trunk flexion-extension tasks and during double leg raising task were found to be positively correlated with radiological assesment (p < 0.05)., Conclusion: In our study, a systematic clinical assessment was proved to be useful in determination of possible spondylolisthesis cases. Radiological assessments are required in order to make the diagnosis clear and to determine the grade and prognosis of spondylolisthesis. Advanced imaging techniques like MRI and CT have to be used when neurological symptoms are present, and when surgical intervention is indicated.

Published
2009
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47. The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis.

Author

Kalpakcioglu B and Senel K

Subjects
Catalase metabolism, Glucose-6-Phosphate metabolism, Glutathione Reductase metabolism, Humans, Reactive Oxygen Species immunology, Reactive Oxygen Species metabolism, Superoxide Dismutase metabolism, Arthritis, Rheumatoid enzymology, Arthritis, Rheumatoid physiopathology, Free Radical Scavengers immunology, Oxidative Stress physiology
Abstract

Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis, a systemic autoimmune disease characterized by chronic inflammation of the synovial joints, ultimately leading to joint destruction and permanent disability, affecting 1% of the world population. Oxidative stress in rheumatoid inflammation, due to the fact that antioxidant systems are impaired in RA and caused by fee radicals, might have an essential role in etiology of RA. This review includes the interrelation of antioxidants against free radicals in RA patients. There is much evidence that antioxidant team that covers glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phopshate destroy reactive oxygen species and other free radicals through enzymatic as well as nonenzymatic means. The change in relative levels of antioxidants vis-à-vis free radical formation and level could be used as indicators for effective and earlier diagnosis of RA.

Published
2008
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48. Effects of dynamic exercise on circulating IGF-1 and IGFBP-3 levels in patients with rheumatoid arthritis or ankylosing spondylitis.

Author

Karatay S, Yildirim K, Melikoglu MA, Akcay F, and Senel K

Subjects
Adult, Arthritis, Rheumatoid therapy, C-Reactive Protein biosynthesis, Female, Humans, Male, Models, Statistical, Spondylitis, Ankylosing therapy, Treatment Outcome, Arthritis, Rheumatoid blood, Exercise, Insulin-Like Growth Factor Binding Protein 3 blood, Insulin-Like Growth Factor I biosynthesis, Spondylitis, Ankylosing blood
Abstract

This study was performed to determine the effects of short-term dynamic exercise on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in the patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Patients with RA or AS and healthy controls were recruited. Dynamic treadmill exercise therapy was accomplished for 20 min/session with all of the participants. There were five sessions per week for 2 weeks. Morning stiffness duration, body pain, Stanford health assessment questionnaire, Ritchie articular index, Bath ankylosing spondylitis disease activity index (BASDAI), and Bath ankylosing spondylitis functional index (BASFI) were evaluated in the RA and AS patients. Laboratory assessments included: erythrocyte sedimentation rate, serum C-reactive protein, IGF-1, and IGFBP-3. Clinical and laboratory assessments were recorded at baseline and during exercise treatment on days 7 and 15. Twenty patients with RA, 15 with AS, and 14 healthy controls were included in this study. The pain evaluation, Ritchie, BASDAI, and BASFI scores were significantly improved by the exercise treatment in both patient groups. The important increases were found in circulating IGF-1 in RA (p < 0.001) and AS (p = 0.001) at the end of 2 weeks. In control individuals, serum IGF-1 levels showed a significant decline in the first week (p < 0.05). No significant changes were observed on serum IGFBP-3 levels. Our data suggest that serum IGF-1 levels are increased by the dynamic exercise program in RA and AS patients. The increased IGF-1 may play an important role in the beneficial effects of dynamic exercise therapy in these patients.

Published
2007
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49. Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis.

Author

Yildirim K, Senel K, Karatay S, Sisecioglu M, Kiziltunc A, Ugur M, and Akcay F

Subjects
Adult, Aged, Arthritis, Rheumatoid pathology, C-Reactive Protein metabolism, Case-Control Studies, Female, Humans, Male, Middle Aged, Arthritis, Rheumatoid metabolism, E-Selectin blood, Erythrocyte Membrane enzymology, Sodium-Potassium-Exchanging ATPase metabolism
Abstract

We conducted this study to assess serum soluble E-selectin (sE-selectin) levels and erythrocyte membrane Na(+)K(+) ATPase activity in patients with rheumatoid arthritis (RA) and correlate the levels with disease activity. Levels of sE-selectin were measured in the serum of 20 patients with RA and 20 control subjects by an enzyme-linked immunosorbant assay. Na(+)K(+) ATPase activity was determined by a colorimetric method in RA patients and healthy controls. There were no statistically significant differences between the two groups with respect to demographic data such as age and sex (p > 0.05). The serum levels of sE-selectin, ESR and C-reactive protein (CRP) in RA patients were significantly higher than in healthy controls (p < 0.001). Erythrocyte membrane Na(+)K(+) ATPase activity was significantly lower in the RA group than in the control group (p < 0.001). Correlation analysis revealed significant positive correlations between soluble E-selectin and ESR (r = 0.457; p < 0.05) and CRP (r = 0.682; p < 0.01) levels. There were statistically significant negative correlations between erythrocyte membrane Na(+)K(+) ATPase activity and ESR (r = -0.450; p < 0.05) and CRP (r = -0.446; p < 0.05) levels. Additionally, a significant negative correlations between sE-selectin and Na(+)K(+) ATPase activity was observed (r = -0.80; p < 0.001). These results show that decreases in erythrocyte membrane Na(+)K(+) ATPase activity and increases in sE-selectin are observed in RA, and that increased levels of sE-selectin may also reflect disease status or activity., (Copyright 2004 John Wiley & Sons, Ltd.)

Published
2005
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50. Associations between acute phase reactant levels and disease activity score (DAS28) in patients with rheumatoid arthritis.

Author

Yildirim K, Karatay S, Melikoglu MA, Gureser G, Ugur M, and Senel K

Subjects
Adult, Aged, Arthritis, Rheumatoid physiopathology, Blood Sedimentation, Female, Ferritins blood, Fibrinogen analysis, Haptoglobins analysis, Humans, Male, Middle Aged, Arthritis, Rheumatoid blood, C-Reactive Protein analysis, Health Status, Severity of Illness Index
Abstract

Serum levels of acute phase reactants (APR) were measured in patients with rheumatoid arthritis (RA) and the correlations of these parameters with the disease activity score (DAS28) were investigated. The study included 47 patients with RA and 50 healthy controls. Laboratory tests included erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), haptoglobin (Hp), ferritin, and plasma fibrinogen. Disease activity was assessed using the DAS28 score. The means (+/- SD) of ESR, CRP, Hp, ferritin, and fibrinogen levels were respectively 36.0 +/- 23.5 mm/hr, 2.4 +/- 1.9 mg/dl, 121.3 +/- 34.2 mg/dl, 67.7 +/- 36.2 ng/ml, and 371.2 +/- 96.0 mg/dl in the patients with RA, vs 16.4 +/- 11.3 mm/hr, 0.4 +/- 0.3 mg/dl, 104.0 +/- 35.3 mg/dl, 50.9 +/- 23 ng/ml, and 332.2 +/- 58.5 mg/dl in the controls. All of the APR levels were significantly higher in patients vs controls (p < 0.001 for ESR and CRP; p < 0.05 for Hp, ferritin, and fibrinogen). There were significant correlations between serum APR levels and disease activity based on DAS28 score in RA patients (for CRP, r = 0.650, p <0.01; for Hp, r = 0.331, p < 0.05; for ferritin, r = 0.299, p < 0.05; for fibrinogen, r = 0.373, p < 0.01). This study indicates that serum CRP, among the various ARP tests, is the most useful biochemical marker for evaluating the disease activity of patients with RA.

Published
2004

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