1. Synthesis and biological evaluation of thiazole and thiadiazole derivatives as potential anticancer agents
- Author
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Sedanur Ekrek, Sevil Şenkardeş, Ömer Erdoğan, Özge Çevik, and Ekrek S., ŞENKARDEŞ S., ERDOĞAN Ö., ÇEVİK Ö.
- Subjects
STRUCTURAL-CHARACTERIZATION ,1,3,4-THIADIAZOLE ,Kimya (çeşitli) ,Temel Bilimler (SCI) ,INHIBITION ,thiadiazole ,Organik Kimya ,Biochemistry ,Kimya ,Anticancer activity ,Inorganic Chemistry ,thiosemicarbazone ,KİMYA, İNORGANİK VE NÜKLEER ,CHEMISTRY ,HYBRIDS ,Biyokimya ,KİMYA, ORGANİK ,Biyoinorganik Kimya ,İnorganik Kimya ,CHEMISTRY, INORGANIC & NUCLEAR ,Bioinorganic Chemistry ,Temel Bilimler ,Organic Chemistry ,apoptosis ,CHEMISTRY, ORGANIC ,General Chemistry ,CANCER ,Genel Kimya ,Fizik Bilimleri ,Chemistry (miscellaneous) ,BAX ,Natural Sciences (SCI) ,Physical Sciences ,Natural Sciences ,thiazole - Abstract
A new series of 4-methyl-2-{2-[(aryl)methylidene]hydrazinyl}-1,3-thiazole (2a-i), N-(4-acetyl-5-aryl)4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamides (3a-b) and N-(5-(4-(substituted phenyl)-1,3,4-thiadiazol-2-yl)acetamides (3c-i) were synthesized by the reaction of 2-((aryl)methylene)hydrazine-1-carbothioamides (1a-i) and acetic anhydride or chloroacetone. The cytotoxic activities of the products were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against Hela cervical cancer, MCF-7 breast carcinoma and HT-29 colorectal cancer cell lines. Thiazole based compounds 2a, 2b, 2f and 2i, bearing 4-bromothiophen-2-yl, naphthalen-2-yl, 2,5-difluorophenyl and 4-(trifluoromethoxy)phenyl moieties, respectively; also N-(4-acetyl-5-(naphthalen-2-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide (3b) and N-(5-(2,6-difluorophenyl)-1,3,4-thiadiazol-2-yl)acetamide (3d) exhibited significant anticancer activity against three cancer cell lines. Moreover, these active compounds were further evaluated by apoptotic protein levels. The results showed that these thiazole and thiadiazole compounds induced apoptosis of cancer cells.
- Published
- 2022