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The effect of a saline cathartic combined with activated charcoal or activated charcoal alone on aspirin bioavailability was characterized in six healthy volunteers. Using a random, Latin-square design, subjects were given 975 mg aspirin followed by either water alone, 15 Gm activated charcoal (AC), or 15 Gm activated charcoal plus 20 Gm sodium sulfate (AC + SS) separated by one week. Both AC (44.16 ± 16.85 μg/ml) and AC + SS (58.61 ± 10.63 μg/ml) decreased ( P < 0.001) the maximal plasma salicylate concentration ( Cpmax) compared to control (86.61 ± 12.69 μg/ml). Urinary salicylate recovery was decreased ( P < 0.01) for AC (57.88 ± 16.26 per cent) and AC + SS (61.00 ± 11.49 per cent) as compared to control (93.73 ± 6.83 per cent), while for area under the plasma concentration-time curve ( AUC) only AC showed a decrease ( P < 0.01) compared to control. Neither AC nor AC + SS differed from each other for Cpmax, AUC, or cumulative urinary recovery. Our findings indicate that the addition of sodium sulfate to activated charcoal has no added effect on limiting aspirin absorption relative to activated charcoal alone. [ABSTRACT FROM AUTHOR]

Information Resources Useful in Forensic Toxicology. STAFFORD, D. T., AND LOGAN, B. K. (1990). . , 411–419.This paper addresses information resources available to forensic toxicologists. The approach taken here is to discuss those resources found useful in problem solving situations. First, attempt to obtain information from someone familiar with the problem. This is generally the most efficient mechanism to use. The next most efficient mechanism is to search the published literature, electronically using bibliographic databases, if possible. The least efficient method of obtaining information is to go into the laboratory and generate the desired information. In many situations, however, the problem must be solved, or the information confirmed, in the laboratory. Suggested sources of information have been listed in the appendices. These are not intended to be exhaustive, but rather to stimulate and direct the access to information resources. [ABSTRACT FROM PUBLISHER]