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2. Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?

Author

João C. Setubal, Alberto José da Silva Duarte, Ana Paula Cury, Layla Farage Martins, Carlos Morais, Aline Maria Da Silva, Edson Abdala, Raquel Girardello, and Flavia Rossi

Subjects
0301 basic medicine, Carbapenem, Carbapenem-Susceptible, 030106 microbiology, Bacteremia, Microbial Sensitivity Tests, Drug resistance, Biology, ST156, Microbiology, 03 medical and health sciences, Plasmid, Drug Resistance, Multiple, Bacterial, Ampicillin, medicine, polycyclic compounds, Humans, Cefoxitin, Escherichia coli Infections, Aged, lcsh:R5-920, Escherichia Coli, Polymyxin Resistance, Colistin, Escherichia coli Proteins, General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Virology, Anti-Bacterial Agents, Ciprofloxacin, Carbapenems, bacteria, Female, MCR-1, Colistin Resistance, lcsh:Medicine (General), Brazil, Rapid Communication, Plasmids, medicine.drug
Abstract

OBJECTIVE: We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma. METHODS: Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS. RESULTS: The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6’)Ib-cr and blaTEM1. CONCLUSION: Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible mcr-1 producers, as colistin susceptibility is commonly tested only among carbapenem-resistant isolates.

Published
2017

3. Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?

Author

Flavia Rossi, Raquel Girardello, Carlos Morais, Ana Paula Cury, Layla Farage Martins, Aline Maria da Silva, Edson Abdala, João Carlos Setubal, and Alberto José da Silva Duarte

Subjects
Colistin Resistance, Polymyxin Resistance, Escherichia Coli, Carbapenem-Susceptible, ST156, Medicine (General), R5-920
Abstract

OBJECTIVE: We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma. METHODS: Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS. RESULTS: The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6’)Ib-cr and blaTEM1. CONCLUSION: Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible mcr-1 producers, as colistin susceptibility is commonly tested only among carbapenem-resistant isolates.

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