1. Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection
- Author
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Hoffmann, M, Pantazis, N, Martin, GE, Hickling, S, Hurst, J, Meyerowitz, J, Willberg, CB, Robinson, N, Brown, H, Fisher, M, Kinloch, S, Babiker, A, Weber, J, Nwokolo, N, Fox, J, Fidler, S, Phillips, R, Frater, J, and SPARTAC and CHERUB Investigators
- Subjects
Medical Microbiology ,QH301-705.5 ,Virology ,Immunology ,SPARTAC and CHERUB Investigators ,Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,Microbiology - Abstract
The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 infection and associate with immune dysfunction. We evaluated participants (n = 122) recruited to the SPARTAC randomised clinical trial to determine whether CD8 T cell exhaustion markers PD-1, Lag-3 and Tim-3 were associated with immune activation and disease progression. Expression of PD-1, Tim-3, Lag-3 and CD38 on CD8 T cells from the closest pre-therapy time-point to seroconversion was measured by flow cytometry, and correlated with surrogate markers of HIV-1 disease (HIV-1 plasma viral load (pVL) and CD4 T cell count) and the trial endpoint (time to CD4 count
- Published
- 2016