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Abstract The human spleen contracts in response to stress‐induced catecholamine secretion, resulting in a temporary rise in haemoglobin concentration ([Hb]). Recent findings highlighted enhanced splenic response to exercise at high altitude in Sherpa, possibly due to a blunted splenic response to hypoxia. To explore the potential blunted splenic contraction in Sherpas at high altitude, we examined changes in spleen volume during hyperoxic breathing, comparing acclimatized Sherpa with acclimatized individuals of lowland ancestry. Our study included 14 non‐Sherpa (7 female) residing at altitude for a mean continuous duration of 3 months and 46 Sherpa (24 female) with an average of 4 years altitude exposure. Participants underwent a hyperoxic breathing test at altitude (4300 m; barrometric pressure = ∼430 torr; PO2 = ∼90 torr). Throughout the test, we measured spleen volume using ultrasonography and monitored oxygen saturation (SpO2). During rest, Sherpa exhibited larger spleens (226 ± 70 mL) compared to non‐Sherpa (165 ± 34 mL; P

This article presents the newly introduced model for EU policy-making, based on combined ‘bottom-up’ and ‘place-based’ approaches by establishing rural science-society-policy interfaces – Multi-Actor Platforms (MAPs). MAPs are open forums for exchanging relevant ideas in solving region’s most urgent place-based challenges, performing co-learning, and acting as knowledge co-creation platforms for the contribution of creating reflective research and policy agendas for the future of Europe’s rural areas. The main aim of this paper is to explore the challenges and prospects for the determinants of socioeconomic development (i.e., entrepreneurship, social economy, and sustainable and resilient value chains) in rural areas, based on SHERPA science-society-policy interface co-learning and co-creation results in Lithuanian MAP. Research results show that the combined bottom-up and place-based approaches with the help of regional MAPs as science-society-policy rural interfaces hold high potential to be applied to develop reflective research and policy agendas for the regions in the EU.

The human spleen contracts in response to stress‐induced catecholamine secretion, resulting in a temporary rise in haemoglobin concentration ([Hb]). Recent findings highlighted enhanced splenic response to exercise at high altitude in Sherpa, possibly due to a blunted splenic response to hypoxia. To explore the potential blunted splenic contraction in Sherpas at high altitude, we examined changes in spleen volume during hyperoxic breathing, comparing acclimatized Sherpa with acclimatized individuals of lowland ancestry. Our study included 14 non‐Sherpa (7 female) residing at altitude for a mean continuous duration of 3 months and 46 Sherpa (24 female) with an average of 4 years altitude exposure. Participants underwent a hyperoxic breathing test at altitude (4300 m; barrometric pressure = ∼430 torr; PO2${P_{{{\mathrm{O}}_{\mathrm{2}}}}}$ = ∼90 torr). Throughout the test, we measured spleen volume using ultrasonography and monitored oxygen saturation (SpO2${S_{{\mathrm{p}}{{\mathrm{O}}_{\mathrm{2}}}}}$). During rest, Sherpa exhibited larger spleens (226 ± 70 mL) compared to non‐Sherpa (165 ± 34 mL; P < 0.001; effect size (ES) = 0.95, 95% CI: 0.3–1.6). In response to hyperoxia, non‐Sherpa demonstrated 22 ± 12% increase in spleen size (35 ± 17 mL, 95% CI: 20.7–48.9; P < 0.001; ES = 1.8, 95% CI: 0.93–2.66), while spleen size remained unchanged in Sherpa (−2 ± 13 mL, 95% CI: −2.4 to 7.3; P = 0.640; ES = 0.18, 95% CI: −0.10 to 0.47). Our findings suggest that Sherpa and non‐Sherpas of lowland ancestry exhibit distinct variations in spleen volume during hyperoxia at high altitude, potentially indicating two distinct splenic functions. In Sherpa, this phenomenon may signify a diminished splenic response to altitude‐related hypoxia at rest, potentially contributing to enhanced splenic contractions during physical stress. Conversely, non‐Sherpa experienced a transient increase in spleen size during hyperoxia, indicating an active tonic contraction, which may influence early altitude acclimatization in lowlanders by raising [Hb]. What is the central question of this study?Indigenous Sherpa exhibit greater spleen size and enhanced exercise‐induced contraction at high altitude compared to lowlanders: how does spleen size of Sherpa and lowlanders respond to hyperoxic breathing at high altitude?What is the main finding and its importance?Sherpa do not experience any changes in spleen size when subjected to hyperoxic breathing at high altitude, whereas lowlanders show a 20% increase in spleen size under similar conditions. This may represent adaptive traits in Sherpa, potentially enhancing the spleen's capacity for contractions during increased metabolic demands. [ABSTRACT FROM AUTHOR]

Endocrine therapy is the main treatment for hormone receptor-positive (HR+) breast cancer. However, advanced tumors develop resistance to endocrine therapy, rendering it ineffective as the disease progresses. There are several molecular mechanisms of primary and secondary endocrine resistance. Resistance can develop due to either alteration of the estrogen receptor pathway (e.g., ESR1 mutations) or upstream growth factors signaling pathways (e.g., PI3K/Akt/mTOR pathway). Despite progress in the development of molecularly targeted anticancer therapies, the emergence of resistance remains a major limitation and an area of unmet need. In this article, we review the mechanisms of acquired endocrine resistance in HR+ advanced breast cancer and discuss current and future investigational therapeutic approaches. [ABSTRACT FROM AUTHOR]

This memoriam honors Barbara Frances Kelly, our friend and colleague, who passed away on 14 December, 2022. [ABSTRACT FROM AUTHOR]

Abstract Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lowlanders (n = 20) and two Sherpa groups. All Sherpa were born and raised at altitude. One group (ascent Sherpa, n = 11) left altitude and after de‐acclimatization in Kathmandu for ∼7 days re‐ascended with the lowlanders over 8–10 days to 5050 m. The second Sherpa group (non‐ascent Sherpa, n = 12) remained continuously at altitude. Pulmonary artery systolic pressure (PASP) and pulmonary vascular resistance (PVR) were measured while breathing ambient air and following supplemental oxygen. During ascent PASP and PVR increased in lowlanders and ascent Sherpa; however, with supplemental oxygen, lowlanders had significantly greater decrease in PASP (P = 0.02) and PVR (P = 0.02). After ∼14 days at 5050 m, PASP decreased with supplemental oxygen (mean decrease: 3.9 mmHg, 95% CI 2.1–5.7 mmHg, P

Endothelin, high altitude, hypoxia, hypoxic pulmonary vasoconstriction, nitric oxide, reactive oxygen species, Sherpa, vascular remodelling Global alveolar hypoxia leads to sustained vasoconstriction and consequent elevation in pulmonary vascular resistance (PVR) and pulmonary artery pressure (PAP). Keywords: endothelin; high altitude; hypoxia; hypoxic pulmonary vasoconstriction; nitric oxide; reactive oxygen species; Sherpa; vascular remodelling EN endothelin high altitude hypoxia hypoxic pulmonary vasoconstriction nitric oxide reactive oxygen species Sherpa vascular remodelling 1 4 4 01/03/23 20230101 NES 230101 More than 140 million people live above 2,500 m a.s.l. [Extracted from the article]

New Findings: What is the central question of this study?How does hypoxic pulmonary vasoconstriction and the response to supplemental oxygen change over time at high altitude?What is the main finding and its importance?Lowlanders and partially de‐acclimatized Sherpa both demonstrated pulmonary vascular responsiveness to supplemental oxygen that was maintained for 12 days' exposure to progressively increasing altitude. An additional 2 weeks' acclimatization at 5050 m altitude rendered the pulmonary vasculature minimally responsive to oxygen similar to the fully acclimatized non‐ascent Sherpa. Additional hypoxic exposure at that time point did not augment hypoxic pulmonary vasoconstriction. Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lowlanders (n = 20) and two Sherpa groups. All Sherpa were born and raised at altitude. One group (ascent Sherpa, n = 11) left altitude and after de‐acclimatization in Kathmandu for ∼7 days re‐ascended with the lowlanders over 8–10 days to 5050 m. The second Sherpa group (non‐ascent Sherpa, n = 12) remained continuously at altitude. Pulmonary artery systolic pressure (PASP) and pulmonary vascular resistance (PVR) were measured while breathing ambient air and following supplemental oxygen. During ascent PASP and PVR increased in lowlanders and ascent Sherpa; however, with supplemental oxygen, lowlanders had significantly greater decrease in PASP (P = 0.02) and PVR (P = 0.02). After ∼14 days at 5050 m, PASP decreased with supplemental oxygen (mean decrease: 3.9 mmHg, 95% CI 2.1–5.7 mmHg, P < 0.001); however, PVR was unchanged (P = 0.49). In conclusion, PASP and PVR increased with gradual ascent to altitude and decreased via oxygen supplementation in both lowlanders and ascent Sherpa. Following ∼14 days at 5050 m altitude, there was no change in PVR to hypoxia or O2 supplementation in lowlanders or either Sherpa group. These data show that both duration of exposure and residential altitude influence the pulmonary vascular responses to hypoxia. [ABSTRACT FROM AUTHOR]

Engine damage as a consequence of foreign object debris (FOD) during flight is frequently caused by birds. One approach to minimising disruption caused by this damage is to provide flight crew with accurate information relating to the continuing operational status of the aircraft's engines. Before designing such avionic systems however, understanding of current procedures is needed. Hierarchical Task Analysis (HTA) and Systematic Human Error Reduction and Prediction Approach (SHERPA) were used to identify potential failures that flight crew may make when managing an engine bird strike. Workshops with commercial pilots generated insights into current practice and a commercial pilot SME reviewed outputs for accuracy. Over 200 potential failures were identified, most commonly related to communication. Remedial measures, considering future avionic systems, are proposed to mitigate identified failures. This analysis provides a starting point for future design concepts for assisting flight crew in dealing with engine malfunction due to FOD strikes. Practitioner summary: Hierarchical Task Analysis was conducted to show all tasks involved in dealing with an in-flight aircraft engine bird strike. Systematic Human Error Reduction and Prediction Approach analysis was performed and over 200 possible failures were identified when managing this event. Remedial measures are proposed to help mitigate possible failures. [ABSTRACT FROM AUTHOR]

Introduction: In examining the unfortunate events that have taken place in the industrial and health sectors, human error is considered as the main cause of these events. Given the sensitivity and importance of medical careers, the occurrence of errors can lead to irreparable consequences. The purpose of this study was to investigate the human error in the emergency department of Imam Khomeini Hospital in Jiroft. methods: This study was a cross-sectional and descriptive one. Emergency nurses' job duties have been analyzed by interviewing emergency nurses and studying nursing job guidelines and procedures using hierarchical task analysis. Finally, using the Systematic Human Error Reduction and Prediction Approach, human errors in nursing care were analyzed. Results: Generally, 4 tasks, 18 sub-tasks and 91 types of errors related to nursing activities were identified. Number of errors found, 27 (30%) Action errors, 18 (20%) Checking errors, 19 (21%) Retrieval errors, 12 (13%) communication errors, and 15 (16%) selection errors Were. As can be seen, the largest number of errors was related to the type of Action errors. Conclusion: Considering the results of the present study, the highest numbers of errors were related to Action and Checking errors respectively, which due to the sensitivity of nursing jobs and especially in the emergency department, require the use of highly skilled people to perform tasks that require high concentration and accuracy.

Abstract Background Wild edible plants (WEPs) are non-cultivated and non-domesticated plants used for food. WEPs provided food, nutrition, herbs and other plant products for people in underdeveloped areas, such as the Everest region, to maintain their daily lives. Chenthang Town is the only Sherpa ethnic township in Tibet, China. The core purpose of this research is to investigate, collect and record the WEPs and related local knowledge and functions within the Sherpa community. The ultimate goal is to answer the question of why Sherpa people choose these particular plants. Materials and methods The field study was carried out in the six Sherpa communities of Chenthang Township from September 2019 to August 2020. The WEPs and related local knowledge were collected through semistructured interviews and direct observations. The field work was performed with the assistance of local guides. During the field survey, we collected plant specimens based on the principle of one plant with one vernacular name. In this study, we utilised a use report (UR) and cultural importance index (CI) to evaluate the comprehensive utilization value of WEPs in the daily diet of Sherpa people. Results We interviewed 78 people individually who provided us with 1199 use reports. In total, we collected 84 WEPs belonging to 65 genera in 41 families. These species were identified as 78 distinct ethno-species by local people, and the vernacular name of each ethno-species was recorded. Then, these use reports were classified into six use categories. All these plants were native wild plants. In these plants, Arisaema utile, Sorbus cuspidata and Elaeagnus umbellata have been introduced into home gardens by local people. Following the description of the Sherpa people, we articulated a collection calendar for WEPs. The Sherpa collect WEPs throughout nearly the entire year, January and February being the exceptions. Conclusion The collection calendar of wild edible plants reflects the wisdom of the Sherpa in terms of survival. The Sherpa cleverly survive the food shortage periods by harnessing the phenology of different species. In general, WEPs can provide the Sherpa with seasonal carbohydrates, nutrition, healthcare supplements and other products and services necessary for survival, which is likely why the Sherpa choose these plants.

According to recent reports, human errors may cause major systemic disasters at different levels of an organization. Therefore, human reliability assessment is an essential and systematic approach to the analysis and reduction of human errors in industries. The aim of this study is to propose a new approach for analyzing human reliability in order to minimize the defects and shortcomings of conventional methods in this field. The relevant hypotheses of the twelve-step approach indicate that all evaluations are performed at a continuous time and in a varying environment, and all variables are independent of each other. In the proposed approach, a combination of techniques (such as HTA, SHERPA, Markov, etc.) is used for identifying human errors and measuring human reliability. To measure the function of this new approach, a case study between four milling machine operators in workshops of Saipa Automobile Company for six months was considered. Finally, the results show the ease of use and enough clarity of the proposed approach for analysts' use. [ABSTRACT FROM AUTHOR]

To improve the forecasting accuracy of a radiation emulator in a weather prediction model over the Korean peninsula, the learning rate used in neural network training was automatically optimized using the Sherpa. The Sherpa experiment results were compared with two control simulation results using learning rates of 0.0001 and 1 for different batch sizes (full to 500). In the offline evaluation, the Sherpa results showed significant improvements in predicting longwave/shortwave heating rates and fluxes compared to the lowest learning rate results, whereas the improvements compared to the highest learning rate were relatively small because the optimized values by the Sherpa were 0.4756–0.6656. The online evaluation results over one month, which were linked with the weather prediction model, demonstrated the usefulness of Sherpa on a universal performance for the radiation emulator. In particular, at the full batch size, Sherpa contributed to reducing the one-week forecast errors for longwave/shortwave fluxes, skin temperature, and precipitation by 39–125%, 137–159%, and 24–26%, respectively, compared with the two control simulations. Considering the widespread use of parallel learning based on full batch, Sherpa can contribute to producing robust results regardless of batch sizes used in neural network training for developing radiation emulators. [ABSTRACT FROM AUTHOR]

Ascent to high altitude is accompanied by a reduction in partial pressure of inspired oxygen, which leads to interconnected adjustments within the neuromuscular system. This review describes the unique challenge that such an environment poses to neuromuscular fatigability (peripheral, central and supraspinal) for individuals who normally reside near to sea level (SL) (<1000 m; ie, lowlanders) and for native highlanders, who represent the manifestation of high altitude‐related heritable adaptations across millennia. Firstly, the effect of acute exposure to high altitude‐related hypoxia on neuromuscular fatigability will be examined. Under these conditions, both supraspinal and peripheral fatigability are increased compared with SL. The specific mechanisms contributing to impaired performance are dependent on the exercise paradigm and amount of muscle mass involved. Next, the effect of chronic exposure to high altitude (ie, acclimatization of ~7‐28 days) will be considered. With acclimatization, supraspinal fatigability is restored to SL values, regardless of the amount of muscle mass involved, whereas peripheral fatigability remains greater than SL except when exercise involves a small amount of muscle mass (eg, knee extensors). Indeed, when whole‐body exercise is involved, peripheral fatigability is not different to acute high‐altitude exposure, due to competing positive (haematological and muscle metabolic) and negative (respiratory‐mediated) effects of acclimatization on neuromuscular performance. In the final section, we consider evolutionary adaptations of native highlanders (primarily Himalayans of Tibet and Nepal) that may account for their superior performance at altitude and lesser degree of neuromuscular fatigability compared with acclimatized lowlanders, for both single‐joint and whole‐body exercise. [ABSTRACT FROM AUTHOR]

Introduction: Despite widespread efforts to reduce human error in different occupations, unsafe practices and behaviors are still the main cause of many accidents. The occurrence of medical errors in health care systems as one of the most important factors in decreasing the quality of services in this field has received much attention in recent years. Therefore, this study aimed to identify and evaluate all kinds of human error among nurses of Yazd Mother hospital. Materials and Methods: This cross-sectional and descriptive-analytical study was conducted at Yazd Mother hospital in 2019. All nursing duties in gynecology, infertility, emergency, neonatal intensive care, and in vitro fertilization were identified and subdivided using hierarchical task analysis (HTA) and then analyzed using SHERPA method. Results: The highest number of errors was in a gynecology (83), infertility (73), emergency (54), neonatal intensive care (31) and in vitro fertilization, respectively. The highest percentage of errors was related to performance in all sectors. The least frequent error was selection error. Conclusion: The results of this study showed that functional errors account for a large proportion of errors, which should be the priority of control strategies in each segment for these types of errors in order to prevent such errors. The magnitude of the errors identified after the proposed control solutions in all sections indicated the fact that acceptable solutions can be achieved by applying these strategies.

Introduction: The development of residential and industrial areas has led to increasing gas consumption and overcrowding in gas supply networks. Accordingly, hazards and risks caused by human errors, processing and mechanical failures in pipelines, and gas leaks are on a rise. Several techniques have been so far proposed for identifying and controlling human errors. The main purpose of this study was to compare two human error evaluation techniques, namely, Human Error Template (HET) and Systematic Human Error Reduction and Prediction Approach (SHERPA) in gas supply operations using the analytic hierarchy process (AHP) to select a suitable method. Material and Methods: This cross-sectional descriptive study was to identify the human error modes in one of the gas supply projects operating by Kurdistan Gas Company, Kurdistan, Iran. Different tasks in gas supply operations were accordingly determined by the health, safety, and environment (HSE) unit, then the ones susceptible to human errors were selected and analyzed through task analysis technique. The next step was to weight and rank the human errors by evaluating indexes based on many variables including accuracy, sensitivity, and quantity of the errors as well as usability, time, and education analysis using the Expert Choice software (ver. 11). Results: According to the findings of this research, the criteria were ranked based on accuracy (0.339), sensitivity (0.322), quantity of errors (0.118), usability (0.116), time (0.056), education (0.050), and analysis. The inconsistency ratio was also equal to 0.1, which meant that the subjective judgments were accepted. Conclusion: The results also showed that the analysis of human errors, using the HET, required less training and time, while the number of the detected errors and applicability in the SHERPA was greater. Considering the weight of the criteria, their importance in determining the superior technique and the weight of each one in relation to the criteria, the contribution of that method in the relevant criterion was expressed. Calculating the final weight of the techniques revealed that SHERPA with a weight of 0.53 was more practical compared with HET with a weight of 0.46.

Introduction: Cranes are of the major causes of accidents in the construction industries. As human error mostly causes crane accidents, this study aims to investigate the human errors of tower crane operators in the construction projects using SHERPA and CREAM techniques. Material and Method: In this research, first, all of the tasks of the tower crane operator were identified and analyzed. Then, adopting SHERPA technique, probable operator errors were identified in each task and the control modes and error probability were determined by CREAM technique. Finally, all the human errors risks were assessed and the actions for risk control were defined to control them in the acceptable level. Result: According to the SHERPA technique, 148 errors were identified in the crane operator tasks. The human error assessment showed that monitoring the anti-collision system with the risk probability of 0.0003 has the highest control factor, while monitoring the existing guards with the risk probability of 0.056 has the lowest control factor. Also, the important tasks with high human errors were monitoring the guards with the cognitive risk probability of 0.07 and the tasks with cognitive risk probability of 0.05. Conclusion: The findings in this study indicated that using complementary qualitative and quantitative methods can provide identification and prioritization of identified errors. This can help the organization to allocate limited organizational resources to control unacceptable risks and increase the efficiency and effectiveness eventually.

In view of upcoming more stringent air quality limits and the ambition to align with the WHO guidelines, nitrogen dioxide (NO 2) pollution from traffic and other sources will remain a problem in the EU. To assess the impact of traffic measures and emission reductions in other sectors on NO 2 -concentrations, an EU-wide high-resolution NO 2 source apportionment web-application was developed. The application allows users to define scenarios in a user-friendly way and quickly visualize the NO 2 -concentrations at measurement stations and in cities. The user can configure a new Euro 7/VII emission standard and additionally define urban access regulations scenarios in cities. To capture the spatial scales of NO 2 pollution, the SHERPA source-receptor model was used in combination with the QUARK kernel dispersion model. The first model considers long-distance impacts, the latter considers the strong concentration gradients close to roads. This paper focuses on the methodology, a follow-up paper describes the web-application. • We present a method for fast sectoral and spatial NO 2 source apportionment. • The road transport sector is considered in high detail and at 100-m resolution. • The impact of a new vehicle emission standard for NO x can be simulated. • The effect of urban access regulations can be simulated in 948 European cities. • NO 2 concentration effects are visualized at measurement stations and over cities. [ABSTRACT FROM AUTHOR]

In this manuscript we present the SHERPA-Cloud online simplified air quality model, which is an evolution of the previous offline SHERPA model. SHERPA-cloud is a meta-model of a full Chemical Transport Model, and can be used to screen how policies would impact air quality. The main advantages of SHERPA-cloud (in comparison to the previous model version) are its speed (5 time faster than the offline version), its accessibility (permanent online availability) and its easier and more cost-effective maintenance (automatic updates can be shared more easily, and tool developments are facilitated). From the IT infrastructure and technologies points of view, the SHERPA-Cloud is based on an in-house cloud system called BDAP (Big Data Analytic Platform) which provides a 'JupyterLab' service and tools to create dashboards using 'Voilà' technology. SHERPA-Cloud is a useful easy-to-use tool in the hands of policy makers, citizens, NGOs and industries, that allows for interactive and participative policy developments. Indeed, it allows to quickly quantify changes in air quality resulting from the implementation of emission reduction strategies, in terms of both geographical or sectoral policies. • SHERPA-Cloud is an online simplified surrogate model, mimicking a full Air Quality Model. • SHERPA-Cloud replaces the offline version of SHERPA. • The online version is 5 times faster than the offline one, and it is more intuitive and easy-to-use. • Other advantages are accessibility, automatic updates, scalability and cost-effectiveness. • SHERPA-Cloud is fully based on open-source technologies, and is freely available online. [ABSTRACT FROM AUTHOR]

Background: Industrial incidents are one of the major problems of todaychr('39')s societies. Studies in this field show that the main and most important cause of error occurrence is human factor. Therefore, the aim of this study was to identify and evaluate the risk of human error in the activities related to the operation of electrical installations of the Tehran Province Electricity Distribution Company. Methods: This study is a qualitative and cross-sectional research was conducted by direct observation of the activities and documents, interview. Tasks and subtasks were selected and analyzed using Hierarchical task Analysis, (HTA).The results were presented in the form of HTA. Finally, according to the instructions of SHERPA, the relevant worksheet was completed. Results: The analysis of SHERPA worksheets showed that a total of 3399 errors were detected for 759 tasks as 39.57% of them were action errors, 32.4% review type, 7.32% recovery type, 19.64% communication type and 1.80% were selective errors. According to the results of risk assessment, 12.47% of the errors were unacceptable risks level, 59.57% were undesirable, and 20.2% were acceptable risks but need to be revised and the rest, 7.33% acceptable with no need for revision or safe ones. Conclusion: According to the results, the most common type of error was action errors and in order to reduce this type of errors, using necessary corrective measures such as proper selection of people for occupations, training, monitoring, using smart machines, using tag out systems and checking at the suitable time and updating the instructions would be useful and effective countermeasures.

Introduction: in many occupational environments, the occurrence of a human error can lead to a catastrophic incident that human errors are the main cause of accidents, Methods: The current research was conducted to Identification and evaluation of human errors of operator of digger. The main duties and responsibilities of the operator of the cockpit operator were determined based on the HTA (Hierarchy Analysis) method, which included 4 main tasks and 29 s Sub-tasks. Then, the SHERPA method was used to identify the human errors associated with the operator's Sub-tasks. Number of 76 of human error was identified and evaluated. 38 Human error related to Inspection Sub-tasks, 20 cases of Operation section, 12 cases in the reporting section and there were 6 human errors in the Shift shifting section. Results: Based on the results of this study, 12human errors at an unacceptable level, 26 errors at undesirable levels, 34 at acceptable level with revision, and 2 at acceptable level without revision. The results of the research showed that conducting activities such as conversations with mobile phones at the time of controlling the thread in the well, the most important human error is for the operator that high probability of occurrence of this error has led to this priority number of risk. Conclusion: In general, the results of the research showed that the SHERPA technique could be used as an effective and useful way to study human errors in oil industry control rooms such as the drill cabin.

Background: Wild edible plants (WEPs) are non-cultivated and non-domesticated plants used for food. WEPs provided food, nutrition, herbs and other plant products for people in underdeveloped areas, such as the Everest region, to maintain their daily lives. Chenthang Town is the only Sherpa ethnic township in Tibet, China. The core purpose of this research is to investigate, collect and record the WEPs and related local knowledge and functions within the Sherpa community. The ultimate goal is to answer the question of why Sherpa people choose these particular plants. Materials and methods: The field study was carried out in the six Sherpa communities of Chenthang Township from September 2019 to August 2020. The WEPs and related local knowledge were collected through semistructured interviews and direct observations. The field work was performed with the assistance of local guides. During the field survey, we collected plant specimens based on the principle of one plant with one vernacular name. In this study, we utilised a use report (UR) and cultural importance index (CI) to evaluate the comprehensive utilization value of WEPs in the daily diet of Sherpa people. Results: We interviewed 78 people individually who provided us with 1199 use reports. In total, we collected 84 WEPs belonging to 65 genera in 41 families. These species were identified as 78 distinct ethno-species by local people, and the vernacular name of each ethno-species was recorded. Then, these use reports were classified into six use categories. All these plants were native wild plants. In these plants, Arisaema utile, Sorbus cuspidata and Elaeagnus umbellata have been introduced into home gardens by local people. Following the description of the Sherpa people, we articulated a collection calendar for WEPs. The Sherpa collect WEPs throughout nearly the entire year, January and February being the exceptions. Conclusion: The collection calendar of wild edible plants reflects the wisdom of the Sherpa in terms of survival. The Sherpa cleverly survive the food shortage periods by harnessing the phenology of different species. In general, WEPs can provide the Sherpa with seasonal carbohydrates, nutrition, healthcare supplements and other products and services necessary for survival, which is likely why the Sherpa choose these plants. [ABSTRACT FROM AUTHOR]

Technological advancement brings opportunities for enhanced information, support, and functionality within the flight deck. Whilst this has many benefits to the pilot and the overall safety of the aircraft, the practical integration of new technologies needs to be carefully considered throughout the entirety of the design process. The application of Human Factors methods must ensure that new technologies do not expose the system to new failures. This paper compares two methods of generating design recommendations for new technological features; the system human error reduction and prediction approach (SHERPA) and the Design with Intent (DwI) method. The assimilation of the recommendations from both methods presents interesting findings that highlight the benefits of integrating end-users within structured Human Factors methods to generate effective and usable technological interfaces. Case examples showing the similarities and differences between the concepts that the two methods generate are presented. The practicalities in using each approach within a Human Factors-driven design process are also discussed. The findings highlight the importance of end-user engagement in the early phases of the design lifecycle and how this relates to a Human Factors approach to design. [ABSTRACT FROM AUTHOR]

Patients treated with hemodialysis (HD) repeatedly undergo intradialytic low arterial oxygen saturation and low central venous oxygen saturation, reflecting an imbalance between upper body systemic oxygen supply and demand, which are associated with increased mortality. Abnormalities along the entire oxygen cascade, with impaired diffusive and convective oxygen transport, contribute to the reduced tissue oxygen supply. HD treatment impairs pulmonary gas exchange and reduces ventilatory drive, whereas ultrafiltration can reduce tissue perfusion due to a decline in cardiac output. In addition to these factors, capillary rarefaction and reduced mitochondrial efficacy can further affect the balance between cellular oxygen supply and demand. Whereas it has been convincingly demonstrated that a reduced perfusion of heart and brain during HD contributes to organ damage, the significance of systemic hypoxia remains uncertain, although it may contribute to oxidative stress, systemic inflammation, and accelerated senescence. These abnormalities along the oxygen cascade of patients treated with HD appear to be diametrically opposite to the situation in Tibetan highlanders and Sherpa, whose physiology adapted to the inescapable hypobaric hypoxia of their living environment over many generations. Their adaptation includes pulmonary, vascular, and metabolic alterations with enhanced capillary density, nitric oxide production, and mitochondrial efficacy without oxidative stress. Improving the tissue oxygen supply in patients treated with HD depends primarily on preventing hemodynamic instability by increasing dialysis time/frequency or prescribing cool dialysis. Whether dietary or pharmacological interventions, such as the administration of L-arginine, fermented food, nitrate, nuclear factor erythroid 2-related factor 2 agonists, or prolyl hydroxylase 2 inhibitors, improve clinical outcome in patients treated with HD warrants future research. [ABSTRACT FROM AUTHOR]

Key points: Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family, and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction.It is uncertain whether iron regulation is altered in lowlanders during either (1) ascent to high altitude, or (2) following partial acclimatization, when compared to high‐altitude adapted Sherpa.During ascent to 5050 m, the rise in pulmonary artery systolic pressure (PASP) was blunted in Sherpa, compared to lowlanders; however, upon arrival to 5050 m, PASP levels were comparable in both groups, but the reduction in iron bioavailability was more prevalent in lowlanders compared to Sherpa.Following partial acclimatization to 5050 m, there were differential influences of iron status manipulation (via iron infusion or chelation) at rest and during exercise between lowlanders and Sherpa on the pulmonary vasculature. To examine the adaptational role of iron bioavailability on the pulmonary vascular responses to acute and chronic hypobaric hypoxia, the haematological and cardiopulmonary profile of lowlanders and Sherpa were determined during: (1) a 9‐day ascent to 5050 m (20 lowlanders; 12 Sherpa), and (2) following partial acclimatization (11 ± 4 days) to 5050 m (18 lowlanders; 20 Sherpa), where both groups received an i.v. infusion of either iron (iron (iii)‐hydroxide sucrose) or an iron chelator (desferrioxamine). During ascent, there were reductions in iron status in both lowlanders and Sherpa; however, Sherpa appeared to demonstrate a more efficient capacity to mobilize stored iron, compared to lowlanders, when expressed as a Δhepcidin per unit change in either body iron or the soluble transferrin receptor index, between 3400–5050 m (P = 0.016 and P = 0.029, respectively). The rise in pulmonary artery systolic pressure (PASP) was blunted in Sherpa, compared to lowlanders during ascent; however, PASP was comparable in both groups upon arrival to 5050 m. Following partial acclimatization, despite Sherpa demonstrating a blunted hypoxic ventilatory response and greater resting hypoxaemia, they had similar hypoxic pulmonary vasoconstriction when compared to lowlanders at rest. Iron‐infusion attenuated PASP in both groups at rest (P = 0.005), while chelation did not exaggerate PASP in either group at rest or during exaggerated hypoxaemia (PIO2 = 67 mmHg). During exercise at 25% peak wattage, PASP was only consistently elevated in Sherpa, which persisted following both iron infusion or chelation. These findings provide new evidence on the complex interplay of iron regulation on pulmonary vascular regulation during acclimatization and adaptation to high altitude. Key points: Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family, and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction.It is uncertain whether iron regulation is altered in lowlanders during either (1) ascent to high altitude, or (2) following partial acclimatization, when compared to high‐altitude adapted Sherpa.During ascent to 5050 m, the rise in pulmonary artery systolic pressure (PASP) was blunted in Sherpa, compared to lowlanders; however, upon arrival to 5050 m, PASP levels were comparable in both groups, but the reduction in iron bioavailability was more prevalent in lowlanders compared to Sherpa.Following partial acclimatization to 5050 m, there were differential influences of iron status manipulation (via iron infusion or chelation) at rest and during exercise between lowlanders and Sherpa on the pulmonary vasculature. [ABSTRACT FROM AUTHOR]

Mountain ecosystems are considered vulnerable to early impacts of climate change. Whether and how local residents of these areas perceive these changes, however, remain under-studied questions. By conducting a household survey in the Khumbu region of Nepal, this study assessed local residents' experience-based perception of changes in climate trends and patterns, perceived risk, and attitudes towards climate issues. Multivariate cluster analysis based on residents' climate change beliefs revealed three segments: "Cautious," "Disengaged," and "Alarmed." A comparison of these segments along key psychosocial constructs of Protection Motivation Theory (PMT) revealed significant inter-segment differences in residents' perception of severity, vulnerability, response efficacy, self-efficacy, and response cost associated with engaging in mitigating behavior. Results shed light on how residents of high elevation areas that are considered to be exposed to early impacts of climate change perceive the risk and intend to respond. These findings could also assist stakeholders working in other similar mountain ecosystems in understanding vulnerability and in working towards climate readiness. [ABSTRACT FROM AUTHOR]

زمینه و اهداف: در مشاغل حساس، ترتیب انجام مراحل کار از اهمیت بسزایی برخوردار است، به ­طوری که در صورت فراموشی یا عدم انجام آن به هر دلیلی پیامدهای ناگواری به ­همراه خواهد داشت. هدف از این تحقیق، شناسایی و ارزیابی خطای انسانی در مشاغل حساس از دو دیدگاه شناسایی خطای انسانی در یکی از پست­های برق فشار قوی می­باشد. مواد و روش ­ها: این مطالعه توصیفی به­صورت مقطعی با بهره­گیری از دو تکنیک TAFEI وSHERPA ، به شناسایی خطای اپراتور پرداخته است. اطلاعات لازم در این مطالعه از طریق مشاهده مستقیم فعالیت، مصاحبه و بررسی وظایف با استفاده از روش HTA بدست آمد. در نهایت، دو تکنیک به لحاظ شناسایی خطا و حوزه کاربردی مقایسه گردید. در طول مدت مطالعه، کلیه موازین اخلاقی رعایت گردید. یافته ­ها: نتایج جدول ماتریس در وظیفه شغلی مورد نظر با استفاده از روش TAFEI، 29 مورد انتقال غیر قانونی را نشان داد، بنابراین 29 خطای انسانی شناسایی گردید، در حالی که کل خطاها با روش SHERPA، 25 مورد شناسایی گردید. نتیجه ­گیری: نتایج این مطالعه نشان می­دهد که روش TAFEI در شناسایی تعداد خطاهای انسانی، در این حوزه بهتر عمل می­کند و از طرفی، روش SHERPA می­تواند نقاط ضعف روش TAFEIرا پوشش و سطح ریسک ارائه نماید؛ لذا توصیه می­شود، تحلیل‌گر تکنیک­های مختلف HEI موجود را در مطالعه موردی مشابه، برای دستیابی به شناسایی بهتر در نظر بگیرد و روشی را که در جهت برآورده کردن نیازها مناسب می­داند اعمال کند.

The storyline clauses of a narrative push a story forward through time while supportive clauses slow down or stop the temporal movement of a story. This distinction between the functions of event clauses and non-event clauses in narrative discourse has been studied in various languages around the world.This paper applies a textlinguistics approach to discourse to describe the morpho-syntactic and lexico-semanic features that distinguish types of storyline clauses from types of supportive material in five Sherpa personal experience narratives. Once the storyline markers are described, I then compare my results with Schöttelndreyer’s (1978) study of storyline in Sherpa. Based on this comparison, I suggest a reevaluation of Schöttelndreyer’s classification of personal experience narratives. While Schöttelndreyer suggests that there are four personal experience narrative genres each normally characterized by one storyline marker, the analysis presented in this paper leads to the conclusion that the norm is for personal experience narratives to exhibit multiple storyline markers with each marker performing a different evidential or attitudinal function rather than representing a primary indicator of genre.

Background and aims: Human errors have great connection with patientchr('39')s health and safety in clinical centers. Emergency departments of clinical centers can be deeply effected by human errors due to the importance and speciefity of the clinical process. This study was performed for assessment clinical care related human errors with SHERPA approach and its possible connection with nursechr('39')s safety climate. Methods: The study performed on 100 nurses who served in two emergency departments of hospital and also all other departments which the nurses had the major of their experience in emergency department. A standard Safety attitude questionnaire was used for assessment of nursechr('39')s affective criteria on human errors rate. All clinical care processes were investigated for imprinting human errors by SHERPA approach and HTA method. All results were analysed by SPSS software. Results: The results for human error identification and risk assessment by SHERPA approach was depicted for total 10 major processes and 88 major tasks, 610 errors could possibly affect the clinical care program quality and also patients and nurses. Performing drug orders with 148 (24%) was the major emergency departmentchr('39')s process. The major types of identified errors were performance errors with 355 errors (58%). The numbers of checking errors were 129 (21%), the identified errors on communication were 54 (9%), the errors on selection were 49 (8%) and finaly, errors on fixing the problems (recovery errors) were 23 (4%). After determining the number and types of identified errors, risk priority number was calculated with stimation of occurance and severity of each risk. The risults demonstrated that from total identified errors, 144 errors (24%) were unacceptable, 194 errors were undesirable, 178 errors (29%) were minor errors with minimum correction needed and there were 94 errors (15%) with no consequences. The results of safety climate questionnaire showed that communication between nurses in clinical centers depends on age, job duration and gender (P-Value < 0.05). Comunication with physicians also depens on gender and job duration (P-Value < 0.05) and the results for nurses safety climate investigation demonstrated that parametrs such as knowledge and communicating with supervisors have most influence for domination of positive safety climate in clinicals centers and hospitals. Conclusion: Preventing medical errors is a crucial part of ensuring quality patient care. Errors in clinical care and rehabilitation procedures have particular significance in ensuring quality care and patient safety.

User experience is the focus of interaction design, and designing for errors is crucial for improving user experience. One method of designing for errors is to identify human errors and then initiate corrective actions on high‐risk errors to reduce their adverse effects. In this study, we proposed a hybrid approach for risk analysis of human error concerning user experience of interactive systems. In this approach, systematic human error reduction and prediction approach (SHERPA) is first adopted to identify human error concerning user experience. Subsequently, failure mode and effect analysis (FMEA) is used to analyze the risk factors of the error, including occurrence, severity, and detection. Fuzzy technique for order preference by similarity to ideal solution (TOPSIS) is then used to calculate the risk priority number to rank the errors. Finally, corrective actions for high‐risk errors are recommended. An in‐vehicle information system was used to demonstrate the proposed approach. The results indicated that the proposed approach can effectively analyze the risk of human error concerning user experience and be used as a universal reliability approach for improving user experience in interaction design. [ABSTRACT FROM AUTHOR]

Lowland-dwelling populations exhibit persistent sympathetic hyperactivity at altitude that alters vascular function. High-altitude populations, such as Sherpa, have previously exhibited greater peripheral blood flow in response to acute stress than Lowlanders, which may be explained through lower sympathetic activity. Our purpose was to determine whether Sherpa exhibit lower sympathetic reactivity to stress than Lowlanders. Muscle sympathetic nerve activity (MSNA; microneurography) was measured at rest in Lowlanders (n = 14; age = 27 - 6 yr) at 344 m and between 1 and 10 days at 5,050 m. Sherpa (age = 32 ± 11 yr) were tested at 5,050 m (n = 8). Neurovascular reactivity (i.e., change in MSNA patterns) was measured during maximal end-expiratory apnea, isometric hand grip (IHG; 30% maximal voluntary contraction for 2-min), and postexercise circulatory occlusion (PECO; 3 min). Burst frequency (bursts/min) and incidence (bursts/100 heartbeats) and total normalized SNA (arbitrary units/min) were analyzed at rest, immediately before apnea breakpoint, and during the last minute of IHG and PECO. Vascular responses to apnea, IHG, and PECO were also measured. MSNA reactivity to apnea was smaller in Sherpa than Lowlanders at 5,050 m, although blood pressure responses were similar between groups. MSNA increases in Lowlanders during apnea at 5,050 m were significantly lower than at 344 m (P < 0.05), indicating that a possible sympathetic ceiling was reached in Lowlanders at 5,050 m. MSNA increased similarly during IHG and PECO in Lowlanders at both 334 m and 5,050 m and in Sherpa at 5,050 m, while vascular changes (mean brachial arterial pressure, contralateral brachial flow and resistance) were similar between groups. Sherpa demonstrate overall lower sympathetic reactivity that may be a result of heightened vascular responsiveness to potential apneic stress at altitude. [ABSTRACT FROM AUTHOR]

This article explores western big mountain climbing practices in the Himalaya as 'secular' processes of identity formation with historical roots in Victorian efforts at sublimation. Such practices necessitate a series of social, embodied, and psychical distinctions structuring (and structured by) a white, western masculine identity. Looking to news and video documentary narratives by and about the late Swiss mountaineer Ueli Steck, this article works to situate big mountain climbing discourses as relevant to the academic study of religion through the notion of the sublime and its relationship to secularisation (broadly construed). It also situates big mountain climbing discourses in terms of contemporary postcolonial and critical whiteness scholarship on social identity. The notion of the subliminal is both the descriptive goal of many climbing pursuits, and also the means of denying the white masculine identity forged through such processes. Making use of critical social theoretic lenses as offered by both Pierre Bourdieu and Jean-François Bayart, big mountain climbing is shown as a space of white masculine identity formation supported by various appeals to 'sacred/profane' distinctions – both embodied and discursive. Through these distinctions, in big mountain climbing, colonial contact's impact on structural realities makes possible a salient white masculine identity that is forged and disavowed through twin confrontations with the land and the indigenous peoples inhabiting it. [ABSTRACT FROM AUTHOR]